Gene Page: EPHX2

Summary ?
GeneID2053
SymbolEPHX2
SynonymsCEH|SEH
Descriptionepoxide hydrolase 2
ReferenceMIM:132811|HGNC:HGNC:3402|Ensembl:ENSG00000120915|HPRD:00582|Vega:OTTHUMG00000102115
Gene typeprotein-coding
Map location8p21
Pascal p-value8.982E-5
Sherlock p-value0.262
Fetal beta-1.162
eGeneCaudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hypothalamus
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWAScatGenome-wide Association StudiesThis data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGC128Genome-wide Association StudyA multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.031 
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.00057 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.03086 

Section I. Genetics and epigenetics annotation

@CV:PGC128

SNP IDChromosomePositionAllelePFunctionGeneUp/Down Distance
rs73229090chr827442127AC1.952E-8intergenicEPHX2,CLUdist=39688;dist=12307

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10958899chr910128700EPHX220530.11trans
rs10958907chr910131580EPHX220530.09trans
rs1322159chr910132695EPHX220530.17trans
rs192069chrX76053555EPHX220530.07trans
rs16983508chrX99747940EPHX220530.12trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AAMP0.900.88
GRK60.890.88
COBRA10.890.88
ATG4B0.890.87
STK250.890.86
BBS10.890.88
THAP40.890.85
RIC8A0.890.88
B4GALT70.880.87
TMUB20.880.86
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.75-0.70
AF347015.21-0.75-0.74
AF347015.8-0.74-0.71
AF347015.31-0.74-0.70
AF347015.27-0.73-0.72
MT-CYB-0.72-0.69
AF347015.33-0.72-0.68
AF347015.2-0.71-0.68
AF347015.15-0.70-0.67
AF347015.26-0.69-0.66

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000287magnesium ion bindingIEA-
GO:0004301epoxide hydrolase activityIDA10862610 
GO:0016787hydrolase activityIEA-
GO:0042803protein homodimerization activityNAS10862610 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008217regulation of blood pressureNAS10862610 
GO:0008152metabolic processIEA-
GO:0009636response to toxinNAS10862610 
GO:0017144drug metabolic processNAS10862610 
GO:0006805xenobiotic metabolic processNAS10862610 
GO:0006800oxygen and reactive oxygen species metabolic processNAS10862610 
GO:0006954inflammatory responseNAS10862610 
GO:0006874cellular calcium ion homeostasisNAS10862610 
GO:0019439aromatic compound catabolic processIEA-
GO:0045909positive regulation of vasodilationNAS10862610 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolNAS10862610 
GO:0005625soluble fractionNAS10862610 
GO:0005737cytoplasmIEA-
GO:0005777peroxisomeIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ARACHIDONIC ACID METABOLISM 5836All SZGR 2.0 genes in this pathway
KEGG PEROXISOME 7847All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN 12686All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN 162116All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
LANDIS BREAST CANCER PROGRESSION DN 7043All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 DN 14993All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM UP 176111All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203134All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261153All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487286All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA DN 6544All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 DN 6438All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA DN 7445All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546351All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C7 6844All SZGR 2.0 genes in this pathway
YANG MUC2 TARGETS DUODENUM 3MO DN 2314All SZGR 2.0 genes in this pathway
YANG MUC2 TARGETS DUODENUM 6MO DN 2112All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282183All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593372All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN 274165All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G123 DN 5130All SZGR 2.0 genes in this pathway
KAPOSI LIVER CANCER MET DN 65All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE DN 8054All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 DN 7447All SZGR 2.0 genes in this pathway
NIELSEN LEIOMYOSARCOMA DN 1811All SZGR 2.0 genes in this pathway
BAE BRCA1 TARGETS UP 7547All SZGR 2.0 genes in this pathway
NOUSHMEHR GBM SILENCED BY METHYLATION 5032All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
WANG CLASSIC ADIPOGENIC TARGETS OF PPARG 2615All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN 213127All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 36HR 15288All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 227149All SZGR 2.0 genes in this pathway