SZGR2

Summary ?

GeneID	1961
Symbol	EGR4
Synonyms	NGFI-C\|NGFIC\|PAT133
Description	early growth response 4
Reference	MIM:128992\|HGNC:HGNC:3241\|Ensembl:ENSG00000135625\|HPRD:00550\|Vega:OTTHUMG00000129774
Gene type	protein-coding
Map location	2p13
Pascal p-value	1.631E-6
Sherlock p-value	0.938
Fetal beta	-2.285
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Expression	Meta-analysis of gene expression	P value: 1.547
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs7607353	chr2	72577225	EGR4	1961	0.04	cis
rs12059674	chr1	57630277	EGR4	1961	0.14	trans
rs17126801	chr1	65098162	EGR4	1961	0.04	trans
rs7511937		0	EGR4	1961	0.09	trans
rs2782784	chr1	71195282	EGR4	1961	0.17	trans
rs17689089	chr1	77740105	EGR4	1961	0.08	trans
rs17100231	chr1	77761339	EGR4	1961	0.01	trans
rs17100274	chr1	77774412	EGR4	1961	4.884E-5	trans
rs6664544	chr1	92524192	EGR4	1961	0.05	trans
rs12403481	chr1	109503655	EGR4	1961	0.13	trans
rs17029293	chr1	112567844	EGR4	1961	0.2	trans
rs17649760	chr1	150425940	EGR4	1961	0.12	trans
rs16837984	chr1	157042626	EGR4	1961	0.01	trans
rs16837989	chr1	157046286	EGR4	1961	0.09	trans
rs16838012	chr1	157048974	EGR4	1961	0.01	trans
rs16838014		0	EGR4	1961	0.01	trans
rs6666937	chr1	170286842	EGR4	1961	1.092E-5	trans
rs12071422	chr1	185573879	EGR4	1961	0.07	trans
rs16843112	chr1	198420657	EGR4	1961	0.15	trans
rs697455	chr1	202512075	EGR4	1961	0.17	trans
rs3748669	chr1	207077022	EGR4	1961	0.1	trans
rs6673109	chr1	207253132	EGR4	1961	0	trans
rs12034521	chr1	239717679	EGR4	1961	0	trans
snp_a-1990354		0	EGR4	1961	7.102E-4	trans
rs6432434	chr2	14160930	EGR4	1961	0.1	trans
rs12329305	chr2	19552912	EGR4	1961	0.12	trans
rs12611832	chr2	31196248	EGR4	1961	0.16	trans
rs12614732	chr2	31199913	EGR4	1961	0.16	trans
rs7560081	chr2	62793238	EGR4	1961	0.03	trans
rs17029079	chr2	64736071	EGR4	1961	0.12	trans
rs17038084	chr2	85192280	EGR4	1961	0	trans
rs17024035	chr2	100968559	EGR4	1961	0.01	trans
rs7574684	chr2	100992911	EGR4	1961	0.01	trans
rs17024129	chr2	100995144	EGR4	1961	0.01	trans
rs17024136	chr2	100995382	EGR4	1961	0.1	trans
rs7585898	chr2	100998292	EGR4	1961	0.01	trans
rs6716367	chr2	101000013	EGR4	1961	0.13	trans
rs1370627	chr2	101009384	EGR4	1961	0.01	trans
rs4149509	chr2	101023698	EGR4	1961	0.05	trans
rs6707117	chr2	136855504	EGR4	1961	7.911E-8	trans
rs10189091	chr2	143471999	EGR4	1961	0.05	trans
snp_a-2198363		0	EGR4	1961	0.16	trans
rs16838911	chr2	156087569	EGR4	1961	0	trans
rs7608942	chr2	182820100	EGR4	1961	0	trans
rs16829401	chr2	233538391	EGR4	1961	0.02	trans
rs17040622	chr3	4440673	EGR4	1961	0.08	trans
rs17684934	chr3	4443547	EGR4	1961	0	trans
rs17040633	chr3	4446836	EGR4	1961	0	trans
rs17756483	chr3	4451309	EGR4	1961	0	trans
rs17685441	chr3	4465165	EGR4	1961	0	trans
rs9863778	chr3	55375950	EGR4	1961	0.05	trans
rs997245	chr3	61844600	EGR4	1961	6.689E-5	trans
rs2875492	chr3	86006209	EGR4	1961	0.16	trans
rs16843128	chr3	100713413	EGR4	1961	0.02	trans
rs1381835	chr3	110600595	EGR4	1961	0.15	trans
rs4631023	chr4	8101794	EGR4	1961	0.18	trans
rs7684087	chr4	21673380	EGR4	1961	0.07	trans
rs16989064	chr4	33639397	EGR4	1961	0.06	trans
rs4469113	chr4	41461062	EGR4	1961	0	trans
rs2643038	chr4	62313218	EGR4	1961	0.13	trans
rs6827713	chr4	79936877	EGR4	1961	0.15	trans
rs6881821	chr5	8578465	EGR4	1961	0.01	trans
