Gene Page: PPT1

Summary ?
GeneID5538
SymbolPPT1
SynonymsCLN1|INCL|PPT
Descriptionpalmitoyl-protein thioesterase 1
ReferenceMIM:600722|HGNC:HGNC:9325|Ensembl:ENSG00000131238|HPRD:07203|Vega:OTTHUMG00000004495
Gene typeprotein-coding
Map location1p32
Pascal p-value0.835
Sherlock p-value0.316
Fetal beta-1.213
DMG1 (# studies)
eGeneCaudate basal ganglia
Cerebellum
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 11 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg19736671140562678PPT14.55E-8-0.0071.24E-5DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NECAB20.800.78
CNTN60.790.65
ANXA30.780.53
CALB20.770.55
EGFL60.750.53
NEFL0.730.68
DOK70.710.59
OTX20.71-0.04
TP53I30.700.08
SLC17A60.690.43
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FOXG1B-0.27-0.36
SMTN-0.26-0.53
ISLR2-0.25-0.27
SIGIRR-0.25-0.43
ZEB2-0.25-0.32
LZTS1-0.24-0.27
TTC28-0.24-0.34
EMX1-0.24-0.22
MPPED1-0.24-0.24
NEUROD2-0.24-0.30

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0016787hydrolase activityIEA-
GO:0008474palmitoyl-(protein) hydrolase activityIDA10658183 |10737604 
GO:0008474palmitoyl-(protein) hydrolase activityIEA-
GO:0008474palmitoyl-(protein) hydrolase activityIMP7637805 
GO:0008474palmitoyl-(protein) hydrolase activityISS-
GO:0016290palmitoyl-CoA hydrolase activityIDA10658183 
GO:0016290palmitoyl-CoA hydrolase activityISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentIEPBrain (GO term level: 7)10992246 
GO:0007420brain developmentIMPBrain (GO term level: 7)7637805 
GO:0048666neuron developmentTASneuron (GO term level: 9)11136716 
GO:0007269neurotransmitter secretionIEAneuron, axon, Synap, serotonin, Neurotransmitter, dopamine (GO term level: 8)-
GO:0050803regulation of synapse structure and activityNASneuron, Synap (GO term level: 7)11136716 
GO:0043524negative regulation of neuron apoptosisIMPneuron (GO term level: 9)10737604 |11020216 
GO:0007399nervous system developmentIMPneurite (GO term level: 5)7637805 
GO:0002084protein depalmitoylationIDA10658183 |10737604 
GO:0002084protein depalmitoylationISS-
GO:0006309DNA fragmentation during apoptosisIDA15929065 
GO:0006464protein modification processIEA-
GO:0016042lipid catabolic processIDA8816748 
GO:0007042lysosomal lumen acidificationIMP11722572 
GO:0008306associative learningIEA-
GO:0008344adult locomotory behaviorIEA-
GO:0007625grooming behaviorIEA-
GO:0007601visual perceptionIEA-
GO:0015031protein transportIMP10737604 
GO:0050896response to stimulusIEA-
GO:0051181cofactor transportIMP16542649 
GO:0051186cofactor metabolic processIMP16542649 
GO:0048260positive regulation of receptor-mediated endocytosisIMP16542649 
GO:0031579membrane raft organizationIMP15929065 
GO:0030149sphingolipid catabolic processTAS16542649 
GO:0030308negative regulation of cell growthIMP10737604 
GO:0032429regulation of phospholipase A2 activityIEA-
GO:0044257cellular protein catabolic processIEA-
GO:0048549positive regulation of pinocytosisIMP16542649 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043025cell somaIEAaxon, dendrite (GO term level: 4)-
GO:0008021synaptic vesicleIDASynap, Neurotransmitter (GO term level: 12)12483688 
GO:0030425dendriteIEAneuron, axon, dendrite (GO term level: 6)-
GO:0030424axonIDAneuron, axon, Neurotransmitter (GO term level: 6)12483688 
GO:0005794Golgi apparatusIDA7637805 
GO:0005829cytosolISS-
GO:0005576extracellular regionIDA8895569 
GO:0005576extracellular regionISS-
GO:0005615extracellular spaceIEA-
GO:0005624membrane fractionISS-
GO:0005634nucleusIDA10992246 
GO:0005764lysosomeIDA8895569 |11020216 
GO:0005764lysosomeISS-
GO:0045121membrane raftIDA15929065 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG LYSOSOME 12183All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305185All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418263All SZGR 2.0 genes in this pathway
LUI THYROID CANCER PAX8 PPARG DN 4529All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414287All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517309All SZGR 2.0 genes in this pathway
WIELAND UP BY HBV INFECTION 10166All SZGR 2.0 genes in this pathway
CROMER METASTASIS UP 7946All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR UP 180125All SZGR 2.0 genes in this pathway
JIANG HYPOXIA CANCER 8352All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293203All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457302All SZGR 2.0 genes in this pathway
ZHAN LATE DIFFERENTIATION GENES UP 3324All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE UP 10575All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
WANG THOC1 TARGETS DN 2014All SZGR 2.0 genes in this pathway