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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: RAF1

Summary

GeneID

5894

Symbol

RAF1

Synonyms

CRAF|NS5|Raf-1|c-Raf

Description

v-raf-1 murine leukemia viral oncogene homolog 1

Locus tag

Gene type

protein-coding

Map location

3p25

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.006

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.1134

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

RAD50

0.95

BCLAF1

0.94

0.95

PRPF4B

0.93

0.95

DDX46

0.93

0.95

NARG1

0.93

0.95

ATRX

0.93

0.96

ZMYM2

0.93

FBXO11

0.93

0.94

ZNF33A

0.93

0.94

RBM26

0.93

0.95

Top 10 negatively co-expressed genes

FXYD1

-0.73

-0.85

AF347015.31

-0.73

-0.85

TSC22D4

-0.73

-0.82

MT-CO2

-0.72

-0.85

IFI27

-0.72

-0.85

AF347015.27

-0.71

-0.82

AIFM3

-0.71

-0.77

ENHO

-0.70

-0.87

AF347015.33

-0.70

-0.81

HIGD1B

-0.70

-0.85

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0005057

receptor signaling protein activity

IEA

GO:0005515

protein binding

IPI

9624170 |10433554

GO:0005524

ATP binding

IEA

GO:0004674

protein serine/threonine kinase activity

IEA

GO:0016740

transferase activity

IEA

GO:0008270

zinc ion binding

IEA

GO:0019992

diacylglycerol binding

IEA

GO:0046872

metal ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006468

protein amino acid phosphorylation

TAS

8063729

GO:0007265

Ras protein signal transduction

EXP

11520933

GO:0007010

cytoskeleton organization

IEA

GO:0008283

cell proliferation

TAS

8063729

GO:0048011

nerve growth factor receptor signaling pathway

IEA

GO:0006915

apoptosis

TAS

8929532

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005829

cytosol

EXP

9069260

GO:0005741

mitochondrial outer membrane

TAS

8929532

GO:0005886

plasma membrane

EXP

9069260

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1	-	HPRD,BioGRID	10576742
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	-	HPRD,BioGRID	8349631
BAG1	RAP46	BCL2-associated athanogene	-	HPRD,BioGRID	8692945
BCL2	Bcl-2	B-cell CLL/lymphoma 2	-	HPRD,BioGRID	8910675 \|8929532
BCL2L1	BCL-XL/S \| BCL2L \| BCLX \| Bcl-X \| DKFZp781P2092 \| bcl-xL \| bcl-xS	BCL2-like 1	Reconstituted Complex	BioGRID	8929532
BRAF	B-RAF1 \| BRAF1 \| FLJ95109 \| MGC126806 \| MGC138284 \| RAFB1	v-raf murine sarcoma viral oncogene homolog B1	B-RAF interacts with C-RAF. This interaction was modelled on a demonstrated interaction between human B-RAF and monkey C-RAF .	BIND	15035987
BRAF	B-RAF1 \| BRAF1 \| FLJ95109 \| MGC126806 \| MGC138284 \| RAFB1	v-raf murine sarcoma viral oncogene homolog B1	-	HPRD,BioGRID	11325826
CCT3	CCT-gamma \| CCTG \| PIG48 \| TCP-1-gamma \| TRIC5	chaperonin containing TCP1, subunit 3 (gamma)	RAF1 (C-Raf) interacts with CCT3 (hC87).	BIND	12620389
			C-RAF interacts with CCT3.	BIND	12620389
			Two-hybrid	BioGRID	12620389
CDC25A	CDC25A2	cell division cycle 25 homolog A (S. pombe)	-	HPRD,BioGRID	9230211 \|10373531
CFLAR	CASH \| CASP8AP1 \| CLARP \| Casper \| FLAME \| FLAME-1 \| FLAME1 \| FLIP \| I-FLICE \| MRIT \| c-FLIP \| c-FLIPL \| c-FLIPR \| c-FLIPS	CASP8 and FADD-like apoptosis regulator	-	HPRD,BioGRID	10837247
CNKSR1	CNK \| CNK1 \| KSR	connector enhancer of kinase suppressor of Ras 1	-	HPRD,BioGRID	15075335
CNKSR2	CNK2 \| KIAA0902 \| KSR2	connector enhancer of kinase suppressor of Ras 2	Affinity Capture-Western	BioGRID	14597674
COPS3	SGN3	COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)	RAF1 (C-Raf) interacts with COPS3 (SGN3).	BIND	12620389
COPS3	SGN3		C-RAF interacts with SGN3.	BIND	12620389
CPS1	-	carbamoyl-phosphate synthetase 1, mitochondrial	RAF1 (C-Raf) interacts with CPS1.	BIND	12620389
