| Tag | Content |
|---|---|
| Uniprot ID | Q9JJN6 |
| Entrez ID | 67087 |
| Genbank protein ID | BAC29336.1; BAB03457.1; BAB22883.1; BAC33287.1; AAH38253.1; BAB26052.1; |
| Genbank nucleotide ID | NM_001141930.1; NM_023465.4; |
| Ensembl protein ID | ENSMUSP00000030839; ENSMUSP00000101317; |
| Ensembl nucleotide ID | ENSMUSG00000028988 |
| Gene name | Beta-catenin-interacting protein 1 |
| Gene symbol | Ctnnbip1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 15148409 |
| Functional description | Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. |
| Sequence | MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVSS QLSQLPQHSI 60 DQGAEDVVMA FSRSETEDRR Q 81 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CTNNBIP1 | 614630 | Q5E9N2 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | CLSTN1 | 479600 | E2QVY5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | CTNNBIP1 | 102173591 | A0A452FWJ1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CTNNBIP1 | 56998 | Q9NSA3 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ctnnbip1 | 67087 | Q9JJN6 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | CTNNBIP1 | 749394 | H2R3P1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | CTNNBIP1 | A0A287ADI4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Ctnnbip1 | 503000 | Q4KM58 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ctnnbip1 | 58117 | Q9I903 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO:0008013 | beta-catenin binding | ISO |
| GO:0008013 | beta-catenin binding | IPI |
| GO:0008013 | beta-catenin binding | IBA |
| GO:0070016 | armadillo repeat domain binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA |
| GO:0001658 | branching involved in ureteric bud morphogenesis | IMP |
| GO:0002528 | regulation of vascular permeability involved in acute inflammatory response | ISO |
| GO:0009952 | anterior/posterior pattern specification | IMP |
| GO:0016055 | Wnt signaling pathway | IPI |
| GO:0030178 | negative regulation of Wnt signaling pathway | IDA |
| GO:0030178 | negative regulation of Wnt signaling pathway | IBA |
| GO:0031333 | negative regulation of protein-containing complex assembly | IDA |
| GO:0032091 | negative regulation of protein binding | ISO |
| GO:0043392 | negative regulation of DNA binding | IDA |
| GO:0043433 | negative regulation of DNA-binding transcription factor activity | ISO |
| GO:0043433 | negative regulation of DNA-binding transcription factor activity | IDA |
| GO:0045657 | positive regulation of monocyte differentiation | ISO |
| GO:0045669 | positive regulation of osteoblast differentiation | ISO |
| GO:0048662 | negative regulation of smooth muscle cell proliferation | IMP |
| GO:0060633 | negative regulation of transcription initiation from RNA polymerase II promoter | IDA |
| GO:0072201 | negative regulation of mesenchymal cell proliferation | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | TAS |
| GO:0005634 | nucleus | IBA |
| GO:0005737 | cytoplasm | ISO |
| GO:0005737 | cytoplasm | TAS |
| GO:0005829 | cytosol | ISO |
| GO:0005829 | cytosol | IBA |
| GO:0030877 | beta-catenin destruction complex | ISO |
| GO:0030877 | beta-catenin destruction complex | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-195721 | Signaling by WNT | IEA |
| R-MMU-201681 | TCF dependent signaling in response to WNT | IEA |
| R-MMU-3769402 | Deactivation of the beta-catenin transactivating complex | IEA |
| Pfam ID | Pfam Term |
|---|---|
| PF06384 | ICAT |