Gene Page: MAG
Summary ?
| GeneID | 4099 |
| Symbol | MAG |
| Synonyms | GMA|S-MAG|SIGLEC-4A|SIGLEC4A|SPG75 |
| Description | myelin associated glycoprotein |
| Reference | MIM:159460|HGNC:HGNC:6783|Ensembl:ENSG00000105695|HPRD:01160|Vega:OTTHUMG00000183296 |
| Gene type | protein-coding |
| Map location | 19q13.1 |
| Pascal p-value | 0.307 |
| Fetal beta | -2.189 |
| eGene | Myers' cis & trans |
| Support | G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Association | A combined odds ratio method (Sun et al. 2008), association studies | 2 | Link to SZGene |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophrenias,schizotypal | Click to show details |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0233 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs5003961 | chr7 | 78072443 | MAG | 4099 | 0.13 | trans | ||
| rs4515471 | chr7 | 78072585 | MAG | 4099 | 0.13 | trans | ||
| rs10259327 | chr7 | 78074924 | MAG | 4099 | 0.13 | trans | ||
| rs7830259 | chr8 | 14087643 | MAG | 4099 | 0.03 | trans | ||
| rs17109739 | chr14 | 80148280 | MAG | 4099 | 0.15 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SECISBP2L | 0.87 | 0.87 |
| SPTLC2 | 0.87 | 0.83 |
| FAR1 | 0.84 | 0.83 |
| PTPN11 | 0.83 | 0.83 |
| ITCH | 0.83 | 0.83 |
| STRN | 0.82 | 0.83 |
| CPD | 0.81 | 0.83 |
| CDC42BPA | 0.81 | 0.84 |
| TTLL7 | 0.81 | 0.82 |
| ZFP106 | 0.81 | 0.81 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C1orf61 | -0.51 | -0.65 |
| SERF2 | -0.46 | -0.53 |
| IL32 | -0.46 | -0.50 |
| RAB34 | -0.45 | -0.54 |
| DBI | -0.45 | -0.55 |
| C16orf74 | -0.44 | -0.51 |
| C1orf54 | -0.44 | -0.49 |
| ENHO | -0.44 | -0.51 |
| DPM3 | -0.43 | -0.54 |
| AF347015.21 | -0.43 | -0.43 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005529 | sugar binding | IEA | - | |
| GO:0005515 | protein binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007155 | cell adhesion | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0016020 | membrane | IEA | - | |
| GO:0016021 | integral to membrane | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| COL1A1 | OI4 | collagen, type I, alpha 1 | Reconstituted Complex | BioGRID | 2446864 |
| COL2A1 | ANFH | AOM | COL11A3 | MGC131516 | SEDC | collagen, type II, alpha 1 | - | HPRD,BioGRID | 2446864 |
| COL3A1 | EDS4A | FLJ34534 | collagen, type III, alpha 1 | - | HPRD,BioGRID | 2446864 |
| COL4A1 | arresten | collagen, type IV, alpha 1 | Reconstituted Complex | BioGRID | 2446864 |
| COL5A1 | - | collagen, type V, alpha 1 | Reconstituted Complex | BioGRID | 2446864 |
| COL6A1 | OPLL | collagen, type VI, alpha 1 | Reconstituted Complex | BioGRID | 2446864 |
| COL9A1 | DJ149L1.1.2 | EDM6 | FLJ40263 | MED | collagen, type IX, alpha 1 | - | HPRD,BioGRID | 2446864 |
| COL9A2 | DJ39G22.4 | EDM2 | MED | collagen, type IX, alpha 2 | - | HPRD | 2446864 |
| COL9A3 | DJ885L7.4.1 | EDM3 | FLJ90759 | IDD | MED | collagen, type IX, alpha 3 | - | HPRD | 2446864 |
| FN1 | CIG | DKFZp686F10164 | DKFZp686H0342 | DKFZp686I1370 | DKFZp686O13149 | ED-B | FINC | FN | FNZ | GFND | GFND2 | LETS | MSF | fibronectin 1 | - | HPRD | 11423128 |
| FYN | MGC45350 | SLK | SYN | FYN oncogene related to SRC, FGR, YES | - | HPRD,BioGRID | 7525550 |
| MAP1B | DKFZp686E1099 | DKFZp686F1345 | FLJ38954 | FUTSCH | MAP5 | microtubule-associated protein 1B | - | HPRD,BioGRID | 11733546 |
| MBP | MGC99675 | myelin basic protein | - | HPRD | 12237860 |
| NGFR | CD271 | Gp80-LNGFR | TNFRSF16 | p75(NTR) | p75NTR | nerve growth factor receptor (TNFR superfamily, member 16) | - | HPRD | 12011108 |
| PLP1 | MMPL | PLP | PLP/DM20 | PMD | SPG2 | proteolipid protein 1 | - | HPRD | 12237860 |
| PRNP | ASCR | CD230 | CJD | GSS | MGC26679 | PRIP | PrP | PrP27-30 | PrP33-35C | PrPc | prion | prion protein | - | HPRD | 15146195 |
| RTN4R | NGR | NOGOR | reticulon 4 receptor | - | HPRD | 12089450 |12160746 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CELL ADHESION MOLECULES CAMS | 134 | 93 | All SZGR 2.0 genes in this pathway |
| PID P75 NTR PATHWAY | 69 | 51 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALLING BY NGF | 217 | 167 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | 91 | 65 | All SZGR 2.0 genes in this pathway |
| REACTOME BASIGIN INTERACTIONS | 30 | 23 | All SZGR 2.0 genes in this pathway |
| REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | 81 | 61 | All SZGR 2.0 genes in this pathway |
| REACTOME HEMOSTASIS | 466 | 331 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| ROPERO HDAC2 TARGETS | 114 | 71 | All SZGR 2.0 genes in this pathway |
| ASTON MAJOR DEPRESSIVE DISORDER DN | 160 | 110 | All SZGR 2.0 genes in this pathway |
| PENG LEUCINE DEPRIVATION UP | 142 | 93 | All SZGR 2.0 genes in this pathway |
| TARTE PLASMA CELL VS PLASMABLAST UP | 398 | 262 | All SZGR 2.0 genes in this pathway |
| KUMAR TARGETS OF MLL AF9 FUSION | 405 | 264 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS STEM CELL LONG TERM | 302 | 191 | All SZGR 2.0 genes in this pathway |
| LEE AGING NEOCORTEX UP | 89 | 59 | All SZGR 2.0 genes in this pathway |
| JIANG AGING CEREBRAL CORTEX DN | 54 | 43 | All SZGR 2.0 genes in this pathway |
| LEIN OLIGODENDROCYTE MARKERS | 74 | 53 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |
| BHAT ESR1 TARGETS NOT VIA AKT1 UP | 211 | 131 | All SZGR 2.0 genes in this pathway |
| BHAT ESR1 TARGETS VIA AKT1 UP | 281 | 183 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |
| ALFANO MYC TARGETS | 239 | 156 | All SZGR 2.0 genes in this pathway |