Gene Page: CD82
Summary ?
| GeneID | 3732 |
| Symbol | CD82 |
| Synonyms | 4F9|C33|GR15|IA4|KAI1|R2|SAR2|ST6|TSPAN27 |
| Description | CD82 molecule |
| Reference | MIM:600623|HGNC:HGNC:6210|Ensembl:ENSG00000085117|HPRD:09004|Vega:OTTHUMG00000166472 |
| Gene type | protein-coding |
| Map location | 11p11.2 |
| Pascal p-value | 0.006 |
| eGene | Hippocampus Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0275 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs2198151 | chr11 | 45475603 | CD82 | 3732 | 0.2 | cis | ||
| rs11038480 | chr11 | 45481556 | CD82 | 3732 | 0.14 | cis | ||
| rs896338 | chr11 | 45487120 | CD82 | 3732 | 0.14 | cis | ||
| rs10769153 | chr11 | 45499023 | CD82 | 3732 | 0.18 | cis |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| GDPD5 | 0.86 | 0.86 |
| FAM20C | 0.78 | 0.83 |
| CHRNB2 | 0.77 | 0.83 |
| AP1B1 | 0.77 | 0.85 |
| SLC38A7 | 0.77 | 0.85 |
| PVR | 0.76 | 0.83 |
| RRP12 | 0.76 | 0.86 |
| GRWD1 | 0.76 | 0.81 |
| ZDHHC5 | 0.75 | 0.83 |
| DTX2 | 0.75 | 0.72 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.57 | -0.67 |
| AF347015.21 | -0.55 | -0.72 |
| MT-CO2 | -0.54 | -0.65 |
| AF347015.8 | -0.54 | -0.65 |
| COPZ2 | -0.53 | -0.64 |
| AL139819.3 | -0.53 | -0.66 |
| AF347015.2 | -0.53 | -0.61 |
| HIGD1B | -0.52 | -0.64 |
| AF347015.27 | -0.52 | -0.65 |
| AF347015.33 | -0.52 | -0.62 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15205336 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0016020 | membrane | IEA | - | |
| GO:0016021 | integral to membrane | IEA | - | |
| GO:0005886 | plasma membrane | TAS | 7754374 | |
| GO:0005887 | integral to plasma membrane | TAS | 1842498 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| BCL3 | BCL4 | D19S37 | B-cell CLL/lymphoma 3 | BCL3 interacts with the CD82 (KAI1) promoter. | BIND | 15829968 |
| CANX | CNX | FLJ26570 | IP90 | P90 | calnexin | - | HPRD | 11350933 |
| CD151 | GP27 | MER2 | PETA-3 | RAPH | SFA1 | TSPAN24 | CD151 molecule (Raph blood group) | Affinity Capture-Western | BioGRID | 15492270 |
| CD19 | B4 | MGC12802 | CD19 molecule | Affinity Capture-Western | BioGRID | 7636191 |9804823 |
| CD4 | CD4mut | CD4 molecule | - | HPRD,BioGRID | 7636191 |
| CD46 | MCP | MGC26544 | MIC10 | TLX | TRA2.10 | CD46 molecule, complement regulatory protein | Affinity Capture-Western | BioGRID | 10741407 |
| CD63 | LAMP-3 | ME491 | MLA1 | OMA81H | TSPAN30 | CD63 molecule | - | HPRD,BioGRID | 9759843 |
| CD9 | 5H9 | BA2 | BTCC-1 | DRAP-27 | GIG2 | MIC3 | MRP-1 | P24 | TSPAN29 | CD9 molecule | Affinity Capture-Western | BioGRID | 15492270 |
| CTNNB1 | CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923 | catenin (cadherin-associated protein), beta 1, 88kDa | CTNNB1 (beta-catenin) interacts with the CD82 (KAI1) promoter. | BIND | 15829968 |
| EGFR | ERBB | ERBB1 | HER1 | PIG61 | mENA | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | - | HPRD,BioGRID | 10985391 |
| ERBB2 | CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | - | HPRD,BioGRID | 14576349 |
