Gene Page: CLDN11

Summary ?
GeneID5010
SymbolCLDN11
SynonymsOSP|OTM
Descriptionclaudin 11
ReferenceMIM:601326|HGNC:HGNC:8514|HPRD:03207|
Gene typeprotein-coding
Map location3q26.2-q26.3
Pascal p-value0.017
Sherlock p-value0.418
eGeneMyers' cis & trans
SupportG2Cdb.humanPSD

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWAScatGenome-wide Association StudiesThis data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs651185chr1233871029CLDN1150100.12trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GART0.880.85
PABPCP50.880.89
ZNF5120.870.85
TMEM570.870.85
PRPSAP20.870.84
DHX570.870.86
XRN20.870.87
TRAFD10.870.84
CEP570.870.87
ARFGAP30.870.83
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HLA-F-0.71-0.77
C5orf53-0.70-0.74
AF347015.31-0.68-0.81
MT-CO2-0.68-0.83
AF347015.27-0.67-0.80
AF347015.33-0.67-0.81
AIFM3-0.67-0.69
FBXO2-0.66-0.65
CA4-0.66-0.72
MT-CYB-0.66-0.80

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005198structural molecule activityIEA-
GO:0042802identical protein bindingISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008366axon ensheathmentIEAneuron, axon (GO term level: 12)-
GO:0007155cell adhesionIEA-
GO:0007283spermatogenesisIEA-
GO:0016338calcium-independent cell-cell adhesionISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005923tight junctionISSBrain (GO term level: 10)-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CELL ADHESION MOLECULES CAMS 13493All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION 13486All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION 11878All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION 12077All SZGR 2.0 genes in this pathway
REACTOME CELL CELL JUNCTION ORGANIZATION 5631All SZGR 2.0 genes in this pathway
REACTOME TIGHT JUNCTION INTERACTIONS 2911All SZGR 2.0 genes in this pathway
REACTOME CELL JUNCTION ORGANIZATION 7843All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN 198110All SZGR 2.0 genes in this pathway
CORRE MULTIPLE MYELOMA UP 7445All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537339All SZGR 2.0 genes in this pathway
ZIRN TRETINOIN RESPONSE WT1 UP 2314All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637377All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP 236139All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER A 10063All SZGR 2.0 genes in this pathway
SUNG METASTASIS STROMA UP 11070All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS 212121All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR DN 191123All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY UP 250168All SZGR 2.0 genes in this pathway
MATZUK MALE REPRODUCTION SERTOLI 2823All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS DN 9753All SZGR 2.0 genes in this pathway
PIONTEK PKD1 TARGETS DN 1812All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS GROWING 243155All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567365All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN 414237All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
WANG THOC1 TARGETS DN 2014All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364236All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.11791861A,m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5061791851Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-2059819881A,m8hsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-25/32/92/363/367131413211A,m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC