Gene Page: ABL2
Summary ?
| GeneID | 27 |
| Symbol | ABL2 |
| Synonyms | ABLL|ARG |
| Description | ABL proto-oncogene 2, non-receptor tyrosine kinase |
| Reference | MIM:164690|HGNC:HGNC:77|Ensembl:ENSG00000143322|HPRD:01259|Vega:OTTHUMG00000035199 |
| Gene type | protein-coding |
| Map location | 1q25.2 |
| Fetal beta | 0.187 |
| DMG | 1 (# studies) |
| eGene | Caudate basal ganglia Cerebellum Cortex Frontal Cortex BA9 Nucleus accumbens basal ganglia Putamen basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Nishioka_2013 | Genome-wide DNA methylation analysis | The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. | 1 |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0114 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg04691540 | 1 | 179198414 | ABL2 | -0.03 | 0.34 | DMG:Nishioka_2013 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10913690 | 1 | 179067071 | ABL2 | ENSG00000143322.15 | 3.501E-6 | 0.01 | 131748 | gtex_brain_putamen_basal |
| rs3813642 | 1 | 179070120 | ABL2 | ENSG00000143322.15 | 3.555E-6 | 0.01 | 128699 | gtex_brain_putamen_basal |
| rs3813643 | 1 | 179070334 | ABL2 | ENSG00000143322.15 | 3.57E-6 | 0.01 | 128485 | gtex_brain_putamen_basal |
| rs4651012 | 1 | 179071865 | ABL2 | ENSG00000143322.15 | 3.501E-6 | 0.01 | 126954 | gtex_brain_putamen_basal |
| rs4651013 | 1 | 179072966 | ABL2 | ENSG00000143322.15 | 3.501E-6 | 0.01 | 125853 | gtex_brain_putamen_basal |
| rs12130276 | 1 | 179082525 | ABL2 | ENSG00000143322.15 | 1.016E-6 | 0.01 | 116294 | gtex_brain_putamen_basal |
| rs4652357 | 1 | 179083000 | ABL2 | ENSG00000143322.15 | 2.235E-6 | 0.01 | 115819 | gtex_brain_putamen_basal |
| rs10913695 | 1 | 179083469 | ABL2 | ENSG00000143322.15 | 9.166E-7 | 0.01 | 115350 | gtex_brain_putamen_basal |
| rs397694195 | 1 | 179083665 | ABL2 | ENSG00000143322.15 | 1.822E-6 | 0.01 | 115154 | gtex_brain_putamen_basal |
| rs2171959 | 1 | 179087934 | ABL2 | ENSG00000143322.15 | 8.161E-7 | 0.01 | 110885 | gtex_brain_putamen_basal |
| rs10913696 | 1 | 179088721 | ABL2 | ENSG00000143322.15 | 7.681E-7 | 0.01 | 110098 | gtex_brain_putamen_basal |
| rs10913697 | 1 | 179088744 | ABL2 | ENSG00000143322.15 | 8.154E-7 | 0.01 | 110075 | gtex_brain_putamen_basal |
| rs1858551 | 1 | 179089213 | ABL2 | ENSG00000143322.15 | 8.145E-7 | 0.01 | 109606 | gtex_brain_putamen_basal |
| rs9726961 | 1 | 179089475 | ABL2 | ENSG00000143322.15 | 8.145E-7 | 0.01 | 109344 | gtex_brain_putamen_basal |
| rs9728480 | 1 | 179089491 | ABL2 | ENSG00000143322.15 | 8.145E-7 | 0.01 | 109328 | gtex_brain_putamen_basal |
| rs9727252 | 1 | 179089518 | ABL2 | ENSG00000143322.15 | 5.674E-7 | 0.01 | 109301 | gtex_brain_putamen_basal |
| rs9727861 | 1 | 179092612 | ABL2 | ENSG00000143322.15 | 1.447E-6 | 0.01 | 106207 | gtex_brain_putamen_basal |
| rs9729199 | 1 | 179092613 | ABL2 | ENSG00000143322.15 | 1.608E-6 | 0.01 | 106206 | gtex_brain_putamen_basal |
