| Tag | Content |
|---|---|
| Uniprot ID | Q5RJI4; B6F136; Q3UZD3; Q8VBZ6; |
| Entrez ID | 106522 |
| Genbank protein ID | BAE21924.1; BAH66379.1; BAG82823.1; AAH86639.1; AAH22157.1; |
| Genbank nucleotide ID | NM_134117.2; XM_011246234.1; |
| Ensembl protein ID | ENSMUSP00000129238 |
| Ensembl nucleotide ID | ENSMUSG00000024247 |
| Gene name | Extracellular tyrosine-protein kinase PKDCC |
| Gene symbol | Pkdcc |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 19465597; 23792766; 19097194; |
| Functional description | Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). May also have serine/threonine protein kinase activity (PubMed:25171405). Required for longitudinal bone growth through regulation of chondrocyte differentiation (PubMed:19097194, PubMed:23792766). May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (PubMed:19465597). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). |
| Sequence | MRRRRAAVAA GFCASFLLGS VLNVLFAPGS EPPRPGQSPG SSAAPGPGRR GGRGELARQI 60 RERYEEVQRY SRGGPGPGAG RPERRRLMDL APGGPGLQRP RPPRVRSPPD GAPGWPPAPG 120 PGSPGPGPRL GCAALRNVSG AQYVGSGYTK AVYRVRLPGG AAVALKAVDF SGHDLGSCVR 180 EFGARRGCYR LAAHKLLKEM VLLERLRHPN VLQLYGYCYQ DSEGIPDTLT TITELGAPVE 240 MIQLLQTSWE DRFRICLSLG RLLHHLAHSP LGSVTLLDFR PRQFVLVNGE LKVTDLDDAR 300 VEETPCTSSA DCTLEFPARN FSLPCSAQGW CEGMNEKRNL YNAYRFFFTY LLPHSAPPSL 360 RPLLDSIVNA TGELAWGVDE TLAQLETALH LFRSGQYLQN STSSRAEYQR IPDSAITQED 420 YRCWPSYHHG GCLLSVFNLA EAIDVCESHA QCRAFVVTNQ TTWTGRKLVF FKTGWNQVVP 480 DAGKTTYVKA PG 492 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PKDCC | 102177986 | A0A452E7H5 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PKDCC | 91461 | Q504Y2 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pkdcc | 106522 | Q5RJI4 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PKDCC | H2QHT1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | PKDCC | F1S4U8 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | pkdcca | F1QBU5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004672 | protein kinase activity | IDA |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | ISO |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | IDA |
| GO:0005524 | ATP binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001501 | skeletal system development | IMP |
| GO:0015031 | protein transport | IEA |
| GO:0018108 | peptidyl-tyrosine phosphorylation | ISO |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IDA |
| GO:0030154 | cell differentiation | IEA |
| GO:0030282 | bone mineralization | IMP |
| GO:0030501 | positive regulation of bone mineralization | IMP |
| GO:0032332 | positive regulation of chondrocyte differentiation | IMP |
| GO:0035108 | limb morphogenesis | IMP |
| GO:0035264 | multicellular organism growth | IMP |
| GO:0042997 | negative regulation of Golgi to plasma membrane protein transport | IDA |
| GO:0048286 | lung alveolus development | IMP |
| GO:0048566 | embryonic digestive tract development | IMP |
| GO:0060021 | roof of mouth development | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005576 | extracellular region | ISO |
| GO:0005576 | extracellular region | IDA |
| GO:0005794 | Golgi apparatus | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|
| Keyword ID | Keyword Term |
|---|---|
| KW-0025 | Alternative splicing |
| KW-0067 | ATP-binding |
| KW-0217 | Developmental protein |
| KW-0221 | Differentiation |
| KW-0325 | Glycoprotein |
| KW-0333 | Golgi apparatus |
| KW-0418 | Kinase |
| KW-0547 | Nucleotide-binding |
| KW-0892 | Osteogenesis |
| KW-0597 | Phosphoprotein |
| KW-0653 | Protein transport |
| KW-1185 | Reference proteome |
| KW-0964 | Secreted |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0813 | Transport |
| KW-0829 | Tyrosine-protein kinase |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50011 | PROTEIN_KINASE_DOM |
| Pfam ID | Pfam Term |
|---|---|
| PF12260 | PIP49_C |