Gene Page: VPS11

Summary
GeneID  55823
Symbol  VPS11
Synonyms  END1|PEP5|RNF108|hVPS11
Description  vacuolar protein sorting 11 homolog (S. cerevisiae)
See related  HGNC:14583|MIM:608549|Ensembl:ENSG00000160695|HPRD:12258|
Locus tag  -
Gene type  protein-coding
Map location  11q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.006 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RWDD2A0.830.79
UBE2E10.810.78
KLHDC20.790.77
EIF1B0.790.78
MRPS350.780.75
ACTR100.780.71
HACL10.780.75
ORC5L0.780.75
CIRH1A0.780.76
NUPL20.780.73
Top 10 negatively co-expressed genes
AF347015.18-0.62-0.66
AF347015.26-0.62-0.59
MT-CO2-0.61-0.53
AF347015.8-0.60-0.56
AF347015.2-0.60-0.54
MT-CYB-0.60-0.54
AF347015.15-0.57-0.53
AF347015.31-0.56-0.51
AF347015.21-0.56-0.49
AC098691.2-0.56-0.60
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI15231747 
GO:0005524ATP bindingIEA-
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0015031protein transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005765lysosomal membraneIEA-
GO:0005769early endosomeIEA-
GO:0016020membraneIEA-
GO:0005884actin filamentIEA-
GO:0031902late endosome membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BCAR1CAS | CAS1 | CASS1 | CRKAS | P130Casbreast cancer anti-estrogen resistance 1Two-hybridBioGRID16169070 
LSM1CASM | YJL124CLSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)Two-hybridBioGRID15231747 
MARK3CTAK1 | KP78 | PAR1AMAP/microtubule affinity-regulating kinase 3Two-hybridBioGRID16169070 
STX1AHPC-1 | STX1 | p35-1syntaxin 1A (brain)VPS11 interacts with STX1A (Syntaxin-1). This interaction was modeled on a demonstrated interaction between human VPS11 and STX1A (Syntaxin-1) from an unspecified species.BIND14623309 
STX6-syntaxin 6Vps11 interacts with Stx6 (Syntaxin-6). This interaction was modeled on a demonstrated interaction between human Vps11 and Stx6 (Syntaxin-6) from an unspecified species.BIND14623309 
STX7-syntaxin 7VPS11 interacts with STX7 (Syntaxin-7). This interaction was modeled on a demonstrated interaction between human VPS11 and STX7 (Syntaxin-7) from an unspecified species.BIND14623309 
-HPRD,BioGRID11382755 
STX8CARBsyntaxin 8VPS11 interacts with STX8 (Syntaxin-8). This interaction was modeled on a demonstrated interaction between human VPS11 and STX8 (Syntaxin-8) from an unspecified species.BIND14623309 
VPS16hVPS16vacuolar protein sorting 16 homolog (S. cerevisiae)-HPRD,BioGRID11382755 
VPS18KIAA1475 | PEP3vacuolar protein sorting 18 homolog (S. cerevisiae)-HPRD,BioGRID11382755 
VPS33AFLJ22395 | FLJ23187vacuolar protein sorting 33 homolog A (S. cerevisiae)-HPRD,BioGRID11382755 
VPS45H1 | H1VPS45 | VPS45A | VPS45B | VPS54A | VSP45 | VSP45Avacuolar protein sorting 45 homolog (S. cerevisiae)VPS11 interacts with VPS45A (VPS45). This interaction was modeled on a demonstrated interaction between human VPS11 and rat VPS45.BIND14623309 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
LEE_LIVER_CANCER_ACOX1_DN 6539All SZGR genes in this pathway
YAGI_AML_SURVIVAL 12987All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR 532309All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
MCCABE_BOUND_BY_HOXC6 469239All SZGR genes in this pathway
MCCABE_HOXC6_TARGETS_CANCER_UP 3123All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway


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