Gene Page: SMG5

Summary
GeneID  23381
Symbol  SMG5
Synonyms  EST1B|FLJ34864|KIAA1089|LPTS-RP1|LPTSRP1|RP11-54H19.7|SMG-5
Description  Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)
See related  HGNC:24644|MIM:610962|Ensembl:ENSG00000198952|HPRD:16869|
Locus tag  -
Gene type  protein-coding
Map location  1q21.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NID20.810.52
SLC26A20.760.52
COL3A10.760.34
NID10.760.45
COL6A30.760.19
CD930.740.46
FBN20.740.55
COL4A10.730.46
COL1A20.730.29
SLC6A40.720.34
Top 10 negatively co-expressed genes
C5orf53-0.37-0.47
AF347015.31-0.35-0.51
MT-CO2-0.35-0.52
AF347015.27-0.34-0.50
AF347015.33-0.34-0.49
ASPHD1-0.34-0.34
MT-CYB-0.34-0.49
HLA-F-0.34-0.38
AF347015.8-0.34-0.50
CXCL14-0.33-0.49
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12699629 |14636577 
GO:0051721protein phosphatase 2A bindingIDA14636577 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decayTAS16488880 
GO:0006406mRNA export from nucleusTAS16488880 
GO:0035303regulation of dephosphorylationIMP14636577 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA14636577 
GO:0005737cytoplasmIDA14636577 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
SMG161E3.4 | ATX | KIAA0421 | LIPPI-3-kinase-related kinase SMG-1-HPRD14636577 
SMG6C17orf31 | EST1A | KIAA0732 | SMG-6Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)-HPRD12699629 
SMG7C1orf16 | EST1C | FLJ23717 | KIAA0250 | SGA56M | SMG-7Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)-HPRD14636577 
SMG7 interacts with SMG5.BIND15721257 
TERTEST2 | TCS1 | TP2 | TRT | hEST2telomerase reverse transcriptase-HPRD,BioGRID12699629 
UPF1FLJ43809 | FLJ46894 | HUPF1 | KIAA0221 | NORF1 | RENT1 | pNORF1UPF1 regulator of nonsense transcripts homolog (yeast)-HPRD14636577 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_HDAC_CLASSI_PATHWAY 6650All SZGR genes in this pathway
PID_TELOMERASE_PATHWAY 6848All SZGR genes in this pathway
REACTOME_METABOLISM_OF_MRNA 284128All SZGR genes in this pathway
REACTOME_METABOLISM_OF_RNA 330155All SZGR genes in this pathway
REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX 17657All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_UP 290177All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 335193All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
LIAO_HAVE_SOX4_BINDING_SITES 4026All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
FAELT_B_CLL_WITH_VH3_21_UP 4430All SZGR genes in this pathway
HU_GENOTOXIC_DAMAGE_4HR 3528All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN 354216All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_7 7646All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-433-3p103910461A,m8hsa-miR-433brainAUCAUGAUGGGCUCCUCGGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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