| Tag | Content |
|---|---|
| Uniprot ID | Q9JM00 |
| Entrez ID | 64571 |
| Genbank protein ID | AAF25690.1 |
| Genbank nucleotide ID | NM_022636.1 |
| Ensembl protein ID | ENSRNOP00000011743 |
| Ensembl nucleotide ID | ENSRNOG00000008824 |
| Gene name | Ventral anterior homeobox 1 |
| Gene symbol | Vax1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk (By similarity). |
| Sequence | MFGKTDKMDV RCHSDTEAAR VSKNAHKESR EIKGAEGSLP AAFLKEPQGA FSASGASEDC 60 NKSKSNSSAD PDYCRRILVR DAKGSIREII LPKGLDLDRP KRTRTSFTAE QLYRLEMEFQ 120 RCQYVVGRER TELARQLNLS ETQVKVWFQN RRTKQKKDQG KDSELRSVVS ETAATCSVLR 180 LLEQGRLLSP PGLPALLPPC ATGALGSALR GPSLPALGAG AAAGSAAAAA AAATAPGPAG 240 AASQHPPAVG GAPGPGPAGP GGLHAGAPTA SHGLFSLPVP SLLGSVASRL SSAPLTMAGS 300 LAGNLQELSA RYLSSSAFEP YSRTNNKEGA EKKALD 336 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | VAX1 | 486906 | E2QUC0 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | VAX1 | 102190017 | A0A452DMM9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | VAX1 | 11023 | Q5SQQ9 | CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Vax1 | 22326 | Q2NKI2 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | VAX1 | 740057 | A0A2I3TJG6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | VAX1 | 100157019 | F1S4S0 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Vax1 | 64571 | Q9JM00 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | vax1 | 373870 | A0A0R4I9B5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0031490 | chromatin DNA binding |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding |
| GO:0007411 | axon guidance |
| GO:0007420 | brain development |
| GO:0043010 | camera-type eye development |
| GO:0030154 | cell differentiation |
| GO:0007417 | central nervous system development |
| GO:0007406 | negative regulation of neuroblast proliferation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0007399 | nervous system development |
| GO:0030182 | neuron differentiation |
| GO:0001764 | neuron migration |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| GO:0060021 | roof of mouth development |
| GO:0035914 | skeletal muscle cell differentiation |
| Pfam ID | Pfam Term |
|---|---|
| PF00046 | Homeodomain |