Gene Page: EHMT2

Summary
GeneID  10919
Symbol  EHMT2
Synonyms  BAT8|C6orf30|DKFZp686H08213|FLJ35547|G9A|KMT1C|NG36|NG36/G9a
Description  euchromatic histone-lysine N-methyltransferase 2
See related  HGNC:14129|MIM:604599|Ensembl:ENSG00000204371|HPRD:06854|
Locus tag  DADB-333F21.8
Gene type  protein-coding
Map location  6p21.31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.033 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RCBTB20.750.76
CBFB0.720.76
CTPS20.710.75
TP53RK0.700.73
ZNF200.700.72
SFRS30.700.78
MAPRE10.690.77
ZNF160.690.75
C10orf1190.690.78
RYK0.690.74
Top 10 negatively co-expressed genes
AF347015.33-0.54-0.75
MT-CO2-0.54-0.75
HLA-F-0.53-0.68
TINAGL1-0.53-0.68
FXYD1-0.53-0.72
AIFM3-0.52-0.66
MT-CYB-0.52-0.73
AF347015.8-0.52-0.73
PTH1R-0.52-0.66
ZNF385A-0.51-0.64
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingNAS8457211 
GO:0016740transferase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0008168methyltransferase activityIEA-
GO:0018024histone-lysine N-methyltransferase activityIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007130synaptonemal complex assemblyIEASynap (GO term level: 11)-
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA-
GO:0000239pachyteneIEA-
GO:0007286spermatid developmentIEA-
GO:0007281germ cell developmentIEA-
GO:0008150biological_processND-
GO:0009566fertilizationIEA-
GO:0016568chromatin modificationIEA-
GO:0035265organ growthIEA-
GO:0051567histone H3-K9 methylationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005575cellular_componentND-
GO:0005634nucleusIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARD1AARD1 | DXS707 | MGC71248 | TE2ARD1 homolog A, N-acetyltransferase (S. cerevisiae)Two-hybridBioGRID16189514 
BAT2LDKFZp781F05101 | DKFZp781K12107 | KIAA0515 | LQFBS-1 | MGC10526HLA-B associated transcript 2-likeAffinity Capture-Western
Two-hybrid		BioGRID16189514 
C10orf12DKFZp564P1916 | FLJ13022chromosome 10 open reading frame 12Two-hybridBioGRID16189514 
CCDC33FLJ23168 | FLJ32855 | MGC34145coiled-coil domain containing 33Two-hybridBioGRID16189514 
E4F1E4F | MGC99614E4F transcription factor 1Two-hybridBioGRID16189514 
H3F3BH3.3B | H3F3AH3 histone, family 3B (H3.3B)Two-hybridBioGRID16189514 
HGSHRS | ZFYVE8hepatocyte growth factor-regulated tyrosine kinase substrateTwo-hybridBioGRID16189514 
KLF12AP-2rep | AP2REP | HSPC122Kruppel-like factor 12Two-hybridBioGRID16189514 
KLF6BCD1 | COPEB | CPBP | DKFZp686N0199 | GBF | PAC1 | ST12 | ZF9Kruppel-like factor 6Two-hybridBioGRID16189514 
LIMS1PINCH | PINCH1LIM and senescent cell antigen-like domains 1Two-hybridBioGRID16189514 
LMO2RBTN2 | RBTNL1 | RHOM2 | TTG2LIM domain only 2 (rhombotin-like 1)Two-hybridBioGRID16189514 
LNX1LNX | MPDZ | PDZRN2ligand of numb-protein X 1Two-hybridBioGRID16189514 
PLOD3LH3procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3Two-hybridBioGRID16189514 
RESTNRSF | XBRRE1-silencing transcription factorNRSF interacts with G9a.BIND15200951 
THAP7MGC10963THAP domain containing 7Two-hybridBioGRID16189514 
XAGE2GAGED3 | XAGE-2X antigen family, member 2Two-hybridBioGRID16189514 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_LYSINE_DEGRADATION 4429All SZGR genes in this pathway
PID_AR_TF_PATHWAY 5338All SZGR genes in this pathway
REACTOME_RNA_POL_I_TRANSCRIPTION 8964All SZGR genes in this pathway
REACTOME_TRANSCRIPTION 210127All SZGR genes in this pathway
REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION 12280All SZGR genes in this pathway
REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION 2514All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 335193All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_DN 180101All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_GREEN_DN 2512All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_UP 456228All SZGR genes in this pathway
KIM_WT1_TARGETS_8HR_DN 12984All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP 293179All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_UP 10869All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_DN 12179All SZGR genes in this pathway
PAL_PRMT5_TARGETS_UP 203135All SZGR genes in this pathway
KIM_GASTRIC_CANCER_CHEMOSENSITIVITY 10364All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_4 307185All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_POOR_SURVIVAL_DN 2215All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
FLOTHO_PEDIATRIC_ALL_THERAPY_RESPONSE_DN 2917All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_UP 207143All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D 882506All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-326177183m8hsa-miR-326CCUCUGGGCCCUUCCUCCAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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