| Tag | Content |
|---|---|
| Uniprot ID | Q8K0G8; Q8CEK2; |
| Entrez ID | 77411 |
| Genbank protein ID | AAH31444.1; BAC25635.1; |
| Genbank nucleotide ID | NM_176838.2 |
| Ensembl protein ID | ENSMUSP00000111639 |
| Ensembl nucleotide ID | ENSMUSG00000084128 |
| Gene name | Epithelial splicing regulatory protein 2 |
| Gene symbol | Esrp2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CLP |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 26371508 |
| Functional description | mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). |
| Sequence | MTPPPPPPPP PGPDPAVDSA TDPCPEPQSL VVLFGATAGA LGPDLGSDET DLILLVWQVV 60 EPRSRQVGTL HKSLVRAEAA ALSPQCREAS GLSADSLARA ESLDKVLQQF SQLVSGDVAL 120 LGGGPYVLCT DGQQLLRQVL HPEASRKNLV LPDTFFSFYD LRREFHMQHP STCSARDLTV 180 GTMAQDLGLE TDATEDDFGV WEVKTMVAVI LHLLEGSNGQ LFSKPEVVKQ KYETGPCSKA 240 DVVDNETVVR ARGLPWQSSD QDVARFFKGL NIARGGVALC LNAQGRRNGE ALIRFVDSEQ 300 RDLALQRHKH HMGVRYIEVY KATGEEFVKI AGGTSLEVAR FLSREDQVIL RLRGLPFSAG 360 PTDVLGFLGP ECPVTGGADG LLFVRHPDGR PTGDAFALFA CEELAQAALR RHKGMLGKRY 420 IELFRSTAAE VQQVLNRYAA SPLLPTLTAP LLPIPFPLAG GTGRDCVRLR GLPYTATIED 480 ILSFLGEAAA DIRPHGVHMV LNQQGRPSGD AFIQMMSVER ALAAAQRCHK KMMKERYVEV 540 VPCSTEEMSR VLMGGSLSRS GLSPPPCKLP CLSPPTYATF QATPALIPTE TTALYPSSAL 600 LPAARVPAAA TPLAYYPGPA TQLYMNYTAY YPSPPVSPTT VGYLTTPPTA LASTPTTMLS 660 QPGALVRMQG VPYTAGMKDL LSVFQAYQLA PDDYTTLMPV GDPPRTVLQA PKEWVCL 717 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ESRP2 | 489745 | F1PA85 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ESRP2 | 102181230 | A0A452FYS9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ESRP2 | 80004 | Q9H6T0 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Esrp2 | 77411 | Q8K0G8 | CLP | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ESRP2 | A0A2I3SHP8 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | ESRP2 | 100355035 | G1SF15 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Esrp2 | 307810 | G3V8M2 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003729 | mRNA binding | ISS |
| GO:0003729 | mRNA binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000380 | alternative mRNA splicing, via spliceosome | IGI |
| GO:0043484 | regulation of RNA splicing | ISS |
| GO:0043484 | regulation of RNA splicing | ISO |
| GO:0050679 | positive regulation of epithelial cell proliferation | IGI |
| GO:0060441 | epithelial tube branching involved in lung morphogenesis | IGI |
| GO:0060445 | branching involved in salivary gland morphogenesis | IGI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | ISS |
| GO:0005634 | nucleus | ISO |
| GO:0005654 | nucleoplasm | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-190236 | Signaling by FGFR | IEA |
| R-MMU-5654738 | Signaling by FGFR2 | IEA |
| R-MMU-6803529 | FGFR2 alternative splicing | IEA |
| R-MMU-9006934 | Signaling by Receptor Tyrosine Kinases | IEA |