SZGR2

Summary ?

GeneID	5894
Symbol	RAF1
Synonyms	CMD1NN\|CRAF\|NS5\|Raf-1\|c-Raf
Description	Raf-1 proto-oncogene, serine/threonine kinase
Reference	MIM:164760\|HGNC:HGNC:9829\|Ensembl:ENSG00000132155\|HPRD:01265\|Vega:OTTHUMG00000129789
Gene type	protein-coding
Map location	3p25
Pascal p-value	0.01
Sherlock p-value	0.43
Fetal beta	1.215
DMG	2 (# studies)
eGene	Myers' cis & trans
Support	CANABINOID DOPAMINE METABOTROPIC GLUTAMATE RECEPTOR SEROTONIN G2Cdb.humanNRC G2Cdb.humanPSP Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	2
DMG:Nishioka_2013	Genome-wide DNA methylation analysis	The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls.	2
GSMA_I	Genome scan meta-analysis	Psr: 0.006
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.1134

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg09326546	3	12705291	RAF1		-0.025	0.25	DMG:Nishioka_2013
cg09326546	3	12705291	RAF1	9.24E-9	-0.008	4.15E-6	DMG:Jaffe_2016

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs16829545	chr2	151977407	RAF1	5894	2.8E-5	trans
rs7787830	chr7	98797019	RAF1	5894	0.05	trans
rs16955618	chr15	29937543	RAF1	5894	4.884E-5	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
RAD50	0.95	0.95
BCLAF1	0.94	0.95
PRPF4B	0.93	0.95
DDX46	0.93	0.95
NARG1	0.93	0.95
ATRX	0.93	0.96
ZMYM2	0.93	0.93
FBXO11	0.93	0.94
ZNF33A	0.93	0.94
RBM26	0.93	0.95

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
FXYD1	-0.73	-0.85
AF347015.31	-0.73	-0.85
TSC22D4	-0.73	-0.82
MT-CO2	-0.72	-0.85
IFI27	-0.72	-0.85
AF347015.27	-0.71	-0.82
AIFM3	-0.71	-0.77
ENHO	-0.70	-0.87
AF347015.33	-0.70	-0.81
HIGD1B	-0.70	-0.85

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0005057	receptor signaling protein activity	IEA		-
GO:0005515	protein binding	IPI		9624170 \|10433554
GO:0005524	ATP binding	IEA		-
GO:0004674	protein serine/threonine kinase activity	IEA		-
GO:0016740	transferase activity	IEA		-
GO:0008270	zinc ion binding	IEA		-
GO:0019992	diacylglycerol binding	IEA		-
GO:0046872	metal ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006468	protein amino acid phosphorylation	TAS		8063729
GO:0007265	Ras protein signal transduction	EXP		11520933
GO:0007010	cytoskeleton organization	IEA		-
GO:0008283	cell proliferation	TAS		8063729
GO:0048011	nerve growth factor receptor signaling pathway	IEA		-
GO:0006915	apoptosis	TAS		8929532
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		9069260
GO:0005741	mitochondrial outer membrane	TAS		8929532
GO:0005886	plasma membrane	EXP		9069260

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1	-	HPRD,BioGRID	10576742
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	-	HPRD,BioGRID	8349631
BAG1	RAP46	BCL2-associated athanogene	-	HPRD,BioGRID	8692945
BCL2	Bcl-2	B-cell CLL/lymphoma 2	-	HPRD,BioGRID	8910675 \|8929532
BCL2L1	BCL-XL/S \| BCL2L \| BCLX \| Bcl-X \| DKFZp781P2092 \| bcl-xL \| bcl-xS	BCL2-like 1	Reconstituted Complex	BioGRID	8929532
BRAF	B-RAF1 \| BRAF1 \| FLJ95109 \| MGC126806 \| MGC138284 \| RAFB1	v-raf murine sarcoma viral oncogene homolog B1	B-RAF interacts with C-RAF. This interaction was modelled on a demonstrated interaction between human B-RAF and monkey C-RAF .	BIND	15035987
BRAF	B-RAF1 \| BRAF1 \| FLJ95109 \| MGC126806 \| MGC138284 \| RAFB1	v-raf murine sarcoma viral oncogene homolog B1	-	HPRD,BioGRID	11325826
CCT3	CCT-gamma \| CCTG \| PIG48 \| TCP-1-gamma \| TRIC5	chaperonin containing TCP1, subunit 3 (gamma)	RAF1 (C-Raf) interacts with CCT3 (hC87).	BIND	12620389
CCT3	CCT-gamma \| CCTG \| PIG48 \| TCP-1-gamma \| TRIC5	chaperonin containing TCP1, subunit 3 (gamma)	C-RAF interacts with CCT3.	BIND	12620389
CCT3	CCT-gamma \| CCTG \| PIG48 \| TCP-1-gamma \| TRIC5	chaperonin containing TCP1, subunit 3 (gamma)	Two-hybrid	BioGRID	12620389
CDC25A	CDC25A2	cell division cycle 25 homolog A (S. pombe)	-	HPRD,BioGRID	9230211 \|10373531
CFLAR	CASH \| CASP8AP1 \| CLARP \| Casper \| FLAME \| FLAME-1 \| FLAME1 \| FLIP \| I-FLICE \| MRIT \| c-FLIP \| c-FLIPL \| c-FLIPR \| c-FLIPS	CASP8 and FADD-like apoptosis regulator	-	HPRD,BioGRID	10837247
