Gene Page: BCAP31

Summary ?
GeneID10134
SymbolBCAP31
Synonyms6C6-AG|BAP31|CDM|DDCH|DXS1357E
DescriptionB-cell receptor-associated protein 31
ReferenceMIM:300398|HGNC:HGNC:16695|Ensembl:ENSG00000185825|HPRD:02319|Vega:OTTHUMG00000024218
Gene typeprotein-coding
Map locationXq28
Sherlock p-value0.988
Fetal beta-0.763
SupportRNA AND PROTEIN SYNTHESIS
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
THAP110.930.94
DCAKD0.930.92
MED160.920.91
RIC8A0.910.92
GGA10.910.92
E4F10.910.90
SCAP0.910.91
MED220.910.91
ZNF5740.910.91
FPGS0.910.86
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.27-0.72-0.84
MT-CO2-0.71-0.82
AF347015.31-0.71-0.81
AF347015.8-0.70-0.83
AF347015.33-0.70-0.80
MT-CYB-0.68-0.80
AF347015.21-0.67-0.85
AF347015.15-0.66-0.79
AF347015.2-0.64-0.78
AF347015.26-0.64-0.78

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingNASNeurotransmitter (GO term level: 4)-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006955immune responseNAS-
GO:0006915apoptosisIEA-
GO:0006886intracellular protein transportIEA-
GO:0016192vesicle-mediated transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000139Golgi membraneIEA-
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005783endoplasmic reticulumIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneIDA8706661 
GO:0033116ER-Golgi intermediate compartment membraneIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTG1ACT | ACTG | DFNA20 | DFNA26actin, gamma 1-HPRD,BioGRID10958671 
APPAAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2amyloid beta (A4) precursor protein-HPRD,BioGRID12529377 
BCAP29BAP29 | DKFZp686M2086B-cell receptor-associated protein 29-HPRD,BioGRID12886015 
BCAP316C6-AG | BAP31 | CDM | DXS1357EB-cell receptor-associated protein 31-HPRD,BioGRID12886015 
BCL2Bcl-2B-cell CLL/lymphoma 2-HPRD,BioGRID9334338 
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1-HPRD,BioGRID9334338 
CANXCNX | FLJ26570 | IP90 | P90calnexin-HPRD11851433 
CASP1ICE | IL1BC | P45caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)-HPRD,BioGRID9334338 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidase-HPRD,BioGRID9334338 
IGHDFLJ00382 | FLJ46727 | MGC29633immunoglobulin heavy constant delta-HPRD12886015 
MYH10MGC134913 | MGC134914 | NMMHCBmyosin, heavy chain 10, non-muscle-HPRD,BioGRID10958671 
PLP2A4 | A4-LSB | MGC126187proteolipid protein 2 (colonic epithelium-enriched)-HPRD12529377 
PTPLB-protein tyrosine phosphatase-like (proline instead of catalytic arginine), member bBAP31 interacts with PTPLB.BIND15024066 
VAMP2FLJ11460 | SYB2 | VAMP-2vesicle-associated membrane protein 2 (synaptobrevin 2)Reconstituted ComplexBioGRID9396746 
VAMP3CEBvesicle-associated membrane protein 3 (cellubrevin)-HPRD,BioGRID9396746 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 4026All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS 14894All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC EXECUTION PHASE 5437All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP 372227All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362238All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN 206136All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517309All SZGR 2.0 genes in this pathway
POMEROY MEDULLOBLASTOMA DESMOPLASIC VS CLASSIC UP 6238All SZGR 2.0 genes in this pathway
LIN APC TARGETS 7755All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157105All SZGR 2.0 genes in this pathway
KLEIN PRIMARY EFFUSION LYMPHOMA UP 5129All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN 245154All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337230All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555346All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408274All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 5 12678All SZGR 2.0 genes in this pathway
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION UP 6440All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270181All SZGR 2.0 genes in this pathway
WORSCHECH TUMOR REJECTION DN 106All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS DN 14593All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338225All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418282All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408276All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457302All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668419All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G6 UP 6543All SZGR 2.0 genes in this pathway
KESHELAVA MULTIPLE DRUG RESISTANCE 8856All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL IL3RA 96All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS DURATION CORR DN 14690All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658397All SZGR 2.0 genes in this pathway