Gene Page: ADRA1A

Summary ?
GeneID148
SymbolADRA1A
SynonymsADRA1C|ADRA1L1|ALPHA1AAR
Descriptionadrenoceptor alpha 1A
ReferenceMIM:104221|HGNC:HGNC:277|Ensembl:ENSG00000120907|HPRD:00081|Vega:OTTHUMG00000099459
Gene typeprotein-coding
Map location8p21.2
Pascal p-value0.116
Fetal beta-1.316
DMG1 (# studies)
SupportGPCR SIGNALLING

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
ADT:Sun_2012Systematic Investigation of Antipsychotic Drugs and Their TargetsA total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes.
CV:GWAScatGenome-wide Association StudiesThis data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
GSMA_IGenome scan meta-analysisPsr: 0.031 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.03086 
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.00057 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg00460235826723946ADRA1A2.16E-8-0.0127.31E-6DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C12orf340.720.69
SOX80.660.67
PLEKHG30.650.65
KCNJ20.650.48
SH3RF20.650.58
DACT20.620.37
SLC35D30.610.34
MME0.600.24
PRIMA10.600.66
GPR1490.590.37
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GPM6A-0.32-0.44
GPR22-0.31-0.43
EMID1-0.31-0.41
EMX1-0.31-0.42
MPPED1-0.31-0.44
DPP4-0.30-0.42
ZNF238-0.30-0.39
SNX7-0.30-0.44
ULBP2-0.29-0.38
NEUROD6-0.29-0.49

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004937alpha1-adrenergic receptor activityNAS9490024 
GO:0004937alpha1-adrenergic receptor activityTAS7737411 
GO:0004935adrenoceptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayTAS10860850 
GO:0007267cell-cell signalingTAS8396931 
GO:0007243protein kinase cascadeTAS10671514 
GO:0007165signal transductionTAS8396931 
GO:0008285negative regulation of cell proliferationTAS10860850 
GO:0006939smooth muscle contractionTAS8183249 
GO:0006915apoptosisTAS10671514 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS8396931 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CALCIUM SIGNALING PATHWAY 178134All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 11581All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205136All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME AMINE LIGAND BINDING RECEPTORS 3833All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184116All SZGR 2.0 genes in this pathway
REACTOME G ALPHA1213 SIGNALLING EVENTS 7456All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390236All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244165All SZGR 2.0 genes in this pathway
LEE LIVER CANCER 4929All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING UP 7451All SZGR 2.0 genes in this pathway
OUILLETTE CLL 13Q14 DELETION UP 7440All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510309All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE DN 6948All SZGR 2.0 genes in this pathway
GYORFFY MITOXANTRONE RESISTANCE 5735All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway