Gene: Inpp5e

Basic information

Tag Content
Uniprot ID Q9WVR1; A0A0G2K6T4;
Entrez ID 114089
Genbank protein ID EDL93496.1; BAA82150.1; EDL93498.1;
Genbank nucleotide ID NM_053632.1; XM_006233667.3;
Ensembl protein ID ENSRNOP00000073935
Ensembl nucleotide ID ENSRNOG00000019039
Gene name Phosphatidylinositol polyphosphate 5-phosphatase type IV
Gene symbol Inpp5e
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate PtdIns (4,5)P2 and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Specific for lipid substrates, inactive towards water soluble inositol phosphates (By similarity) (PubMed:10405344). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity).
Sequence
MPSKSACLRH TEAPGQLEGR MLQGQLSNPE KKLIPTSASL PAADSQSSQT NSMPPLSMPA 60
KPSNQNLQAK ANLITPQPPI RPKLERTLSL DDKGWRRRRF RGSQEDLTVQ NGASPCRGSL 120
QDSVAQSPAY SRPLPCLSTS LQEIPKPRRA TGSEGGSPSL WSDCLSGMIS TSLDLLHREA 180
ASGGPHSRLA SLRATHTPPA MDLNIASSSL RTANKVDPEH TDYKLRMQNR LVRAHSNLGP 240
SRPRSPLAGD DHSIHSARSS FSLLAPIRTK DIRSRSYLEG SLLASGALLG ADELARYFPD 300
RNMALFVATW NMQGQKELPA SLDEFLLPTE ADYTQDLYVI GVQEGCSDRR EWETRLQETL 360
GPQYVLLSSA AHGVLYMSLF IRRDLIWFCS EVEYSTVTTR IVSQIKTKGA LGVSFTFFGT 420
SFLFITSHFT SGDGKVAERL LDYNRTIQAL ALPRNVPDTN PYRSSAGDVT TRFDEVFWFG 480
DFNFRLSGGR VAVEAFLKQD PEVDVLALLQ HDQLTREMKK GSIFKGFEEA EIHFLPSYKF 540
DIGKDTYDST SKQRTPSYTD RVLYKSRHKG DICPMKYSSC PGIKTSDHRP VYGLFRVKVR 600
PGRDNIPLAA GKFDRELYLI GIKRRISKEI QRQEALKSQS SSAVCTVS 648

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologINPP5E506349E1BAU6Bos taurusPredictionMore>>
1:1 orthologINPP5E102172073A0A452DQV4Capra hircusPredictionMore>>
1:1 orthologINPP5E56623Q9NRR6Homo sapiensPredictionMore>>
1:1 orthologInpp5e64436Q9JII1CPOMus musculusPublicationMore>>
1:1 orthologINPP5EA0A2I3TQ29Pan troglodytesPredictionMore>>
1:1 orthologINPP5EA0A287AEE9Sus scrofaPredictionMore>>
1:1 orthologInpp5e114089Q9WVR1Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005930 axoneme
GO:0005929 cilium
GO:0005737 cytoplasm
GO:0032580 Golgi cisterna membrane
GO:0000139 Golgi membrane
GO:0005886 plasma membrane
GO:0001726 ruffle
GO:0004445 inositol-polyphosphate 5-phosphatase activity
GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity
GO:0046855 inositol phosphate dephosphorylation
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:1903565 negative regulation of protein localization to cilium
GO:0017148 negative regulation of translation
GO:0046856 phosphatidylinositol dephosphorylation
GO:0046488 phosphatidylinositol metabolic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1003 Cell membrane
KW-0966 Cell projection
KW-0969 Cilium
KW-0963 Cytoplasm
KW-0206 Cytoskeleton
KW-0333 Golgi apparatus
KW-0378 Hydrolase
KW-0443 Lipid metabolism
KW-0449 Lipoprotein
KW-0472 Membrane
KW-0488 Methylation
KW-0597 Phosphoprotein
KW-0636 Prenylation
KW-1185 Reference proteome
KW-0677 Repeat

Interpro

InterPro ID InterPro Term
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR042478 INPP5E
IPR000300 IPPc

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF03372 Exo_endo_phos