Gene Page: DRD3
Summary ?
| GeneID | 1814 |
| Symbol | DRD3 |
| Synonyms | D3DR|ETM1|FET1 |
| Description | dopamine receptor D3 |
| Reference | MIM:126451|HGNC:HGNC:3024|Ensembl:ENSG00000151577|HPRD:00540|Vega:OTTHUMG00000159334 |
| Gene type | protein-coding |
| Map location | 3q13.3 |
| Pascal p-value | 0.351 |
| Fetal beta | -0.024 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| ADT:Sun_2012 | Systematic Investigation of Antipsychotic Drugs and Their Targets | A total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes. | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Association | A combined odds ratio method (Sun et al. 2008), association studies | 3 | Link to SZGene |
| GSMA_IIE | Genome scan meta-analysis (European-ancestry samples) | Psr: 0.04359 | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.04047 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophrenias,schizotypal | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 9 | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0219 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AFF3 | 0.93 | 0.89 |
| MFHAS1 | 0.92 | 0.91 |
| GRIK3 | 0.91 | 0.92 |
| LIMCH1 | 0.91 | 0.85 |
| DOPEY2 | 0.90 | 0.88 |
| ITSN1 | 0.89 | 0.85 |
| FAM59A | 0.89 | 0.88 |
| TIAM2 | 0.89 | 0.83 |
| TSHZ3 | 0.89 | 0.86 |
| EML1 | 0.89 | 0.87 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SERPINB6 | -0.66 | -0.70 |
| AF347015.31 | -0.60 | -0.76 |
| COPZ2 | -0.59 | -0.72 |
| HSD17B14 | -0.59 | -0.69 |
| MT-CO2 | -0.59 | -0.75 |
| FXYD1 | -0.58 | -0.74 |
| HIGD1B | -0.58 | -0.75 |
| IFI27 | -0.58 | -0.73 |
| RHOC | -0.58 | -0.69 |
| AF347015.27 | -0.58 | -0.73 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0001592 | dopamine D3 receptor activity | IEA | dopamine (GO term level: 10) | - |
| GO:0004872 | receptor activity | IEA | - | |
| GO:0005515 | protein binding | IEA | - | |
| GO:0008144 | drug binding | ISS | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0060161 | positive regulation of dopamine receptor signaling pathway | IEA | dopamine (GO term level: 10) | - |
| GO:0060160 | negative regulation of dopamine receptor signaling pathway | IEA | dopamine (GO term level: 10) | - |
| GO:0048715 | negative regulation of oligodendrocyte differentiation | IEA | oligodendrocyte, Glial (GO term level: 12) | - |
| GO:0051584 | regulation of dopamine uptake | IC | Synap, Neurotransmitter, dopamine (GO term level: 11) | 8301582 |
| GO:0014059 | regulation of dopamine secretion | IEA | dopamine (GO term level: 10) | - |
| GO:0007195 | dopamine receptor, adenylate cyclase inhibiting pathway | IDA | dopamine (GO term level: 12) | 7907363 |18424554 |
| GO:0007191 | dopamine receptor, adenylate cyclase activating pathway | IEA | dopamine (GO term level: 12) | - |
| GO:0042417 | dopamine metabolic process | IC | Neurotransmitter, dopamine (GO term level: 8) | 8301582 |
| GO:0002016 | regulation of blood volume by renin-angiotensin | IEA | - | |
| GO:0002031 | G-protein coupled receptor internalization | IDA | 18424554 | |
| GO:0001975 | response to amphetamine | IEA | - | |
| GO:0007186 | G-protein coupled receptor protein signaling pathway | IEA | - | |
| GO:0007194 | negative regulation of adenylate cyclase activity | IDA | 7907363 | |
| GO:0007165 | signal transduction | IEA | - | |
| GO:0008542 | visual learning | IEA | - | |
| GO:0007626 | locomotory behavior | IEA | - | |
| GO:0006874 | cellular calcium ion homeostasis | IDA | 7911712 | |
| GO:0042493 | response to drug | ISS | - | |
| GO:0050883 | musculoskeletal movement, spinal reflex action | IEA | - | |
| GO:0019216 | regulation of lipid metabolic process | IEA | - | |
| GO:0030814 | regulation of cAMP metabolic process | IDA | 8666994 | |
| GO:0032922 | circadian regulation of gene expression | IEA | - | |
| GO:0043278 | response to morphine | IEA | - | |
| GO:0040014 | regulation of multicellular organism growth | IEA | - | |
| GO:0045840 | positive regulation of mitosis | ISS | - | |
| GO:0048148 | behavioral response to cocaine | IEA | - | |
| GO:0050709 | negative regulation of protein secretion | IDA | 16839358 | |
| GO:0050482 | arachidonic acid secretion | IDA | 8301582 | |
| GO:0045776 | negative regulation of blood pressure | IEA | - | |
| GO:0045471 | response to ethanol | IEA | - | |
| GO:0051898 | negative regulation of protein kinase B signaling cascade | IEA | - | |
| GO:0060134 | prepulse inhibition | IMP | 18325483 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005624 | membrane fraction | IEA | - | |
| GO:0005886 | plasma membrane | IEA | - | |
| GO:0005887 | integral to plasma membrane | IC | 8301582 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CLIC6 | CLIC1L | chloride intracellular channel 6 | - | HPRD,BioGRID | 14499480 |
| EPB41 | 4.1R | EL1 | HE | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | - | HPRD | 12181426 |
| EPB41L1 | 4.1N | DKFZp686H17242 | KIAA0338 | MGC11072 | erythrocyte membrane protein band 4.1-like 1 | - | HPRD,BioGRID | 12181426 |
| EPB41L2 | 4.1-G | DKFZp781D1972 | DKFZp781H1755 | erythrocyte membrane protein band 4.1-like 2 | - | HPRD | 12181426 |
| FLNA | ABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2 | filamin A, alpha (actin binding protein 280) | Dopamine receptor D3 interacts with filamin A. This interaction was modeled on a demonstrated interaction between human FLN-A and D3 from unspecified source. | BIND | 11320256 |
| FLNA | ABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2 | filamin A, alpha (actin binding protein 280) | - | HPRD,BioGRID | 11911837 |
| FREQ | DKFZp761L1223 | FLUP | NCS-1 | NCS1 | frequenin homolog (Drosophila) | Affinity Capture-Western | BioGRID | 12351722 |
| FREQ | DKFZp761L1223 | FLUP | NCS-1 | NCS1 | frequenin homolog (Drosophila) | The D3 dopamine receptor interacts with NCS-1. | BIND | 12351722 |
| GIPC1 | C19orf3 | GIPC | GLUT1CBP | Hs.6454 | IIP-1 | MGC15889 | MGC3774 | NIP | RGS19IP1 | SEMCAP | SYNECTIIN | SYNECTIN | TIP-2 | GIPC PDZ domain containing family, member 1 | Two-hybrid | BioGRID | 14499480 |
| GNAI1 | Gi | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | - | HPRD | 10978845 |
| GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | D3 interacts with Grb2. | BIND | 9843378 |
| GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | - | HPRD,BioGRID | 11384839 |
| MPDZ | DKFZp781P216 | FLJ25909 | FLJ34626 | FLJ90240 | MUPP1 | multiple PDZ domain protein | - | HPRD,BioGRID | 14499480 |
| NCK1 | MGC12668 | NCK | NCKalpha | NCK adaptor protein 1 | D3 interacts with Nck. | BIND | 9843378 |
| RDX | DFNB24 | radixin | Two-hybrid | BioGRID | 14499480 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION | 272 | 195 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY GPCR | 920 | 449 | All SZGR 2.0 genes in this pathway |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | 305 | 177 | All SZGR 2.0 genes in this pathway |
| REACTOME AMINE LIGAND BINDING RECEPTORS | 38 | 33 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR DOWNSTREAM SIGNALING | 805 | 368 | All SZGR 2.0 genes in this pathway |
| REACTOME G ALPHA I SIGNALLING EVENTS | 195 | 114 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR LIGAND BINDING | 408 | 246 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 24HR DN | 148 | 102 | All SZGR 2.0 genes in this pathway |
| KAYO AGING MUSCLE DN | 123 | 76 | All SZGR 2.0 genes in this pathway |
| KONDO PROSTATE CANCER WITH H3K27ME3 | 196 | 93 | All SZGR 2.0 genes in this pathway |
| MITSIADES RESPONSE TO APLIDIN UP | 439 | 257 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |