Gene Page: MTNR1A
Summary ?
| GeneID | 4543 |
| Symbol | MTNR1A |
| Synonyms | MEL-1A-R|MT1 |
| Description | melatonin receptor 1A |
| Reference | MIM:600665|HGNC:HGNC:7463|Ensembl:ENSG00000168412|HPRD:02812|Vega:OTTHUMG00000185575 |
| Gene type | protein-coding |
| Map location | 4q35.1 |
| Pascal p-value | 0.137 |
| Fetal beta | -0.055 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0109 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs17130039 | chr1 | 83964563 | MTNR1A | 4543 | 0.02 | trans | ||
| rs12141773 | chr1 | 90518762 | MTNR1A | 4543 | 0.04 | trans | ||
| rs12126598 | chr1 | 118794217 | MTNR1A | 4543 | 0.08 | trans | ||
| rs2502827 | chr1 | 176044216 | MTNR1A | 4543 | 0.06 | trans | ||
| rs17572651 | chr1 | 218943612 | MTNR1A | 4543 | 0 | trans | ||
| rs615141 | chr1 | 241806978 | MTNR1A | 4543 | 0.09 | trans | ||
| snp_a-1919794 | 0 | MTNR1A | 4543 | 5.209E-6 | trans | |||
| rs17480400 | chr2 | 40094800 | MTNR1A | 4543 | 0 | trans | ||
| rs6719422 | chr2 | 80459300 | MTNR1A | 4543 | 0.18 | trans | ||
| rs6738200 | chr2 | 80460260 | MTNR1A | 4543 | 0.18 | trans | ||
| rs12104712 | chr2 | 82644947 | MTNR1A | 4543 | 0.11 | trans | ||
| rs3811060 | chr2 | 114429210 | MTNR1A | 4543 | 0.11 | trans | ||
| rs11122994 | chr2 | 124412552 | MTNR1A | 4543 | 0.18 | trans | ||
| rs16834224 | chr2 | 154649845 | MTNR1A | 4543 | 0.04 | trans | ||
| rs3845734 | chr2 | 171125572 | MTNR1A | 4543 | 0.01 | trans | ||
| rs7584986 | chr2 | 184111432 | MTNR1A | 4543 | 3.961E-9 | trans | ||
| rs6726013 | chr2 | 189064570 | MTNR1A | 4543 | 0 | trans | ||
| rs6729020 | chr2 | 189064719 | MTNR1A | 4543 | 1.263E-4 | trans | ||
| rs13397537 | chr2 | 189737534 | MTNR1A | 4543 | 0.11 | trans | ||
| rs7560722 | chr2 | 190252921 | MTNR1A | 4543 | 2.008E-5 | trans | ||
| rs13410658 | chr2 | 206342081 | MTNR1A | 4543 | 0.12 | trans | ||
| rs11130978 | chr3 | 64668862 | MTNR1A | 4543 | 0.01 | trans | ||
| rs11130979 | chr3 | 64670404 | MTNR1A | 4543 | 0.08 | trans | ||
| rs1678094 | chr3 | 66294775 | MTNR1A | 4543 | 0.15 | trans | ||
| rs516836 | chr3 | 172057558 | MTNR1A | 4543 | 0 | trans | ||
| rs1285074 | chr3 | 172096819 | MTNR1A | 4543 | 0 | trans | ||
| rs1523326 | chr3 | 172106276 | MTNR1A | 4543 | 0 | trans | ||
| rs7635430 | chr3 | 180152035 | MTNR1A | 4543 | 0.02 | trans | ||
| rs7670366 | chr4 | 14752726 | MTNR1A | 4543 | 2.868E-4 | trans | ||
| snp_a-1976228 | 0 | MTNR1A | 4543 | 0.03 | trans | |||
| rs6826731 | chr4 | 72130691 | MTNR1A | 4543 | 0.01 | trans | ||
| rs3804184 | chr4 | 85507020 | MTNR1A | 4543 | 0.17 | trans | ||
| rs729243 | chr4 | 121585650 | MTNR1A | 4543 | 0.07 | trans | ||
