Gene Page: AHI1
Summary ?
| GeneID | 54806 |
| Symbol | AHI1 |
| Synonyms | AHI-1|JBTS3|ORF1|dJ71N10.1 |
| Description | Abelson helper integration site 1 |
| Reference | MIM:608894|HGNC:HGNC:21575|Ensembl:ENSG00000135541|HPRD:10597|Vega:OTTHUMG00000015631 |
| Gene type | protein-coding |
| Map location | 6q23.3 |
| Pascal p-value | 0.055 |
| Sherlock p-value | 0.372 |
| Fetal beta | -0.912 |
| eGene | Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Hippocampus Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans |
| Support | Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Association | A combined odds ratio method (Sun et al. 2008), association studies | 2 | Link to SZGene |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10994209 | chr10 | 61877705 | AHI1 | 54806 | 0.1 | trans | ||
| rs72556118 | 6 | 135623751 | AHI1 | ENSG00000135541.16 | 2.718E-6 | 0 | 194636 | gtex_brain_putamen_basal |
| rs3833484 | 6 | 135623752 | AHI1 | ENSG00000135541.16 | 2.717E-6 | 0 | 194635 | gtex_brain_putamen_basal |
| rs6928977 | 6 | 135626348 | AHI1 | ENSG00000135541.16 | 3.766E-6 | 0 | 192039 | gtex_brain_putamen_basal |
| rs6935146 | 6 | 135627369 | AHI1 | ENSG00000135541.16 | 1.501E-6 | 0 | 191018 | gtex_brain_putamen_basal |
| rs6918097 | 6 | 135635549 | AHI1 | ENSG00000135541.16 | 2.313E-6 | 0 | 182838 | gtex_brain_putamen_basal |
| rs9321500 | 6 | 135641369 | AHI1 | ENSG00000135541.16 | 4.072E-6 | 0 | 177018 | gtex_brain_putamen_basal |
| rs9321501 | 6 | 135641417 | AHI1 | ENSG00000135541.16 | 3.35E-6 | 0 | 176970 | gtex_brain_putamen_basal |
| rs2064430 | 6 | 135642756 | AHI1 | ENSG00000135541.16 | 3.35E-6 | 0 | 175631 | gtex_brain_putamen_basal |
| rs2064431 | 6 | 135645203 | AHI1 | ENSG00000135541.16 | 3.357E-6 | 0 | 173184 | gtex_brain_putamen_basal |
| rs1012645 | 6 | 135645447 | AHI1 | ENSG00000135541.16 | 3.355E-6 | 0 | 172940 | gtex_brain_putamen_basal |
| rs2179779 | 6 | 135649816 | AHI1 | ENSG00000135541.16 | 2.74E-6 | 0 | 168571 | gtex_brain_putamen_basal |
| rs6570001 | 6 | 135651721 | AHI1 | ENSG00000135541.16 | 3.386E-7 | 0 | 166666 | gtex_brain_putamen_basal |
| rs2614279 | 6 | 135653357 | AHI1 | ENSG00000135541.16 | 2.82E-6 | 0 | 165030 | gtex_brain_putamen_basal |
| rs2614278 | 6 | 135653398 | AHI1 | ENSG00000135541.16 | 3.505E-6 | 0 | 164989 | gtex_brain_putamen_basal |
| rs9321502 | 6 | 135656252 | AHI1 | ENSG00000135541.16 | 1.321E-6 | 0 | 162135 | gtex_brain_putamen_basal |
| rs2746421 | 6 | 135661629 | AHI1 | ENSG00000135541.16 | 3.515E-6 | 0 | 156758 | gtex_brain_putamen_basal |
| rs2746425 | 6 | 135664365 | AHI1 | ENSG00000135541.16 | 3.517E-6 | 0 | 154022 | gtex_brain_putamen_basal |
| rs2746426 | 6 | 135666432 | AHI1 | ENSG00000135541.16 | 3.696E-6 | 0 | 151955 | gtex_brain_putamen_basal |
| rs2746427 | 6 | 135669097 | AHI1 | ENSG00000135541.16 | 3.522E-6 | 0 | 149290 | gtex_brain_putamen_basal |
| rs2746429 | 6 | 135673284 | AHI1 | ENSG00000135541.16 | 3.349E-6 | 0 | 145103 | gtex_brain_putamen_basal |
| rs2746430 | 6 | 135673292 | AHI1 | ENSG00000135541.16 | 3.876E-6 | 0 | 145095 | gtex_brain_putamen_basal |
| rs2614258 | 6 | 135677202 | AHI1 | ENSG00000135541.16 | 4.141E-7 | 0 | 141185 | gtex_brain_putamen_basal |
| rs2614259 | 6 | 135677252 | AHI1 | ENSG00000135541.16 | 3.352E-6 | 0 | 141135 | gtex_brain_putamen_basal |
| rs2614276 | 6 | 135681704 | AHI1 | ENSG00000135541.16 | 3.519E-7 | 0 | 136683 | gtex_brain_putamen_basal |
| rs7748148 | 6 | 135684623 | AHI1 | ENSG00000135541.16 | 1.193E-7 | 0 | 133764 | gtex_brain_putamen_basal |
| rs2746431 | 6 | 135687201 | AHI1 | ENSG00000135541.16 | 3.582E-6 | 0 | 131186 | gtex_brain_putamen_basal |
| rs2246852 | 6 | 135691792 | AHI1 | ENSG00000135541.16 | 3.252E-7 | 0 | 126595 | gtex_brain_putamen_basal |
| rs6908428 | 6 | 135793706 | AHI1 | ENSG00000135541.16 | 1.652E-6 | 0 | 24681 | gtex_brain_putamen_basal |
| rs12206850 | 6 | 135797808 | AHI1 | ENSG00000135541.16 | 4.159E-6 | 0 | 20579 | gtex_brain_putamen_basal |
