Gene Page: EPHA2

Summary
GeneID  1969
Symbol  EPHA2
Synonyms  ECK
Description  EPH receptor A2
See related  HGNC:3386|MIM:176946|Ensembl:ENSG00000142627|HPRD:01494|
Locus tag  -
Gene type  protein-coding
Map location  1p36
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PSMA70.930.95
PSMD130.910.92
RUVBL20.900.93
CCT70.900.90
EIF60.900.94
RRP90.890.90
DCTPP10.890.92
WIBG0.890.90
CFL10.890.90
C19orf100.890.92
Top 10 negatively co-expressed genes
AF347015.8-0.75-0.76
AF347015.33-0.75-0.77
AF347015.27-0.74-0.77
AF347015.15-0.74-0.77
MT-CYB-0.74-0.76
MT-CO2-0.74-0.72
AF347015.2-0.73-0.75
AF347015.26-0.73-0.78
AF347015.31-0.72-0.72
AF347015.9-0.67-0.73
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004872receptor activityIEA-
GO:0005003ephrin receptor activityIEA-
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030182neuron differentiationIEAneuron (GO term level: 8)-
GO:0006468protein amino acid phosphorylationIEA-
GO:0007165signal transductionTAS2174105 
GO:0048013ephrin receptor signaling pathwayIEA-
GO:0007275multicellular organismal developmentTAS7918100 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005887integral to plasma membraneTAS2174105 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACP1HAAP | MGC111030 | MGC3499acid phosphatase 1, soluble-HPRD,BioGRID12167657 
EFNA1B61 | ECKLG | EFL1 | EPLG1 | LERK1 | TNFAIP4ephrin-A1The membrane bound ligand B61 interacts with the receptor ECK. This interaction was modeled on a demonstrated interaction between B61 from human and ECK from mouse.BIND7973638 |8755474 
-HPRD7973638 |8755474 
EFNA2ELF-1 | EPLG6 | HEK7-L | LERK6ephrin-A2-HPRD8755474 
EFNA3EFL2 | EPLG3 | Ehk1-L | LERK3ephrin-A3The membrane bound ligand EHK1-L interacts with the receptor ECK. This interaction was modeled on a demonstrated interaction between EHK1-L from human and ECK from mouse.BIND7973638 |8755474 
-HPRD12907451 
EFNA4EFL4 | EPLG4 | LERK4 | MGC125826ephrin-A4-HPRD10607706 
-HPRD8755474 |10607706 
EFNA5AF1 | EFL5 | EPLG7 | GLC1M | LERK7 | RAGSephrin-A5-HPRD9245480 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID12400011 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID7982920 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD,BioGRID10655584 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11Affinity Capture-WesternBioGRID10655584 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD,BioGRID12400011 
SLASLA1 | SLAPSrc-like-adaptor-HPRD,BioGRID7543898 
TNFAIP1B12 | B61 | EDP1 | MGC2317tumor necrosis factor, alpha-induced protein 1 (endothelial)-HPRD7536959 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
PID_ARF6_PATHWAY 3527All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
PID_EPHA_FWDPATHWAY 3429All SZGR genes in this pathway
PID_ECADHERIN_STABILIZATION_PATHWAY 4234All SZGR genes in this pathway
PID_EPHA2_FWD_PATHWAY 1916All SZGR genes in this pathway
LIU_PROSTATE_CANCER_DN 481290All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_DN 2113All SZGR genes in this pathway
KOBAYASHI_EGFR_SIGNALING_6HR_DN 1813All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_UP 290177All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_DN 11879All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_UP 176123All SZGR genes in this pathway
NAGASHIMA_EGF_SIGNALING_UP 5840All SZGR genes in this pathway
KIM_WT1_TARGETS_UP 214155All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_FOREVER_DN 3123All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION_DN 4534All SZGR genes in this pathway
SCHAVOLT_TARGETS_OF_TP53_AND_TP63 1612All SZGR genes in this pathway
WANG_METHYLATED_IN_BREAST_CANCER 3525All SZGR genes in this pathway
FURUKAWA_DUSP6_TARGETS_PCI35_DN 7440All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
ROPERO_HDAC2_TARGETS 11471All SZGR genes in this pathway
AMIT_EGF_RESPONSE_120_HELA 6947All SZGR genes in this pathway
AMIT_EGF_RESPONSE_120_MCF10A 4328All SZGR genes in this pathway
SMITH_TERT_TARGETS_UP 14591All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP 214133All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_UP 225139All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_DN 371218All SZGR genes in this pathway
MAHAJAN_RESPONSE_TO_IL1A_DN 7657All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C5 2111All SZGR genes in this pathway
VERRECCHIA_DELAYED_RESPONSE_TO_TGFB1 3926All SZGR genes in this pathway
CHEN_PDGF_TARGETS 199All SZGR genes in this pathway
JACKSON_DNMT1_TARGETS_UP 7757All SZGR genes in this pathway
BILD_E2F3_ONCOGENIC_SIGNATURE 246153All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE 261166All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN 274165All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN 159105All SZGR genes in this pathway
HUANG_DASATINIB_RESISTANCE_UP 8153All SZGR genes in this pathway
FIRESTEIN_CTNNB1_PATHWAY 3323All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_ESR1_DN 240153All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 142103All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2 277172All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_DN 267160All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_12HR_UP 2918All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_24HR_DN 4332All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_32HR_DN 3928All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_48HR_DN 4029All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_DN 3619All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_DN 8859All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_UP 242159All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_3_DN 4224All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_4_DN 159All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP 259159All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_1 4633All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
PHONG_TNF_TARGETS_UP 6343All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
ZWANG_CLASS_3_TRANSIENTLY_INDUCED_BY_EGF 222159All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/506472478m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-141/200a7547611A,m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-2248338391Ahsa-miR-224CAAGUCACUAGUGGUUCCGUUUA
miR-2636431A,m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-93.hd/291-3p/294/295/302/372/373/5202232301A,m8hsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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