| ERBB3 | ErbB-3 | HER3 | LCCS2 | MDA-BF-1 | MGC88033 | c-erbB-3 | c-erbB3 | erbB3-S | p180-ErbB3 | p45-sErbB3 | p85-sErbB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | - | HPRD,BioGRID | 14576349 |
| HBEGF | DTR | DTS | DTSF | HEGFL | heparin-binding EGF-like growth factor | - | HPRD,BioGRID | 10749879 |
| HLA-DMA | D6S222E | DMA | HLADM | RING6 | major histocompatibility complex, class II, DM alpha | - | HPRD | 9759843 |
| HLA-DMB | D6S221E | RING7 | major histocompatibility complex, class II, DM beta | Affinity Capture-Western | BioGRID | 9759843 |
| HLA-DOB | DOB | major histocompatibility complex, class II, DO beta | Affinity Capture-Western | BioGRID | 9759843 |
| HLA-DRA | HLA-DRA1 | major histocompatibility complex, class II, DR alpha | - | HPRD,BioGRID | 9759843 |
| IGSF8 | CD316 | CD81P3 | EWI2 | PGRL | immunoglobulin superfamily, member 8 | Affinity Capture-Western | BioGRID | 12750295 |
| ITGA3 | CD49C | FLJ34631 | FLJ34704 | GAP-B3 | GAPB3 | MSK18 | VCA-2 | VL3A | VLA3a | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | - | HPRD | 8757325 |
| ITGA4 | CD49D | IA4 | MGC90518 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | - | HPRD | 8757325 |
| ITGA6 | CD49f | DKFZp686J01244 | FLJ18737 | ITGA6B | VLA-6 | integrin, alpha 6 | - | HPRD | 8757325 |
| ITGAL | CD11A | LFA-1 | LFA1A | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | Affinity Capture-Western | BioGRID | 10602019 |
| ITGB1 | CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLAB | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | - | HPRD | 8757325 |
| ITGB2 | CD18 | LAD | LCAMB | LFA-1 | MAC-1 | MF17 | MFI7 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | - | HPRD | 10602019 |
| KAT5 | ESA1 | HTATIP | HTATIP1 | PLIP | TIP | TIP60 | cPLA2 | K(lysine) acetyltransferase 5 | HTATIP (Tip60) interacts with the CD82 (KAI1) promoter. | BIND | 15829968 |
| LRP1 | A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5 | low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) | - | HPRD | 9804823 |
| MAP3K1 | MAPKKK1 | MEKK | MEKK1 | mitogen-activated protein kinase kinase kinase 1 | MAP3K1 (MEKK1) interacts with the CD82 (KAI1) promoter. | BIND | 15829968 |
| MAP3K7IP2 | FLJ21885 | KIAA0733 | TAB2 | mitogen-activated protein kinase kinase kinase 7 interacting protein 2 | An unspecified isoform of MAP3K7IP2 (TAB2) interacts with the CD82 (KAI1) promoter. | BIND | 15829968 |
| NCOR1 | KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoR | nuclear receptor co-repressor 1 | NCOR1 (N-CoR) interacts with the CD82 (KAI1) promoter. | BIND | 15829968 |
| NFKB1 | DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | NFKB1 (p50) interacts with the CD82 (KAI1) promoter. | BIND | 15829968 |
| POLR2A | MGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1 | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | POLR2A (pol II) interacts with the CD82 (KAI1) promoter. | BIND | 15829968 |
| PTGFRN | CD315 | CD9P-1 | EWI-F | FLJ11001 | FPRP | KIAA1436 | SMAP-6 | prostaglandin F2 receptor negative regulator | Affinity Capture-Western | BioGRID | 11278880 |
