Gene Page: CYP2D6
Summary ?
| GeneID | 1565 |
| Symbol | CYP2D6 |
| Synonyms | CPD6|CYP2D|CYP2D7AP|CYP2D7BP|CYP2D7P2|CYP2D8P2|CYP2DL1|CYPIID6|P450-DB1|P450C2D|P450DB1 |
| Description | cytochrome P450 family 2 subfamily D member 6 |
| Reference | MIM:124030|HGNC:HGNC:2625|Ensembl:ENSG00000100197|HPRD:00487|Vega:OTTHUMG00000150918 |
| Gene type | protein-coding |
| Map location | 22q13.1 |
| Pascal p-value | 4.381E-8 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| ADT:Sun_2012 | Systematic Investigation of Antipsychotic Drugs and Their Targets | A total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes. | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Association | A combined odds ratio method (Sun et al. 2008), association studies | 1 | Link to SZGene |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs17478227 | chr22 | 42654326 | CYP2D6 | 1565 | 0.02 | cis | ||
| rs1107553 | chr22 | 42667472 | CYP2D6 | 1565 | 0.05 | cis | ||
| rs1107554 | chr22 | 42667593 | CYP2D6 | 1565 | 0.01 | cis | ||
| rs637440 | chr10 | 13099341 | CYP2D6 | 1565 | 0.14 | trans | ||
| rs56234624 | 22 | 42388826 | CYP2D6 | ENSG00000100197.16 | 2.356E-6 | 0 | 138082 | gtex_brain_ba24 |
| rs2097561 | 22 | 42389431 | CYP2D6 | ENSG00000100197.16 | 2.356E-6 | 0 | 137477 | gtex_brain_ba24 |
| rs2097562 | 22 | 42389500 | CYP2D6 | ENSG00000100197.16 | 2.356E-6 | 0 | 137408 | gtex_brain_ba24 |
| rs739296 | 22 | 42389948 | CYP2D6 | ENSG00000100197.16 | 2.356E-6 | 0 | 136960 | gtex_brain_ba24 |
| rs7290907 | 22 | 42390209 | CYP2D6 | ENSG00000100197.16 | 2.356E-6 | 0 | 136699 | gtex_brain_ba24 |
| rs7290655 | 22 | 42390225 | CYP2D6 | ENSG00000100197.16 | 2.356E-6 | 0 | 136683 | gtex_brain_ba24 |
| rs4822079 | 22 | 42394612 | CYP2D6 | ENSG00000100197.16 | 2.777E-7 | 0 | 132296 | gtex_brain_ba24 |
| rs8138080 | 22 | 42396371 | CYP2D6 | ENSG00000100197.16 | 2.356E-6 | 0 | 130537 | gtex_brain_ba24 |
| rs9623489 | 22 | 42397026 | CYP2D6 | ENSG00000100197.16 | 2.356E-6 | 0 | 129882 | gtex_brain_ba24 |
| rs11090066 | 22 | 42398195 | CYP2D6 | ENSG00000100197.16 | 2.356E-6 | 0 | 128713 | gtex_brain_ba24 |
| rs9623490 | 22 | 42398266 | CYP2D6 | ENSG00000100197.16 | 2.356E-6 | 0 | 128642 | gtex_brain_ba24 |
| rs9620006 | 22 | 42399547 | CYP2D6 | ENSG00000100197.16 | 2.345E-6 | 0 | 127361 | gtex_brain_ba24 |
| rs9611700 | 22 | 42401514 | CYP2D6 | ENSG00000100197.16 | 1.703E-6 | 0 | 125394 | gtex_brain_ba24 |
| rs2413663 | 22 | 42402399 | CYP2D6 | ENSG00000100197.16 | 2.356E-6 | 0 | 124509 | gtex_brain_ba24 |
| rs59993856 | 22 | 42403980 | CYP2D6 | ENSG00000100197.16 | 2.356E-6 | 0 | 122928 | gtex_brain_ba24 |
| rs9607869 | 22 | 42418110 | CYP2D6 | ENSG00000100197.16 | 1.622E-6 | 0 | 108798 | gtex_brain_ba24 |
| . | 22 | 42433463 | CYP2D6 | ENSG00000100197.16 | 7.569E-8 | 0 | 93445 | gtex_brain_ba24 |
| rs9607871 | 22 | 42436322 | CYP2D6 | ENSG00000100197.16 | 2.608E-7 | 0 | 90586 | gtex_brain_ba24 |
| rs28715885 | 22 | 42441091 | CYP2D6 | ENSG00000100197.16 | 1.067E-10 | 0 | 85817 | gtex_brain_ba24 |
| rs133357 | 22 | 42442235 | CYP2D6 | ENSG00000100197.16 | 2.34E-6 | 0 | 84673 | gtex_brain_ba24 |
| rs133358 | 22 | 42442539 | CYP2D6 | ENSG00000100197.16 | 2.322E-6 | 0 | 84369 | gtex_brain_ba24 |
| rs58099562 | 22 | 42453772 | CYP2D6 | ENSG00000100197.16 | 7.573E-11 | 0 | 73136 | gtex_brain_ba24 |
| rs201653716 | 22 | 42453846 | CYP2D6 | ENSG00000100197.16 | 4.078E-7 | 0 | 73062 | gtex_brain_ba24 |
| rs1063392 | 22 | 42454950 | CYP2D6 | ENSG00000100197.16 | 2.654E-6 | 0 | 71958 | gtex_brain_ba24 |
| rs2013960 | 22 | 42457912 | CYP2D6 | ENSG00000100197.16 | 1.691E-6 | 0 | 68996 | gtex_brain_ba24 |
| rs2854827 | 22 | 42461918 | CYP2D6 | ENSG00000100197.16 | 1.754E-7 | 0 | 64990 | gtex_brain_ba24 |
| rs133373 | 22 | 42465788 | CYP2D6 | ENSG00000100197.16 | 9.407E-10 | 0 | 61120 | gtex_brain_ba24 |
| rs133376 | 22 | 42466905 | CYP2D6 | ENSG00000100197.16 | 2.69E-7 | 0 | 60003 | gtex_brain_ba24 |
| rs45441993 | 22 | 42471738 | CYP2D6 | ENSG00000100197.16 | 1.649E-9 | 0 | 55170 | gtex_brain_ba24 |
| rs2413667 | 22 | 42472237 | CYP2D6 | ENSG00000100197.16 | 1.412E-11 | 0 | 54671 | gtex_brain_ba24 |
| rs133383 | 22 | 42473603 | CYP2D6 | ENSG00000100197.16 | 1.661E-7 | 0 | 53305 | gtex_brain_ba24 |
| rs144111991 | 22 | 42480628 | CYP2D6 | ENSG00000100197.16 | 8.681E-11 | 0 | 46280 | gtex_brain_ba24 |
| rs5758574 | 22 | 42481400 | CYP2D6 | ENSG00000100197.16 | 9.191E-11 | 0 | 45508 | gtex_brain_ba24 |
| rs7245 | 22 | 42481849 | CYP2D6 | ENSG00000100197.16 | 2.686E-7 | 0 | 45059 | gtex_brain_ba24 |
| rs2284087 | 22 | 42485671 | CYP2D6 | ENSG00000100197.16 | 1.197E-10 | 0 | 41237 | gtex_brain_ba24 |
| rs5751211 | 22 | 42486056 | CYP2D6 | ENSG00000100197.16 | 1.174E-12 | 0 | 40852 | gtex_brain_ba24 |
| . | 22 | 42487613 | CYP2D6 | ENSG00000100197.16 | 8.971E-11 | 0 | 39295 | gtex_brain_ba24 |
| rs5758576 | 22 | 42488163 | CYP2D6 | ENSG00000100197.16 | 1.069E-12 | 0 | 38745 | gtex_brain_ba24 |
| rs5758577 | 22 | 42489434 | CYP2D6 | ENSG00000100197.16 | 1.361E-7 | 0 | 37474 | gtex_brain_ba24 |
| rs5758578 | 22 | 42490292 | CYP2D6 | ENSG00000100197.16 | 1.385E-10 | 0 | 36616 | gtex_brain_ba24 |
| rs5758579 | 22 | 42491479 | CYP2D6 | ENSG00000100197.16 | 8.674E-13 | 0 | 35429 | gtex_brain_ba24 |
| rs57117731 | 22 | 42492985 | CYP2D6 | ENSG00000100197.16 | 8.605E-13 | 0 | 33923 | gtex_brain_ba24 |