| rs2793798 | 1 | 179094843 | ABL2 | ENSG00000143322.15 | 8.145E-7 | 0.01 | 103976 | gtex_brain_putamen_basal |
| rs2793797 | 1 | 179097206 | ABL2 | ENSG00000143322.15 | 8.145E-7 | 0.01 | 101613 | gtex_brain_putamen_basal |
| rs2486995 | 1 | 179098475 | ABL2 | ENSG00000143322.15 | 8.145E-7 | 0.01 | 100344 | gtex_brain_putamen_basal |
| rs2486997 | 1 | 179098770 | ABL2 | ENSG00000143322.15 | 6.302E-7 | 0.01 | 100049 | gtex_brain_putamen_basal |
| rs2493124 | 1 | 179099021 | ABL2 | ENSG00000143322.15 | 8.132E-7 | 0.01 | 99798 | gtex_brain_putamen_basal |
| rs1856968 | 1 | 179100045 | ABL2 | ENSG00000143322.15 | 8.145E-7 | 0.01 | 98774 | gtex_brain_putamen_basal |
| rs1856967 | 1 | 179100121 | ABL2 | ENSG00000143322.15 | 5.913E-7 | 0.01 | 98698 | gtex_brain_putamen_basal |
| rs2816187 | 1 | 179101606 | ABL2 | ENSG00000143322.15 | 8.016E-7 | 0.01 | 97213 | gtex_brain_putamen_basal |
| rs2793796 | 1 | 179103687 | ABL2 | ENSG00000143322.15 | 6.35E-7 | 0.01 | 95132 | gtex_brain_putamen_basal |
| rs2636287 | 1 | 179103701 | ABL2 | ENSG00000143322.15 | 2.322E-6 | 0.01 | 95118 | gtex_brain_putamen_basal |
| rs2816196 | 1 | 179103877 | ABL2 | ENSG00000143322.15 | 7.365E-7 | 0.01 | 94942 | gtex_brain_putamen_basal |
| rs2636274 | 1 | 179106899 | ABL2 | ENSG00000143322.15 | 8.145E-7 | 0.01 | 91920 | gtex_brain_putamen_basal |
| rs2791943 | 1 | 179107430 | ABL2 | ENSG00000143322.15 | 8.145E-7 | 0.01 | 91389 | gtex_brain_putamen_basal |
| rs2791942 | 1 | 179108081 | ABL2 | ENSG00000143322.15 | 2.099E-6 | 0.01 | 90738 | gtex_brain_putamen_basal |
| rs2636276 | 1 | 179111060 | ABL2 | ENSG00000143322.15 | 8.124E-7 | 0.01 | 87759 | gtex_brain_putamen_basal |
| rs2791941 | 1 | 179112435 | ABL2 | ENSG00000143322.15 | 8.119E-7 | 0.01 | 86384 | gtex_brain_putamen_basal |
| rs2258221 | 1 | 179113369 | ABL2 | ENSG00000143322.15 | 1.071E-6 | 0.01 | 85450 | gtex_brain_putamen_basal |
| rs2258217 | 1 | 179113508 | ABL2 | ENSG00000143322.15 | 2.635E-6 | 0.01 | 85311 | gtex_brain_putamen_basal |
| rs2791940 | 1 | 179115485 | ABL2 | ENSG00000143322.15 | 8.145E-7 | 0.01 | 83334 | gtex_brain_putamen_basal |
| rs2816183 | 1 | 179116474 | ABL2 | ENSG00000143322.15 | 8.145E-7 | 0.01 | 82345 | gtex_brain_putamen_basal |
| rs2816185 | 1 | 179117740 | ABL2 | ENSG00000143322.15 | 8.476E-7 | 0.01 | 81079 | gtex_brain_putamen_basal |
| rs2816186 | 1 | 179122779 | ABL2 | ENSG00000143322.15 | 8.104E-7 | 0.01 | 76040 | gtex_brain_putamen_basal |
| rs965401 | 1 | 179133221 | ABL2 | ENSG00000143322.15 | 4.983E-7 | 0.01 | 65598 | gtex_brain_putamen_basal |
| rs2816189 | 1 | 179136269 | ABL2 | ENSG00000143322.15 | 5.592E-7 | 0.01 | 62550 | gtex_brain_putamen_basal |
| rs2087559 | 1 | 179139933 | ABL2 | ENSG00000143322.15 | 6.454E-7 | 0.01 | 58886 | gtex_brain_putamen_basal |
| rs2793793 | 1 | 179140145 | ABL2 | ENSG00000143322.15 | 6.44E-7 | 0.01 | 58674 | gtex_brain_putamen_basal |
| rs2636280 | 1 | 179156375 | ABL2 | ENSG00000143322.15 | 6.465E-7 | 0.01 | 42444 | gtex_brain_putamen_basal |
| rs2816197 | 1 | 179158406 | ABL2 | ENSG00000143322.15 | 5.68E-7 | 0.01 | 40413 | gtex_brain_putamen_basal |
| rs2816198 | 1 | 179158736 | ABL2 | ENSG00000143322.15 | 6.465E-7 | 0.01 | 40083 | gtex_brain_putamen_basal |
| rs2816199 | 1 | 179158932 | ABL2 | ENSG00000143322.15 | 6.465E-7 | 0.01 | 39887 | gtex_brain_putamen_basal |
| rs2793812 | 1 | 179159399 | ABL2 | ENSG00000143322.15 | 6.45E-7 | 0.01 | 39420 | gtex_brain_putamen_basal |
| rs2816202 | 1 | 179162437 | ABL2 | ENSG00000143322.15 | 6.479E-7 | 0.01 | 36382 | gtex_brain_putamen_basal |
| rs2816203 | 1 | 179163857 | ABL2 | ENSG00000143322.15 | 6.407E-7 | 0.01 | 34962 | gtex_brain_putamen_basal |
| rs2816204 | 1 | 179164558 | ABL2 | ENSG00000143322.15 | 6.457E-7 | 0.01 | 34261 | gtex_brain_putamen_basal |
| rs2816206 | 1 | 179168805 | ABL2 | ENSG00000143322.15 | 2.219E-6 | 0.01 | 30014 | gtex_brain_putamen_basal |
| rs2816208 | 1 | 179171248 | ABL2 | ENSG00000143322.15 | 7.655E-7 | 0.01 | 27571 | gtex_brain_putamen_basal |
| rs2816209 | 1 | 179171494 | ABL2 | ENSG00000143322.15 | 2.268E-6 | 0.01 | 27325 | gtex_brain_putamen_basal |
| rs2066279 | 1 | 179172856 | ABL2 | ENSG00000143322.15 | 8.087E-7 | 0.01 | 25963 | gtex_brain_putamen_basal |
| rs2793806 | 1 | 179180424 | ABL2 | ENSG00000143322.15 | 2.495E-6 | 0.01 | 18395 | gtex_brain_putamen_basal |
| rs2130576 | 1 | 179181102 | ABL2 | ENSG00000143322.15 | 6.455E-7 | 0.01 | 17717 | gtex_brain_putamen_basal |
| rs2816214 | 1 | 179181546 | ABL2 | ENSG00000143322.15 | 6.455E-7 | 0.01 | 17273 | gtex_brain_putamen_basal |
| rs2816213 | 1 | 179183766 | ABL2 | ENSG00000143322.15 | 7.157E-7 | 0.01 | 15053 | gtex_brain_putamen_basal |
| rs2636281 | 1 | 179184140 | ABL2 | ENSG00000143322.15 | 2.483E-6 | 0.01 | 14679 | gtex_brain_putamen_basal |
| rs2636282 | 1 | 179184620 | ABL2 | ENSG00000143322.15 | 7.53E-7 | 0.01 | 14199 | gtex_brain_putamen_basal |
| rs2816211 | 1 | 179192238 | ABL2 | ENSG00000143322.15 | 6.465E-7 | 0.01 | 6581 | gtex_brain_putamen_basal |
| rs2816210 | 1 | 179193932 | ABL2 | ENSG00000143322.15 | 1.376E-6 | 0.01 | 4887 | gtex_brain_putamen_basal |
| rs2636265 | 1 | 179199076 | ABL2 | ENSG00000143322.15 | 6.138E-7 | 0.01 | -257 | gtex_brain_putamen_basal |
| rs2816167 | 1 | 179200657 | ABL2 | ENSG00000143322.15 | 2.421E-6 | 0.01 | -1838 | gtex_brain_putamen_basal |
| rs2793803 | 1 | 179201438 | ABL2 | ENSG00000143322.15 | 6.465E-7 | 0.01 | -2619 | gtex_brain_putamen_basal |
| rs2793799 | 1 | 179202209 | ABL2 | ENSG00000143322.15 | 2.39E-6 | 0.01 | -3390 | gtex_brain_putamen_basal |
| rs5779012 | 1 | 179214631 | ABL2 | ENSG00000143322.15 | 3.228E-6 | 0.01 | -15812 | gtex_brain_putamen_basal |
| rs2816170 | 1 | 179214726 | ABL2 | ENSG00000143322.15 | 8.045E-7 | 0.01 | -15907 | gtex_brain_putamen_basal |