| rs1496267 | chr4 | 121588840 | MTNR1A | 4543 | 0.07 | trans | ||
| rs268485 | chr5 | 9426200 | MTNR1A | 4543 | 0.04 | trans | ||
| rs268531 | chr5 | 9442191 | MTNR1A | 4543 | 0.03 | trans | ||
| rs2115110 | chr5 | 38193428 | MTNR1A | 4543 | 0.02 | trans | ||
| rs17762315 | chr5 | 76807576 | MTNR1A | 4543 | 0.04 | trans | ||
| rs10491487 | chr5 | 80323367 | MTNR1A | 4543 | 0.14 | trans | ||
| rs1560919 | chr5 | 89587250 | MTNR1A | 4543 | 9.388E-4 | trans | ||
| rs328970 | chr5 | 125158530 | MTNR1A | 4543 | 0.03 | trans | ||
| rs1368303 | chr5 | 147672388 | MTNR1A | 4543 | 5.045E-21 | trans | ||
| rs6881602 | chr5 | 150940233 | MTNR1A | 4543 | 0.06 | trans | ||
| rs532347 | chr6 | 18476659 | MTNR1A | 4543 | 0.01 | trans | ||
| rs536700 | chr6 | 18486417 | MTNR1A | 4543 | 0 | trans | ||
| rs12207530 | chr6 | 18592708 | MTNR1A | 4543 | 0.02 | trans | ||
| rs12193629 | chr6 | 18599109 | MTNR1A | 4543 | 0.02 | trans | ||
| rs9296185 | chr6 | 36530602 | MTNR1A | 4543 | 0 | trans | ||
| snp_a-4265713 | 0 | MTNR1A | 4543 | 0.1 | trans | |||
| rs4897051 | chr6 | 149118925 | MTNR1A | 4543 | 6.359E-5 | trans | ||
| rs176506 | chr7 | 105755564 | MTNR1A | 4543 | 0.07 | trans | ||
| rs176510 | chr7 | 105757908 | MTNR1A | 4543 | 0.07 | trans | ||
| rs10081372 | chr7 | 117708733 | MTNR1A | 4543 | 0.03 | trans | ||
| rs2530313 | chr7 | 148112233 | MTNR1A | 4543 | 0.11 | trans | ||
| rs2622248 | chr7 | 153530407 | MTNR1A | 4543 | 0.13 | trans | ||
| rs17079498 | chr8 | 3018343 | MTNR1A | 4543 | 0.13 | trans | ||
| rs17079506 | chr8 | 3020422 | MTNR1A | 4543 | 0.11 | trans | ||
| rs17074430 | chr8 | 5517681 | MTNR1A | 4543 | 0.06 | trans | ||
| rs4872540 | chr8 | 22598980 | MTNR1A | 4543 | 3.004E-8 | trans | ||
| rs6989594 | chr8 | 126303866 | MTNR1A | 4543 | 1.208E-8 | trans | ||
| rs16908622 | chr8 | 139231604 | MTNR1A | 4543 | 0 | trans | ||
| rs10974644 | chr9 | 469264 | MTNR1A | 4543 | 0.19 | trans | ||
| rs10963807 | chr9 | 18857088 | MTNR1A | 4543 | 0.18 | trans | ||
| rs10963808 | chr9 | 18857236 | MTNR1A | 4543 | 0.18 | trans | ||
| rs7862903 | chr9 | 18862657 | MTNR1A | 4543 | 0.18 | trans | ||
| rs11140924 | chr9 | 87917975 | MTNR1A | 4543 | 0.01 | trans | ||
| rs1352754 | chr9 | 109443275 | MTNR1A | 4543 | 0.01 | trans | ||
| rs10985440 | chr9 | 124664643 | MTNR1A | 4543 | 0.14 | trans | ||
| rs17263352 | chr9 | 124811572 | MTNR1A | 4543 | 1.065E-5 | trans | ||
| rs9409946 | chr9 | 138293640 | MTNR1A | 4543 | 0.03 | trans | ||
| rs7912228 | chr10 | 12658396 | MTNR1A | 4543 | 0.03 | trans | ||
| snp_a-1910005 | 0 | MTNR1A | 4543 | 0.05 | trans | |||
| rs17115171 | chr10 | 104624671 | MTNR1A | 4543 | 0.01 | trans | ||
