Gene Page: KCND2

Summary
GeneID  3751
Symbol  KCND2
Synonyms  KIAA1044|KV4.2|MGC119702|MGC119703|RK5
Description  potassium voltage-gated channel, Shal-related subfamily, member 2
See related  HGNC:6238|MIM:605410|Ensembl:ENSG00000184408|HPRD:09254|
Locus tag  -
Gene type  protein-coding
Map location  7q31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0018 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
EXOC40.880.92
SLC37A30.870.90
TMEM185A0.870.89
GPR850.870.87
POLR1B0.860.89
NCOA50.860.90
TDG0.860.90
NKAIN20.860.82
TSPAN140.850.89
TBC1D140.850.89
Top 10 negatively co-expressed genes
AIFM3-0.67-0.74
AF347015.31-0.67-0.81
FXYD1-0.66-0.82
MT-CO2-0.66-0.82
TSC22D4-0.66-0.76
HEPN1-0.65-0.73
C5orf53-0.65-0.70
HLA-F-0.65-0.73
HSD17B14-0.65-0.76
S100B-0.65-0.78
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI11287421 
GO:0005515protein bindingNAS11102480 
GO:0005244voltage-gated ion channel activityIEA-
GO:0005249voltage-gated potassium channel activityNAS11102480 
GO:0008270zinc ion bindingIEA-
GO:0030955potassium ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)11102480 
GO:0001508regulation of action potentialTAS11102480 
GO:0006811ion transportIEA-
GO:0006813potassium ion transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043197dendritic spineNASSynap, dendrite (GO term level: 7)11102480 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0009986cell surfaceIDA12493773 
GO:0008076voltage-gated potassium channel complexIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)Two-hybridBioGRID12435606 
FLNCABP-280 | ABP280A | ABPA | ABPL | FLJ10186 | FLN2filamin C, gamma (actin binding protein 280)Reconstituted Complex
Two-hybrid		BioGRID11102480 
FREQDKFZp761L1223 | FLUP | NCS-1 | NCS1frequenin homolog (Drosophila)Affinity Capture-WesternBioGRID11606724 
IL16FLJ16806 | FLJ42735 | FLJ44234 | HsT19289 | IL-16 | LCF | prIL-16interleukin 16 (lymphocyte chemoattractant factor)-HPRD,BioGRID10479680 
KCNIP1KCHIP1 | MGC95 | VABPKv channel interacting protein 1KChIP1 interacts with Kv4.2 in a Ca2+ dependent manner.BIND15184042 
KCNIP4CALP | KCHIP4 | MGC44947Kv channel interacting protein 4-HPRD11847232 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS 4332All SZGR genes in this pathway
REACTOME_POTASSIUM_CHANNELS 9868All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
WATTEL_AUTONOMOUS_THYROID_ADENOMA_UP 7347All SZGR genes in this pathway
KIM_MYCL1_AMPLIFICATION_TARGETS_UP 1311All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_12HR_UP 11679All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP 487286All SZGR genes in this pathway
LEE_TARGETS_OF_PTCH1_AND_SUFU_DN 8369All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
MCCLUNG_COCAINE_REWARD_5D 7962All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN 264159All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MIKKELSEN_MEF_ICP_WITH_H3K27ME3 206108All SZGR genes in this pathway
MIKKELSEN_IPS_ICP_WITH_H3K4ME3_AND_H327ME3 12683All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3_AND_H3K27ME3 13785All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3 445257All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_UP 163111All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_DN 244157All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/206159816041Ahsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-129-5p3413471Ahsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-140158164m8hsa-miR-140brainAGUGGUUUUACCCUAUGGUAG
miR-149174217481Ahsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-186487493m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-200bc/429693699m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-2054584641Ahsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-2182362421Ahsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-324-3p4975031Ahsa-miR-324-3pCCACUGCCCCAGGUGCUGCUGG
miR-324-5p655661m8hsa-miR-324-5pCGCAUCCCCUAGGGCAUUGGUGU
miR-333323381Ahsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-338241224191A,m8hsa-miR-338brainUCCAGCAUCAGUGAUUUUGUUGA
miR-362238923951Ahsa-miR-362AAUCCUUGGAACCUAGGUGUGAGU
miR-3636156211Ahsa-miR-363AUUGCACGGUAUCCAUCUGUAA
miR-5396456521A,m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
miR-93.hd/291-3p/294/295/302/372/373/5205745801Ahsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.