Gene Page: PFKFB2

Summary
GeneID  5208
Symbol  PFKFB2
Synonyms  DKFZp781D2217|MGC138308|MGC138310|PFK-2/FBPase-2
Description  6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
See related  HGNC:8873|MIM:171835|Ensembl:ENSG00000123836|HPRD:01383|
Locus tag  -
Gene type  protein-coding
Map location  1q31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0296 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:00038736-phosphofructo-2-kinase activityEXP9464277 
GO:00038736-phosphofructo-2-kinase activityTAS9652401 
GO:0005524ATP bindingIEA-
GO:0004331fructose-2,6-bisphosphate 2-phosphatase activityIEA-
GO:0016787hydrolase activityIEA-
GO:0016740transferase activityIEA-
GO:0016301kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006003fructose 2,6-bisphosphate metabolic processIEA-
GO:0008152metabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP9464277 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GCKGK | GLK | HHF3 | HK4 | HKIV | HXKP | MODY2glucokinase (hexokinase 4)-HPRD,BioGRID11522786 
YWHAQ14-3-3 | 1C5 | HS1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide-HPRD,BioGRID12853467 
YWHAZKCIP-1 | MGC111427 | MGC126532 | MGC138156tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide-HPRD12853467 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM 3423All SZGR genes in this pathway
REACTOME_GLYCOLYSIS 2918All SZGR genes in this pathway
REACTOME_METABOLISM_OF_CARBOHYDRATES 247154All SZGR genes in this pathway
REACTOME_GLUCOSE_METABOLISM 6942All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP 191128All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP 214133All SZGR genes in this pathway
CHEN_LVAD_SUPPORT_OF_FAILING_HEART_DN 4232All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_48HR_DN 161105All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 720440All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD2_DN 4629All SZGR genes in this pathway
MOOTHA_GLYCOLYSIS 2113All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_DN 10971All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-26541854241Ahsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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