Summary ?
GeneID1399
SymbolCRKL
Synonyms-
Descriptionv-crk avian sarcoma virus CT10 oncogene homolog-like
ReferenceMIM:602007|HGNC:HGNC:2363|Ensembl:ENSG00000099942|HPRD:03596|Vega:OTTHUMG00000150807
Gene typeprotein-coding
Map location22q11.21
Pascal p-value0.235
Sherlock p-value0.371
Fetal beta0.07
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CNV:YESCopy number variation studiesManual curation
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GSMA_IGenome scan meta-analysisPsr: 0.031 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1445 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg137207442221271392CRKL2.82E-10-0.0146.59E-7DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SLC8A20.900.91
CCDC85A0.890.90
FBXO410.890.89
TLN20.880.89
KIAA10450.870.89
RAB11FIP40.870.86
CLSTN10.870.86
LRP110.860.89
PIP5K1C0.860.86
SULT4A10.860.89
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AP002478.3-0.52-0.53
AL139819.3-0.51-0.50
AF347015.21-0.51-0.38
GNG11-0.48-0.44
C11orf67-0.48-0.51
NSBP1-0.48-0.52
C1orf54-0.48-0.45
AF347015.18-0.47-0.38
RAB13-0.46-0.55
AL138743.2-0.46-0.46

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005070SH3/SH2 adaptor activityTAS8798523 
GO:0005515protein bindingIPI9788432 |16284401 
GO:0004713protein tyrosine kinase activityTAS8361759 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001568blood vessel developmentIEA-
GO:0007265Ras protein signal transductionTAS8798523 
GO:0007254JNK cascadeTAS8798523 
GO:0007242intracellular signaling cascadeTAS8361759 
GO:0009952anterior/posterior pattern formationIEA-
GO:0009887organ morphogenesisIEA-
GO:0007507heart developmentIEA-
GO:0007389pattern specification processIEA-
GO:0060017parathyroid gland developmentIEA-
GO:0048538thymus developmentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIDA18029348 
GO:0005886plasma membraneIDA18029348 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinaseAffinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID7926767 |8083188 
|8978305 |9820532 
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD7493940 
ANK3ANKYRIN-G | FLJ45464ankyrin 3, node of Ranvier (ankyrin G)Affinity Capture-WesternBioGRID10907644 
BCAR1CAS | CAS1 | CASS1 | CRKAS | P130Casbreast cancer anti-estrogen resistance 1-HPRD,BioGRID10753828 
BCRALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHLbreakpoint cluster regionAffinity Capture-Western
Far Western
Two-hybrid
BioGRID8978305 |9747873 
|10194128 |15143164 
BLNKBASH | BLNK-S | LY57 | MGC111051 | SLP-65 | SLP65B-cell linker-HPRD,BioGRID11489945 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequenceAffinity Capture-Western
Reconstituted Complex
BioGRID9092574 |9162067 
|9344843 |9461587 
|9590251 |9820532 
|10204582 |10907644 
|11133830 |12244174 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequence-HPRD9162067 |9590251 
|12244174 
CBLBDKFZp686J10223 | DKFZp779A0729 | DKFZp779F1443 | FLJ36865 | FLJ41152 | Nbla00127 | RNF56Cas-Br-M (murine) ecotropic retroviral transforming sequence b-HPRD,BioGRID10022120 
CD34-CD34 molecule-HPRD,BioGRID11389015 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)-HPRD9614078 
DNM2CMTDI1 | CMTDIB | DI-CMTB | DYN2 | DYNIIdynamin 2An unspecified isoform of Dyn2 interacts with CrkL. This interaction was modeled on a demonstrated interaction between human Dyn2 and CrkL from an unspecified species.BIND15696170 
DOCK2FLJ46592 | KIAA0209dedicator of cytokinesis 2-HPRD,BioGRID12393632 
DOK1MGC117395 | MGC138860 | P62DOKdocking protein 1, 62kDa (downstream of tyrosine kinase 1)-HPRD,BioGRID11071635 
EPORMGC138358erythropoietin receptor-HPRD,BioGRID11443118 
ETV6TEL | TEL/ABLets variant 6Affinity Capture-WesternBioGRID15143164 
