| Tag | Content |
|---|---|
| Uniprot ID | Q9JII1; Q3TCC9; |
| Entrez ID | 64436 |
| Genbank protein ID | AAF86957.1; BAC37823.1; BAE42028.1; BAE32374.1; AAH80295.1; AAH52717.1; |
| Genbank nucleotide ID | NM_001290437.1; NM_033134.3; |
| Ensembl protein ID | ENSMUSP00000119485 |
| Ensembl nucleotide ID | ENSMUSG00000026925 |
| Gene name | Phosphatidylinositol polyphosphate 5-phosphatase type IV |
| Gene symbol | Inpp5e |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 19668215 |
| Functional description | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Specific for lipid substrates, inactive towards water soluble inositol phosphates. Specific for lipid substrates, inactive towards water soluble inositol phosphates (By similarity) (PubMed:10806194). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (PubMed:19668215). |
| Sequence | MPSKSACLRH TEAPGQLEGR MLQGQPPNTE KKLIPTPGFL PASDSQGSET NPMPPFSIPA 60 KTSNQNPQTK ANLITPQPPI RPKLERTLSL DDKGWRRRRF RGSQEDLTVQ NGASPCRGSL 120 QDSVAQSPAY SRPLPCLSTS LQEIPKSRRA TGSEGGSPSL WSDCLSGMIS TSLDLLHRDA 180 ASGGPPSRLA SLHASHTPPA MDLSIASSSL RTANKVDPEH TDYKLRMQTR LVRAHSNLGP 240 SRPRSPLAGD DHSIHSARSF SLLAPIRTKD IRSRSYLEGS LLASGALLGA EELARYFPDR 300 NMALFVATWN MQGQKELPAS LDEFLLPTEA DYTQDLYVIG IQEGCSDRRE WETRLQETLG 360 PQYVLLSSAA HGVLYMSLFI RRDLIWFCSE VEYSTVTTRI VSQIKTKGAL GVSFTFFGTS 420 FLFITSHFTS GDGKVAERLL DYSRTIQALA LPRNVPDTNP YRSSAGDVTT RFDEVFWFGD 480 FNFRLSGGRV AVEAFLKQKP EVDVLALLQH DQLTREMKKG SIFRGFEEAE IHFLPSYKFD 540 IGKDTYDSTS KQRTPSYTDR VLYKSRHKGD ICPMKYSSCP GIKTSDHRPV YGLFQVKVRP 600 GRDNIPLAAG KFDRELYLIG IKRRISKEIQ RQEALKSQSS SAVCTVS 647 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | INPP5E | 506349 | E1BAU6 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | INPP5E | 102172073 | A0A452DQV4 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | INPP5E | 56623 | Q9NRR6 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Inpp5e | 64436 | Q9JII1 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | INPP5E | A0A2I3TQ29 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | INPP5E | A0A287AEE9 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Inpp5e | 114089 | Q9WVR1 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004439 | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | IDA |
| GO:0004445 | inositol-polyphosphate 5-phosphatase activity | ISO |
| GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | ISO |
| GO:0106019 | phosphatidylinositol-4,5-bisphosphate phosphatase activity | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling | ISO |
| GO:0017148 | negative regulation of translation | ISO |
| GO:0046488 | phosphatidylinositol metabolic process | IDA |
| GO:0046488 | phosphatidylinositol metabolic process | IMP |
| GO:0046855 | inositol phosphate dephosphorylation | IDA |
| GO:0046856 | phosphatidylinositol dephosphorylation | IDA |
| GO:1903565 | negative regulation of protein localization to cilium | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000139 | Golgi membrane | IDA |
| GO:0001726 | ruffle | ISO |
| GO:0005737 | cytoplasm | ISO |
| GO:0005886 | plasma membrane | ISO |
| GO:0005929 | cilium | IDA |
| GO:0005930 | axoneme | ISO |
| GO:0005930 | axoneme | IDA |
| GO:0032580 | Golgi cisterna membrane | IEA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1430728 | Metabolism | IEA |
| R-MMU-1483255 | PI Metabolism | IEA |
| R-MMU-1483257 | Phospholipid metabolism | IEA |
| R-MMU-1660514 | Synthesis of PIPs at the Golgi membrane | IEA |
| R-MMU-1852241 | Organelle biogenesis and maintenance | IEA |
| R-MMU-556833 | Metabolism of lipids | IEA |
| R-MMU-5617833 | Cilium Assembly | IEA |
| R-MMU-5620920 | Cargo trafficking to the periciliary membrane | IEA |
| R-MMU-5624958 | ARL13B-mediated ciliary trafficking of INPP5E | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-1003 | Cell membrane |
| KW-0966 | Cell projection |
| KW-0969 | Cilium |
| KW-0963 | Cytoplasm |
| KW-0206 | Cytoskeleton |
| KW-0333 | Golgi apparatus |
| KW-0378 | Hydrolase |
| KW-0443 | Lipid metabolism |
| KW-0449 | Lipoprotein |
| KW-0472 | Membrane |
| KW-0488 | Methylation |
| KW-0597 | Phosphoprotein |
| KW-0636 | Prenylation |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| Pfam ID | Pfam Term |
|---|---|
| PF03372 | Exo_endo_phos |