| rs7342081 | chr10 | 109850869 | MTNR1A | 4543 | 0.08 | trans | ||
| rs393130 | chr11 | 8268948 | MTNR1A | 4543 | 0.17 | trans | ||
| rs2448265 | chr11 | 80086922 | MTNR1A | 4543 | 1.887E-4 | trans | ||
| rs2512904 | chr11 | 129835746 | MTNR1A | 4543 | 0.07 | trans | ||
| rs1356198 | chr12 | 73637834 | MTNR1A | 4543 | 0.18 | trans | ||
| rs11106191 | chr12 | 78060911 | MTNR1A | 4543 | 0.01 | trans | ||
| rs11107996 | chr12 | 95737141 | MTNR1A | 4543 | 0.14 | trans | ||
| rs12424084 | chr12 | 100917854 | MTNR1A | 4543 | 0.03 | trans | ||
| rs12716680 | chr13 | 42196469 | MTNR1A | 4543 | 0.15 | trans | ||
| rs7996604 | chr13 | 42224412 | MTNR1A | 4543 | 0.03 | trans | ||
| rs17112934 | chr14 | 28106608 | MTNR1A | 4543 | 0.11 | trans | ||
| rs6574032 | chr14 | 72335217 | MTNR1A | 4543 | 0.06 | trans | ||
| rs17104720 | chr14 | 77127308 | MTNR1A | 4543 | 5.9E-8 | trans | ||
| rs6574467 | chr14 | 79179744 | MTNR1A | 4543 | 0 | trans | ||
| rs10146003 | chr14 | 79191170 | MTNR1A | 4543 | 0 | trans | ||
| rs17122939 | chr14 | 87521795 | MTNR1A | 4543 | 0.04 | trans | ||
| rs16955618 | chr15 | 29937543 | MTNR1A | 4543 | 1.942E-5 | trans | ||
| rs8024924 | chr15 | 33921330 | MTNR1A | 4543 | 0.14 | trans | ||
| rs12050602 | chr15 | 52596555 | MTNR1A | 4543 | 0.17 | trans | ||
| rs2414599 | chr15 | 58851618 | MTNR1A | 4543 | 0.01 | trans | ||
| snp_a-1830894 | 0 | MTNR1A | 4543 | 3.167E-13 | trans | |||
| rs16945344 | chr15 | 62884132 | MTNR1A | 4543 | 0.12 | trans | ||
| snp_a-2175755 | 0 | MTNR1A | 4543 | 0.03 | trans | |||
| rs16949722 | chr15 | 95615191 | MTNR1A | 4543 | 0.07 | trans | ||
| rs13330413 | chr16 | 12767047 | MTNR1A | 4543 | 0.03 | trans | ||
| rs1437198 | chr16 | 66366553 | MTNR1A | 4543 | 0 | trans | ||
| rs6499075 | chr16 | 66387395 | MTNR1A | 4543 | 9.094E-4 | trans | ||
| rs7192631 | chr16 | 85396819 | MTNR1A | 4543 | 0.05 | trans | ||
| rs11079771 | chr17 | 45372664 | MTNR1A | 4543 | 0.2 | trans | ||
| rs7219624 | chr17 | 59460163 | MTNR1A | 4543 | 0.08 | trans | ||
| rs17823633 | chr17 | 68851458 | MTNR1A | 4543 | 0.02 | trans | ||
| rs16952078 | chr18 | 7531387 | MTNR1A | 4543 | 0.06 | trans | ||
| rs7231520 | chr18 | 35136345 | MTNR1A | 4543 | 0.05 | trans | ||
| rs4799960 | chr18 | 35252611 | MTNR1A | 4543 | 0.05 | trans | ||
| rs3786464 | chr18 | 55138931 | MTNR1A | 4543 | 0 | trans | ||
| rs17070739 | chr18 | 60819382 | MTNR1A | 4543 | 0.09 | trans | ||
| rs17085767 | chr18 | 69839397 | MTNR1A | 4543 | 1.74E-10 | trans | ||
| rs17058466 | chr18 | 73605344 | MTNR1A | 4543 | 0.01 | trans | ||
| rs7247284 | chr19 | 12921185 | MTNR1A | 4543 | 0.02 | trans | ||
