Gene Page: IFI44L

Summary ?
GeneID10964
SymbolIFI44L
SynonymsC1orf29|GS3686
Descriptioninterferon induced protein 44 like
ReferenceMIM:613975|HGNC:HGNC:17817|Ensembl:ENSG00000137959|HPRD:13728|Vega:OTTHUMG00000009724
Gene typeprotein-coding
Map location1p31.1
Pascal p-value0.036
Sherlock p-value0.934
Fetal beta-1.02
DMG1 (# studies)
eGeneCerebellar Hemisphere
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.02692 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg03607951179085586IFI44L5.499E-4-0.7260.049DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2046622chr179610142IFI44L109648.534E-4cis
rs17384589chr165186953IFI44L109640.2trans
rs17092900chr173003409IFI44L109641.892E-5trans
rs2046622chr179610142IFI44L109640.06trans
rs12091025chr1149989802IFI44L109640.1trans
rs11205098chr1152717431IFI44L109640.02trans
rs16857588chr211675145IFI44L109640trans
rs10495652chr217139288IFI44L109640.19trans
rs6531271chr217139932IFI44L109640.19trans
rs12620194chr217148003IFI44L109640.19trans
snp_a-21429220IFI44L109640.16trans
rs1900263chr280376061IFI44L109640trans
rs10496239chr280376968IFI44L109640trans
rs11679783chr280377391IFI44L109640trans
rs17018721chr280385148IFI44L109640.01trans
rs2862022chr280388509IFI44L109640trans
rs17043176chr2114025371IFI44L109640trans
rs10186260chr2129538777IFI44L109640.03trans
rs1318548chr3126771941IFI44L109640.15trans
rs890527chr3140774852IFI44L109640.06trans
rs6789808chr3154492082IFI44L109640.09trans
rs7612673chr3154499328IFI44L109640trans
rs10461085chr430717743IFI44L109640.06trans
rs11942278chr458922687IFI44L109640.19trans
rs4544093chr465754438IFI44L109640.11trans
rs7688236chr486804077IFI44L109640.09trans
rs17009913chr4126440148IFI44L109640.06trans
rs159171chr521186325IFI44L109640.07trans
rs1678893chr531763244IFI44L109643.299E-7trans
snp_a-22745050IFI44L109640.04trans
rs12109985chr5114077013IFI44L109640.18trans
rs4705861chr5131800763IFI44L109640.05trans
rs6871931chr5170255590IFI44L109640.13trans
rs10516136chr5176381368IFI44L109640.15trans
rs13176869chr5179203478IFI44L109641.064E-4trans
rs9396602chr615766500IFI44L109640.2trans
rs6924019chr680536275IFI44L109640.14trans
rs17668963chr684811128IFI44L109640.04trans
rs1080960chr684815420IFI44L109640trans
rs133627530IFI44L109640trans
rs7741955chr684829621IFI44L109648.759E-4trans
rs17186320chr684897846IFI44L109640.19trans
rs6454356chr684917509IFI44L109640.13trans
rs12524136chr684935440IFI44L109643.035E-4trans
rs16883826chr691671158IFI44L109640.04trans
rs7765650chr6145384057IFI44L109640.03trans
rs9397692chr6154487314IFI44L109647.501E-7trans
rs10485060chr6154516100IFI44L109649.857E-6trans
rs9384190chr6154524473IFI44L109641.296E-5trans
rs17292544chr6154544809IFI44L109642.752E-8trans
rs4591922chr721612318IFI44L109640.05trans
rs17171716chr740505332IFI44L109642.602E-5trans
rs2912911chr752874173IFI44L109640.14trans
rs1608900chr764225505IFI44L109640.15trans
rs17160749chr777689922IFI44L109646.179E-4trans
rs3779321chr777691378IFI44L109646.179E-4trans
rs11974883chr778068523IFI44L109642.55E-4trans
rs6586742chr818208340IFI44L109640.06trans
rs12675530chr891155099IFI44L109640.1trans
rs6986838chr891194553IFI44L109640.01trans
rs1355060chr8118717710IFI44L109640.09trans
rs10283729chr92981636IFI44L109640.01trans
rs10816182chr99795184IFI44L109640.11trans
rs201062chr1010985931IFI44L109640.08trans
rs10833134chr1119627526IFI44L109640.13trans
rs10833144chr1119656451IFI44L109641.407E-4trans
rs4753181chr1195661957IFI44L109640.02trans
rs2508654chr11120405519IFI44L109640.14trans
rs2605422chr1259148638IFI44L109640.04trans
rs2645865chr1259151393IFI44L109640.1trans
rs2712516chr1259152364IFI44L109640.04trans
rs11613629chr12104972976IFI44L109640.19trans
rs17040848chr12109070958IFI44L109640.08trans
rs17061055chr1340835399IFI44L109641.949E-6trans
rs17066364chr1345515988IFI44L109641.052E-6trans
rs3783149chr1345582764IFI44L109640.01trans
rs7332969chr1345612902IFI44L109641.052E-6trans
rs11838472chr1373741148IFI44L109640trans
rs7322605chr1373743787IFI44L109640trans
rs10484008chr1489376562IFI44L109640trans
rs10150770chr1495375311IFI44L109640.02trans
rs16955413chr1529677652IFI44L109645.699E-8trans
rs4457950chr1535445709IFI44L109640.01trans
rs16944395chr1561897800IFI44L109640.07trans
rs11071740chr1563595650IFI44L109640.18trans
rs290551chr1563697138IFI44L109640.08trans
rs16969948chr1578864785IFI44L109640.2trans
rs3794689chr1671600536IFI44L109640.15trans
rs16955238chr1681415690IFI44L109646.264E-4trans
rs16955255chr1681420130IFI44L109640trans
rs16955259chr1681420188IFI44L109646.264E-4trans
rs8098388chr1824080746IFI44L109640.03trans
rs8085520chr1840184498IFI44L109640.14trans
rs8105452chr1911854016IFI44L109642.005E-4trans
rs8104298chr1911867512IFI44L109641.208E-5trans
rs16979927chr2055019249IFI44L109644.783E-9trans
rs9625645chr2229318298IFI44L109640.16trans
rs17331284chrX6962964IFI44L109640.02trans
rs17347454chrX23347700IFI44L109645.325E-9trans
rs5952435chrX47321870IFI44L109640.15trans
rs689365chrX97074769IFI44L109647.195E-7trans
rs108561330IFI44L109640trans
rs16995164chrX148536507IFI44L109640.02trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PIK3R30.810.82
TES0.770.62
RASGEF1B0.760.70
VAT10.740.75
ZIC30.730.41
ANUBL10.730.77
GPRIN20.730.70
PCDH170.730.75
FOXP20.720.73
GPR137C0.720.78
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.49-0.76
HLA-F-0.48-0.64
TMEM54-0.48-0.56
MT-CO2-0.47-0.75
AF347015.27-0.47-0.72
FXYD1-0.47-0.74
SLC16A11-0.47-0.60
C5orf53-0.47-0.62
PTH1R-0.46-0.64
TSC22D4-0.46-0.67

Section III. Gene Ontology annotation

Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006955immune responseIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP 182110All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP 15791All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP 194122All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D UP 175108All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP 204140All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION UP 12678All SZGR 2.0 genes in this pathway
MAHADEVAN RESPONSE TO MP470 UP 2011All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER CLUSTER 1 4423All SZGR 2.0 genes in this pathway
EINAV INTERFERON SIGNATURE IN CANCER 2716All SZGR 2.0 genes in this pathway
SEITZ NEOPLASTIC TRANSFORMATION BY 8P DELETION UP 7347All SZGR 2.0 genes in this pathway
LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL DN 11458All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358245All SZGR 2.0 genes in this pathway
SEMBA FHIT TARGETS UP 117All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
RADAEVA RESPONSE TO IFNA1 UP 5240All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG UP 7850All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING UP 8356All SZGR 2.0 genes in this pathway
ROETH TERT TARGETS UP 1411All SZGR 2.0 genes in this pathway
BENNETT SYSTEMIC LUPUS ERYTHEMATOSUS 3121All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246180All SZGR 2.0 genes in this pathway
LIANG SILENCED BY METHYLATION 2 5334All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway
BROWNE INTERFERON RESPONSIVE GENES 6844All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318220All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 12HR UP 11168All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P2 7955All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282183All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299167All SZGR 2.0 genes in this pathway
MOSERLE IFNA RESPONSE 3119All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN 216143All SZGR 2.0 genes in this pathway
ALONSO METASTASIS DN 2617All SZGR 2.0 genes in this pathway
MUELLER COMMON TARGETS OF AML FUSIONS DN 3121All SZGR 2.0 genes in this pathway
LEE SP4 THYMOCYTE 1411All SZGR 2.0 genes in this pathway
YAGI AML WITH T 9 11 TRANSLOCATION 13087All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP 7646All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA2 DN 8051All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445257All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364236All SZGR 2.0 genes in this pathway
BOSCO INTERFERON INDUCED ANTIVIRAL MODULE 7848All SZGR 2.0 genes in this pathway
HECKER IFNB1 TARGETS 9554All SZGR 2.0 genes in this pathway