CPS1	-	carbamoyl-phosphate synthetase 1, mitochondrial	C-RAF interacts with CPS1.	BIND	12620389
DMPK	DM \| DM1 \| DM1PK \| DMK \| MDPK \| MT-PK	dystrophia myotonica-protein kinase	-	HPRD	10869570
EFEMP1	DHRD \| DRAD \| FBLN3 \| FBNL \| FLJ35535 \| MGC111353 \| MLVT \| MTLV \| S1-5	EGF-containing fibulin-like extracellular matrix protein 1	RAF1 (C-Raf) interacts with an unspecified isoform of EFEMP1 (FBNL).	BIND	12620389
ERAS	HRAS2 \| HRASP \| MGC126691 \| MGC126693	ES cell expressed Ras	Affinity Capture-Western	BioGRID	12774123
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	-	HPRD,BioGRID	7517401
GNB2	-	guanine nucleotide binding protein (G protein), beta polypeptide 2	Affinity Capture-Western	BioGRID	7782277
GNG4	DKFZp547K1018 \| FLJ23803 \| FLJ34187	guanine nucleotide binding protein (G protein), gamma 4	-	HPRD,BioGRID	7782277
GRB10	GRB-IR \| Grb-10 \| IRBP \| KIAA0207 \| MEG1 \| RSS	growth factor receptor-bound protein 10	-	HPRD,BioGRID	9553107 \|10585452
HRAS	C-BAS/HAS \| C-H-RAS \| C-HA-RAS1 \| CTLO \| H-RASIDX \| HAMSV \| HRAS1 \| K-RAS \| N-RAS \| RASH1	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	-	HPRD	8530446 \|8911690
			Hras interacts with Raf. This interaction was modelled on a demonstrated interaction between Hras and Raf, both from an unspecified species.	BIND	15705808
			Raf interacts with Ras. This interaction was modeled on a demonstrated interaction between human Raf and rat Ras.	BIND	11585923
			RAF1 (C-Raf) interacts with HRAS (Ha-Ras).	BIND	12620389
			Raf-1 interacts with Ras.	BIND	15664191
			C-RAF interacts with Ha-Ras.	BIND	12620389
			Raf interacts with Ras. This interaction was modeled on a demonstrated interaction between Raf and an unspecified source and human Ras.	BIND	7523381 \|8307946
			Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	7862125 \|7969158 \|8530446 \|8628317 \|9150145 \|9154803 \|9523700 \|10369681 \|10783161 \|10882715 \|10922060 \|12379659 \|12620389 \|14654780 \|14724584 \|15031288 \|16803888
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	Raf-1 interacts with Hsp90. This interaction was modeled on a demonstrated interaction between human Raf-1 and monkey Hsp90.	BIND	15618521
HSP90AA1			-	HPRD,BioGRID	8408024
INSR	CD220 \| HHF5	insulin receptor	-	HPRD	11409918
JAK1	JAK1A \| JAK1B \| JTK3	Janus kinase 1 (a protein tyrosine kinase)	-	HPRD,BioGRID	9446616
JAK2	JTK10	Janus kinase 2 (a protein tyrosine kinase)	-	HPRD,BioGRID	8876196
KRAS	C-K-RAS \| K-RAS2A \| K-RAS2B \| K-RAS4A \| K-RAS4B \| KI-RAS \| KRAS1 \| KRAS2 \| NS3 \| RASK2	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	Affinity Capture-Western Two-hybrid	BioGRID	10783161 \|10882715
KSR2	FLJ25965	kinase suppressor of ras 2	-	HPRD	12975377
LCK	YT16 \| p56lck \| pp58lck	lymphocyte-specific protein tyrosine kinase	-	HPRD,BioGRID	8939988
LRPAP1	A2MRAP \| A2RAP \| HBP44 \| MGC138272 \| MRAP \| RAP	low density lipoprotein receptor-related protein associated protein 1	Two-hybrid	BioGRID	10783161
MAP2K1	MAPKK1 \| MEK1 \| MKK1 \| PRKMK1	mitogen-activated protein kinase kinase 1	Reconstituted Complex	BioGRID	10757792
			Raf interacts with and phosphorylates Mek1	BIND	14724641
			MEK1 interacts with and is phosphorylated by Raf-1. This interaction was modeled on a demonstrated interaction between human MEK1 and Raf-1 from an unspecified species.	BIND	15866172
			MEK1 interacts with c-Raf	BIND	8621729
			-	HPRD	11604401
MAP2K2	FLJ26075 \| MAPKK2 \| MEK2 \| MKK2 \| PRKMK2	mitogen-activated protein kinase kinase 2	Raf interacts with Mek2.	BIND	14724641
MAP3K1	MAPKKK1 \| MEKK \| MEKK1	mitogen-activated protein kinase kinase kinase 1	MEKK1 interacts with Raf-1.	BIND	10969079
