Gene Page: GLI2

Summary
GeneID  2736
Symbol  GLI2
Synonyms  HPE9|THP1|THP2
Description  GLI-Kruppel family member GLI2
See related  HGNC:4318|MIM:165230|Ensembl:ENSG00000074047|HPRD:01312|
Locus tag  -
Gene type  protein-coding
Map location  2q14
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.023 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00755 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 7 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIDA15994174 
GO:0008270zinc ion bindingIDA8378770 
GO:0016563transcription activator activityIDA15175043 
GO:0046872metal ion bindingIEA-
GO:0043565sequence-specific DNA bindingIDA9557682 |15175043 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007411axon guidanceISSaxon (GO term level: 13)-
GO:0048666neuron developmentISSneuron (GO term level: 9)-
GO:0021965spinal cord ventral commissure morphogenesisISSneuron, axon (GO term level: 15)-
GO:0030902hindbrain developmentISSBrain (GO term level: 8)-
GO:0021517ventral spinal cord developmentISSneuron (GO term level: 8)-
GO:0021508floor plate formationISSneuron, Glial (GO term level: 10)-
GO:0021775smoothened signaling pathway involved in ventral spinal cord interneuron specificationISSneuron (GO term level: 12)-
GO:0000122negative regulation of transcription from RNA polymerase II promoterIMP15994174 
GO:0001501skeletal system developmentISS-
GO:0001822kidney developmentISS-
GO:0002076osteoblast developmentISS-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0009954proximal/distal pattern formationISS-
GO:0007224smoothened signaling pathwayIDA15994174 
GO:0008283cell proliferationIDA15994174 
GO:0007507heart developmentISS-
GO:0007442hindgut morphogenesisISS-
GO:0007389pattern specification processISS-
GO:0042475odontogenesis of dentine-containing toothISS-
GO:0021983pituitary gland developmentISS-
GO:0048754branching morphogenesis of a tubeISS-
GO:0030879mammary gland developmentISS-
GO:0030324lung developmentISS-
GO:0035295tube developmentISS-
GO:0030903notochord developmentISS-
GO:0021513spinal cord dorsal/ventral patterningISS-
GO:0021696cerebellar cortex morphogenesisISS-
GO:0045740positive regulation of DNA replicationIDA12165851 
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA12165851 |15994174 
GO:0048566embryonic gut developmentISS-
GO:0048589developmental growthISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005634nucleusIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CREB1CREB | MGC9284cAMP responsive element binding protein 1-HPRD,BioGRID10074179 
STK36DKFZp434N0223 | FU | KIAA1278serine/threonine kinase 36, fused homolog (Drosophila)-HPRD,BioGRID10806483 
SUFUPRO1280 | SUFUH | SUFUXLsuppressor of fused homolog (Drosophila)-HPRD,BioGRID10564661 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding proteinTBP interacts with GLI-2. This interaction was modeled on a demonstrated interaction between TBP from an unspecified species and human GLI-2.BIND11160734 
ZIC1ZIC | ZNF201Zic family member 1 (odd-paired homolog, Drosophila)-HPRD,BioGRID11238441 
ZIC2HPE5Zic family member 2 (odd-paired homolog, Drosophila)-HPRD,BioGRID11238441 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_HEDGEHOG_SIGNALING_PATHWAY 5642All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_BASAL_CELL_CARCINOMA 5544All SZGR genes in this pathway
BIOCARTA_SHH_PATHWAY 1615All SZGR genes in this pathway
PID_HEDGEHOG_2PATHWAY 2217All SZGR genes in this pathway
PID_HEDGEHOG_GLI_PATHWAY 4835All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_UP 290177All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_DN 260143All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_DN 232139All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_UP 162116All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
SNIJDERS_AMPLIFIED_IN_HEAD_AND_NECK_TUMORS 3727All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_7 2722All SZGR genes in this pathway
LEE_TARGETS_OF_PTCH1_AND_SUFU_UP 5337All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_DN 160101All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
PODAR_RESPONSE_TO_ADAPHOSTIN_DN 1816All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP 14985All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
VALK_AML_CLUSTER_2 2914All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_CLASSICAL 162122All SZGR genes in this pathway
FOSTER_KDM1A_TARGETS_DN 211119All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-182141014171A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-30-5p953959m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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