| Tag | Content |
|---|---|
| Uniprot ID | Q8BFU0; Q7TPX3; |
| Entrez ID | 239405 |
| Genbank protein ID | BAC33974.1; BAC39893.1; |
| Genbank nucleotide ID | XM_006520905.1; NM_172815.3; |
| Ensembl protein ID | ENSMUSP00000154600; ENSMUSP00000067325; |
| Ensembl nucleotide ID | ENSMUSG00000051920 |
| Gene name | R-spondin-2 |
| Gene symbol | Rspo2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO,CLP |
| Developmental stage | E14.5, E15.5 |
| Data sources | Manually collected |
| Reference | 17904116; 12782276; 21237142; 19233133; |
| Functional description | Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors (PubMed:21693646). During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (By similarity). |
| Sequence | MRFCLFSFAL IILNCMDYSQ CQGNRWRRNK RASYVSNPIC KGCLSCSKDN GCSRCQQKLF 60 FFLRREGMRQ YGECLHSCPS GYYGHRAPDM NRCARCRIEN CDSCFSKDFC TKCKVGFYLH 120 RGRCFDECPD GFAPLDETME CVEGCEVGHW SEWGTCSRNN RTCGFKWGLE TRTRQIVKKP 180 AKDTIPCPTI AESRRCKMAM RHCPGGKRTP KAKEKRNKKK RRKLIERAQE QHSVFLATDR 240 VNQ 243 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RSPO2 | 482004 | F1P932 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | RSPO2 | 100860771 | A0A452FDY5 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RSPO2 | 100056523 | A8C9U1 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | RSPO2 | 340419 | Q6UXX9 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Rspo2 | 239405 | Q8BFU0 | CPO,CLP | E14.5, E15.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | RSPO2 | 464335 | A0A2I3RH49 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | RSPO2 | A0A5G2RDB4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Rspo2 | 500863 | I7GAZ6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | rspo2 | 566054 | F1Q5C9 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005102 | signaling receptor binding | ISO |
| GO:0008201 | heparin binding | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001649 | osteoblast differentiation | IGI |
| GO:0016055 | Wnt signaling pathway | IEA |
| GO:0030177 | positive regulation of Wnt signaling pathway | ISO |
| GO:0030282 | bone mineralization | IGI |
| GO:0035115 | embryonic forelimb morphogenesis | IGI |
| GO:0035115 | embryonic forelimb morphogenesis | IMP |
| GO:0035116 | embryonic hindlimb morphogenesis | IGI |
| GO:0035116 | embryonic hindlimb morphogenesis | IMP |
| GO:0042489 | negative regulation of odontogenesis of dentin-containing tooth | IMP |
| GO:0060173 | limb development | ISO |
| GO:0060437 | lung growth | IMP |
| GO:0060441 | epithelial tube branching involved in lung morphogenesis | IMP |
| GO:0060535 | trachea cartilage morphogenesis | IGI |
| GO:0071542 | dopaminergic neuron differentiation | IMP |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | IDA |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | IGI |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005576 | extracellular region | IDA |
| GO:0009986 | cell surface | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-195721 | Signaling by WNT | IEA |
| R-MMU-201681 | TCF dependent signaling in response to WNT | IEA |
| R-MMU-4641263 | Regulation of FZD by ubiquitination | IEA |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50092 | TSP1 |
| Pfam ID | Pfam Term |
|---|---|
| PF15913 | Furin-like_2 |