Gene Page: NOTCH2

Summary
GeneID  4853
Symbol  NOTCH2
Synonyms  AGS2|hN2
Description  Notch homolog 2 (Drosophila)
See related  HGNC:7882|MIM:600275|Ensembl:ENSG00000134250|HPRD:02606|
Locus tag  -
Gene type  protein-coding
Map location  1p13-p11
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
ExpressionExpressionP value: 1.399 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MFSD40.920.78
CREG20.910.69
CAMKK10.900.89
MAST30.900.82
SV2B0.900.81
IQSEC10.890.84
SYN10.890.84
KIAA12170.880.91
IQSEC20.880.89
PI4KA0.880.81
Top 10 negatively co-expressed genes
BCL7C-0.47-0.53
GTF3C6-0.44-0.36
C9orf46-0.44-0.39
C21orf57-0.44-0.44
FAM36A-0.43-0.29
HEBP2-0.41-0.50
EXOSC8-0.40-0.25
AC006276.2-0.40-0.32
RPL23A-0.39-0.38
FADS2-0.39-0.25
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityNAS9244302 
GO:0003706ligand-regulated transcription factor activityTAS9244302 
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingNAS12531696 
GO:0046982protein heterodimerization activityNAS9244302 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentNASneurite (GO term level: 5)12760378 
GO:0001709cell fate determinationTAS9244302 
GO:0006355regulation of transcription, DNA-dependentTAS9244302 
GO:0006350transcriptionIEA-
GO:0016049cell growthIDA11306509 
GO:0007219Notch signaling pathwayIEA-
GO:0006917induction of apoptosisTAS12531696 
GO:0009887organ morphogenesisIEP12531696 
GO:0007050cell cycle arrestIDA11306509 
GO:0019827stem cell maintenanceTAS11306509 
GO:0008285negative regulation of cell proliferationIDA11306509 
GO:0006916anti-apoptosisTAS12531696 
GO:0007275multicellular organismal developmentNAS9244302 
GO:0030154cell differentiationIEA-
GO:0050793regulation of developmental processIEA-
GO:0030097hemopoiesisTAS1303260 
GO:0046579positive regulation of Ras protein signal transductionIDA11306509 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA1303260 
GO:0009986cell surfaceIDA9244302 
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneIDA9244302 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CNTN1F3 | GP135contactin 1-HPRD,BioGRID14567914 
DLL1DELTA1 | DL1 | Deltadelta-like 1 (Drosophila)-HPRD,BioGRID10958687 
DTX1hDx-1deltex homolog 1 (Drosophila)-HPRD9244302 
GSK3B-glycogen synthase kinase 3 beta-HPRD,BioGRID12794074 
JAG1AGS | AHD | AWS | CD339 | HJ1 | JAGL1 | MGC104644jagged 1 (Alagille syndrome)-HPRD,BioGRID10551863 |10958687 
JAG2HJ2 | SER2jagged 2-HPRD,BioGRID10958687 
LFNGSCDO3LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase-HPRD11346656 
MAML1KIAA0200 | Mam-1 | Mam1mastermind-like 1 (Drosophila)-HPRD,BioGRID11101851 
MFNG-MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase-HPRD11346656 
RBPJCBF1 | IGKJRB | IGKJRB1 | KBF2 | MGC61669 | RBP-J | RBPJK | RBPSUH | SUH | cslrecombination signal binding protein for immunoglobulin kappa J region-HPRD,BioGRID9032325 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_DORSO_VENTRAL_AXIS_FORMATION 2521All SZGR genes in this pathway
KEGG_NOTCH_SIGNALING_PATHWAY 4735All SZGR genes in this pathway
PID_NOTCH_PATHWAY 5949All SZGR genes in this pathway
REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION 2917All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH2 1210All SZGR genes in this pathway
REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING 4424All SZGR genes in this pathway
REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI 1610All SZGR genes in this pathway
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 352181All SZGR genes in this pathway
REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY 138All SZGR genes in this pathway
REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR 128All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH 10364All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
RHEIN_ALL_GLUCOCORTICOID_THERAPY_UP 7841All SZGR genes in this pathway
PROVENZANI_METASTASIS_DN 13694All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_DN 200112All SZGR genes in this pathway
SHEPARD_BMYB_TARGETS 7441All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_DN 185111All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C1 1915All SZGR genes in this pathway
VERRECCHIA_EARLY_RESPONSE_TO_TGFB1 5843All SZGR genes in this pathway
VERRECCHIA_DELAYED_RESPONSE_TO_TGFB1 3926All SZGR genes in this pathway
MOREIRA_RESPONSE_TO_TSA_DN 1816All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C4 1310All SZGR genes in this pathway
LEIN_CHOROID_PLEXUS_MARKERS 10361All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_DN 249165All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
BREDEMEYER_RAG_SIGNALING_NOT_VIA_ATM_UP 6229All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN 315201All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_DN 235144All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
BRUNEAU_HEART_GREAT_VESSELS_AND_VALVULOGENESIS 88All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_UP 10575All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
FUKUSHIMA_TNFSF11_TARGETS 1614All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
DUAN_PRDM5_TARGETS 7952All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_UP 163111All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-23241524221A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-34/44924662472m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-409-5p310031061Ahsa-miR-409-5pAGGUUACCCGAGCAACUUUGCA
miR-485-3p30853091m8hsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU
miR-929072913m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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