Gene Page: ARHGAP5

Summary
GeneID  394
Symbol  ARHGAP5
Synonyms  GFI2|RhoGAP5|p190-B
Description  Rho GTPase activating protein 5
See related  HGNC:675|MIM:602680|Ensembl:ENSG00000100852|HPRD:04060|
Locus tag  -
Gene type  protein-coding
Map location  14q12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.047 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GPR340.740.62
ADORA30.730.60
C1QC0.730.65
RGS100.730.66
CD860.720.62
LAPTM50.710.62
CD530.710.64
AIF10.700.64
LY860.700.61
CTSS0.700.64
Top 10 negatively co-expressed genes
ZNF814-0.33-0.37
ANKRD36-0.30-0.35
CRIPAK-0.30-0.31
AC005921.3-0.29-0.31
AC004148.1-0.29-0.37
SLFNL1-0.29-0.27
CYP2D6-0.29-0.33
DUOX1-0.29-0.26
AC174470.2-0.28-0.27
AC092143.1-0.28-0.34
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005100Rho GTPase activator activityTAS8537347 
GO:0003924GTPase activityTAS8537347 
GO:0005096GTPase activator activityIEA-
GO:0005525GTP bindingIEA-
GO:0042169SH2 domain bindingIPI1689011 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007155cell adhesionTAS8537347 
GO:0007266Rho protein signal transductionTAS8537347 
GO:0007165signal transductionIEA-
GO:0007264small GTPase mediated signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005737cytoplasmTAS8537347 
GO:0016020membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ITGA5CD49e | FNRA | VLA5Aintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)-HPRD8537347 
ITGB1CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLABintegrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)-HPRD8537347 
PXNFLJ16691paxillinAffinity Capture-WesternBioGRID10092539 
RASA1CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAPRAS p21 protein activator (GTPase activating protein) 1GAP interacts with p190. This interaction was modeled on a demonstrated interaction between human GAP and rat p190.BIND1689011 |8344248 
|10769036 
-HPRD8537347 
RHOAARH12 | ARHA | RHO12 | RHOH12ras homolog gene family, member AAffinity Capture-Western
Reconstituted Complex		BioGRID12842009 
RND1ARHS | FLJ42294 | RHO6 | RHOSRho family GTPase 1Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID12842009 
RND2ARHN | RHO7 | RhoNRho family GTPase 2Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID12842009 
RND3ARHE | Rho8 | RhoE | memBRho family GTPase 3Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID12842009 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 11878All SZGR genes in this pathway
BIOCARTA_D4GDI_PATHWAY 138All SZGR genes in this pathway
BIOCARTA_ECM_PATHWAY 2417All SZGR genes in this pathway
BIOCARTA_MYOSIN_PATHWAY 3122All SZGR genes in this pathway
BIOCARTA_RHO_PATHWAY 3223All SZGR genes in this pathway
PID_RHOA_REG_PATHWAY 4630All SZGR genes in this pathway
PID_RAC1_PATHWAY 5437All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_UP 7950All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP 194122All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_UP 142104All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 214139All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
JI_RESPONSE_TO_FSH_DN 5843All SZGR genes in this pathway
LINDVALL_IMMORTALIZED_BY_TERT_DN 8056All SZGR genes in this pathway
BURTON_ADIPOGENESIS_11 5740All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 720440All SZGR genes in this pathway
LEIN_CEREBELLUM_MARKERS 8547All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
ZHENG_FOXP3_TARGETS_IN_THYMUS_UP 196137All SZGR genes in this pathway
KONDO_EZH2_TARGETS 245148All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_DN 12081All SZGR genes in this pathway
OUYANG_PROSTATE_CANCER_PROGRESSION_UP 2014All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_UP 298174All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_DN 185116All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
CROONQUIST_NRAS_VS_STROMAL_STIMULATION_UP 4126All SZGR genes in this pathway
PYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP 19395All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_UP 9362All SZGR genes in this pathway
ONGUSAHA_BRCA1_TARGETS_DN 149All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
GUO_TARGETS_OF_IRS1_AND_IRS2 9867All SZGR genes in this pathway
VANOEVELEN_MYOGENESIS_SIN3A_TARGETS 220133All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-137104110471Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-15/16/195/424/49712101216m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-15321522158m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-1867057111Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-1911481154m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-194227222791A,m8hsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-21816501656m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-223106210681Ahsa-miR-223UGUCAGUUUGUCAAAUACCCC
miR-28142614321Ahsa-miR-28brainAAGGAGCUCACAGUCUAUUGAG
miR-299-5p9429481Ahsa-miR-299-5pUGGUUUACCGUCCCACAUACAU
miR-320175117571Ahsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-369-3p156915751Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-374156915761A,m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-376c188818941Ahsa-miR-376cAACAUAGAGGAAAUUCCACG
miR-486189218991A,m8hsa-miR-486UCCUGUACUGAGCUGCCCCGAG
miR-493-5p18901896m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-494252925351Ahsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-49522932299m8hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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