| rs390018 | 1 | 179215747 | ABL2 | ENSG00000143322.15 | 9.645E-7 | 0.01 | -16928 | gtex_brain_putamen_basal |
| rs422684 | 1 | 179215918 | ABL2 | ENSG00000143322.15 | 3.397E-7 | 0.01 | -17099 | gtex_brain_putamen_basal |
| rs1687165 | 1 | 179217236 | ABL2 | ENSG00000143322.15 | 8.467E-7 | 0.01 | -18417 | gtex_brain_putamen_basal |
| rs60293082 | 1 | 179217317 | ABL2 | ENSG00000143322.15 | 3.045E-6 | 0.01 | -18498 | gtex_brain_putamen_basal |
| rs380474 | 1 | 179217448 | ABL2 | ENSG00000143322.15 | 8.467E-7 | 0.01 | -18629 | gtex_brain_putamen_basal |
| rs400976 | 1 | 179217582 | ABL2 | ENSG00000143322.15 | 8.467E-7 | 0.01 | -18763 | gtex_brain_putamen_basal |
| rs1173077 | 1 | 179220878 | ABL2 | ENSG00000143322.15 | 8.467E-7 | 0.01 | -22059 | gtex_brain_putamen_basal |
| rs451088 | 1 | 179222840 | ABL2 | ENSG00000143322.15 | 2.627E-7 | 0.01 | -24021 | gtex_brain_putamen_basal |
| rs1078872 | 1 | 179223726 | ABL2 | ENSG00000143322.15 | 4.237E-7 | 0.01 | -24907 | gtex_brain_putamen_basal |
| rs915337 | 1 | 179223751 | ABL2 | ENSG00000143322.15 | 4.237E-7 | 0.01 | -24932 | gtex_brain_putamen_basal |
| rs377785 | 1 | 179224067 | ABL2 | ENSG00000143322.15 | 4.244E-7 | 0.01 | -25248 | gtex_brain_putamen_basal |
| rs434283 | 1 | 179224180 | ABL2 | ENSG00000143322.15 | 4.251E-7 | 0.01 | -25361 | gtex_brain_putamen_basal |
| rs411266 | 1 | 179224861 | ABL2 | ENSG00000143322.15 | 4.292E-7 | 0.01 | -26042 | gtex_brain_putamen_basal |
| rs2816176 | 1 | 179247494 | ABL2 | ENSG00000143322.15 | 3.341E-6 | 0.01 | -48675 | gtex_brain_putamen_basal |
| rs2816177 | 1 | 179248952 | ABL2 | ENSG00000143322.15 | 3.334E-6 | 0.01 | -50133 | gtex_brain_putamen_basal |
| rs372675 | 1 | 179249358 | ABL2 | ENSG00000143322.15 | 3.18E-6 | 0.01 | -50539 | gtex_brain_putamen_basal |
| rs2816178 | 1 | 179249538 | ABL2 | ENSG00000143322.15 | 3.101E-6 | 0.01 | -50719 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PYCR2 | 0.77 | 0.80 |
| SIL1 | 0.74 | 0.75 |
| DNPEP | 0.74 | 0.72 |
| ACO2 | 0.71 | 0.73 |
| COQ9 | 0.71 | 0.70 |
| CD81 | 0.70 | 0.73 |
| NDUFAF3 | 0.70 | 0.70 |
| NINJ1 | 0.70 | 0.71 |
| HS1BP3 | 0.69 | 0.70 |
| ENO1 | 0.69 | 0.68 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FAM159B | -0.42 | -0.52 |
| EIF5B | -0.40 | -0.45 |
| ANKRD12 | -0.39 | -0.35 |
| PHF14 | -0.36 | -0.36 |
| THOC2 | -0.36 | -0.35 |
| KIAA2022 | -0.35 | -0.20 |
| WNK3 | -0.34 | -0.16 |
| AC016138.1 | -0.34 | -0.23 |
| SEC62 | -0.34 | -0.31 |
| CEP170 | -0.34 | -0.16 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | - | |
| GO:0000287 | magnesium ion binding | IDA | 15886098 | |
| GO:0005515 | protein binding | IEA | - | |
| GO:0005515 | protein binding | IPI | 15886098 | |
| GO:0005524 | ATP binding | IEA | - | |
| GO:0004713 | protein tyrosine kinase activity | IEA | - | |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | IEA | - | |