| rs5758580 | 22 | 42493875 | CYP2D6 | ENSG00000100197.16 | 8.27E-13 | 0 | 33033 | gtex_brain_ba24 |
| rs6002607 | 22 | 42496506 | CYP2D6 | ENSG00000100197.16 | 1.254E-7 | 0 | 30402 | gtex_brain_ba24 |
| rs6002608 | 22 | 42496629 | CYP2D6 | ENSG00000100197.16 | 1.254E-7 | 0 | 30279 | gtex_brain_ba24 |
| rs9611734 | 22 | 42502070 | CYP2D6 | ENSG00000100197.16 | 5.405E-13 | 0 | 24838 | gtex_brain_ba24 |
| rs2413668 | 22 | 42505841 | CYP2D6 | ENSG00000100197.16 | 1.121E-10 | 0 | 21067 | gtex_brain_ba24 |
| rs5751216 | 22 | 42508937 | CYP2D6 | ENSG00000100197.16 | 7.687E-11 | 0 | 17971 | gtex_brain_ba24 |
| rs3985938 | 22 | 42511727 | CYP2D6 | ENSG00000100197.16 | 4.111E-13 | 0 | 15181 | gtex_brain_ba24 |
| rs2413670 | 22 | 42511822 | CYP2D6 | ENSG00000100197.16 | 7.654E-11 | 0 | 15086 | gtex_brain_ba24 |
| rs2413671 | 22 | 42511825 | CYP2D6 | ENSG00000100197.16 | 7.654E-11 | 0 | 15083 | gtex_brain_ba24 |
| rs5751220 | 22 | 42516205 | CYP2D6 | ENSG00000100197.16 | 1.281E-7 | 0 | 10703 | gtex_brain_ba24 |
| rs5751221 | 22 | 42516366 | CYP2D6 | ENSG00000100197.16 | 3.301E-13 | 0 | 10542 | gtex_brain_ba24 |
| rs5758586 | 22 | 42517471 | CYP2D6 | ENSG00000100197.16 | 2.615E-13 | 0 | 9437 | gtex_brain_ba24 |
| rs5758587 | 22 | 42517636 | CYP2D6 | ENSG00000100197.16 | 1.185E-10 | 0 | 9272 | gtex_brain_ba24 |
| rs5751222 | 22 | 42517922 | CYP2D6 | ENSG00000100197.16 | 2.37E-13 | 0 | 8986 | gtex_brain_ba24 |
| rs6002626 | 22 | 42517989 | CYP2D6 | ENSG00000100197.16 | 1.382E-7 | 0 | 8919 | gtex_brain_ba24 |
| rs5758589 | 22 | 42518382 | CYP2D6 | ENSG00000100197.16 | 9.011E-11 | 0 | 8526 | gtex_brain_ba24 |
| rs34385013 | 22 | 42521929 | CYP2D6 | ENSG00000100197.16 | 2.896E-9 | 0 | 4979 | gtex_brain_ba24 |
| rs4078247 | 22 | 42521985 | CYP2D6 | ENSG00000100197.16 | 1.478E-13 | 0 | 4923 | gtex_brain_ba24 |
| rs35028622 | 22 | 42522074 | CYP2D6 | ENSG00000100197.16 | 2.89E-9 | 0 | 4834 | gtex_brain_ba24 |
| rs28371738 | 22 | 42522392 | CYP2D6 | ENSG00000100197.16 | 1.479E-13 | 0 | 4516 | gtex_brain_ba24 |
| rs1135840 | 22 | 42522613 | CYP2D6 | ENSG00000100197.16 | 2.886E-9 | 0 | 4295 | gtex_brain_ba24 |
| rs2004511 | 22 | 42523211 | CYP2D6 | ENSG00000100197.16 | 1.351E-13 | 0 | 3697 | gtex_brain_ba24 |
| rs1058172 | 22 | 42523528 | CYP2D6 | ENSG00000100197.16 | 4.464E-8 | 0 | 3380 | gtex_brain_ba24 |
| rs58440431 | 22 | 42524696 | CYP2D6 | ENSG00000100197.16 | 1.473E-13 | 0 | 2212 | gtex_brain_ba24 |
| rs3892097 | 22 | 42524947 | CYP2D6 | ENSG00000100197.16 | 1.133E-10 | 0 | 1961 | gtex_brain_ba24 |
| rs1058164 | 22 | 42525132 | CYP2D6 | ENSG00000100197.16 | 2.738E-10 | 0 | 1776 | gtex_brain_ba24 |
| rs28371705 | 22 | 42525798 | CYP2D6 | ENSG00000100197.16 | 8.476E-9 | 0 | 1110 | gtex_brain_ba24 |
| rs28371704 | 22 | 42525811 | CYP2D6 | ENSG00000100197.16 | 8.234E-9 | 0 | 1097 | gtex_brain_ba24 |
| rs28371703 | 22 | 42525821 | CYP2D6 | ENSG00000100197.16 | 1.241E-8 | 0 | 1087 | gtex_brain_ba24 |
| rs28371702 | 22 | 42525952 | CYP2D6 | ENSG00000100197.16 | 2.829E-9 | 0 | 956 | gtex_brain_ba24 |
| rs28371699 | 22 | 42526484 | CYP2D6 | ENSG00000100197.16 | 4.118E-9 | 0 | 424 | gtex_brain_ba24 |
| rs1065852 | 22 | 42526694 | CYP2D6 | ENSG00000100197.16 | 1.488E-13 | 0 | 214 | gtex_brain_ba24 |
| rs1080989 | 22 | 42527793 | CYP2D6 | ENSG00000100197.16 | 2.239E-13 | 0 | -885 | gtex_brain_ba24 |
| rs202238012 | 22 | 42528027 | CYP2D6 | ENSG00000100197.16 | 4.415E-8 | 0 | -1119 | gtex_brain_ba24 |
| rs28735595 | 22 | 42528028 | CYP2D6 | ENSG00000100197.16 | 1.223E-6 | 0 | -1120 | gtex_brain_ba24 |
| rs28588594 | 22 | 42528224 | CYP2D6 | ENSG00000100197.16 | 3.984E-13 | 0 | -1316 | gtex_brain_ba24 |
| rs28680494 | 22 | 42528851 | CYP2D6 | ENSG00000100197.16 | 2.628E-8 | 0 | -1943 | gtex_brain_ba24 |
| rs28439297 | 22 | 42528858 | CYP2D6 | ENSG00000100197.16 | 5.454E-9 | 0 | -1950 | gtex_brain_ba24 |
| rs28360521 | 22 | 42528976 | CYP2D6 | ENSG00000100197.16 | 1.534E-11 | 0 | -2068 | gtex_brain_ba24 |
| rs28568508 | 22 | 42529219 | CYP2D6 | ENSG00000100197.16 | 4.637E-13 | 0 | -2311 | gtex_brain_ba24 |
| rs28566059 | 22 | 42529321 | CYP2D6 | ENSG00000100197.16 | 1.185E-12 | 0 | -2413 | gtex_brain_ba24 |
| rs28542726 | 22 | 42529407 | CYP2D6 | ENSG00000100197.16 | 4.695E-9 | 0 | -2499 | gtex_brain_ba24 |
| rs267608268 | 22 | 42530096 | CYP2D6 | ENSG00000100197.16 | 4.561E-9 | 0 | -3188 | gtex_brain_ba24 |
| rs28579115 | 22 | 42530826 | CYP2D6 | ENSG00000100197.16 | 1.168E-8 | 0 | -3918 | gtex_brain_ba24 |
| rs375969824 | 22 | 42531064 | CYP2D6 | ENSG00000100197.16 | 5.359E-9 | 0 | -4156 | gtex_brain_ba24 |
| rs28670611 | 22 | 42531210 | CYP2D6 | ENSG00000100197.16 | 5.544E-9 | 0 | -4302 | gtex_brain_ba24 |
| rs2743449 | 22 | 42534148 | CYP2D6 | ENSG00000100197.16 | 1.75E-10 | 0 | -7240 | gtex_brain_ba24 |
| rs2743450 | 22 | 42534601 | CYP2D6 | ENSG00000100197.16 | 1.512E-12 | 0 | -7693 | gtex_brain_ba24 |
| rs2743451 | 22 | 42534682 | CYP2D6 | ENSG00000100197.16 | 1.44E-10 | 0 | -7774 | gtex_brain_ba24 |
| rs587707332 | 22 | 42534864 | CYP2D6 | ENSG00000100197.16 | 1.679E-10 | 0 | -7956 | gtex_brain_ba24 |
| rs2743453 | 22 | 42534956 | CYP2D6 | ENSG00000100197.16 | 1.522E-12 | 0 | -8048 | gtex_brain_ba24 |
| rs2743454 | 22 | 42535636 | CYP2D6 | ENSG00000100197.16 | 7.884E-12 | 0 | -8728 | gtex_brain_ba24 |
| rs2743455 | 22 | 42536064 | CYP2D6 | ENSG00000100197.16 | 3.852E-8 | 0 | -9156 | gtex_brain_ba24 |
| rs2092118 | 22 | 42536211 | CYP2D6 | ENSG00000100197.16 | 4.391E-8 | 0 | -9303 | gtex_brain_ba24 |
| rs1058174 | 22 | 42536263 | CYP2D6 | ENSG00000100197.16 | 2.828E-10 | 0 | -9355 | gtex_brain_ba24 |
| rs2743456 | 22 | 42536313 | CYP2D6 | ENSG00000100197.16 | 7.711E-13 | 0 | -9405 | gtex_brain_ba24 |
| rs2860373 | 22 | 42537029 | CYP2D6 | ENSG00000100197.16 | 3.422E-7 | 0 | -10121 | gtex_brain_ba24 |
| rs2743457 | 22 | 42537252 | CYP2D6 | ENSG00000100197.16 | 4.482E-10 | 0 | -10344 | gtex_brain_ba24 |
| rs1800754 | 22 | 42537597 | CYP2D6 | ENSG00000100197.16 | 2.986E-10 | 0 | -10689 | gtex_brain_ba24 |
| rs2267444 | 22 | 42538071 | CYP2D6 | ENSG00000100197.16 | 3.997E-10 | 0 | -11163 | gtex_brain_ba24 |
| rs2267446 | 22 | 42538084 | CYP2D6 | ENSG00000100197.16 | 4.453E-12 | 0 | -11176 | gtex_brain_ba24 |
| rs3021083 | 22 | 42538103 | CYP2D6 | ENSG00000100197.16 | 3.54E-10 | 0 | -11195 | gtex_brain_ba24 |
| rs36093924 | 22 | 42538399 | CYP2D6 | ENSG00000100197.16 | 2.296E-9 | 0 | -11491 | gtex_brain_ba24 |
| rs3021082 | 22 | 42538508 | CYP2D6 | ENSG00000100197.16 | 1.893E-7 | 0 | -11600 | gtex_brain_ba24 |
| rs56023519 | 22 | 42538509 | CYP2D6 | ENSG00000100197.16 | 1.886E-7 | 0 | -11601 | gtex_brain_ba24 |
| . | 22 | 42538514 | CYP2D6 | ENSG00000100197.16 | 1.782E-7 | 0 | -11606 | gtex_brain_ba24 |
| rs2267448 | 22 | 42538618 | CYP2D6 | ENSG00000100197.16 | 1.39E-10 | 0 | -11710 | gtex_brain_ba24 |
| rs2856955 | 22 | 42538669 | CYP2D6 | ENSG00000100197.16 | 6.576E-7 | 0 | -11761 | gtex_brain_ba24 |
| rs2743459 | 22 | 42538704 | CYP2D6 | ENSG00000100197.16 | 3.31E-8 | 0 | -11796 | gtex_brain_ba24 |
| rs2743460 | 22 | 42538885 | CYP2D6 | ENSG00000100197.16 | 3.042E-12 | 0 | -11977 | gtex_brain_ba24 |
| rs2854740 | 22 | 42538897 | CYP2D6 | ENSG00000100197.16 | 1.794E-10 | 0 | -11989 | gtex_brain_ba24 |
| rs2743461 | 22 | 42540551 | CYP2D6 | ENSG00000100197.16 | 2.17E-9 | 0 | -13643 | gtex_brain_ba24 |
| rs3021076 | 22 | 42540667 | CYP2D6 | ENSG00000100197.16 | 2.808E-13 | 0 | -13759 | gtex_brain_ba24 |
| rs3020731 | 22 | 42540668 | CYP2D6 | ENSG00000100197.16 | 3.52E-14 | 0 | -13760 | gtex_brain_ba24 |
| rs3021079 | 22 | 42540863 | CYP2D6 | ENSG00000100197.16 | 2.469E-13 | 0 | -13955 | gtex_brain_ba24 |
| rs2856960 | 22 | 42540896 | CYP2D6 | ENSG00000100197.16 | 3.789E-13 | 0 | -13988 | gtex_brain_ba24 |
| rs2856957 | 22 | 42541285 | CYP2D6 | ENSG00000100197.16 | 2.516E-13 | 0 | -14377 | gtex_brain_ba24 |
| rs4467371 | 22 | 42541328 | CYP2D6 | ENSG00000100197.16 | 2.518E-13 | 0 | -14420 | gtex_brain_ba24 |
| rs5758605 | 22 | 42541349 | CYP2D6 | ENSG00000100197.16 | 9.047E-7 | 0 | -14441 | gtex_brain_ba24 |
| rs5751226 | 22 | 42541394 | CYP2D6 | ENSG00000100197.16 | 2.522E-13 | 0 | -14486 | gtex_brain_ba24 |
| rs5758606 | 22 | 42541656 | CYP2D6 | ENSG00000100197.16 | 7.635E-14 | 0 | -14748 | gtex_brain_ba24 |
| rs5751227 | 22 | 42542153 | CYP2D6 | ENSG00000100197.16 | 2.597E-13 | 0 | -15245 | gtex_brain_ba24 |
| rs2142694 | 22 | 42542870 | CYP2D6 | ENSG00000100197.16 | 2.677E-9 | 0 | -15962 | gtex_brain_ba24 |
| rs2743462 | 22 | 42543288 | CYP2D6 | ENSG00000100197.16 | 9.339E-7 | 0 | -16380 | gtex_brain_ba24 |
| rs5996120 | 22 | 42543960 | CYP2D6 | ENSG00000100197.16 | 1.962E-13 | 0 | -17052 | gtex_brain_ba24 |
| rs75274740 | 22 | 42544551 | CYP2D6 | ENSG00000100197.16 | 1.605E-12 | 0 | -17643 | gtex_brain_ba24 |
| rs5751228 | 22 | 42544758 | CYP2D6 | ENSG00000100197.16 | 5.481E-13 | 0 | -17850 | gtex_brain_ba24 |
| rs5751229 | 22 | 42545221 | CYP2D6 | ENSG00000100197.16 | 2.575E-12 | 0 | -18313 | gtex_brain_ba24 |
| rs28493713 | 22 | 42546018 | CYP2D6 | ENSG00000100197.16 | 1.426E-8 | 0 | -19110 | gtex_brain_ba24 |
| rs59390354 | 22 | 42546852 | CYP2D6 | ENSG00000100197.16 | 1.934E-13 | 0 | -19944 | gtex_brain_ba24 |
| rs5758608 | 22 | 42547229 | CYP2D6 | ENSG00000100197.16 | 3.148E-13 | 0 | -20321 | gtex_brain_ba24 |
| rs5758609 | 22 | 42547317 | CYP2D6 | ENSG00000100197.16 | 3.162E-13 | 0 | -20409 | gtex_brain_ba24 |
| rs5758610 | 22 | 42547409 | CYP2D6 | ENSG00000100197.16 | 3.174E-13 | 0 | -20501 | gtex_brain_ba24 |
| rs2743465 | 22 | 42547739 | CYP2D6 | ENSG00000100197.16 | 1.416E-6 | 0 | -20831 | gtex_brain_ba24 |
| rs8137366 | 22 | 42547755 | CYP2D6 | ENSG00000100197.16 | 7.04E-9 | 0 | -20847 | gtex_brain_ba24 |
| rs5758611 | 22 | 42548094 | CYP2D6 | ENSG00000100197.16 | 1.034E-8 | 0 | -21186 | gtex_brain_ba24 |
| rs5758612 | 22 | 42548178 | CYP2D6 | ENSG00000100197.16 | 7.059E-9 | 0 | -21270 | gtex_brain_ba24 |
| rs5758613 | 22 | 42549164 | CYP2D6 | ENSG00000100197.16 | 1.046E-8 | 0 | -22256 | gtex_brain_ba24 |
| rs1997659 | 22 | 42550287 | CYP2D6 | ENSG00000100197.16 | 9.327E-9 | 0 | -23379 | gtex_brain_ba24 |
| rs2236779 | 22 | 42551344 | CYP2D6 | ENSG00000100197.16 | 6.123E-13 | 0 | -24436 | gtex_brain_ba24 |
| rs742086 | 22 | 42552253 | CYP2D6 | ENSG00000100197.16 | 1.517E-8 | 0 | -25345 | gtex_brain_ba24 |
| rs5751230 | 22 | 42553353 | CYP2D6 | ENSG00000100197.16 | 6.123E-13 | 0 | -26445 | gtex_brain_ba24 |
| rs2899354 | 22 | 42554409 | CYP2D6 | ENSG00000100197.16 | 6.123E-13 | 0 | -27501 | gtex_brain_ba24 |
| rs5758618 | 22 | 42554839 | CYP2D6 | ENSG00000100197.16 | 9.521E-9 | 0 | -27931 | gtex_brain_ba24 |
| rs5751231 | 22 | 42555861 | CYP2D6 | ENSG00000100197.16 | 9.521E-9 | 0 | -28953 | gtex_brain_ba24 |
| rs9611746 | 22 | 42561365 | CYP2D6 | ENSG00000100197.16 | 6.127E-13 | 0 | -34457 | gtex_brain_ba24 |
| rs4453786 | 22 | 42563308 | CYP2D6 | ENSG00000100197.16 | 6.123E-13 | 0 | -36400 | gtex_brain_ba24 |
| rs375059981 | 22 | 42563525 | CYP2D6 | ENSG00000100197.16 | 6.291E-13 | 0 | -36617 | gtex_brain_ba24 |
| rs201603285 | 22 | 42563531 | CYP2D6 | ENSG00000100197.16 | 6.291E-13 | 0 | -36623 | gtex_brain_ba24 |
| rs34614590 | 22 | 42563532 | CYP2D6 | ENSG00000100197.16 | 4.736E-13 | 0 | -36624 | gtex_brain_ba24 |
| rs62240864 | 22 | 42563889 | CYP2D6 | ENSG00000100197.16 | 1.862E-10 | 0 | -36981 | gtex_brain_ba24 |
| rs5758622 | 22 | 42563933 | CYP2D6 | ENSG00000100197.16 | 6.123E-13 | 0 | -37025 | gtex_brain_ba24 |
| rs5751232 | 22 | 42564304 | CYP2D6 | ENSG00000100197.16 | 6.123E-13 | 0 | -37396 | gtex_brain_ba24 |
| rs9607882 | 22 | 42567451 | CYP2D6 | ENSG00000100197.16 | 6.123E-13 | 0 | -40543 | gtex_brain_ba24 |
| rs714002 | 22 | 42569024 | CYP2D6 | ENSG00000100197.16 | 5.968E-9 | 0 | -42116 | gtex_brain_ba24 |
| . | 22 | 42569247 | CYP2D6 | ENSG00000100197.16 | 6.245E-9 | 0 | -42339 | gtex_brain_ba24 |
| rs738257 | 22 | 42569298 | CYP2D6 | ENSG00000100197.16 | 6.123E-13 | 0 | -42390 | gtex_brain_ba24 |
| rs713811 | 22 | 42569870 | CYP2D6 | ENSG00000100197.16 | 5.968E-9 | 0 | -42962 | gtex_brain_ba24 |
| rs2011944 | 22 | 42569999 | CYP2D6 | ENSG00000100197.16 | 5.968E-9 | 0 | -43091 | gtex_brain_ba24 |
| rs5758626 | 22 | 42572363 | CYP2D6 | ENSG00000100197.16 | 3.234E-12 | 0 | -45455 | gtex_brain_ba24 |
| rs5758627 | 22 | 42572547 | CYP2D6 | ENSG00000100197.16 | 3.248E-12 | 0 | -45639 | gtex_brain_ba24 |
| rs1989375 | 22 | 42573139 | CYP2D6 | ENSG00000100197.16 | 2.197E-12 | 0 | -46231 | gtex_brain_ba24 |
| rs5758629 | 22 | 42574555 | CYP2D6 | ENSG00000100197.16 | 3.186E-12 | 0 | -47647 | gtex_brain_ba24 |
| rs9607885 | 22 | 42578596 | CYP2D6 | ENSG00000100197.16 | 5.509E-12 | 0 | -51688 | gtex_brain_ba24 |
| rs5758635 | 22 | 42579923 | CYP2D6 | ENSG00000100197.16 | 1.336E-8 | 0 | -53015 | gtex_brain_ba24 |
| rs5758637 | 22 | 42580933 | CYP2D6 | ENSG00000100197.16 | 6.111E-12 | 0 | -54025 | gtex_brain_ba24 |
| rs5758638 | 22 | 42582394 | CYP2D6 | ENSG00000100197.16 | 1.969E-12 | 0 | -55486 | gtex_brain_ba24 |
| rs5751239 | 22 | 42592239 | CYP2D6 | ENSG00000100197.16 | 5.008E-7 | 0 | -65331 | gtex_brain_ba24 |
| rs5751240 | 22 | 42595258 | CYP2D6 | ENSG00000100197.16 | 1.732E-12 | 0 | -68350 | gtex_brain_ba24 |
| rs6002655 | 22 | 42603814 | CYP2D6 | ENSG00000100197.16 | 1.05E-6 | 0 | -76906 | gtex_brain_ba24 |
| rs5758651 | 22 | 42609148 | CYP2D6 | ENSG00000100197.16 | 1.732E-12 | 0 | -82240 | gtex_brain_ba24 |
| rs5758652 | 22 | 42612408 | CYP2D6 | ENSG00000100197.16 | 1.857E-12 | 0 | -85500 | gtex_brain_ba24 |
| rs932376 | 22 | 42614362 | CYP2D6 | ENSG00000100197.16 | 3.229E-13 | 0 | -87454 | gtex_brain_ba24 |
| . | 22 | 42614823 | CYP2D6 | ENSG00000100197.16 | 1.736E-12 | 0 | -87915 | gtex_brain_ba24 |
| rs67613113 | 22 | 42614825 | CYP2D6 | ENSG00000100197.16 | 1.723E-12 | 0 | -87917 | gtex_brain_ba24 |
| rs5751243 | 22 | 42617177 | CYP2D6 | ENSG00000100197.16 | 1.732E-12 | 0 | -90269 | gtex_brain_ba24 |
| rs5751244 | 22 | 42617411 | CYP2D6 | ENSG00000100197.16 | 1.732E-12 | 0 | -90503 | gtex_brain_ba24 |
| . | 22 | 42618494 | CYP2D6 | ENSG00000100197.16 | 5.759E-10 | 0 | -91586 | gtex_brain_ba24 |
| rs5758657 | 22 | 42618669 | CYP2D6 | ENSG00000100197.16 | 1.732E-12 | 0 | -91761 | gtex_brain_ba24 |
| rs1033459 | 22 | 42619067 | CYP2D6 | ENSG00000100197.16 | 1.585E-12 | 0 | -92159 | gtex_brain_ba24 |
| rs1033460 | 22 | 42619308 | CYP2D6 | ENSG00000100197.16 | 1.732E-12 | 0 | -92400 | gtex_brain_ba24 |
| rs5751245 | 22 | 42620940 | CYP2D6 | ENSG00000100197.16 | 2.317E-13 | 0 | -94032 | gtex_brain_ba24 |
| rs55867855 | 22 | 42623258 | CYP2D6 | ENSG00000100197.16 | 1.743E-12 | 0 | -96350 | gtex_brain_ba24 |
| rs17002902 | 22 | 42625509 | CYP2D6 | ENSG00000100197.16 | 1.635E-12 | 0 | -98601 | gtex_brain_ba24 |
| rs5758662 | 22 | 42628088 | CYP2D6 | ENSG00000100197.16 | 1.593E-12 | 0 | -101180 | gtex_brain_ba24 |
| rs56906457 | 22 | 42628335 | CYP2D6 | ENSG00000100197.16 | 7.597E-12 | 0 | -101427 | gtex_brain_ba24 |
| rs5758666 | 22 | 42632833 | CYP2D6 | ENSG00000100197.16 | 3.52E-13 | 0 | -105925 | gtex_brain_ba24 |
| rs5751247 | 22 | 42633054 | CYP2D6 | ENSG00000100197.16 | 3.904E-13 | 0 | -106146 | gtex_brain_ba24 |
| rs5758667 | 22 | 42633204 | CYP2D6 | ENSG00000100197.16 | 1.746E-12 | 0 | -106296 | gtex_brain_ba24 |
| rs111404889 | 22 | 42638205 | CYP2D6 | ENSG00000100197.16 | 2.264E-12 | 0 | -111297 | gtex_brain_ba24 |
| rs58654759 | 22 | 42642576 | CYP2D6 | ENSG00000100197.16 | 2.72E-12 | 0 | -115668 | gtex_brain_ba24 |
| rs55906806 | 22 | 42644471 | CYP2D6 | ENSG00000100197.16 | 9.616E-10 | 0 | -117563 | gtex_brain_ba24 |
| rs5758681 | 22 | 42645091 | CYP2D6 | ENSG00000100197.16 | 4.375E-12 | 0 | -118183 | gtex_brain_ba24 |
| rs5758682 | 22 | 42645202 | CYP2D6 | ENSG00000100197.16 | 3.327E-12 | 0 | -118294 | gtex_brain_ba24 |
| rs200890675 | 22 | 42646472 | CYP2D6 | ENSG00000100197.16 | 1.059E-9 | 0 | -119564 | gtex_brain_ba24 |
| rs200979396 | 22 | 42646473 | CYP2D6 | ENSG00000100197.16 | 2.373E-9 | 0 | -119565 | gtex_brain_ba24 |
| rs34107327 | 22 | 42648353 | CYP2D6 | ENSG00000100197.16 | 3.252E-12 | 0 | -121445 | gtex_brain_ba24 |
| rs5758684 | 22 | 42649509 | CYP2D6 | ENSG00000100197.16 | 3.317E-12 | 0 | -122601 | gtex_brain_ba24 |
| rs56400210 | 22 | 42651536 | CYP2D6 | ENSG00000100197.16 | 3.164E-9 | 0 | -124628 | gtex_brain_ba24 |
| rs17478227 | 22 | 42654327 | CYP2D6 | ENSG00000100197.16 | 9.031E-10 | 0 | -127419 | gtex_brain_ba24 |
| rs5758686 | 22 | 42655377 | CYP2D6 | ENSG00000100197.16 | 3.413E-12 | 0 | -128469 | gtex_brain_ba24 |
| rs5758687 | 22 | 42656588 | CYP2D6 | ENSG00000100197.16 | 3.398E-12 | 0 | -129680 | gtex_brain_ba24 |
| rs739146 | 22 | 42660414 | CYP2D6 | ENSG00000100197.16 | 1.732E-12 | 0 | -133506 | gtex_brain_ba24 |
| rs5758688 | 22 | 42662501 | CYP2D6 | ENSG00000100197.16 | 3.603E-12 | 0 | -135593 | gtex_brain_ba24 |
| rs5751258 | 22 | 42663871 | CYP2D6 | ENSG00000100197.16 | 3.904E-12 | 0 | -136963 | gtex_brain_ba24 |
| rs56111723 | 22 | 42664883 | CYP2D6 | ENSG00000100197.16 | 2.194E-12 | 0 | -137975 | gtex_brain_ba24 |
| rs5758689 | 22 | 42664972 | CYP2D6 | ENSG00000100197.16 | 4.045E-12 | 0 | -138064 | gtex_brain_ba24 |
| rs55644935 | 22 | 42666069 | CYP2D6 | ENSG00000100197.16 | 3.33E-11 | 0 | -139161 | gtex_brain_ba24 |
| rs1107553 | 22 | 42667473 | CYP2D6 | ENSG00000100197.16 | 3.933E-12 | 0 | -140565 | gtex_brain_ba24 |
| rs1107554 | 22 | 42667594 | CYP2D6 | ENSG00000100197.16 | 3.933E-12 | 0 | -140686 | gtex_brain_ba24 |
| rs55750942 | 22 | 42667962 | CYP2D6 | ENSG00000100197.16 | 9.667E-11 | 0 | -141054 | gtex_brain_ba24 |
| rs5758690 | 22 | 42668295 | CYP2D6 | ENSG00000100197.16 | 4.064E-12 | 0 | -141387 | gtex_brain_ba24 |
| rs5758691 | 22 | 42668504 | CYP2D6 | ENSG00000100197.16 | 3.933E-12 | 0 | -141596 | gtex_brain_ba24 |
| rs5758692 | 22 | 42669029 | CYP2D6 | ENSG00000100197.16 | 3.66E-12 | 0 | -142121 | gtex_brain_ba24 |
| rs1001587 | 22 | 42670111 | CYP2D6 | ENSG00000100197.16 | 3.933E-12 | 0 | -143203 | gtex_brain_ba24 |
| rs1001586 | 22 | 42670293 | CYP2D6 | ENSG00000100197.16 | 3.933E-12 | 0 | -143385 | gtex_brain_ba24 |
| rs739147 | 22 | 42671066 | CYP2D6 | ENSG00000100197.16 | 3.933E-12 | 0 | -144158 | gtex_brain_ba24 |
| rs5758698 | 22 | 42684818 | CYP2D6 | ENSG00000100197.16 | 2.873E-12 | 0 | -157910 | gtex_brain_ba24 |
| rs5758699 | 22 | 42688034 | CYP2D6 | ENSG00000100197.16 | 2.377E-13 | 0 | -161126 | gtex_brain_ba24 |
| rs17002947 | 22 | 42688532 | CYP2D6 | ENSG00000100197.16 | 2.889E-10 | 0 | -161624 | gtex_brain_ba24 |
| rs4822072 | 22 | 42360833 | CYP2D6 | ENSG00000100197.16 | 2.884E-6 | 0 | 166075 | gtex_brain_putamen_basal |
| rs2899350 | 22 | 42363408 | CYP2D6 | ENSG00000100197.16 | 6.083E-8 | 0 | 163500 | gtex_brain_putamen_basal |
| rs739294 | 22 | 42381726 | CYP2D6 | ENSG00000100197.16 | 4.251E-8 | 0 | 145182 | gtex_brain_putamen_basal |
| rs133294 | 22 | 42382805 | CYP2D6 | ENSG00000100197.16 | 3.446E-6 | 0 | 144103 | gtex_brain_putamen_basal |
| rs6519301 | 22 | 42385967 | CYP2D6 | ENSG00000100197.16 | 3.452E-6 | 0 | 140941 | gtex_brain_putamen_basal |
| rs133300 | 22 | 42389839 | CYP2D6 | ENSG00000100197.16 | 1.392E-6 | 0 | 137069 | gtex_brain_putamen_basal |
| rs133301 | 22 | 42390093 | CYP2D6 | ENSG00000100197.16 | 1.392E-6 | 0 | 136815 | gtex_brain_putamen_basal |
| rs133303 | 22 | 42395242 | CYP2D6 | ENSG00000100197.16 | 1.39E-6 | 0 | 131666 | gtex_brain_putamen_basal |
| rs133305 | 22 | 42395960 | CYP2D6 | ENSG00000100197.16 | 1.392E-6 | 0 | 130948 | gtex_brain_putamen_basal |
| rs133306 | 22 | 42396150 | CYP2D6 | ENSG00000100197.16 | 1.392E-6 | 0 | 130758 | gtex_brain_putamen_basal |
| rs133307 | 22 | 42396568 | CYP2D6 | ENSG00000100197.16 | 1.392E-6 | 0 | 130340 | gtex_brain_putamen_basal |
| rs5758537 | 22 | 42397042 | CYP2D6 | ENSG00000100197.16 | 1.392E-6 | 0 | 129866 | gtex_brain_putamen_basal |
| rs71751842 | 22 | 42398849 | CYP2D6 | ENSG00000100197.16 | 9.08E-7 | 0 | 128059 | gtex_brain_putamen_basal |
| rs129855 | 22 | 42399325 | CYP2D6 | ENSG00000100197.16 | 1.392E-6 | 0 | 127583 | gtex_brain_putamen_basal |
| rs129856 | 22 | 42399396 | CYP2D6 | ENSG00000100197.16 | 1.392E-6 | 0 | 127512 | gtex_brain_putamen_basal |
| rs129857 | 22 | 42399686 | CYP2D6 | ENSG00000100197.16 | 1.392E-6 | 0 | 127222 | gtex_brain_putamen_basal |
| rs6002571 | 22 | 42400416 | CYP2D6 | ENSG00000100197.16 | 1.392E-6 | 0 | 126492 | gtex_brain_putamen_basal |
| rs133313 | 22 | 42401749 | CYP2D6 | ENSG00000100197.16 | 1.392E-6 | 0 | 125159 | gtex_brain_putamen_basal |
| rs133314 | 22 | 42401841 | CYP2D6 | ENSG00000100197.16 | 1.392E-6 | 0 | 125067 | gtex_brain_putamen_basal |
| rs133317 | 22 | 42402386 | CYP2D6 | ENSG00000100197.16 | 4.053E-9 | 0 | 124522 | gtex_brain_putamen_basal |
| rs133318 | 22 | 42402480 | CYP2D6 | ENSG00000100197.16 | 6.907E-7 | 0 | 124428 | gtex_brain_putamen_basal |
| rs133320 | 22 | 42403853 | CYP2D6 | ENSG00000100197.16 | 1.392E-6 | 0 | 123055 | gtex_brain_putamen_basal |
| rs133322 | 22 | 42405659 | CYP2D6 | ENSG00000100197.16 | 1.482E-6 | 0 | 121249 | gtex_brain_putamen_basal |
| rs133323 | 22 | 42405922 | CYP2D6 | ENSG00000100197.16 | 2.987E-6 | 0 | 120986 | gtex_brain_putamen_basal |