EVLRNB6Enah/Vasp-like-HPRD10945997 
FCGR1ACD64 | CD64A | FCRI | FLJ18345 | IGFR1Fc fragment of IgG, high affinity Ia, receptor (CD64)-HPRD,BioGRID9820532 
GAB1-GRB2-associated binding protein 1-HPRD,BioGRID10753869 
GAB2KIAA0571GRB2-associated binding protein 2-HPRD,BioGRID11334882 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID10477741 
IFNAR1AVP | IFN-alpha-REC | IFNAR | IFNBR | IFRCinterferon (alpha, beta and omega) receptor 1-HPRD11167825 
INPP5DMGC104855 | MGC142140 | MGC142142 | SHIP | SHIP1 | SIP-145 | hp51CNinositol polyphosphate-5-phosphatase, 145kDaAffinity Capture-Western
Reconstituted Complex
BioGRID11443118 
IRS4IRS-4 | PY160insulin receptor substrate 4-HPRD,BioGRID9614078 
KIDINS220ARMS | MGC163482kinase D-interacting substrate, 220kDa-HPRD15167895 
KITC-Kit | CD117 | PBT | SCFRv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog-HPRD,BioGRID9092574 
MAP4K1HPK1mitogen-activated protein kinase kinase kinase kinase 1HPK1, a Ste-20 homologous serine/threonine kinase phosphorylates CrkL, a Crk-like adaptor proteinBIND9891069 
MAP4K1HPK1mitogen-activated protein kinase kinase kinase kinase 1-HPRD,BioGRID9891069 |11279207 
MAP4K5GCKR | KHS | KHS1 | MAPKKKK5mitogen-activated protein kinase kinase kinase kinase 5-HPRD,BioGRID10648385 
NEDD9CAS-L | CAS2 | CASL | CASS2 | HEF1 | dJ49G10.2 | dJ761I2.1neural precursor cell expressed, developmentally down-regulated 9-HPRD9020138 |9405482 
|9498705 
NEDD9CAS-L | CAS2 | CASL | CASS2 | HEF1 | dJ49G10.2 | dJ761I2.1neural precursor cell expressed, developmentally down-regulated 9Affinity Capture-Western
Reconstituted Complex
BioGRID9020138 |9162067 
|9498705 |9820532 
PDGFRACD140A | MGC74795 | PDGFR2 | Rhe-PDGFRAplatelet-derived growth factor receptor, alpha polypeptide-HPRD,BioGRID9546424 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)Affinity Capture-WesternBioGRID9461587 
PIK3R2P85B | p85 | p85-BETAphosphoinositide-3-kinase, regulatory subunit 2 (beta)-HPRD,BioGRID9092574 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2Two-hybridBioGRID15494733 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11-HPRD,BioGRID9344843 
PXNFLJ16691paxillin-HPRD,BioGRID7493940 
RAPGEF1C3G | DKFZp781P1719 | GRF2Rap guanine nucleotide exchange factor (GEF) 1Crk-L interacts with C3G.BIND8621483 
RAPGEF1C3G | DKFZp781P1719 | GRF2Rap guanine nucleotide exchange factor (GEF) 1-HPRD,BioGRID8621483 |9344843 
|9374471 
RICSGC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAPRho GTPase-activating protein-HPRD,BioGRID12446789 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD,BioGRID9344843 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)-HPRD9162067 
STAT5AMGF | STAT5signal transducer and activator of transcription 5A-HPRD,BioGRID9837784 |11167825 
SYKDKFZp313N1010 | FLJ25043 | FLJ37489spleen tyrosine kinaseCrkL interacts with Syk.BIND11313252 
SYKDKFZp313N1010 | FLJ25043 | FLJ37489spleen tyrosine kinase-HPRD,BioGRID11313252 
TGFB1I1ARA55 | HIC-5 | HIC5 | TSC-5transforming growth factor beta 1 induced transcript 1-HPRD9858471 |11463817 
TYK2JTK1tyrosine kinase 2-HPRD,BioGRID9374471 
WASIMD2 | THC | WASPWiskott-Aldrich syndrome (eczema-thrombocytopenia)-HPRD,BioGRID11313252 
WASIMD2 | THC | WASPWiskott-Aldrich syndrome (eczema-thrombocytopenia)CrkL interacts with WASP.BIND11313252 
WIPF1MGC111041 | PRPL-2 | WASPIP | WIPWAS/WASL interacting protein family, member 1WIP interacts with CrkL.BIND12504004 
ZAP70FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70zeta-chain (TCR) associated protein kinase 70kDaZAP-70 interacts with CrkL. This interaction was modeled on a demonstrated interaction between human ZAP-70 and CrkL from an unspecified species.BIND10419455 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG MAPK SIGNALING PATHWAY 267205All SZGR 2.0 genes in this pathway
