Gene Page: NKX2-5

Summary
GeneID  1482
Symbol  NKX2-5
Synonyms  CHNG5|CSX|CSX1|NKX2.5|NKX2E|NKX4-1
Description  NK2 transcription factor related, locus 5 (Drosophila)
See related  HGNC:2488|MIM:600584|Ensembl:ENSG00000183072|HPRD:02787|
Locus tag  -
Gene type  protein-coding
Map location  5q34
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.0276 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIDA11431700 
GO:0005515protein bindingIPI11431700 |12499378 
GO:0005515protein bindingISS-
GO:0016564transcription repressor activityISS-
GO:0016563transcription activator activityIEA-
GO:0046982protein heterodimerization activityIEA-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000122negative regulation of transcription from RNA polymerase II promoterISS-
GO:0001570vasculogenesisIEA-
GO:0001947heart loopingIEA-
GO:0055007cardiac muscle cell differentiationIEA-
GO:0007512adult heart developmentIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0048738cardiac muscle developmentIEA-
GO:0035050embryonic heart tube developmentIEA-
GO:0030097hemopoiesisIEA-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIGI10206974 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005667transcription factor complexISS-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GATA4MGC126629GATA binding protein 4Nkx2.5 interacts with GATA4.BIND15542826 
-HPRD,BioGRID10948187 
HIPK1KIAA0630 | MGC26642 | MGC33446 | MGC33548 | Myak | Nbak2homeodomain interacting protein kinase 1-HPRD9748262 
HIPK2DKFZp686K02111 | FLJ23711 | PRO0593homeodomain interacting protein kinase 2-HPRD9748262 
JARID2JMJjumonji, AT rich interactive domain 2JMJ interacts with Nkx2.5.BIND15542826 
SRFMCM1serum response factor (c-fos serum response element-binding transcription factor)-HPRD8887666 
TBX5HOST-box 5-HPRD,BioGRID11431700 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_ALK_PATHWAY 3729All SZGR genes in this pathway
BIOCARTA_NFAT_PATHWAY 5645All SZGR genes in this pathway
PID_SMAD2_3NUCLEAR_PATHWAY 8263All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_HBZ 4127All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_HEMGN 3121All SZGR genes in this pathway
MARTIN_INTERACT_WITH_HDAC 4431All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_UP 13493All SZGR genes in this pathway
INGRAM_SHH_TARGETS_UP 12779All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
CHEN_LVAD_SUPPORT_OF_FAILING_HEART_DN 4232All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_10HR_UP 10169All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
GU_PDEF_TARGETS_DN 3920All SZGR genes in this pathway
BRUNEAU_SEPTATION_VENTRICULAR 108All SZGR genes in this pathway
BRUNEAU_HEART_GREAT_VESSELS_AND_VALVULOGENESIS 88All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K27ME3 7959All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K27ME3 269159All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway


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