rs1697073	chr5	30907267	EGR4	1961	0.09	trans
rs2115110	chr5	38193428	EGR4	1961	0	trans
rs16873956	chr5	44312488	EGR4	1961	0.1	trans
rs10040715	chr5	57594207	EGR4	1961	3.821E-8	trans
rs13189446	chr5	61572988	EGR4	1961	0.16	trans
rs16890628	chr5	61612280	EGR4	1961	0.15	trans
rs16890651	chr5	61629538	EGR4	1961	0.18	trans
rs153869	chr5	61754994	EGR4	1961	0.16	trans
rs40290	chr5	61817141	EGR4	1961	0.08	trans
rs32170	chr5	61847072	EGR4	1961	0.16	trans
snp_a-4217300		0	EGR4	1961	3.294E-4	trans
rs1862599	chr5	82095088	EGR4	1961	0.07	trans
rs163953	chr5	92289536	EGR4	1961	0.1	trans
rs17134275	chr5	100634998	EGR4	1961	0.02	trans
rs10063272	chr5	103540974	EGR4	1961	0.06	trans
rs2963232	chr5	103713882	EGR4	1961	0.03	trans
rs2900115	chr5	117414349	EGR4	1961	0.07	trans
rs2141482	chr5	136760477	EGR4	1961	2.881E-5	trans
rs2189803	chr5	137684661	EGR4	1961	8.811E-6	trans
rs17209139	chr5	142552525	EGR4	1961	0.08	trans
rs259913	chr5	169370782	EGR4	1961	7.35E-4	trans
rs2116811	chr5	171820051	EGR4	1961	0.02	trans
rs195429	chr6	37354434	EGR4	1961	0.15	trans
rs17069168	chr6	108335432	EGR4	1961	0.16	trans
rs17069171	chr6	108335593	EGR4	1961	0.11	trans
rs4289676	chr6	123999302	EGR4	1961	0.01	trans
rs2030024	chr6	131014624	EGR4	1961	0	trans
rs10485094	chr6	131071433	EGR4	1961	3.882E-4	trans
rs17059517	chr6	131076254	EGR4	1961	0	trans
rs9402280	chr6	131102770	EGR4	1961	0.01	trans
rs7767456	chr6	134356119	EGR4	1961	0.12	trans
rs12164028	chr6	136929934	EGR4	1961	0.12	trans
rs17080121	chr6	151009189	EGR4	1961	0.14	trans
rs12529269	chr6	153543829	EGR4	1961	0.02	trans
rs10872699	chr6	153544252	EGR4	1961	2.708E-4	trans
rs1321606	chr6	153545278	EGR4	1961	0.01	trans
rs10945911	chr6	164047509	EGR4	1961	3.734E-4	trans
rs6461881	chr7	25837688	EGR4	1961	0.11	trans
rs13239699	chr7	26377619	EGR4	1961	0.2	trans
rs17156078	chr7	27988688	EGR4	1961	0.11	trans
rs12701006	chr7	30147298	EGR4	1961	5.332E-4	trans
rs1419793	chr7	34697630	EGR4	1961	3.562E-4	trans
rs17621151	chr7	53572911	EGR4	1961	0.02	trans
rs10245449	chr7	80935100	EGR4	1961	0.13	trans
rs10487383	chr7	117671737	EGR4	1961	0.06	trans
rs6958821	chr7	153253566	EGR4	1961	0.08	trans
rs11779237	chr8	1227664	EGR4	1961	0.11	trans
rs10109456	chr8	19565941	EGR4	1961	0.05	trans
rs10102886	chr8	51805574	EGR4	1961	0.03	trans
rs10504194	chr8	56419808	EGR4	1961	0.2	trans
rs1457044	chr8	59257567	EGR4	1961	7.696E-5	trans
rs1457032	chr8	59290536	EGR4	1961	0.01	trans
rs7465259		0	EGR4	1961	0.08	trans
rs10104622	chr8	63333773	EGR4	1961	0.08	trans
rs2218911	chr8	63371015	EGR4	1961	0.08	trans
rs1551199	chr8	63388117	EGR4	1961	0.08	trans
rs1733950	chr8	90062516	EGR4	1961	4.767E-8	trans
rs1240028	chr8	90093357	EGR4	1961	5.466E-4	trans
rs1240087	chr8	90113945	EGR4	1961	0.02	trans
rs318307	chr8	90185459	EGR4	1961	0	trans
rs1483373	chr8	90186442	EGR4	1961	0.04	trans
rs11776005	chr8	90187416	EGR4	1961	0.04	trans
rs1159499	chr8	90196948	EGR4	1961	0.04	trans
rs1355060	chr8	118717710	EGR4	1961	0.05	trans
rs2280828	chr8	118762435	EGR4	1961	0.02	trans
rs4976941	chr8	142744439	EGR4	1961	8.703E-4	trans
rs9298651	chr9	10076275	EGR4	1961	3.826E-4	trans
rs16931013	chr9	10076859	EGR4	1961	3.826E-4	trans
rs16931018	chr9	10077048	EGR4	1961	3.826E-4	trans
rs1109460	chr9	79410224	EGR4	1961	0.15	trans
rs11791891	chr9	87512411	EGR4	1961	0.03	trans
rs2165893	chr9	87531423	EGR4	1961	0.01	trans