CNKSR1	CNK \| CNK1 \| KSR	connector enhancer of kinase suppressor of Ras 1	-	HPRD,BioGRID	15075335
CNKSR2	CNK2 \| KIAA0902 \| KSR2	connector enhancer of kinase suppressor of Ras 2	Affinity Capture-Western	BioGRID	14597674
COPS3	SGN3	COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)	RAF1 (C-Raf) interacts with COPS3 (SGN3).	BIND	12620389
COPS3	SGN3	COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)	C-RAF interacts with SGN3.	BIND	12620389
CPS1	-	carbamoyl-phosphate synthetase 1, mitochondrial	RAF1 (C-Raf) interacts with CPS1.	BIND	12620389
CPS1	-	carbamoyl-phosphate synthetase 1, mitochondrial	C-RAF interacts with CPS1.	BIND	12620389
DMPK	DM \| DM1 \| DM1PK \| DMK \| MDPK \| MT-PK	dystrophia myotonica-protein kinase	-	HPRD	10869570
EFEMP1	DHRD \| DRAD \| FBLN3 \| FBNL \| FLJ35535 \| MGC111353 \| MLVT \| MTLV \| S1-5	EGF-containing fibulin-like extracellular matrix protein 1	RAF1 (C-Raf) interacts with an unspecified isoform of EFEMP1 (FBNL).	BIND	12620389
ERAS	HRAS2 \| HRASP \| MGC126691 \| MGC126693	ES cell expressed Ras	Affinity Capture-Western	BioGRID	12774123
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	-	HPRD,BioGRID	7517401
GNB2	-	guanine nucleotide binding protein (G protein), beta polypeptide 2	Affinity Capture-Western	BioGRID	7782277
GNG4	DKFZp547K1018 \| FLJ23803 \| FLJ34187	guanine nucleotide binding protein (G protein), gamma 4	-	HPRD,BioGRID	7782277
GRB10	GRB-IR \| Grb-10 \| IRBP \| KIAA0207 \| MEG1 \| RSS	growth factor receptor-bound protein 10	-	HPRD,BioGRID	9553107 \|10585452
HRAS	C-BAS/HAS \| C-H-RAS \| C-HA-RAS1 \| CTLO \| H-RASIDX \| HAMSV \| HRAS1 \| K-RAS \| N-RAS \| RASH1	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	-	HPRD	8530446 \|8911690
HRAS	C-BAS/HAS \| C-H-RAS \| C-HA-RAS1 \| CTLO \| H-RASIDX \| HAMSV \| HRAS1 \| K-RAS \| N-RAS \| RASH1	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	Hras interacts with Raf. This interaction was modelled on a demonstrated interaction between Hras and Raf, both from an unspecified species.	BIND	15705808
HRAS	C-BAS/HAS \| C-H-RAS \| C-HA-RAS1 \| CTLO \| H-RASIDX \| HAMSV \| HRAS1 \| K-RAS \| N-RAS \| RASH1	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	Raf interacts with Ras. This interaction was modeled on a demonstrated interaction between human Raf and rat Ras.	BIND	11585923
HRAS	C-BAS/HAS \| C-H-RAS \| C-HA-RAS1 \| CTLO \| H-RASIDX \| HAMSV \| HRAS1 \| K-RAS \| N-RAS \| RASH1	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	RAF1 (C-Raf) interacts with HRAS (Ha-Ras).	BIND	12620389
HRAS	C-BAS/HAS \| C-H-RAS \| C-HA-RAS1 \| CTLO \| H-RASIDX \| HAMSV \| HRAS1 \| K-RAS \| N-RAS \| RASH1	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	Raf-1 interacts with Ras.	BIND	15664191
HRAS	C-BAS/HAS \| C-H-RAS \| C-HA-RAS1 \| CTLO \| H-RASIDX \| HAMSV \| HRAS1 \| K-RAS \| N-RAS \| RASH1	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	C-RAF interacts with Ha-Ras.	BIND	12620389
HRAS	C-BAS/HAS \| C-H-RAS \| C-HA-RAS1 \| CTLO \| H-RASIDX \| HAMSV \| HRAS1 \| K-RAS \| N-RAS \| RASH1	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	Raf interacts with Ras. This interaction was modeled on a demonstrated interaction between Raf and an unspecified source and human Ras.	BIND	7523381 \|8307946
HRAS	C-BAS/HAS \| C-H-RAS \| C-HA-RAS1 \| CTLO \| H-RASIDX \| HAMSV \| HRAS1 \| K-RAS \| N-RAS \| RASH1	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	7862125 \|7969158 \|8530446 \|8628317 \|9150145 \|9154803 \|9523700 \|10369681 \|10783161 \|10882715 \|10922060 \|12379659 \|12620389 \|14654780 \|14724584 \|15031288 \|16803888
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	Raf-1 interacts with Hsp90. This interaction was modeled on a demonstrated interaction between human Raf-1 and monkey Hsp90.	BIND	15618521
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	-	HPRD,BioGRID	8408024