| RUVBL1 | ECP54 | INO80H | NMP238 | PONTIN | Pontin52 | RVB1 | TIH1 | TIP49 | TIP49A | RuvB-like 1 (E. coli) | RUVBL1 (pontin) interacts with the CD82 (KAI1) promoter. | BIND | 15829968 |
| RUVBL2 | CGI-46 | ECP51 | INO80J | REPTIN | RVB2 | TIH2 | TIP48 | TIP49B | RuvB-like 2 (E. coli) | RUVBL2 (reptin) interacts with the CD82 (KAI1) promoter. | BIND | 15829968 |
| VANGL1 | LPP2 | MGC5338 | STB2 | STBM2 | vang-like 1 (van gogh, Drosophila) | - | HPRD | 15205336 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG P53 SIGNALING PATHWAY | 69 | 45 | All SZGR 2.0 genes in this pathway |
| PID P53 DOWNSTREAM PATHWAY | 137 | 94 | All SZGR 2.0 genes in this pathway |
| PID ERA GENOMIC PATHWAY | 65 | 37 | All SZGR 2.0 genes in this pathway |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN | 187 | 115 | All SZGR 2.0 genes in this pathway |
| LEE NEURAL CREST STEM CELL DN | 118 | 79 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE FIMA UP | 544 | 308 | All SZGR 2.0 genes in this pathway |
| LANDIS BREAST CANCER PROGRESSION UP | 44 | 27 | All SZGR 2.0 genes in this pathway |
| LANDIS ERBB2 BREAST PRENEOPLASTIC UP | 20 | 10 | All SZGR 2.0 genes in this pathway |
| LANDIS ERBB2 BREAST TUMORS 324 UP | 150 | 93 | All SZGR 2.0 genes in this pathway |
| GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN | 206 | 136 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS DN | 357 | 212 | All SZGR 2.0 genes in this pathway |
| ONDER CDH1 TARGETS 2 DN | 464 | 276 | All SZGR 2.0 genes in this pathway |
| ONDER CDH1 SIGNALING VIA CTNNB1 | 83 | 58 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS DN | 366 | 238 | All SZGR 2.0 genes in this pathway |
| DELASERNA MYOD TARGETS UP | 89 | 51 | All SZGR 2.0 genes in this pathway |
| VERRECCHIA RESPONSE TO TGFB1 C2 | 25 | 18 | All SZGR 2.0 genes in this pathway |
| VERRECCHIA EARLY RESPONSE TO TGFB1 | 58 | 43 | All SZGR 2.0 genes in this pathway |
| MOREIRA RESPONSE TO TSA UP | 28 | 23 | All SZGR 2.0 genes in this pathway |
| JOSEPH RESPONSE TO SODIUM BUTYRATE UP | 31 | 21 | All SZGR 2.0 genes in this pathway |
| BOCHKIS FOXA2 TARGETS | 425 | 261 | All SZGR 2.0 genes in this pathway |
| GRADE COLON CANCER UP | 871 | 505 | All SZGR 2.0 genes in this pathway |
| QI PLASMACYTOMA UP | 259 | 185 | All SZGR 2.0 genes in this pathway |
| CHANG CORE SERUM RESPONSE DN | 209 | 137 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS DN | 442 | 275 | All SZGR 2.0 genes in this pathway |
| MARTENS BOUND BY PML RARA FUSION | 456 | 287 | All SZGR 2.0 genes in this pathway |
| CHICAS RB1 TARGETS SENESCENT | 572 | 352 | All SZGR 2.0 genes in this pathway |
| DUTERTRE ESTRADIOL RESPONSE 6HR UP | 229 | 149 | All SZGR 2.0 genes in this pathway |
| CHYLA CBFA2T3 TARGETS DN | 242 | 146 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS UP | 745 | 475 | All SZGR 2.0 genes in this pathway |
| VANLOO SP3 TARGETS DN | 89 | 47 | All SZGR 2.0 genes in this pathway |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |
| PHONG TNF RESPONSE VIA P38 COMPLETE | 227 | 151 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |