Gene Page: CRKL

Summary
GeneID  1399
Symbol  CRKL
Synonyms  -
Description  v-crk sarcoma virus CT10 oncogene homolog (avian)-like
See related  HGNC:2363|MIM:602007|Ensembl:ENSG00000099942|HPRD:03596|
Locus tag  -
Gene type  protein-coding
Map location  22q11|22q11.21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1445 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SLC8A20.900.91
CCDC85A0.890.90
FBXO410.890.89
TLN20.880.89
KIAA10450.870.89
RAB11FIP40.870.86
CLSTN10.870.86
LRP110.860.89
PIP5K1C0.860.86
SULT4A10.860.89
Top 10 negatively co-expressed genes
AP002478.3-0.52-0.53
AL139819.3-0.51-0.50
AF347015.21-0.51-0.38
GNG11-0.48-0.44
C11orf67-0.48-0.51
NSBP1-0.48-0.52
C1orf54-0.48-0.45
AF347015.18-0.47-0.38
RAB13-0.46-0.55
AL138743.2-0.46-0.46
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005070SH3/SH2 adaptor activityTAS8798523 
GO:0005515protein bindingIPI9788432 |16284401 
GO:0004713protein tyrosine kinase activityTAS8361759 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001568blood vessel developmentIEA-
GO:0007265Ras protein signal transductionTAS8798523 
GO:0007254JNK cascadeTAS8798523 
GO:0007242intracellular signaling cascadeTAS8361759 
GO:0009952anterior/posterior pattern formationIEA-
GO:0009887organ morphogenesisIEA-
GO:0007507heart developmentIEA-
GO:0007389pattern specification processIEA-
GO:0060017parathyroid gland developmentIEA-
GO:0048538thymus developmentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIDA18029348 
GO:0005886plasma membraneIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinaseAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID7926767 |8083188 
|8978305 |9820532 
-HPRD7493940 
ANK3ANKYRIN-G | FLJ45464ankyrin 3, node of Ranvier (ankyrin G)Affinity Capture-WesternBioGRID10907644 
BCAR1CAS | CAS1 | CASS1 | CRKAS | P130Casbreast cancer anti-estrogen resistance 1-HPRD,BioGRID10753828 
BCRALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHLbreakpoint cluster regionAffinity Capture-Western
Far Western
Two-hybrid		BioGRID8978305 |9747873 
|10194128 |15143164 
BLNKBASH | BLNK-S | LY57 | MGC111051 | SLP-65 | SLP65B-cell linker-HPRD,BioGRID11489945 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequenceAffinity Capture-Western
Reconstituted Complex		BioGRID9092574 |9162067 
|9344843 |9461587 
|9590251 |9820532 
|10204582 |10907644 
|11133830 |12244174 
-HPRD9162067 |9590251 
|12244174 
CBLBDKFZp686J10223 | DKFZp779A0729 | DKFZp779F1443 | FLJ36865 | FLJ41152 | Nbla00127 | RNF56Cas-Br-M (murine) ecotropic retroviral transforming sequence b-HPRD,BioGRID10022120 
CD34-CD34 molecule-HPRD,BioGRID11389015 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)-HPRD9614078 
DNM2CMTDI1 | CMTDIB | DI-CMTB | DYN2 | DYNIIdynamin 2An unspecified isoform of Dyn2 interacts with CrkL. This interaction was modeled on a demonstrated interaction between human Dyn2 and CrkL from an unspecified species.BIND15696170 
DOCK2FLJ46592 | KIAA0209dedicator of cytokinesis 2-HPRD,BioGRID12393632 
DOK1MGC117395 | MGC138860 | P62DOKdocking protein 1, 62kDa (downstream of tyrosine kinase 1)-HPRD,BioGRID11071635 
EPORMGC138358erythropoietin receptor-HPRD,BioGRID11443118 
ETV6TEL | TEL/ABLets variant 6Affinity Capture-WesternBioGRID15143164 
EVLRNB6Enah/Vasp-like-HPRD10945997 
FCGR1ACD64 | CD64A | FCRI | FLJ18345 | IGFR1Fc fragment of IgG, high affinity Ia, receptor (CD64)-HPRD,BioGRID9820532 
GAB1-GRB2-associated binding protein 1-HPRD,BioGRID10753869 
GAB2KIAA0571GRB2-associated binding protein 2-HPRD,BioGRID11334882 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID10477741 
IFNAR1AVP | IFN-alpha-REC | IFNAR | IFNBR | IFRCinterferon (alpha, beta and omega) receptor 1-HPRD11167825 
INPP5DMGC104855 | MGC142140 | MGC142142 | SHIP | SHIP1 | SIP-145 | hp51CNinositol polyphosphate-5-phosphatase, 145kDaAffinity Capture-Western
Reconstituted Complex		BioGRID11443118 
IRS4IRS-4 | PY160insulin receptor substrate 4-HPRD,BioGRID9614078 
KIDINS220ARMS | MGC163482kinase D-interacting substrate, 220kDa-HPRD15167895 
KITC-Kit | CD117 | PBT | SCFRv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog-HPRD,BioGRID9092574 
MAP4K1HPK1mitogen-activated protein kinase kinase kinase kinase 1HPK1, a Ste-20 homologous serine/threonine kinase phosphorylates CrkL, a Crk-like adaptor proteinBIND9891069 
-HPRD,BioGRID9891069 |11279207 
MAP4K5GCKR | KHS | KHS1 | MAPKKKK5mitogen-activated protein kinase kinase kinase kinase 5-HPRD,BioGRID10648385 
NEDD9CAS-L | CAS2 | CASL | CASS2 | HEF1 | dJ49G10.2 | dJ761I2.1neural precursor cell expressed, developmentally down-regulated 9-HPRD9020138 |9405482 
|9498705 
Affinity Capture-Western
Reconstituted Complex		BioGRID9020138 |9162067 
|9498705 |9820532 
PDGFRACD140A | MGC74795 | PDGFR2 | Rhe-PDGFRAplatelet-derived growth factor receptor, alpha polypeptide-HPRD,BioGRID9546424 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)Affinity Capture-WesternBioGRID9461587 
PIK3R2P85B | p85 | p85-BETAphosphoinositide-3-kinase, regulatory subunit 2 (beta)-HPRD,BioGRID9092574 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2Two-hybridBioGRID15494733 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11-HPRD,BioGRID9344843 
PXNFLJ16691paxillin-HPRD,BioGRID7493940 
RAPGEF1C3G | DKFZp781P1719 | GRF2Rap guanine nucleotide exchange factor (GEF) 1Crk-L interacts with C3G.BIND8621483 
-HPRD,BioGRID8621483 |9344843 
|9374471 
RICSGC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAPRho GTPase-activating protein-HPRD,BioGRID12446789 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD,BioGRID9344843 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)-HPRD9162067 
STAT5AMGF | STAT5signal transducer and activator of transcription 5A-HPRD,BioGRID9837784 |11167825 
SYKDKFZp313N1010 | FLJ25043 | FLJ37489spleen tyrosine kinaseCrkL interacts with Syk.BIND11313252 
-HPRD,BioGRID11313252 
TGFB1I1ARA55 | HIC-5 | HIC5 | TSC-5transforming growth factor beta 1 induced transcript 1-HPRD9858471 |11463817 
TYK2JTK1tyrosine kinase 2-HPRD,BioGRID9374471 
WASIMD2 | THC | WASPWiskott-Aldrich syndrome (eczema-thrombocytopenia)-HPRD,BioGRID11313252 
CrkL interacts with WASP.BIND11313252 
WIPF1MGC111041 | PRPL-2 | WASPIP | WIPWAS/WASL interacting protein family, member 1WIP interacts with CrkL.BIND12504004 
ZAP70FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70zeta-chain (TCR) associated protein kinase 70kDaZAP-70 interacts with CrkL. This interaction was modeled on a demonstrated interaction between human ZAP-70 and CrkL from an unspecified species.BIND10419455 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_ERBB_SIGNALING_PATHWAY 8771All SZGR genes in this pathway
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 9771All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA 7060All SZGR genes in this pathway
KEGG_CHRONIC_MYELOID_LEUKEMIA 7359All SZGR genes in this pathway
BIOCARTA_IL2RB_PATHWAY 3826All SZGR genes in this pathway
BIOCARTA_GLEEVEC_PATHWAY 2317All SZGR genes in this pathway
BIOCARTA_INTEGRIN_PATHWAY 3829All SZGR genes in this pathway
BIOCARTA_PYK2_PATHWAY 3124All SZGR genes in this pathway
BIOCARTA_MET_PATHWAY 3730All SZGR genes in this pathway
ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 4535All SZGR genes in this pathway
PID_MET_PATHWAY 8060All SZGR genes in this pathway
PID_REELIN_PATHWAY 2929All SZGR genes in this pathway
PID_IGF1_PATHWAY 3023All SZGR genes in this pathway
PID_IFNG_PATHWAY 4034All SZGR genes in this pathway
PID_EPHA_FWDPATHWAY 3429All SZGR genes in this pathway
PID_TRKR_PATHWAY 6248All SZGR genes in this pathway
PID_TCR_JNK_PATHWAY 1411All SZGR genes in this pathway
PID_PDGFRA_PATHWAY 2218All SZGR genes in this pathway
PID_KIT_PATHWAY 5240All SZGR genes in this pathway
PID_EPO_PATHWAY 3429All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF 12293All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 9576All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_REGULATION_OF_SIGNALING_BY_CBL 1816All SZGR genes in this pathway
REACTOME_IL_3_5_AND_GM_CSF_SIGNALING 4334All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
BIDUS_METASTASIS_UP 214134All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
DARWICHE_PAPILLOMA_PROGRESSION_RISK 7444All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 214139All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_8HR_UP 10573All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_DN 12386All SZGR genes in this pathway
GENTILE_UV_HIGH_DOSE_DN 312203All SZGR genes in this pathway
GENTILE_RESPONSE_CLUSTER_D3 6139All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_DN 12081All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
BONCI_TARGETS_OF_MIR15A_AND_MIR16_1 9175All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
ZEMBUTSU_SENSITIVITY_TO_NIMUSTINE 1713All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
HOLLEMAN_PREDNISOLONE_RESISTANCE_ALL_UP 1915All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-12835653571m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-15/16/195/424/4972026m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-18832593265m8hsa-miR-188CAUCCCUUGCAUGGUGGAGGGU
miR-200bc/429372837351A,m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-204/21132583264m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-2141824m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-224373837441Ahsa-miR-224CAAGUCACUAGUGGUUCCGUUUA
miR-30-5p317431811A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-33532123218m8hsa-miR-335brainUCAAGAGCAAUAACGAAAAAUGU
miR-96261226191A,m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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