| rs133324 | 22 | 42406371 | CYP2D6 | ENSG00000100197.16 | 2.987E-6 | 0 | 120537 | gtex_brain_putamen_basal |
| rs133325 | 22 | 42406820 | CYP2D6 | ENSG00000100197.16 | 2.979E-6 | 0 | 120088 | gtex_brain_putamen_basal |
| rs133326 | 22 | 42406885 | CYP2D6 | ENSG00000100197.16 | 2.987E-6 | 0 | 120023 | gtex_brain_putamen_basal |
| rs133327 | 22 | 42407689 | CYP2D6 | ENSG00000100197.16 | 2.976E-6 | 0 | 119219 | gtex_brain_putamen_basal |
| rs133328 | 22 | 42408079 | CYP2D6 | ENSG00000100197.16 | 2.973E-6 | 0 | 118829 | gtex_brain_putamen_basal |
| rs133330 | 22 | 42409456 | CYP2D6 | ENSG00000100197.16 | 2.959E-6 | 0 | 117452 | gtex_brain_putamen_basal |
| rs2413664 | 22 | 42413978 | CYP2D6 | ENSG00000100197.16 | 5.477E-9 | 0 | 112930 | gtex_brain_putamen_basal |
| rs133336 | 22 | 42416303 | CYP2D6 | ENSG00000100197.16 | 1.342E-6 | 0 | 110605 | gtex_brain_putamen_basal |
| rs133340 | 22 | 42417687 | CYP2D6 | ENSG00000100197.16 | 1.089E-6 | 0 | 109221 | gtex_brain_putamen_basal |
| rs133346 | 22 | 42420855 | CYP2D6 | ENSG00000100197.16 | 1.669E-6 | 0 | 106053 | gtex_brain_putamen_basal |
| rs133347 | 22 | 42423645 | CYP2D6 | ENSG00000100197.16 | 3.24E-7 | 0 | 103263 | gtex_brain_putamen_basal |
| rs133348 | 22 | 42427949 | CYP2D6 | ENSG00000100197.16 | 3.927E-6 | 0 | 98959 | gtex_brain_putamen_basal |
| rs133349 | 22 | 42428727 | CYP2D6 | ENSG00000100197.16 | 2.718E-7 | 0 | 98181 | gtex_brain_putamen_basal |
| rs133351 | 22 | 42431246 | CYP2D6 | ENSG00000100197.16 | 1.51E-10 | 0 | 95662 | gtex_brain_putamen_basal |
| rs5758553 | 22 | 42431429 | CYP2D6 | ENSG00000100197.16 | 2.483E-7 | 0 | 95479 | gtex_brain_putamen_basal |
| rs4822084 | 22 | 42435868 | CYP2D6 | ENSG00000100197.16 | 2.228E-7 | 0 | 91040 | gtex_brain_putamen_basal |
| rs133357 | 22 | 42442235 | CYP2D6 | ENSG00000100197.16 | 1.871E-7 | 0 | 84673 | gtex_brain_putamen_basal |
| rs133358 | 22 | 42442539 | CYP2D6 | ENSG00000100197.16 | 1.836E-7 | 0 | 84369 | gtex_brain_putamen_basal |
| rs34277770 | 22 | 42443908 | CYP2D6 | ENSG00000100197.16 | 2.491E-10 | 0 | 83000 | gtex_brain_putamen_basal |
| . | 22 | 42444779 | CYP2D6 | ENSG00000100197.16 | 4.863E-7 | 0 | 82129 | gtex_brain_putamen_basal |
| rs10854749 | 22 | 42447341 | CYP2D6 | ENSG00000100197.16 | 6.066E-11 | 0 | 79567 | gtex_brain_putamen_basal |
| rs201653716 | 22 | 42453846 | CYP2D6 | ENSG00000100197.16 | 4.547E-9 | 0 | 73062 | gtex_brain_putamen_basal |
| rs1063392 | 22 | 42454950 | CYP2D6 | ENSG00000100197.16 | 1.438E-7 | 0 | 71958 | gtex_brain_putamen_basal |
| rs2013960 | 22 | 42457912 | CYP2D6 | ENSG00000100197.16 | 1.344E-7 | 0 | 68996 | gtex_brain_putamen_basal |
| rs133367 | 22 | 42463366 | CYP2D6 | ENSG00000100197.16 | 4.686E-7 | 0 | 63542 | gtex_brain_putamen_basal |
| rs133373 | 22 | 42465788 | CYP2D6 | ENSG00000100197.16 | 5.766E-15 | 0 | 61120 | gtex_brain_putamen_basal |
| rs133376 | 22 | 42466905 | CYP2D6 | ENSG00000100197.16 | 2.167E-10 | 0 | 60003 | gtex_brain_putamen_basal |
| rs133383 | 22 | 42473603 | CYP2D6 | ENSG00000100197.16 | 1.756E-10 | 0 | 53305 | gtex_brain_putamen_basal |
| rs5758574 | 22 | 42481400 | CYP2D6 | ENSG00000100197.16 | 1.391E-15 | 0 | 45508 | gtex_brain_putamen_basal |
| rs7245 | 22 | 42481849 | CYP2D6 | ENSG00000100197.16 | 9.003E-11 | 0 | 45059 | gtex_brain_putamen_basal |
| rs2284087 | 22 | 42485671 | CYP2D6 | ENSG00000100197.16 | 3.119E-15 | 0 | 41237 | gtex_brain_putamen_basal |
| . | 22 | 42487613 | CYP2D6 | ENSG00000100197.16 | 1.254E-15 | 0 | 39295 | gtex_brain_putamen_basal |
| rs5758577 | 22 | 42489434 | CYP2D6 | ENSG00000100197.16 | 1.263E-10 | 0 | 37474 | gtex_brain_putamen_basal |
| rs5758578 | 22 | 42490292 | CYP2D6 | ENSG00000100197.16 | 1.104E-15 | 0 | 36616 | gtex_brain_putamen_basal |
| rs6002607 | 22 | 42496506 | CYP2D6 | ENSG00000100197.16 | 1.018E-10 | 0 | 30402 | gtex_brain_putamen_basal |
| rs6002608 | 22 | 42496629 | CYP2D6 | ENSG00000100197.16 | 1.014E-10 | 0 | 30279 | gtex_brain_putamen_basal |
| rs2413668 | 22 | 42505841 | CYP2D6 | ENSG00000100197.16 | 5.877E-16 | 0 | 21067 | gtex_brain_putamen_basal |
| rs5751216 | 22 | 42508937 | CYP2D6 | ENSG00000100197.16 | 5.441E-16 | 0 | 17971 | gtex_brain_putamen_basal |
| rs2413670 | 22 | 42511822 | CYP2D6 | ENSG00000100197.16 | 4.977E-16 | 0 | 15086 | gtex_brain_putamen_basal |
| rs2413671 | 22 | 42511825 | CYP2D6 | ENSG00000100197.16 | 4.977E-16 | 0 | 15083 | gtex_brain_putamen_basal |
| rs5751220 | 22 | 42516205 | CYP2D6 | ENSG00000100197.16 | 6.528E-11 | 0 | 10703 | gtex_brain_putamen_basal |
| rs5758587 | 22 | 42517636 | CYP2D6 | ENSG00000100197.16 | 3.534E-16 | 0 | 9272 | gtex_brain_putamen_basal |
| rs6002626 | 22 | 42517989 | CYP2D6 | ENSG00000100197.16 | 5.387E-11 | 0 | 8919 | gtex_brain_putamen_basal |
| rs5758589 | 22 | 42518382 | CYP2D6 | ENSG00000100197.16 | 2.88E-16 | 0 | 8526 | gtex_brain_putamen_basal |
| rs34385013 | 22 | 42521929 | CYP2D6 | ENSG00000100197.16 | 1.579E-15 | 0 | 4979 | gtex_brain_putamen_basal |
| rs35028622 | 22 | 42522074 | CYP2D6 | ENSG00000100197.16 | 1.578E-15 | 0 | 4834 | gtex_brain_putamen_basal |
| rs1135840 | 22 | 42522613 | CYP2D6 | ENSG00000100197.16 | 1.577E-15 | 0 | 4295 | gtex_brain_putamen_basal |
| rs1985842 | 22 | 42523409 | CYP2D6 | ENSG00000100197.16 | 4.438E-8 | 0 | 3499 | gtex_brain_putamen_basal |
| rs1058164 | 22 | 42525132 | CYP2D6 | ENSG00000100197.16 | 7.77E-17 | 0 | 1776 | gtex_brain_putamen_basal |
| rs28371702 | 22 | 42525952 | CYP2D6 | ENSG00000100197.16 | 1.633E-14 | 0 | 956 | gtex_brain_putamen_basal |
| rs28371699 | 22 | 42526484 | CYP2D6 | ENSG00000100197.16 | 1.74E-14 | 0 | 424 | gtex_brain_putamen_basal |
| rs202238012 | 22 | 42528027 | CYP2D6 | ENSG00000100197.16 | 2.845E-15 | 0 | -1119 | gtex_brain_putamen_basal |
| rs28735595 | 22 | 42528028 | CYP2D6 | ENSG00000100197.16 | 8.547E-12 | 0 | -1120 | gtex_brain_putamen_basal |
| rs28680494 | 22 | 42528851 | CYP2D6 | ENSG00000100197.16 | 3.564E-15 | 0 | -1943 | gtex_brain_putamen_basal |
| rs28439297 | 22 | 42528858 | CYP2D6 | ENSG00000100197.16 | 3.564E-15 | 0 | -1950 | gtex_brain_putamen_basal |
| rs28542726 | 22 | 42529407 | CYP2D6 | ENSG00000100197.16 | 3.036E-15 | 0 | -2499 | gtex_brain_putamen_basal |
| rs267608268 | 22 | 42530096 | CYP2D6 | ENSG00000100197.16 | 3.76E-15 | 0 | -3188 | gtex_brain_putamen_basal |
| rs28579115 | 22 | 42530826 | CYP2D6 | ENSG00000100197.16 | 5.043E-14 | 0 | -3918 | gtex_brain_putamen_basal |
| rs375969824 | 22 | 42531064 | CYP2D6 | ENSG00000100197.16 | 4.432E-15 | 0 | -4156 | gtex_brain_putamen_basal |
| rs28670611 | 22 | 42531210 | CYP2D6 | ENSG00000100197.16 | 5.654E-15 | 0 | -4302 | gtex_brain_putamen_basal |
| rs2743449 | 22 | 42534148 | CYP2D6 | ENSG00000100197.16 | 1.482E-15 | 0 | -7240 | gtex_brain_putamen_basal |
| rs2743451 | 22 | 42534682 | CYP2D6 | ENSG00000100197.16 | 6.971E-17 | 0 | -7774 | gtex_brain_putamen_basal |
| rs587707332 | 22 | 42534864 | CYP2D6 | ENSG00000100197.16 | 7.25E-17 | 0 | -7956 | gtex_brain_putamen_basal |
| rs2092118 | 22 | 42536211 | CYP2D6 | ENSG00000100197.16 | 6.467E-14 | 0 | -9303 | gtex_brain_putamen_basal |
| rs2860372 | 22 | 42537023 | CYP2D6 | ENSG00000100197.16 | 2.214E-10 | 0 | -10115 | gtex_brain_putamen_basal |
| rs3020736 | 22 | 42537127 | CYP2D6 | ENSG00000100197.16 | 8.002E-7 | 0 | -10219 | gtex_brain_putamen_basal |
| rs2743458 | 22 | 42537271 | CYP2D6 | ENSG00000100197.16 | 1.938E-8 | 0 | -10363 | gtex_brain_putamen_basal |
| rs1800754 | 22 | 42537597 | CYP2D6 | ENSG00000100197.16 | 2.849E-16 | 0 | -10689 | gtex_brain_putamen_basal |
| rs3021083 | 22 | 42538103 | CYP2D6 | ENSG00000100197.16 | 7.497E-17 | 0 | -11195 | gtex_brain_putamen_basal |
| rs36093924 | 22 | 42538399 | CYP2D6 | ENSG00000100197.16 | 1.216E-13 | 0 | -11491 | gtex_brain_putamen_basal |
| rs2267448 | 22 | 42538618 | CYP2D6 | ENSG00000100197.16 | 3.69E-16 | 0 | -11710 | gtex_brain_putamen_basal |
| rs2856955 | 22 | 42538669 | CYP2D6 | ENSG00000100197.16 | 2.797E-8 | 0 | -11761 | gtex_brain_putamen_basal |
| rs2743459 | 22 | 42538704 | CYP2D6 | ENSG00000100197.16 | 3.476E-13 | 0 | -11796 | gtex_brain_putamen_basal |
| rs2854740 | 22 | 42538897 | CYP2D6 | ENSG00000100197.16 | 5.033E-16 | 0 | -11989 | gtex_brain_putamen_basal |
| rs2743461 | 22 | 42540551 | CYP2D6 | ENSG00000100197.16 | 5.476E-16 | 0 | -13643 | gtex_brain_putamen_basal |
| rs5758605 | 22 | 42541349 | CYP2D6 | ENSG00000100197.16 | 8.187E-11 | 0 | -14441 | gtex_brain_putamen_basal |
| rs2142694 | 22 | 42542870 | CYP2D6 | ENSG00000100197.16 | 2.576E-17 | 0 | -15962 | gtex_brain_putamen_basal |
| rs2743462 | 22 | 42543288 | CYP2D6 | ENSG00000100197.16 | 8.531E-11 | 0 | -16380 | gtex_brain_putamen_basal |
| rs2743465 | 22 | 42547739 | CYP2D6 | ENSG00000100197.16 | 4.182E-12 | 0 | -20831 | gtex_brain_putamen_basal |
| rs5758619 | 22 | 42557710 | CYP2D6 | ENSG00000100197.16 | 2.422E-12 | 0 | -30802 | gtex_brain_putamen_basal |
| rs5758623 | 22 | 42566314 | CYP2D6 | ENSG00000100197.16 | 3.064E-12 | 0 | -39406 | gtex_brain_putamen_basal |
| rs742089 | 22 | 42570458 | CYP2D6 | ENSG00000100197.16 | 1.54E-8 | 0 | -43550 | gtex_brain_putamen_basal |
| rs2413684 | 22 | 42574830 | CYP2D6 | ENSG00000100197.16 | 1.175E-10 | 0 | -47922 | gtex_brain_putamen_basal |
| rs553098570 | 22 | 42579309 | CYP2D6 | ENSG00000100197.16 | 8.13E-10 | 0 | -52401 | gtex_brain_putamen_basal |
| rs2899355 | 22 | 42579520 | CYP2D6 | ENSG00000100197.16 | 1.177E-10 | 0 | -52612 | gtex_brain_putamen_basal |
| rs5751239 | 22 | 42592239 | CYP2D6 | ENSG00000100197.16 | 2.117E-11 | 0 | -65331 | gtex_brain_putamen_basal |
| rs5758645 | 22 | 42598951 | CYP2D6 | ENSG00000100197.16 | 1.168E-10 | 0 | -72043 | gtex_brain_putamen_basal |
| rs5751241 | 22 | 42600589 | CYP2D6 | ENSG00000100197.16 | 1.337E-10 | 0 | -73681 | gtex_brain_putamen_basal |
| rs6002655 | 22 | 42603814 | CYP2D6 | ENSG00000100197.16 | 9.749E-11 | 0 | -76906 | gtex_brain_putamen_basal |
| rs5758653 | 22 | 42613485 | CYP2D6 | ENSG00000100197.16 | 1.161E-10 | 0 | -86577 | gtex_brain_putamen_basal |
| rs2143138 | 22 | 42618340 | CYP2D6 | ENSG00000100197.16 | 2.146E-8 | 0 | -91432 | gtex_brain_putamen_basal |
| rs5758659 | 22 | 42622003 | CYP2D6 | ENSG00000100197.16 | 6.111E-11 | 0 | -95095 | gtex_brain_putamen_basal |
| rs5758660 | 22 | 42623718 | CYP2D6 | ENSG00000100197.16 | 5.622E-11 | 0 | -96810 | gtex_brain_putamen_basal |
| rs5758661 | 22 | 42624445 | CYP2D6 | ENSG00000100197.16 | 2.146E-8 | 0 | -97537 | gtex_brain_putamen_basal |
| rs5758670 | 22 | 42636687 | CYP2D6 | ENSG00000100197.16 | 5.614E-11 | 0 | -109779 | gtex_brain_putamen_basal |
| rs5751250 | 22 | 42639645 | CYP2D6 | ENSG00000100197.16 | 5.339E-11 | 0 | -112737 | gtex_brain_putamen_basal |
