SZGR2

Summary ?

GeneID	11215
Symbol	AKAP11
Synonyms	AKAP-11\|AKAP220\|PPP1R44\|PRKA11
Description	A-kinase anchoring protein 11
Reference	MIM:604696\|HGNC:HGNC:369\|Ensembl:ENSG00000023516\|HPRD:05261\|Vega:OTTHUMG00000016805
Gene type	protein-coding
Map location	13q14.11
Pascal p-value	0.01
eGene	Anterior cingulate cortex BA24 Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Nucleus accumbens basal ganglia Meta

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	TSS distance	eQTL type
rs9590679	13	42814100	AKAP11	ENSG00000023516.7	2.075E-6	-32189	gtex_brain_ba24
rs9315901	13	42817276	AKAP11	ENSG00000023516.7	5.844E-7	-29013	gtex_brain_ba24
rs201384113	13	42822568	AKAP11	ENSG00000023516.7	8.223E-8	-23721	gtex_brain_ba24
rs2044732	13	42833400	AKAP11	ENSG00000023516.7	8.849E-7	-12889	gtex_brain_ba24
rs10492434	13	42838864	AKAP11	ENSG00000023516.7	2.245E-8	-7425	gtex_brain_ba24
rs875008	13	42842698	AKAP11	ENSG00000023516.7	2.556E-8	-3591	gtex_brain_ba24
rs78738581	13	42843630	AKAP11	ENSG00000023516.7	2.025E-7	-2659	gtex_brain_ba24
rs2122242	13	42848853	AKAP11	ENSG00000023516.7	2.182E-7	2564	gtex_brain_ba24
rs9590683	13	42850849	AKAP11	ENSG00000023516.7	2.2E-7	4560	gtex_brain_ba24
rs146061909	13	42861622	AKAP11	ENSG00000023516.7	3.589E-8	15333	gtex_brain_ba24
rs400288	13	42861772	AKAP11	ENSG00000023516.7	3.564E-8	15483	gtex_brain_ba24
rs17521426	13	42868208	AKAP11	ENSG00000023516.7	2.209E-7	21919	gtex_brain_ba24
rs1964482	13	42868708	AKAP11	ENSG00000023516.7	1.923E-7	22419	gtex_brain_ba24
rs9594724	13	42869119	AKAP11	ENSG00000023516.7	2.209E-7	22830	gtex_brain_ba24
rs9594726	13	42894409	AKAP11	ENSG00000023516.7	3.263E-7	48120	gtex_brain_ba24
rs9590686	13	42903018	AKAP11	ENSG00000023516.7	2.209E-7	56729	gtex_brain_ba24
rs9594727	13	42906121	AKAP11	ENSG00000023516.7	2.227E-7	59832	gtex_brain_ba24
rs17521870	13	42907942	AKAP11	ENSG00000023516.7	2.209E-7	61653	gtex_brain_ba24
rs9594729	13	42911922	AKAP11	ENSG00000023516.7	6.983E-8	65633	gtex_brain_ba24
rs9594730	13	42911923	AKAP11	ENSG00000023516.7	6.983E-8	65634	gtex_brain_ba24
rs9594731	13	42911955	AKAP11	ENSG00000023516.7	2.209E-7	65666	gtex_brain_ba24
rs9594732	13	42912853	AKAP11	ENSG00000023516.7	2.213E-7	66564	gtex_brain_ba24
rs9594733	13	42925732	AKAP11	ENSG00000023516.7	3.318E-7	79443	gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0008157	protein phosphatase 1 binding	TAS		10209101
GO:0051018	protein kinase A binding	TAS		10209101
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007243	protein kinase cascade	TAS		10209101
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005813	centrosome	IEA		-
GO:0005737	cytoplasm	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
SOTIRIOU BREAST CANCER GRADE 1 VS 3 DN	52	34	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP	584	356	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215	893	528	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP	424	268	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 DN	65	39	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 DN	64	42	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN	220	147	All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN	249	165	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP	548	370	All SZGR 2.0 genes in this pathway
IVANOVSKA MIR106B TARGETS	90	56	All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 DN	180	116	All SZGR 2.0 genes in this pathway
KRIEG KDM3A TARGETS NOT HYPOXIA	208	107	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	3571	3577	m8	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-130/301	3883	3889	1A	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-15/16/195/424/497	323	330	1A,m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-205	255	261	1A	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-217	839	845	1A	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: AKAP11