| rs16997215 | chr20 | 16101890 | MTNR1A | 4543 | 0 | trans | ||
| rs6099530 | chr20 | 55863422 | MTNR1A | 4543 | 0.01 | trans | ||
| rs6070048 | chr20 | 55868733 | MTNR1A | 4543 | 0.1 | trans | ||
| rs6092455 | chr20 | 55881917 | MTNR1A | 4543 | 0.04 | trans | ||
| rs1002324 | chr20 | 55893550 | MTNR1A | 4543 | 0.04 | trans | ||
| rs6070068 | chr20 | 55919276 | MTNR1A | 4543 | 0.1 | trans | ||
| rs6099582 | chr20 | 55940425 | MTNR1A | 4543 | 0.04 | trans | ||
| rs7362421 | chr20 | 55951039 | MTNR1A | 4543 | 0.04 | trans | ||
| rs2826625 | chr21 | 22341050 | MTNR1A | 4543 | 0.07 | trans | ||
| rs2826648 | chr21 | 22362498 | MTNR1A | 4543 | 0.07 | trans | ||
| rs9980476 | chr21 | 22365306 | MTNR1A | 4543 | 0.07 | trans | ||
| rs2831347 | chr21 | 29387731 | MTNR1A | 4543 | 0.07 | trans | ||
| rs915529 | chr21 | 33726325 | MTNR1A | 4543 | 0.05 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004872 | receptor activity | IEA | - | |
| GO:0008502 | melatonin receptor activity | TAS | 9645677 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007187 | G-protein signaling, coupled to cyclic nucleotide second messenger | TAS | 9645677 | |
| GO:0007165 | signal transduction | IEA | - | |
| GO:0007623 | circadian rhythm | TAS | 9645677 | |
| GO:0007617 | mating behavior | TAS | 7946354 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005886 | plasma membrane | IEA | - | |
| GO:0005887 | integral to plasma membrane | TAS | 8700109 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION | 272 | 195 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY GPCR | 920 | 449 | All SZGR 2.0 genes in this pathway |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | 305 | 177 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR DOWNSTREAM SIGNALING | 805 | 368 | All SZGR 2.0 genes in this pathway |
| REACTOME G ALPHA I SIGNALLING EVENTS | 195 | 114 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR LIGAND BINDING | 408 | 246 | All SZGR 2.0 genes in this pathway |
| ODONNELL TFRC TARGETS UP | 456 | 228 | All SZGR 2.0 genes in this pathway |
| AFFAR YY1 TARGETS DN | 234 | 137 | All SZGR 2.0 genes in this pathway |
| LEE AGING NEOCORTEX DN | 80 | 49 | All SZGR 2.0 genes in this pathway |
| ACEVEDO METHYLATED IN LIVER CANCER DN | 940 | 425 | All SZGR 2.0 genes in this pathway |
| LABBE TGFB1 TARGETS UP | 102 | 64 | All SZGR 2.0 genes in this pathway |
| WEST ADRENOCORTICAL TUMOR DN | 546 | 362 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3 UNMETHYLATED | 228 | 119 | All SZGR 2.0 genes in this pathway |
| SERVITJA LIVER HNF1A TARGETS UP | 135 | 96 | All SZGR 2.0 genes in this pathway |