INSR	CD220 \| HHF5	insulin receptor	-	HPRD	11409918
JAK1	JAK1A \| JAK1B \| JTK3	Janus kinase 1 (a protein tyrosine kinase)	-	HPRD,BioGRID	9446616
JAK2	JTK10	Janus kinase 2 (a protein tyrosine kinase)	-	HPRD,BioGRID	8876196
KRAS	C-K-RAS \| K-RAS2A \| K-RAS2B \| K-RAS4A \| K-RAS4B \| KI-RAS \| KRAS1 \| KRAS2 \| NS3 \| RASK2	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	Affinity Capture-Western Two-hybrid	BioGRID	10783161 \|10882715
KSR2	FLJ25965	kinase suppressor of ras 2	-	HPRD	12975377
LCK	YT16 \| p56lck \| pp58lck	lymphocyte-specific protein tyrosine kinase	-	HPRD,BioGRID	8939988
LRPAP1	A2MRAP \| A2RAP \| HBP44 \| MGC138272 \| MRAP \| RAP	low density lipoprotein receptor-related protein associated protein 1	Two-hybrid	BioGRID	10783161
MAP2K1	MAPKK1 \| MEK1 \| MKK1 \| PRKMK1	mitogen-activated protein kinase kinase 1	Reconstituted Complex	BioGRID	10757792
MAP2K1	MAPKK1 \| MEK1 \| MKK1 \| PRKMK1	mitogen-activated protein kinase kinase 1	Raf interacts with and phosphorylates Mek1	BIND	14724641
MAP2K1	MAPKK1 \| MEK1 \| MKK1 \| PRKMK1	mitogen-activated protein kinase kinase 1	MEK1 interacts with and is phosphorylated by Raf-1. This interaction was modeled on a demonstrated interaction between human MEK1 and Raf-1 from an unspecified species.	BIND	15866172
MAP2K1	MAPKK1 \| MEK1 \| MKK1 \| PRKMK1	mitogen-activated protein kinase kinase 1	MEK1 interacts with c-Raf	BIND	8621729
MAP2K1	MAPKK1 \| MEK1 \| MKK1 \| PRKMK1	mitogen-activated protein kinase kinase 1	-	HPRD	11604401
MAP2K2	FLJ26075 \| MAPKK2 \| MEK2 \| MKK2 \| PRKMK2	mitogen-activated protein kinase kinase 2	Raf interacts with Mek2.	BIND	14724641
MAP3K1	MAPKKK1 \| MEKK \| MEKK1	mitogen-activated protein kinase kinase kinase 1	MEKK1 interacts with Raf-1.	BIND	10969079
MAP3K1	MAPKKK1 \| MEKK \| MEKK1	mitogen-activated protein kinase kinase kinase 1	Affinity Capture-Western Reconstituted Complex	BioGRID	10969079
MAP3K5	ASK1 \| MAPKKK5 \| MEKK5	mitogen-activated protein kinase kinase kinase 5	-	HPRD,BioGRID	11427728
MAPK1	ERK \| ERK2 \| ERT1 \| MAPK2 \| P42MAPK \| PRKM1 \| PRKM2 \| p38 \| p40 \| p41 \| p41mapk	mitogen-activated protein kinase 1	Affinity Capture-Western	BioGRID	11409918
MAPK1	ERK \| ERK2 \| ERT1 \| MAPK2 \| P42MAPK \| PRKM1 \| PRKM2 \| p38 \| p40 \| p41 \| p41mapk	mitogen-activated protein kinase 1	Raf-1 interacts with ERK2. This interaction was modelled on a demonstrated interaction between human Raf-1 and ERK2 from an unspecified species.	BIND	15664191
MAPK3	ERK1 \| HS44KDAP \| HUMKER1A \| MGC20180 \| P44ERK1 \| P44MAPK \| PRKM3	mitogen-activated protein kinase 3	Affinity Capture-Western	BioGRID	11409918
MAPK7	BMK1 \| ERK4 \| ERK5 \| PRKM7	mitogen-activated protein kinase 7	-	HPRD,BioGRID	10531364
MAPK8IP3	DKFZp762N1113 \| FLJ00027 \| JIP3 \| JSAP1 \| KIAA1066 \| SYD2	mitogen-activated protein kinase 8 interacting protein 3	-	HPRD,BioGRID	10523642 \|11044439
MAPK8IP3	DKFZp762N1113 \| FLJ00027 \| JIP3 \| JSAP1 \| KIAA1066 \| SYD2	mitogen-activated protein kinase 8 interacting protein 3	-	HPRD	11044439
MRAS	FLJ42964 \| M-RAs \| R-RAS3 \| RRAS3	muscle RAS oncogene homolog	-	HPRD,BioGRID	10498616
MYC	bHLHe39 \| c-Myc	v-myc myelocytomatosis viral oncogene homolog (avian)	-	HPRD,BioGRID	9315742
NR3C1	GCCR \| GCR \| GR \| GRL	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	-	HPRD,BioGRID	11005817
NRAS	ALPS4 \| N-ras \| NRAS1	neuroblastoma RAS viral (v-ras) oncogene homolog	Nras interacts with Raf. This interaction was modelled on a demonstrated interaction between Nras and Raf, both from an unspecified species.	BIND	15705808
NRAS	ALPS4 \| N-ras \| NRAS1	neuroblastoma RAS viral (v-ras) oncogene homolog	Affinity Capture-Western	BioGRID	10882715
NUDT14	UGPP \| UGPPase	nudix (nucleoside diphosphate linked moiety X)-type motif 14	RAF1 (C-Raf) interacts with NUDT14 (hA21).	BIND	12620389
OIP5	5730547N13Rik \| LINT-25 \| MIS18beta	Opa interacting protein 5	Two-hybrid	BioGRID	12620389