| rs11154803 | 6 | 135798845 | AHI1 | ENSG00000135541.16 | 1.652E-6 | 0 | 19542 | gtex_brain_putamen_basal |
| rs4526212 | 6 | 135804631 | AHI1 | ENSG00000135541.16 | 1.652E-6 | 0 | 13756 | gtex_brain_putamen_basal |
| rs9402706 | 6 | 135806219 | AHI1 | ENSG00000135541.16 | 2.049E-6 | 0 | 12168 | gtex_brain_putamen_basal |
| rs7750586 | 6 | 135827673 | AHI1 | ENSG00000135541.16 | 1.801E-6 | 0 | -9286 | gtex_brain_putamen_basal |
| rs4896153 | 6 | 135833463 | AHI1 | ENSG00000135541.16 | 2.951E-6 | 0 | -15076 | gtex_brain_putamen_basal |
| rs58761508 | 6 | 135835901 | AHI1 | ENSG00000135541.16 | 1.804E-6 | 0 | -17514 | gtex_brain_putamen_basal |
| rs9385726 | 6 | 135836962 | AHI1 | ENSG00000135541.16 | 1.804E-6 | 0 | -18575 | gtex_brain_putamen_basal |
| rs9647635 | 6 | 135841056 | AHI1 | ENSG00000135541.16 | 1.804E-6 | 0 | -22669 | gtex_brain_putamen_basal |
| rs9399148 | 6 | 135844359 | AHI1 | ENSG00000135541.16 | 1.804E-6 | 0 | -25972 | gtex_brain_putamen_basal |
| rs200655578 | 6 | 135848172 | AHI1 | ENSG00000135541.16 | 1.971E-6 | 0 | -29785 | gtex_brain_putamen_basal |
| rs5880258 | 6 | 135848175 | AHI1 | ENSG00000135541.16 | 1.757E-6 | 0 | -29788 | gtex_brain_putamen_basal |
| rs5880259 | 6 | 135867300 | AHI1 | ENSG00000135541.16 | 2.077E-6 | 0 | -48913 | gtex_brain_putamen_basal |
| rs11154806 | 6 | 135873721 | AHI1 | ENSG00000135541.16 | 8.102E-7 | 0 | -55334 | gtex_brain_putamen_basal |
| rs67316642 | 6 | 135891670 | AHI1 | ENSG00000135541.16 | 1.528E-6 | 0 | -73283 | gtex_brain_putamen_basal |
| rs13208505 | 6 | 135893723 | AHI1 | ENSG00000135541.16 | 1.815E-6 | 0 | -75336 | gtex_brain_putamen_basal |
| rs761357 | 6 | 135902599 | AHI1 | ENSG00000135541.16 | 1.72E-6 | 0 | -84212 | gtex_brain_putamen_basal |
| rs4370385 | 6 | 135947310 | AHI1 | ENSG00000135541.16 | 2.647E-6 | 0 | -128923 | gtex_brain_putamen_basal |
| rs9494308 | 6 | 135948804 | AHI1 | ENSG00000135541.16 | 1.298E-6 | 0 | -130417 | gtex_brain_putamen_basal |
| rs12211833 | 6 | 135950204 | AHI1 | ENSG00000135541.16 | 3.677E-6 | 0 | -131817 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ONKEN UVEAL MELANOMA UP | 783 | 507 | All SZGR 2.0 genes in this pathway |
| CHANDRAN METASTASIS TOP50 DN | 45 | 26 | All SZGR 2.0 genes in this pathway |
| THUM SYSTOLIC HEART FAILURE DN | 244 | 147 | All SZGR 2.0 genes in this pathway |
| BARRIER COLON CANCER RECURRENCE UP | 42 | 28 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP | 276 | 165 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 MUTATED SIGNATURE 2 UP | 139 | 83 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 SIGNATURE 3 UP | 341 | 197 | All SZGR 2.0 genes in this pathway |
| GOZGIT ESR1 TARGETS DN | 781 | 465 | All SZGR 2.0 genes in this pathway |
| GAUSSMANN MLL AF4 FUSION TARGETS C DN | 19 | 11 | All SZGR 2.0 genes in this pathway |
| HAMAI APOPTOSIS VIA TRAIL UP | 584 | 356 | All SZGR 2.0 genes in this pathway |
| HATADA METHYLATED IN LUNG CANCER UP | 390 | 236 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS UP | 811 | 508 | All SZGR 2.0 genes in this pathway |
| RICKMAN METASTASIS UP | 344 | 180 | All SZGR 2.0 genes in this pathway |
| BENPORATH CYCLING GENES | 648 | 385 | All SZGR 2.0 genes in this pathway |
| GALE APL WITH FLT3 MUTATED UP | 56 | 35 | All SZGR 2.0 genes in this pathway |
| ACEVEDO METHYLATED IN LIVER CANCER DN | 940 | 425 | All SZGR 2.0 genes in this pathway |
| LIN NPAS4 TARGETS UP | 163 | 100 | All SZGR 2.0 genes in this pathway |
| AGUIRRE PANCREATIC CANCER COPY NUMBER DN | 238 | 145 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS DN | 442 | 275 | All SZGR 2.0 genes in this pathway |
| POOLA INVASIVE BREAST CANCER UP | 288 | 168 | All SZGR 2.0 genes in this pathway |
| CHANDRAN METASTASIS DN | 306 | 191 | All SZGR 2.0 genes in this pathway |
| WHITFIELD CELL CYCLE G2 M | 216 | 124 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY STEM CELL UP | 489 | 314 | All SZGR 2.0 genes in this pathway |