rs17087869	chr9	87535284	EGR4	1961	0.15	trans
rs763623	chr9	87539663	EGR4	1961	0.02	trans
rs3780642	chr9	87553144	EGR4	1961	4.094E-5	trans
rs10992752	chr9	96240578	EGR4	1961	0.19	trans
rs10981864	chr9	116416735	EGR4	1961	0.09	trans
rs2807706	chr9	121744331	EGR4	1961	0.07	trans
rs10739527	chr9	121772512	EGR4	1961	0.18	trans
rs2417062	chr9	130715921	EGR4	1961	0.18	trans
rs6537944	chr9	137312827	EGR4	1961	0.04	trans
rs11252514	chr10	499572	EGR4	1961	0.04	trans
rs772394	chr10	35980024	EGR4	1961	0.03	trans
rs1908351	chr10	57877117	EGR4	1961	0.03	trans
rs3104871	chr10	57878502	EGR4	1961	0	trans
rs901309	chr10	72571899	EGR4	1961	0.16	trans
rs485305	chr10	116048044	EGR4	1961	0.02	trans
rs862785	chr11	20175604	EGR4	1961	0.17	trans
rs16911034	chr11	23302320	EGR4	1961	0.17	trans
rs1789300	chr11	95463631	EGR4	1961	0.04	trans
rs1255149	chr11	95484493	EGR4	1961	0.05	trans
rs3748251	chr11	95519156	EGR4	1961	0.07	trans
rs16922543	chr11	95526116	EGR4	1961	0.07	trans
rs16922622	chr11	95567387	EGR4	1961	0.07	trans
rs2239031	chr12	2336168	EGR4	1961	0.15	trans
rs733593	chr12	6636391	EGR4	1961	0.12	trans
rs374484	chr12	27627159	EGR4	1961	0.01	trans
rs10771436	chr12	28744556	EGR4	1961	0.14	trans
rs8490	chr12	51453904	EGR4	1961	2.772E-4	trans
rs1344796	chr12	76397104	EGR4	1961	0	trans
rs12302525	chr12	89726424	EGR4	1961	0.08	trans
rs10850201	chr12	109903061	EGR4	1961	0.04	trans
rs7296098	chr12	113228993	EGR4	1961	0.14	trans
rs11833075	chr12	122114592	EGR4	1961	0	trans
rs9300277	chr12	128564195	EGR4	1961	0.1	trans
rs3803214	chr13	25740255	EGR4	1961	0.16	trans
rs7982110	chr13	59723428	EGR4	1961	0.02	trans
rs9528250	chr13	61410190	EGR4	1961	0.05	trans
rs7330331	chr13	67403122	EGR4	1961	0.04	trans
rs7327697	chr13	83227456	EGR4	1961	0.01	trans
rs7321205	chr13	89949815	EGR4	1961	0.03	trans
rs17667894	chr13	92014308	EGR4	1961	0.09	trans
rs7156088	chr14	27821865	EGR4	1961	0.01	trans
rs8022005	chr14	61345380	EGR4	1961	2.207E-4	trans
rs10148418	chr14	67003872	EGR4	1961	0.05	trans
rs941539	chr14	93561214	EGR4	1961	0.18	trans
rs1885073	chr14	104357181	EGR4	1961	5.229E-4	trans
rs4465541	chr14	105016846	EGR4	1961	0.03	trans
rs17761129	chr15	24262387	EGR4	1961	0.19	trans
rs16973929	chr15	47395709	EGR4	1961	0.19	trans
rs2414703	chr15	61904602	EGR4	1961	0.15	trans
rs289171	chr15	62576053	EGR4	1961	0.01	trans
rs289161	chr15	62589888	EGR4	1961	0.01	trans
rs4777108	chr15	69383464	EGR4	1961	0.14	trans
rs9635390	chr15	90809632	EGR4	1961	3.235E-4	trans
rs16948375	chr15	94236354	EGR4	1961	0.19	trans
rs8047151	chr16	17209696	EGR4	1961	4.888E-7	trans
rs4271578	chr16	17213886	EGR4	1961	1.363E-5	trans
rs7200513	chr16	17219474	EGR4	1961	1.674E-4	trans
rs3829495	chr16	17221986	EGR4	1961	1.174E-5	trans
rs7193763	chr16	17225534	EGR4	1961	1.488E-4	trans
rs4316748	chr16	55781757	EGR4	1961	0.03	trans
rs276966	chr16	86233753	EGR4	1961	0.17	trans
rs1867231	chr17	13678834	EGR4	1961	0.04	trans
rs7219986	chr17	53263206	EGR4	1961	0.06	trans
rs17817797	chr17	53332496	EGR4	1961	0.01	trans
rs16951770	chr18	7444826	EGR4	1961	0.08	trans
rs7244394	chr18	32223105	EGR4	1961	0.13	trans
rs17074993	chr18	63260128	EGR4	1961	0.13	trans
rs9319807	chr18	68766779	EGR4	1961	0.02	trans
snp_a-1821751		0	EGR4	1961	0	trans
rs1942461	chr18	70509159	EGR4	1961	0.05	trans
