SZGR2

Summary ?

GeneID	394
Symbol	ARHGAP5
Synonyms	GFI2\|RhoGAP5\|p190-B\|p190BRhoGAP
Description	Rho GTPase activating protein 5
Reference	MIM:602680\|HGNC:HGNC:675\|Ensembl:ENSG00000100852\|HPRD:04060\|
Gene type	protein-coding
Map location	14q12
Pascal p-value	0.035

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
GSMA_I	Genome scan meta-analysis	Psr: 0.047

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
GPR34	0.74	0.62
ADORA3	0.73	0.60
C1QC	0.73	0.65
RGS10	0.73	0.66
CD86	0.72	0.62
LAPTM5	0.71	0.62
CD53	0.71	0.64
AIF1	0.70	0.64
LY86	0.70	0.61
CTSS	0.70	0.64

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ZNF814	-0.33	-0.37
ANKRD36	-0.30	-0.35
CRIPAK	-0.30	-0.31
AC005921.3	-0.29	-0.31
AC004148.1	-0.29	-0.37
SLFNL1	-0.29	-0.27
CYP2D6	-0.29	-0.33
DUOX1	-0.29	-0.26
AC174470.2	-0.28	-0.27
AC092143.1	-0.28	-0.34

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005100	Rho GTPase activator activity	TAS		8537347
GO:0003924	GTPase activity	TAS		8537347
GO:0005096	GTPase activator activity	IEA		-
GO:0005525	GTP binding	IEA		-
GO:0042169	SH2 domain binding	IPI		1689011
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007155	cell adhesion	TAS		8537347
GO:0007266	Rho protein signal transduction	TAS		8537347
GO:0007165	signal transduction	IEA		-
GO:0007264	small GTPase mediated signal transduction	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005622	intracellular	IEA		-
GO:0005737	cytoplasm	TAS		8537347
GO:0016020	membrane	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG FOCAL ADHESION	201	138	All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION	118	78	All SZGR 2.0 genes in this pathway
BIOCARTA D4GDI PATHWAY	13	8	All SZGR 2.0 genes in this pathway
BIOCARTA ECM PATHWAY	24	17	All SZGR 2.0 genes in this pathway
BIOCARTA MYOSIN PATHWAY	31	22	All SZGR 2.0 genes in this pathway
BIOCARTA RHO PATHWAY	32	23	All SZGR 2.0 genes in this pathway
PID RHOA REG PATHWAY	46	30	All SZGR 2.0 genes in this pathway
PID RAC1 PATHWAY	54	37	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN	455	304	All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE UP	79	50	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP	194	122	All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP	457	269	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN	805	505	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN	537	339	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP	584	356	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN	514	319	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A UP	142	104	All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER	214	139	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP	424	268	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP	314	201	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH DN	58	43	All SZGR 2.0 genes in this pathway
LINDVALL IMMORTALIZED BY TERT DN	80	56	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 11	57	40	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3	720	440	All SZGR 2.0 genes in this pathway
LEIN CEREBELLUM MARKERS	85	47	All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3	491	310	All SZGR 2.0 genes in this pathway
ZHENG FOXP3 TARGETS IN THYMUS UP	196	137	All SZGR 2.0 genes in this pathway
KONDO EZH2 TARGETS	245	148	All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN	120	81	All SZGR 2.0 genes in this pathway
OUYANG PROSTATE CANCER PROGRESSION UP	20	14	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE	242	168	All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP	298	174	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR DN	185	116	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
CROONQUIST NRAS VS STROMAL STIMULATION UP	41	26	All SZGR 2.0 genes in this pathway
PYEON CANCER HEAD AND NECK VS CERVICAL UP	193	95	All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING UP	93	62	All SZGR 2.0 genes in this pathway
ONGUSAHA BRCA1 TARGETS DN	14	9	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN	505	328	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP	430	288	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway
GUO TARGETS OF IRS1 AND IRS2	98	67	All SZGR 2.0 genes in this pathway
VANOEVELEN MYOGENESIS SIN3A TARGETS	220	133	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-137	1041	1047	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-15/16/195/424/497	1210	1216	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-153	2152	2158	m8	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-186	705	711	1A	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-186	705	711	1A	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-19	1148	1154	m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	1148	1154	m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-194	2272	2279	1A,m8	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-218	1650	1656	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-223	1062	1068	1A	hsa-miR-223	UGUCAGUUUGUCAAAUACCCC
miR-28	1426	1432	1A	hsa-miR-28^brain	AAGGAGCUCACAGUCUAUUGAG
miR-299-5p	942	948	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-320	1751	1757	1A	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-369-3p	1569	1575	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	1569	1576	1A,m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-376c	1888	1894	1A	hsa-miR-376c	AACAUAGAGGAAAUUCCACG
miR-486	1892	1899	1A,m8	hsa-miR-486	UCCUGUACUGAGCUGCCCCGAG
miR-493-5p	1890	1896	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-494	2529	2535	1A	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU
miR-494	2529	2535	1A	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU
miR-495	2293	2299	m8	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
				hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
				hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
				hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: ARHGAP5