Gene Page: RIPK3
Summary ?
| GeneID | 11035 |
| Symbol | RIPK3 |
| Synonyms | RIP3 |
| Description | receptor interacting serine/threonine kinase 3 |
| Reference | MIM:605817|HGNC:HGNC:10021|Ensembl:ENSG00000129465|HPRD:09315|Vega:OTTHUMG00000029349 |
| Gene type | protein-coding |
| Map location | 14q11.2 |
| Pascal p-value | 0.364 |
| DEG p-value | DEG:Sanders_2014:DS1_p=-0.142:DS1_beta=0.049300:DS2_p=5.62e-03:DS2_beta=-0.139:DS2_FDR=5.05e-02 |
| Fetal beta | -0.199 |
| DMG | 1 (# studies) |
| eGene | Nucleus accumbens basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DEG:Sanders_2013 | Microarray | Whole-genome gene expression profiles using microarrays on lymphoblastoid cell lines (LCLs) from 413 cases and 446 controls. | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 4 |
| GSMA_I | Genome scan meta-analysis | Psr: 0.047 | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0122 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg13050240 | 14 | 24809068 | RIPK3 | 2.56E-5 | -0.513 | 0.017 | DMG:Wockner_2014 |
| cg13066043 | 14 | 24808987 | RIPK3 | 1.298E-4 | -0.341 | 0.03 | DMG:Wockner_2014 |
| cg20822579 | 14 | 24809073 | RIPK3 | 1.75E-4 | -0.397 | 0.033 | DMG:Wockner_2014 |
| cg11781986 | 14 | 24808787 | RIPK3 | 3.815E-4 | -0.327 | 0.043 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | - | |
| GO:0004704 | NF-kappaB-inducing kinase activity | IEA | - | |
| GO:0003713 | transcription coactivator activity | TAS | 10339433 | |
| GO:0005524 | ATP binding | IEA | - | |
| GO:0004674 | protein serine/threonine kinase activity | IEA | - | |
| GO:0004674 | protein serine/threonine kinase activity | TAS | 10339433 | |
| GO:0016740 | transferase activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006464 | protein modification process | TAS | 10358032 | |
| GO:0006468 | protein amino acid phosphorylation | IEA | - | |
| GO:0007165 | signal transduction | TAS | 10339433 | |
| GO:0006915 | apoptosis | IEA | - | |
| GO:0007249 | I-kappaB kinase/NF-kappaB cascade | IEA | - | |
| GO:0008624 | induction of apoptosis by extracellular signals | TAS | 10339433 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005622 | intracellular | IEA | - | |
| GO:0005737 | cytoplasm | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| AIFM1 | AIF | MGC111425 | PDCD8 | apoptosis-inducing factor, mitochondrion-associated, 1 | - | HPRD | 14743216 |
| ATAD3A | FLJ10709 | ATPase family, AAA domain containing 3A | - | HPRD | 14743216 |
| CAPZB | CAPB | CAPPB | CAPZ | MGC104401 | MGC129749 | MGC129750 | capping protein (actin filament) muscle Z-line, beta | - | HPRD | 14743216 |
| DBN1 | D0S117E | DKFZp434D064 | drebrin 1 | - | HPRD | 14743216 |
| EEF1D | EF-1D | EF1D | FLJ20897 | FP1047 | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | - | HPRD | 14743216 |
| GNG12 | FLJ31352 | FLJ34695 | guanine nucleotide binding protein (G protein), gamma 12 | - | HPRD | 14743216 |
| HNRNPA1 | HNRPA1 | MGC102835 | heterogeneous nuclear ribonucleoprotein A1 | - | HPRD | 14743216 |
| HSPA8 | HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71 | heat shock 70kDa protein 8 | - | HPRD | 14743216 |
| MPRIP | KIAA0864 | M-RIP | RHOIP3 | p116Rip | myosin phosphatase Rho interacting protein | - | HPRD | 14743216 |
| MRCL3 | MLCB | MRLC3 | myosin regulatory light chain MRCL3 | - | HPRD | 14743216 |
| MYL6 | ESMLC | LC17-GI | LC17-NM | LC17A | LC17B | MLC1SM | MLC3NM | MLC3SM | myosin, light chain 6, alkali, smooth muscle and non-muscle | - | HPRD | 14743216 |
| RIPK1 | FLJ39204 | RIP | RIP1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | - | HPRD,BioGRID | 10339433 |
| SCIN | KIAA1905 | scinderin | - | HPRD | 14743216 |
| SPECC1L | KIAA0376 | SPECC1-like | - | HPRD | 14743216 |
| SPTBN1 | ELF | SPTB2 | betaSpII | spectrin, beta, non-erythrocytic 1 | - | HPRD | 14743216 |
| TIAF1 | MAJN | MYO18A | MYSPDZ | SPR210 | TGFB1-induced anti-apoptotic factor 1 | - | HPRD | 14743216 |
| TICAM1 | MGC35334 | PRVTIRB | TICAM-1 | TRIF | toll-like receptor adaptor molecule 1 | - | HPRD,BioGRID | 15064760 |
| TNFRSF1A | CD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60 | tumor necrosis factor receptor superfamily, member 1A | - | HPRD,BioGRID | 10339433 |
| TPM3 | FLJ41118 | MGC14582 | MGC3261 | MGC72094 | NEM1 | OK/SW-cl.5 | TM-5 | TM3 | TM30 | TM30nm | TPMsk3 | TRK | hscp30 | tropomyosin 3 | - | HPRD | 14743216 |
| TRAF2 | MGC:45012 | TRAP | TRAP3 | TNF receptor-associated factor 2 | - | HPRD,BioGRID | 10339433 |
| TUBA3C | TUBA2 | bA408E5.3 | tubulin, alpha 3c | - | HPRD | 14743216 |
| TUBB2B | DKFZp566F223 | FLJ98847 | MGC8685 | TUBB-PARALOG | bA506K6.1 | tubulin, beta 2B | - | HPRD | 14743216 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CYTOSOLIC DNA SENSING PATHWAY | 56 | 44 | All SZGR 2.0 genes in this pathway |
| REACTOME TRIF MEDIATED TLR3 SIGNALING | 74 | 54 | All SZGR 2.0 genes in this pathway |
| REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | 18 | 15 | All SZGR 2.0 genes in this pathway |
| REACTOME INNATE IMMUNE SYSTEM | 279 | 178 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| SCHLESINGER METHYLATED DE NOVO IN CANCER | 88 | 64 | All SZGR 2.0 genes in this pathway |
| ALCALA APOPTOSIS | 88 | 60 | All SZGR 2.0 genes in this pathway |
| BENPORATH SUZ12 TARGETS | 1038 | 678 | All SZGR 2.0 genes in this pathway |
| BENPORATH EED TARGETS | 1062 | 725 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES WITH H3K27ME3 | 1118 | 744 | All SZGR 2.0 genes in this pathway |
| BENPORATH PRC2 TARGETS | 652 | 441 | All SZGR 2.0 genes in this pathway |
| MATSUDA NATURAL KILLER DIFFERENTIATION | 475 | 313 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS EARLY PROGENITOR | 532 | 309 | All SZGR 2.0 genes in this pathway |
| FIRESTEIN PROLIFERATION | 175 | 125 | All SZGR 2.0 genes in this pathway |
| COLINA TARGETS OF 4EBP1 AND 4EBP2 | 356 | 214 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D | 882 | 506 | All SZGR 2.0 genes in this pathway |
| ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP | 289 | 184 | All SZGR 2.0 genes in this pathway |