rs1942462	chr18	70509823	EGR4	1961	0.05	trans
rs1942463	chr18	70509841	EGR4	1961	0.05	trans
rs1942464	chr18	70509877	EGR4	1961	0.01	trans
rs1942466	chr18	70517154	EGR4	1961	0.05	trans
rs2156494	chr18	70518084	EGR4	1961	0.05	trans
rs17056922	chr18	73086804	EGR4	1961	0.09	trans
rs16980096	chr19	15000921	EGR4	1961	0.1	trans
snp_a-2138575		0	EGR4	1961	0.09	trans
rs234337	chr19	40458724	EGR4	1961	0.03	trans
rs234363	chr19	40474607	EGR4	1961	0.02	trans
rs1797040	chr20	23907743	EGR4	1961	0.13	trans
rs2424603		0	EGR4	1961	0.13	trans
rs6102879	chr20	41138766	EGR4	1961	0.18	trans
rs6026122	chr20	56769083	EGR4	1961	0.01	trans
rs2847443	chr21	14595263	EGR4	1961	0.15	trans
rs2834872	chr21	36634845	EGR4	1961	0.14	trans
rs2834875	chr21	36656119	EGR4	1961	0.08	trans
rs877910	chr21	36658376	EGR4	1961	0.14	trans
rs134028	chr22	28048448	EGR4	1961	0	trans
rs5762317	chr22	28094988	EGR4	1961	0.12	trans
rs5768165	chr22	48318197	EGR4	1961	0.15	trans
rs5768168	chr22	48319334	EGR4	1961	0.15	trans
rs5768173	chr22	48321475	EGR4	1961	0.15	trans
rs16978981	chrX	13538144	EGR4	1961	0	trans
rs4825301	chrX	19476433	EGR4	1961	0.1	trans
rs7879159	chrX	19481591	EGR4	1961	0	trans
rs5909301	chrX	19493776	EGR4	1961	0.12	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003700	transcription factor activity	NAS		1584812
GO:0008270	zinc ion binding	IEA		-
GO:0046872	metal ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0006350	transcription	IEA		-
GO:0008284	positive regulation of cell proliferation	TAS		1658795
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005622	intracellular	IEA		-
GO:0005634	nucleus	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
ST DIFFERENTIATION PATHWAY IN PC12 CELLS	45	35	All SZGR 2.0 genes in this pathway
PID NFAT TFPATHWAY	47	39	All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY	65	56	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP	485	293	All SZGR 2.0 genes in this pathway
NAGASHIMA NRG1 SIGNALING UP	176	123	All SZGR 2.0 genes in this pathway
NAGASHIMA EGF SIGNALING UP	58	40	All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS	355	243	All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS	1038	678	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3	1118	744	All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS	652	441	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN	357	212	All SZGR 2.0 genes in this pathway
SATO SILENCED BY DEACETYLATION IN PANCREATIC CANCER	50	30	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP	461	298	All SZGR 2.0 genes in this pathway
HUANG FOXA2 TARGETS UP	45	28	All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP	439	257	All SZGR 2.0 genes in this pathway
MATZUK SPERMATOCYTE	72	55	All SZGR 2.0 genes in this pathway
MATZUK SPERMATOZOA	114	77	All SZGR 2.0 genes in this pathway
LIN NPAS4 TARGETS DN	68	48	All SZGR 2.0 genes in this pathway
HUNSBERGER EXERCISE REGULATED GENES	31	26	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME3 AND H3K27ME3	142	103	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3	210	148	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY	1725	838	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-326	324	331	1A,m8	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-330	414	420	m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: EGR4