OIP5	5730547N13Rik \| LINT-25 \| MIS18beta	Opa interacting protein 5	C-RAF interacts with OIP5.	BIND	12620389
OIP5	5730547N13Rik \| LINT-25 \| MIS18beta	Opa interacting protein 5	RAF1 (C-Raf) interacts with OIP5 (hC73).	BIND	12620389
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	-	HPRD,BioGRID	11733498
PBK	FLJ14385 \| Nori-3 \| SPK \| TOPK	PDZ binding kinase	RAF1 (C-Raf) interacts with PBK (TOPK).	BIND	12620389
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	-	HPRD,BioGRID	2475255
PEBP1	HCNP \| PBP \| PEBP \| RKIP	phosphatidylethanolamine binding protein 1	-	HPRD	11853019
PEBP1	HCNP \| PBP \| PEBP \| RKIP	phosphatidylethanolamine binding protein 1	RKIP interacts with Raf-1. This interaction was modelled on a demonstrated interaction between RKIP from an unspecified species and Raf-1 from an unspecified species.	BIND	14654844
PEBP1	HCNP \| PBP \| PEBP \| RKIP	phosphatidylethanolamine binding protein 1	Affinity Capture-Western Reconstituted Complex	BioGRID	10757792
PEBP4	CORK-1 \| CORK1 \| GWTM1933 \| MGC22776 \| PRO4408	phosphatidylethanolamine-binding protein 4	Affinity Capture-Western Reconstituted Complex	BioGRID	15302887
PEBP4	CORK-1 \| CORK1 \| GWTM1933 \| MGC22776 \| PRO4408	phosphatidylethanolamine-binding protein 4	hPEBP4 interacts with Raf-1. This interaction was modeled on a demonstrated interaction between human hPEBP4 and mouse Raf-1.	BIND	15302887
PEX5L	PEX5R \| PXR2 \| PXR2B	peroxisomal biogenesis factor 5-like	-	HPRD	15302887
PHB	PHB1	prohibitin	-	HPRD,BioGRID	10523633
PHB	PHB1	prohibitin	RAF1 (c-Raf) interacts with PHB.	BIND	16041367
PHKA2	GSD9A \| MGC133071 \| PHK \| PYK \| PYKL \| XLG \| XLG2	phosphorylase kinase, alpha 2 (liver)	Two-hybrid	BioGRID	12620389
PIN1	DOD \| UBL5	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Raf-1 interacts with Pin1. This interaction was modelled on a demonstrated interaction between human Raf-1 and Pin1 from monkey and unspecified species.	BIND	15664191
PKM2	CTHBP \| MGC3932 \| OIP3 \| PK3 \| PKM \| TCB \| THBP1	pyruvate kinase, muscle	-	HPRD	12620389
PKM2	CTHBP \| MGC3932 \| OIP3 \| PK3 \| PKM \| TCB \| THBP1	pyruvate kinase, muscle	C-RAF interacts with PyK.	BIND	12620389
PKM2	CTHBP \| MGC3932 \| OIP3 \| PK3 \| PKM \| TCB \| THBP1	pyruvate kinase, muscle	RAF1 (C-Raf) interacts with PKM2 (PyK).	BIND	12620389
PPP2R2A	B55-ALPHA \| B55A \| FLJ26613 \| MGC52248 \| PR52A \| PR55A	protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform	RAF1 (c-Raf) interact with an unspecified isoform of PPP2R2A (PP2A-A).	BIND	16041367
PPP2R2B	B55-BETA \| FLJ95686 \| MGC24888 \| PP2A-B55BETA \| PP2A-PR55B \| PP2AB-BETA \| PP2APR55-BETA \| PR2AB-BETA \| PR2AB55-BETA \| PR2APR55-BETA \| PR52B \| PR55-BETA \| SCA12	protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform	RAF1 (c-Raf) interacts with an unspecified isoform of PPP2R2B (PP2A-B).	BIND	16041367
PPP2R2C	B55-GAMMA \| IMYPNO \| IMYPNO1 \| MGC33570 \| PR52 \| PR55G	protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform	RAF1 (c-Raf) interacts with an unspecified isoform of PPP2R2C (PP2A-C).	BIND	16041367
PRKCE	MGC125656 \| MGC125657 \| PKCE \| nPKC-epsilon	protein kinase C, epsilon	-	HPRD,BioGRID	11350735
PRKCZ	PKC-ZETA \| PKC2	protein kinase C, zeta	-	HPRD,BioGRID	10620507
PRKG1	CGKI \| DKFZp686K042 \| FLJ36117 \| MGC71944 \| PGK \| PKG \| PRKG1B \| PRKGR1B \| cGKI-BETA \| cGKI-alpha	protein kinase, cGMP-dependent, type I	Affinity Capture-Western	BioGRID	12237340
PRPF6	ANT-1 \| C20orf14 \| TOM \| U5-102K \| hPrp6	PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)	Two-hybrid	BioGRID	10848612
RAP1A	KREV-1 \| KREV1 \| RAP1 \| SMGP21	RAP1A, member of RAS oncogene family	Co-crystal Structure Reconstituted Complex Two-hybrid	BioGRID	7791872 \|7862125 \|9867809 \|10454553
RAP1A	KREV-1 \| KREV1 \| RAP1 \| SMGP21	RAP1A, member of RAS oncogene family	-	HPRD	7791872\|9867809\|10454553