KEGG ERBB SIGNALING PATHWAY 8771All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY 190128All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201138All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS 9771All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126103All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216144All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137103All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA 7060All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA 7359All SZGR 2.0 genes in this pathway
BIOCARTA IL2RB PATHWAY 3826All SZGR 2.0 genes in this pathway
BIOCARTA GLEEVEC PATHWAY 2317All SZGR 2.0 genes in this pathway
BIOCARTA INTEGRIN PATHWAY 3829All SZGR 2.0 genes in this pathway
BIOCARTA PYK2 PATHWAY 3124All SZGR 2.0 genes in this pathway
BIOCARTA MET PATHWAY 3730All SZGR 2.0 genes in this pathway
ST DIFFERENTIATION PATHWAY IN PC12 CELLS 4535All SZGR 2.0 genes in this pathway
PID MET PATHWAY 8060All SZGR 2.0 genes in this pathway
PID REELIN PATHWAY 2929All SZGR 2.0 genes in this pathway
PID IGF1 PATHWAY 3023All SZGR 2.0 genes in this pathway
PID IFNG PATHWAY 4034All SZGR 2.0 genes in this pathway
PID EPHA FWDPATHWAY 3429All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY 6248All SZGR 2.0 genes in this pathway
PID TCR JNK PATHWAY 1411All SZGR 2.0 genes in this pathway
PID PDGFRA PATHWAY 2218All SZGR 2.0 genes in this pathway
PID KIT PATHWAY 5240All SZGR 2.0 genes in this pathway
PID EPO PATHWAY 3429All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF 12293All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 9576All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 10786All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF SIGNALING BY CBL 1816All SZGR 2.0 genes in this pathway
REACTOME IL 3 5 AND GM CSF SIGNALING 4334All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270204All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459276All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP 214134All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA PROGRESSION RISK 7444All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER 214139All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP 10573All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC DN 12386All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN 312203All SZGR 2.0 genes in this pathway
GENTILE RESPONSE CLUSTER D3 6139All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN 12081All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863514All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
BONCI TARGETS OF MIR15A AND MIR16 1 9175All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442263All SZGR 2.0 genes in this pathway
ZEMBUTSU SENSITIVITY TO NIMUSTINE 1713All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway
HOLLEMAN PREDNISOLONE RESISTANCE ALL UP 1915All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-12835653571m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-15/16/195/424/4972026m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-18832593265m8hsa-miR-188CAUCCCUUGCAUGGUGGAGGGU
miR-200bc/429372837351A,m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-204/21132583264m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-2141824m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-224373837441Ahsa-miR-224CAAGUCACUAGUGGUUCCGUUUA
miR-30-5p317431811A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-33532123218m8hsa-miR-335brainUCAAGAGCAAUAACGAAAAAUGU
miR-96261226191A,m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC