Gene: Vax1

Basic information

Tag Content
Uniprot ID Q9JM00
Entrez ID 64571
Genbank protein ID AAF25690.1
Genbank nucleotide ID NM_022636.1
Ensembl protein ID ENSRNOP00000011743
Ensembl nucleotide ID ENSRNOG00000008824
Gene name Ventral anterior homeobox 1
Gene symbol Vax1
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk (By similarity).
Sequence
MFGKTDKMDV RCHSDTEAAR VSKNAHKESR EIKGAEGSLP AAFLKEPQGA FSASGASEDC 60
NKSKSNSSAD PDYCRRILVR DAKGSIREII LPKGLDLDRP KRTRTSFTAE QLYRLEMEFQ 120
RCQYVVGRER TELARQLNLS ETQVKVWFQN RRTKQKKDQG KDSELRSVVS ETAATCSVLR 180
LLEQGRLLSP PGLPALLPPC ATGALGSALR GPSLPALGAG AAAGSAAAAA AAATAPGPAG 240
AASQHPPAVG GAPGPGPAGP GGLHAGAPTA SHGLFSLPVP SLLGSVASRL SSAPLTMAGS 300
LAGNLQELSA RYLSSSAFEP YSRTNNKEGA EKKALD 336

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologVAX1486906E2QUC0Canis lupus familiarisPredictionMore>>
1:1 orthologVAX1102190017A0A452DMM9Capra hircusPredictionMore>>
1:1 orthologVAX111023Q5SQQ9CL/PHomo sapiensPublicationMore>>
1:1 orthologVax122326Q2NKI2CPOMus musculusPublicationMore>>
1:1 orthologVAX1740057A0A2I3TJG6Pan troglodytesPredictionMore>>
1:1 orthologVAX1100157019F1S4S0Sus scrofaPredictionMore>>
1:1 orthologVax164571Q9JM00Rattus norvegicusPredictionMore>>
1:1 orthologvax1373870A0A0R4I9B5Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005634 nucleus
GO:0031490 chromatin DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0007411 axon guidance
GO:0007420 brain development
GO:0043010 camera-type eye development
GO:0030154 cell differentiation
GO:0007417 central nervous system development
GO:0007406 negative regulation of neuroblast proliferation
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0007399 nervous system development
GO:0030182 neuron differentiation
GO:0001764 neuron migration
GO:0006357 regulation of transcription by RNA polymerase II
GO:0060021 roof of mouth development
GO:0035914 skeletal muscle cell differentiation

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0217 Developmental protein
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0804 Transcription
KW-0805 Transcription regulation

Interpro

InterPro ID InterPro Term
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR000047 HTH_motif
IPR033020 Vax1

PROSITE

PROSITE ID PROSITE Term
PS00027 HOMEOBOX_1
PS50071 HOMEOBOX_2

Pfam

Pfam ID Pfam Term
PF00046 Homeodomain