Gene Page: HLA-G

Summary
GeneID  3135
Symbol  HLA-G
Synonyms  MHC-G
Description  major histocompatibility complex, class I, G
See related  HGNC:4964|MIM:142871|Ensembl:ENSG00000204632|HPRD:00834|
Locus tag  DADB-15K14.8
Gene type  protein-coding
Map location  6p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.033 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GYG10.790.75
TSPAN310.780.68
GCAT0.770.72
CRYL10.770.71
KLHDC90.770.74
HHLA30.770.76
PRDX60.750.74
SULT1A10.750.69
GALT0.750.67
ABHD110.740.70
Top 10 negatively co-expressed genes
RTF1-0.49-0.50
ANKRD12-0.47-0.49
PHF14-0.46-0.51
CHD3-0.45-0.43
THOC2-0.45-0.50
NOL4-0.45-0.39
MYT1L-0.45-0.41
DACT1-0.45-0.42
GRIP1-0.45-0.40
ISLR2-0.45-0.41
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI14500461 
GO:0032393MHC class I receptor activityTAS9539768 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002474antigen processing and presentation of peptide antigen via MHC class IIEA-
GO:0006968cellular defense responseTAS9539768 
GO:0019882antigen processing and presentationIEA-
GO:0006955immune responseIEA-
GO:0006955immune responseNAS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005575cellular_componentND-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0042612MHC class I protein complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
B2M-beta-2-microglobulin-HPRD9228302 
CD8ACD8 | Leu2 | MAL | p32CD8a molecule-HPRD1908512 |10843658|10809759 
in vivo
Reconstituted Complex		BioGRID1908512 |10809759 
|10843658 
COPB1COPB | DKFZp761K102 | FLJ10341coatomer protein complex, subunit beta 1-HPRD,BioGRID12582157 
HLA-GMHC-Gmajor histocompatibility complex, class I, G-HPRD,BioGRID12874224 
KIR2DL4CD158D | G9P | KIR103 | KIR103ASkiller cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4-HPRD,BioGRID10190900 
KLRD1CD94killer cell lectin-like receptor subfamily D, member 1-HPRD,BioGRID9405670 
LILRB1CD85 | CD85J | FLJ37515 | ILT2 | LIR-1 | LIR1 | MIR-7 | MIR7leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1-HPRD,BioGRID9933109 |12853576 
|12874224 
LILRB2CD85D | ILT4 | LILRA6 | LIR-2 | LIR2 | MIR-10 | MIR10leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2-HPRD12853576 
-HPRD,BioGRID9531263 |10190906 
|12853576 |15670976 
TAP1ABC17 | ABCB2 | APT1 | D6S114E | FLJ26666 | FLJ41500 | PSF1 | RING4 | TAP1*0102N | TAP1Ntransporter 1, ATP-binding cassette, sub-family B (MDR/TAP)-HPRD,BioGRID9103419 
TAP2ABC18 | ABCB3 | APT2 | D6S217E | PSF2 | RING11transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)-HPRD,BioGRID9103419 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_CELL_ADHESION_MOLECULES_CAMS 13493All SZGR genes in this pathway
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 8965All SZGR genes in this pathway
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 13792All SZGR genes in this pathway
KEGG_TYPE_I_DIABETES_MELLITUS 4438All SZGR genes in this pathway
KEGG_AUTOIMMUNE_THYROID_DISEASE 5349All SZGR genes in this pathway
KEGG_ALLOGRAFT_REJECTION 3834All SZGR genes in this pathway
KEGG_GRAFT_VERSUS_HOST_DISEASE 4231All SZGR genes in this pathway
KEGG_VIRAL_MYOCARDITIS 7358All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION 7648All SZGR genes in this pathway
REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY 97All SZGR genes in this pathway
REACTOME_ER_PHAGOSOME_PATHWAY 6140All SZGR genes in this pathway
REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL 7037All SZGR genes in this pathway
REACTOME_INTERFERON_GAMMA_SIGNALING 6348All SZGR genes in this pathway
REACTOME_INTERFERON_ALPHA_BETA_SIGNALING 6450All SZGR genes in this pathway
REACTOME_INTERFERON_SIGNALING 159116All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC 2117All SZGR genes in this pathway
REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 251156All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_PROGENITOR_UP 3925All SZGR genes in this pathway
HUTTMANN_B_CLL_POOR_SURVIVAL_UP 276187All SZGR genes in this pathway
PAPASPYRIDONOS_UNSTABLE_ATEROSCLEROTIC_PLAQUE_UP 5236All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_UP 215137All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
LUI_TARGETS_OF_PAX8_PPARG_FUSION 3423All SZGR genes in this pathway
PATTERSON_DOCETAXEL_RESISTANCE 2920All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
MORI_PRE_BI_LYMPHOCYTE_DN 7749All SZGR genes in this pathway
MORI_MATURE_B_LYMPHOCYTE_UP 9062All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
GALE_APL_WITH_FLT3_MUTATED_DN 1710All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_UP 8366All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
JACKSON_DNMT1_TARGETS_UP 7757All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_DN 165106All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_0HR 6348All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_DN 373196All SZGR genes in this pathway
WALLACE_PROSTATE_CANCER_RACE_UP 299167All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
GAURNIER_PSMD4_TARGETS 7355All SZGR genes in this pathway
BREDEMEYER_RAG_SIGNALING_VIA_ATM_NOT_VIA_NFKB_DN 3823All SZGR genes in this pathway
HUPER_BREAST_BASAL_VS_LUMINAL_DN 5944All SZGR genes in this pathway
CHAUHAN_RESPONSE_TO_METHOXYESTRADIOL_DN 10265All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
DEMAGALHAES_AGING_UP 5539All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
KIM_GLIS2_TARGETS_UP 8461All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_COMPLETE 227151All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway


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