| GO:0016740 | transferase activity | IEA | - | |
| GO:0035014 | phosphoinositide 3-kinase regulator activity | IEA | - | |
| GO:0030145 | manganese ion binding | IDA | 15886098 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007155 | cell adhesion | IEA | - | |
| GO:0006464 | protein modification process | TAS | 2198571 | |
| GO:0006468 | protein amino acid phosphorylation | IEA | - | |
| GO:0007165 | signal transduction | TAS | 2198571 | |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IDA | 15886098 | |
| GO:0051353 | positive regulation of oxidoreductase activity | IDA | 12893824 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005856 | cytoskeleton | IEA | - | |
| GO:0005737 | cytoplasm | IEA | - | |
| GO:0005942 | phosphoinositide 3-kinase complex | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG ERBB SIGNALING PATHWAY | 87 | 71 | All SZGR 2.0 genes in this pathway |
| KEGG VIRAL MYOCARDITIS | 73 | 58 | All SZGR 2.0 genes in this pathway |
| REACTOME DEVELOPMENTAL BIOLOGY | 396 | 292 | All SZGR 2.0 genes in this pathway |
| REACTOME AXON GUIDANCE | 251 | 188 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY ROBO RECEPTOR | 30 | 26 | All SZGR 2.0 genes in this pathway |
| FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP | 579 | 346 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE LIVE UP | 485 | 293 | All SZGR 2.0 genes in this pathway |
| OSMAN BLADDER CANCER DN | 406 | 230 | All SZGR 2.0 genes in this pathway |
| GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS MAGENTA UP | 28 | 18 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE FIMA UP | 544 | 308 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE LPS UP | 431 | 237 | All SZGR 2.0 genes in this pathway |
| MYLLYKANGAS AMPLIFICATION HOT SPOT 17 | 25 | 12 | All SZGR 2.0 genes in this pathway |
| SHI SPARC TARGETS UP | 24 | 17 | All SZGR 2.0 genes in this pathway |
| PATIL LIVER CANCER | 747 | 453 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS UP | 1037 | 673 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS UP | 811 | 508 | All SZGR 2.0 genes in this pathway |
| POMEROY MEDULLOBLASTOMA DESMOPLASIC VS CLASSIC UP | 62 | 38 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS EARLY PROGENITOR | 532 | 309 | All SZGR 2.0 genes in this pathway |
| CHANG IMMORTALIZED BY HPV31 UP | 84 | 55 | All SZGR 2.0 genes in this pathway |
| BILD MYC ONCOGENIC SIGNATURE | 206 | 117 | All SZGR 2.0 genes in this pathway |
| CHO NR4A1 TARGETS | 33 | 22 | All SZGR 2.0 genes in this pathway |
| GRESHOCK CANCER COPY NUMBER UP | 323 | 240 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |
| ROESSLER LIVER CANCER METASTASIS UP | 107 | 72 | All SZGR 2.0 genes in this pathway |
| ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF | 516 | 308 | All SZGR 2.0 genes in this pathway |