RAP2A	K-REV \| KREV \| RAP2 \| RbBP-30	RAP2A, member of RAS oncogene family	Raf-1 interacts with Rap2. This interaction was modeled on a demonstrated interaction between Raf-1 from unspecified species and human Rap2.	BIND	15752761
RASD2	MGC:4834 \| Rhes \| TEM2	RASD family, member 2	Reconstituted Complex	BioGRID	14724584
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	-	HPRD,BioGRID	9819434
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	Raf-1 interacts with Rb.	BIND	9819434
RBL2	FLJ26459 \| P130 \| Rb2	retinoblastoma-like 2 (p130)	Raf-1 interacts with p130.	BIND	9819434
RBL2	FLJ26459 \| P130 \| Rb2	retinoblastoma-like 2 (p130)	-	HPRD,BioGRID	9819434
RHEB	MGC111559 \| RHEB2	Ras homolog enriched in brain	-	HPRD,BioGRID	9001246
RHEB	MGC111559 \| RHEB2	Ras homolog enriched in brain	RAF interacts with Rheb.	BIND	15854902
RP6-213H19.1	MASK \| MST4	serine/threonine protein kinase MST4	-	HPRD,BioGRID	11306563
RRAS	-	related RAS viral (r-ras) oncogene homolog	Two-hybrid	BioGRID	10848612
RRAS2	TC21	related RAS viral (r-ras) oncogene homolog 2	RAF1 (C-Raf) interacts with RRAS2 (R-Ras).	BIND	12620389
RRAS2	TC21	related RAS viral (r-ras) oncogene homolog 2	Reconstituted Complex Two-hybrid	BioGRID	10557073 \|10783161
RRAS2	TC21	related RAS viral (r-ras) oncogene homolog 2	-	HPRD	10064593
SFN	YWHAS	stratifin	Affinity Capture-MS	BioGRID	15778465
SHOC2	FLJ60412 \| KIAA0862 \| SIAA0862 \| SOC-2 \| SOC2 \| SUR-8 \| SUR8	soc-2 suppressor of clear homolog (C. elegans)	-	HPRD,BioGRID	10783161
SPRY2	MGC23039 \| hSPRY2	sprouty homolog 2 (Drosophila)	Affinity Capture-Western	BioGRID	12717443
SPRY4	-	sprouty homolog 4 (Drosophila)	-	HPRD,BioGRID	12717443
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD,BioGRID	7517401
STK3	FLJ90748 \| KRS1 \| MST2	serine/threonine kinase 3 (STE20 homolog, yeast)	Raf-1 interacts with MST2. This interaction was modeled on a demonstrated interaction between human Raf-1 and monkey MST2.	BIND	15618521
TIMM50	MGC102733 \| TIM50 \| TIM50L	translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)	C-RAF interacts with TIMM50.	BIND	12620389
TIMM50	MGC102733 \| TIM50 \| TIM50L	translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)	RAF1 (C-Raf) interacts with TIMM50 (hC22).	BIND	12620389
TSC22D3	DIP \| DKFZp313A1123 \| DSIPI \| GILZ \| TSC-22R \| hDIP	TSC22 domain family, member 3	-	HPRD,BioGRID	12391160
UBE2D2	E2(17)KB2 \| PUBC1 \| UBC4 \| UBC4/5 \| UBCH5B	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	Biochemical Activity	BioGRID	11676916
VAV1	VAV	vav 1 guanine nucleotide exchange factor	-	HPRD,BioGRID	8900182
VDAC1	MGC111064 \| PORIN \| PORIN-31-HL	voltage-dependent anion channel 1	Affinity Capture-Western	BioGRID	12079506
YWHAB	GW128 \| HS1 \| KCIP-1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	C-RAF interacts with 14-3-3-beta.	BIND	12620389
YWHAB	GW128 \| HS1 \| KCIP-1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	-	HPRD	8702721 \|12360521
YWHAB	GW128 \| HS1 \| KCIP-1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	RAF1 (C-Raf) interacts with YWHAB (14-3-3-beta).	BIND	12620389
YWHAB	GW128 \| HS1 \| KCIP-1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	8702721 \|10620507 \|10848612 \|12360521 \|12620389
YWHAE	14-3-3E \| FLJ45465 \| KCIP-1 \| MDCR \| MDS	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	-	HPRD,BioGRID	7644510
YWHAE	14-3-3E \| FLJ45465 \| KCIP-1 \| MDCR \| MDS	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	14-3-3-epsilon interacts with Raf-1.	BIND	7644510
YWHAG	14-3-3GAMMA	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	-	HPRD	8702721 \|10433554
YWHAG	14-3-3GAMMA	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	Affinity Capture-MS Affinity Capture-Western	BioGRID	10433554 \|10620507 \|17353931
YWHAH	YWHA1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	-	HPRD,BioGRID	8702721
YWHAQ	14-3-3 \| 1C5 \| HS1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	Affinity Capture-MS Affinity Capture-Western Far Western Reconstituted Complex	BioGRID	8663231 \|10620507 \|10757792 \|17353931