| rs5751251 | 22 | 42640606 | CYP2D6 | ENSG00000100197.16 | 1.429E-9 | 0 | -113698 | gtex_brain_putamen_basal |
| rs5758677 | 22 | 42643039 | CYP2D6 | ENSG00000100197.16 | 5.339E-11 | 0 | -116131 | gtex_brain_putamen_basal |
| rs5751255 | 22 | 42648408 | CYP2D6 | ENSG00000100197.16 | 5.339E-11 | 0 | -121500 | gtex_brain_putamen_basal |
| rs139678799 | 22 | 42650323 | CYP2D6 | ENSG00000100197.16 | 5.339E-11 | 0 | -123415 | gtex_brain_putamen_basal |
| rs134866 | 22 | 42650663 | CYP2D6 | ENSG00000100197.16 | 1.166E-7 | 0 | -123755 | gtex_brain_putamen_basal |
| rs134869 | 22 | 42652074 | CYP2D6 | ENSG00000100197.16 | 6.289E-11 | 0 | -125166 | gtex_brain_putamen_basal |
| rs134870 | 22 | 42652317 | CYP2D6 | ENSG00000100197.16 | 1.361E-7 | 0 | -125409 | gtex_brain_putamen_basal |
| rs134871 | 22 | 42652716 | CYP2D6 | ENSG00000100197.16 | 1.768E-8 | 0 | -125808 | gtex_brain_putamen_basal |
| rs134873 | 22 | 42657566 | CYP2D6 | ENSG00000100197.16 | 5.339E-11 | 0 | -130658 | gtex_brain_putamen_basal |
| rs134877 | 22 | 42662371 | CYP2D6 | ENSG00000100197.16 | 5.339E-11 | 0 | -135463 | gtex_brain_putamen_basal |
| rs134879 | 22 | 42664201 | CYP2D6 | ENSG00000100197.16 | 5.339E-11 | 0 | -137293 | gtex_brain_putamen_basal |
| rs134882 | 22 | 42670965 | CYP2D6 | ENSG00000100197.16 | 5.338E-11 | 0 | -144057 | gtex_brain_putamen_basal |
| rs762995 | 22 | 42672124 | CYP2D6 | ENSG00000100197.16 | 1.311E-7 | 0 | -145216 | gtex_brain_putamen_basal |
| rs397831950 | 22 | 42675960 | CYP2D6 | ENSG00000100197.16 | 5.339E-11 | 0 | -149052 | gtex_brain_putamen_basal |
| rs86669 | 22 | 42680800 | CYP2D6 | ENSG00000100197.16 | 2.146E-8 | 0 | -153892 | gtex_brain_putamen_basal |
| rs134900 | 22 | 42683343 | CYP2D6 | ENSG00000100197.16 | 5.18E-11 | 0 | -156435 | gtex_brain_putamen_basal |
| rs134902 | 22 | 42683997 | CYP2D6 | ENSG00000100197.16 | 5.339E-11 | 0 | -157089 | gtex_brain_putamen_basal |
| rs80506 | 22 | 42689140 | CYP2D6 | ENSG00000100197.16 | 6.622E-10 | 0 | -162232 | gtex_brain_putamen_basal |
| rs134906 | 22 | 42689370 | CYP2D6 | ENSG00000100197.16 | 3.648E-10 | 0 | -162462 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PIAS2 | 0.40 | 0.39 |
| FAM160A1 | 0.38 | 0.37 |
| GOLT1B | 0.37 | 0.37 |
| PCLO | 0.37 | 0.42 |
| NRBF2 | 0.36 | 0.39 |
| CASD1 | 0.36 | 0.37 |
| PLEKHA3 | 0.36 | 0.37 |
| CCDC92 | 0.35 | 0.39 |
| MON2 | 0.35 | 0.39 |
| ZNF280B | 0.35 | 0.43 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| IL32 | -0.34 | -0.34 |
| HIGD1B | -0.34 | -0.33 |
| MT-CYB | -0.34 | -0.31 |
| MT-CO2 | -0.34 | -0.31 |
| CSAG1 | -0.32 | -0.32 |
| AF347015.33 | -0.32 | -0.29 |
| NOSTRIN | -0.31 | -0.30 |
| AF347015.2 | -0.31 | -0.27 |
| AF347015.31 | -0.31 | -0.30 |
| AF347015.8 | -0.30 | -0.29 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005506 | iron ion binding | IEA | - | |
| GO:0004497 | monooxygenase activity | IEA | - | |
| GO:0020037 | heme binding | IEA | - | |
| GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | IEA | - | |
| GO:0009055 | electron carrier activity | IEA | - | |
| GO:0046872 | metal ion binding | IEA | - | |
| GO:0050381 | unspecific monooxygenase activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0055114 | oxidation reduction | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005792 | microsome | IEA | - | |
| GO:0005789 | endoplasmic reticulum membrane | IEA | - | |
| GO:0005783 | endoplasmic reticulum | IEA | - | |
| GO:0016020 | membrane | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG DRUG METABOLISM CYTOCHROME P450 | 72 | 47 | All SZGR 2.0 genes in this pathway |
| REACTOME BIOLOGICAL OXIDATIONS | 139 | 91 | All SZGR 2.0 genes in this pathway |
| REACTOME XENOBIOTICS | 16 | 11 | All SZGR 2.0 genes in this pathway |
| REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | 51 | 34 | All SZGR 2.0 genes in this pathway |
| REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | 70 | 50 | All SZGR 2.0 genes in this pathway |
| GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN | 335 | 193 | All SZGR 2.0 genes in this pathway |
| MCBRYAN PUBERTAL BREAST 3 4WK UP | 214 | 144 | All SZGR 2.0 genes in this pathway |
| SHETH LIVER CANCER VS TXNIP LOSS PAM4 | 261 | 153 | All SZGR 2.0 genes in this pathway |
| ROPERO HDAC2 TARGETS | 114 | 71 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS DN | 357 | 212 | All SZGR 2.0 genes in this pathway |
| HSIAO LIVER SPECIFIC GENES | 244 | 154 | All SZGR 2.0 genes in this pathway |
| KAYO CALORIE RESTRICTION MUSCLE DN | 87 | 59 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS STEM CELL | 254 | 164 | All SZGR 2.0 genes in this pathway |
| RIZKI TUMOR INVASIVENESS 3D DN | 270 | 181 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER RELAPSE IN BRAIN DN | 85 | 58 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER SURVIVAL UP | 185 | 112 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA DN | 267 | 160 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS UP | 504 | 321 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS UP | 745 | 475 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS UP | 682 | 433 | All SZGR 2.0 genes in this pathway |
| DELACROIX RARG BOUND MEF | 367 | 231 | All SZGR 2.0 genes in this pathway |
| RATTENBACHER BOUND BY CELF1 | 467 | 251 | All SZGR 2.0 genes in this pathway |