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	Raf-1 interacts with 14-3-3 zeta. This interaction was modelled on a demonstrated interaction between human Raf-1 and murine 14-3-3-zeta.	BIND	7559537
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	Affinity Capture-Western Reconstituted Complex	BioGRID	7628630 \|9261098 \|10620507 \|10887173
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	-	HPRD	7628630 \|7939632

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG ERBB SIGNALING PATHWAY	87	71	All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY	190	128	All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION	115	81	All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY	76	53	All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION	201	138	All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION	90	68	All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY	137	92	All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY	108	89	All SZGR 2.0 genes in this pathway
KEGG B CELL RECEPTOR SIGNALING PATHWAY	75	56	All SZGR 2.0 genes in this pathway
KEGG FC EPSILON RI SIGNALING PATHWAY	79	58	All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS	97	71	All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION	70	57	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION	70	53	All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON	216	144	All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY	137	103	All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY	101	77	All SZGR 2.0 genes in this pathway
KEGG PROGESTERONE MEDIATED OOCYTE MATURATION	86	59	All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS	102	80	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG COLORECTAL CANCER	62	47	All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA	70	60	All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER	70	56	All SZGR 2.0 genes in this pathway
KEGG ENDOMETRIAL CANCER	52	45	All SZGR 2.0 genes in this pathway
KEGG GLIOMA	65	56	All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER	89	75	All SZGR 2.0 genes in this pathway
KEGG MELANOMA	71	57	All SZGR 2.0 genes in this pathway
KEGG BLADDER CANCER	42	33	All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA	73	59	All SZGR 2.0 genes in this pathway
KEGG ACUTE MYELOID LEUKEMIA	60	47	All SZGR 2.0 genes in this pathway
KEGG NON SMALL CELL LUNG CANCER	54	47	All SZGR 2.0 genes in this pathway
BIOCARTA AT1R PATHWAY	36	28	All SZGR 2.0 genes in this pathway
BIOCARTA SPPA PATHWAY	22	18	All SZGR 2.0 genes in this pathway
BIOCARTA BCR PATHWAY	37	28	All SZGR 2.0 genes in this pathway
BIOCARTA BIOPEPTIDES PATHWAY	45	35	All SZGR 2.0 genes in this pathway
BIOCARTA CDMAC PATHWAY	16	15	All SZGR 2.0 genes in this pathway
BIOCARTA CCR3 PATHWAY	23	21	All SZGR 2.0 genes in this pathway
BIOCARTA CERAMIDE PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA CXCR4 PATHWAY	24	22	All SZGR 2.0 genes in this pathway
BIOCARTA EGF PATHWAY	31	25	All SZGR 2.0 genes in this pathway
BIOCARTA EPO PATHWAY	19	13	All SZGR 2.0 genes in this pathway
BIOCARTA ECM PATHWAY	24	17	All SZGR 2.0 genes in this pathway
BIOCARTA ERK PATHWAY	28	22	All SZGR 2.0 genes in this pathway
BIOCARTA FCER1 PATHWAY	41	30	All SZGR 2.0 genes in this pathway
BIOCARTA FMLP PATHWAY	39	29	All SZGR 2.0 genes in this pathway
BIOCARTA GH PATHWAY	28	22	All SZGR 2.0 genes in this pathway
BIOCARTA IGF1 PATHWAY	21	16	All SZGR 2.0 genes in this pathway
BIOCARTA IL2 PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA IL3 PATHWAY	15	11	All SZGR 2.0 genes in this pathway
BIOCARTA IL6 PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA IL2RB PATHWAY	38	26	All SZGR 2.0 genes in this pathway
BIOCARTA RACCYCD PATHWAY	26	23	All SZGR 2.0 genes in this pathway
BIOCARTA GLEEVEC PATHWAY	23	17	All SZGR 2.0 genes in this pathway
BIOCARTA INSULIN PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA INTEGRIN PATHWAY	38	29	All SZGR 2.0 genes in this pathway
BIOCARTA KERATINOCYTE PATHWAY	46	38	All SZGR 2.0 genes in this pathway
BIOCARTA PYK2 PATHWAY	31	24	All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY	87	68	All SZGR 2.0 genes in this pathway
BIOCARTA IGF1R PATHWAY	23	20	All SZGR 2.0 genes in this pathway
BIOCARTA NGF PATHWAY	18	13	All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY	56	45	All SZGR 2.0 genes in this pathway
BIOCARTA PDGF PATHWAY	32	25	All SZGR 2.0 genes in this pathway
BIOCARTA CDK5 PATHWAY	11	11	All SZGR 2.0 genes in this pathway
BIOCARTA RAS PATHWAY	23	20	All SZGR 2.0 genes in this pathway
BIOCARTA HER2 PATHWAY	22	17	All SZGR 2.0 genes in this pathway
BIOCARTA MAL PATHWAY	19	17	All SZGR 2.0 genes in this pathway
BIOCARTA BARR MAPK PATHWAY	12	11	All SZGR 2.0 genes in this pathway
BIOCARTA BARRESTIN SRC PATHWAY	15	14	All SZGR 2.0 genes in this pathway
BIOCARTA MET PATHWAY	37	30	All SZGR 2.0 genes in this pathway
BIOCARTA GPCR PATHWAY	37	31	All SZGR 2.0 genes in this pathway
BIOCARTA SPRY PATHWAY	18	15	All SZGR 2.0 genes in this pathway
BIOCARTA TCR PATHWAY	49	37	All SZGR 2.0 genes in this pathway
BIOCARTA TPO PATHWAY	24	17	All SZGR 2.0 genes in this pathway
ST GA12 PATHWAY	23	16	All SZGR 2.0 genes in this pathway
ST G ALPHA S PATHWAY	16	11	All SZGR 2.0 genes in this pathway
ST G ALPHA I PATHWAY	35	29	All SZGR 2.0 genes in this pathway
SIG IL4RECEPTOR IN B LYPHOCYTES	27	23	All SZGR 2.0 genes in this pathway
ST ADRENERGIC	36	29	All SZGR 2.0 genes in this pathway
ST INTEGRIN SIGNALING PATHWAY	82	62	All SZGR 2.0 genes in this pathway
SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	51	41	All SZGR 2.0 genes in this pathway
ST T CELL SIGNAL TRANSDUCTION	45	33	All SZGR 2.0 genes in this pathway
SIG BCR SIGNALING PATHWAY	46	38	All SZGR 2.0 genes in this pathway
ST B CELL ANTIGEN RECEPTOR	40	32	All SZGR 2.0 genes in this pathway
PID FCER1 PATHWAY	62	43	All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY	63	52	All SZGR 2.0 genes in this pathway
PID BCR 5PATHWAY	65	50	All SZGR 2.0 genes in this pathway
PID GMCSF PATHWAY	37	31	All SZGR 2.0 genes in this pathway
PID MET PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY	70	51	All SZGR 2.0 genes in this pathway
PID SHP2 PATHWAY	58	46	All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY	69	55	All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY	55	43	All SZGR 2.0 genes in this pathway
PID IGF1 PATHWAY	30	23	All SZGR 2.0 genes in this pathway
PID TCR RAS PATHWAY	14	14	All SZGR 2.0 genes in this pathway
PID CERAMIDE PATHWAY	48	37	All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY	105	78	All SZGR 2.0 genes in this pathway
PID ERBB2 ERBB3 PATHWAY	44	35	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID P38 MK2 PATHWAY	21	19	All SZGR 2.0 genes in this pathway
PID AR NONGENOMIC PATHWAY	31	27	All SZGR 2.0 genes in this pathway
PID ERBB1 INTERNALIZATION PATHWAY	41	35	All SZGR 2.0 genes in this pathway
PID CXCR3 PATHWAY	43	34	All SZGR 2.0 genes in this pathway
PID KIT PATHWAY	52	40	All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY	69	57	All SZGR 2.0 genes in this pathway
PID PI3KCI AKT PATHWAY	35	30	All SZGR 2.0 genes in this pathway
PID MAPK TRK PATHWAY	34	31	All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY	65	56	All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY	65	46	All SZGR 2.0 genes in this pathway
PID FAK PATHWAY	59	45	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT	78	59	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4	90	67	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	22	20	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER	109	80	All SZGR 2.0 genes in this pathway
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	20	17	All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE	87	64	All SZGR 2.0 genes in this pathway
REACTOME ARMS MEDIATED ACTIVATION	17	17	All SZGR 2.0 genes in this pathway
REACTOME PROLONGED ERK ACTIVATION EVENTS	19	18	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO RAS	27	23	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO ERKS	36	30	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO P38 VIA RIT AND RIN	15	14	All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	205	136	All SZGR 2.0 genes in this pathway
REACTOME SHC1 EVENTS IN EGFR SIGNALING	15	13	All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	186	155	All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM	279	221	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL	137	110	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	95	76	All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE	251	188	All SZGR 2.0 genes in this pathway
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	64	49	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS	37	32	All SZGR 2.0 genes in this pathway
REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	27	23	All SZGR 2.0 genes in this pathway
REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	33	28	All SZGR 2.0 genes in this pathway
REACTOME FRS2 MEDIATED CASCADE	36	27	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	100	74	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS	107	86	All SZGR 2.0 genes in this pathway
REACTOME RAP1 SIGNALLING	17	12	All SZGR 2.0 genes in this pathway
REACTOME IL 2 SIGNALING	41	34	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR	108	72	All SZGR 2.0 genes in this pathway
REACTOME SOS MEDIATED SIGNALLING	14	13	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME RAF MAP KINASE CASCADE	10	10	All SZGR 2.0 genes in this pathway
REACTOME SHC MEDIATED SIGNALLING	15	12	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR	112	80	All SZGR 2.0 genes in this pathway
REACTOME SHC RELATED EVENTS	17	13	All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN	309	191	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN	526	357	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 2HR DN	88	53	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP	329	196	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP UP	117	85	All SZGR 2.0 genes in this pathway
BARIS THYROID CANCER DN	59	45	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN	800	473	All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN	203	134	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
TAGHAVI NEOPLASTIC TRANSFORMATION	12	10	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP	424	268	All SZGR 2.0 genes in this pathway
SUNG METASTASIS STROMA UP	110	70	All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 UP	51	30	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR UP	225	139	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C2	54	39	All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH DN	58	43	All SZGR 2.0 genes in this pathway
MEDINA SMARCA4 TARGETS	44	29	All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D5	39	26	All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN	312	203	All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION	175	125	All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002	429	260	All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA	447	277	All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL DN	102	65	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
BRUNEAU SEPTATION VENTRICULAR	10	8	All SZGR 2.0 genes in this pathway
PHESSE TARGETS OF APC AND MBD2 UP	20	14	All SZGR 2.0 genes in this pathway
TERAO AOX4 TARGETS HG UP	28	20	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	139	145	1A	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-19	461	468	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	461	468	1A,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-331	27	34	1A,m8	hsa-miR-331^brain	GCCCCUGGGCCUAUCCUAGAA
miR-503	108	114	1A	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG
miR-7	674	681	1A,m8	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: RAF1