MAP3K1	MAPKKK1 \| MEKK \| MEKK1	mitogen-activated protein kinase kinase kinase 1	Affinity Capture-Western Reconstituted Complex	BioGRID	10969079
MAP3K5	ASK1 \| MAPKKK5 \| MEKK5	mitogen-activated protein kinase kinase kinase 5	-	HPRD,BioGRID	11427728
MAPK1	ERK \| ERK2 \| ERT1 \| MAPK2 \| P42MAPK \| PRKM1 \| PRKM2 \| p38 \| p40 \| p41 \| p41mapk	mitogen-activated protein kinase 1	Affinity Capture-Western	BioGRID	11409918
MAPK1		mitogen-activated protein kinase 1	Raf-1 interacts with ERK2. This interaction was modelled on a demonstrated interaction between human Raf-1 and ERK2 from an unspecified species.	BIND	15664191
MAPK3	ERK1 \| HS44KDAP \| HUMKER1A \| MGC20180 \| P44ERK1 \| P44MAPK \| PRKM3	mitogen-activated protein kinase 3	Affinity Capture-Western	BioGRID	11409918
MAPK7	BMK1 \| ERK4 \| ERK5 \| PRKM7	mitogen-activated protein kinase 7	-	HPRD,BioGRID	10531364
MAPK8IP3	DKFZp762N1113 \| FLJ00027 \| JIP3 \| JSAP1 \| KIAA1066 \| SYD2	mitogen-activated protein kinase 8 interacting protein 3	-	HPRD,BioGRID	10523642 \|11044439
MAPK8IP3	DKFZp762N1113 \| FLJ00027 \| JIP3 \| JSAP1 \| KIAA1066 \| SYD2	mitogen-activated protein kinase 8 interacting protein 3	-	HPRD	11044439
MRAS	FLJ42964 \| M-RAs \| R-RAS3 \| RRAS3	muscle RAS oncogene homolog	-	HPRD,BioGRID	10498616
MYC	bHLHe39 \| c-Myc	v-myc myelocytomatosis viral oncogene homolog (avian)	-	HPRD,BioGRID	9315742
NR3C1	GCCR \| GCR \| GR \| GRL	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	-	HPRD,BioGRID	11005817
NRAS	ALPS4 \| N-ras \| NRAS1	neuroblastoma RAS viral (v-ras) oncogene homolog	Nras interacts with Raf. This interaction was modelled on a demonstrated interaction between Nras and Raf, both from an unspecified species.	BIND	15705808
NRAS	ALPS4 \| N-ras \| NRAS1	neuroblastoma RAS viral (v-ras) oncogene homolog	Affinity Capture-Western	BioGRID	10882715
NUDT14	UGPP \| UGPPase	nudix (nucleoside diphosphate linked moiety X)-type motif 14	RAF1 (C-Raf) interacts with NUDT14 (hA21).	BIND	12620389
OIP5	5730547N13Rik \| LINT-25 \| MIS18beta	Opa interacting protein 5	Two-hybrid	BioGRID	12620389
			C-RAF interacts with OIP5.	BIND	12620389
			RAF1 (C-Raf) interacts with OIP5 (hC73).	BIND	12620389
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	-	HPRD,BioGRID	11733498
PBK	FLJ14385 \| Nori-3 \| SPK \| TOPK	PDZ binding kinase	RAF1 (C-Raf) interacts with PBK (TOPK).	BIND	12620389
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	-	HPRD,BioGRID	2475255
PEBP1	HCNP \| PBP \| PEBP \| RKIP	phosphatidylethanolamine binding protein 1	-	HPRD	11853019
			RKIP interacts with Raf-1. This interaction was modelled on a demonstrated interaction between RKIP from an unspecified species and Raf-1 from an unspecified species.	BIND	14654844
			Affinity Capture-Western Reconstituted Complex	BioGRID	10757792
PEBP4	CORK-1 \| CORK1 \| GWTM1933 \| MGC22776 \| PRO4408	phosphatidylethanolamine-binding protein 4	Affinity Capture-Western Reconstituted Complex	BioGRID	15302887
PEBP4	CORK-1 \| CORK1 \| GWTM1933 \| MGC22776 \| PRO4408	phosphatidylethanolamine-binding protein 4	hPEBP4 interacts with Raf-1. This interaction was modeled on a demonstrated interaction between human hPEBP4 and mouse Raf-1.	BIND	15302887
PEX5L	PEX5R \| PXR2 \| PXR2B	peroxisomal biogenesis factor 5-like	-	HPRD	15302887
PHB	PHB1	prohibitin	-	HPRD,BioGRID	10523633
PHB	PHB1	prohibitin	RAF1 (c-Raf) interacts with PHB.	BIND	16041367
PHKA2	GSD9A \| MGC133071 \| PHK \| PYK \| PYKL \| XLG \| XLG2	phosphorylase kinase, alpha 2 (liver)	Two-hybrid	BioGRID	12620389
PIN1	DOD \| UBL5	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Raf-1 interacts with Pin1. This interaction was modelled on a demonstrated interaction between human Raf-1 and Pin1 from monkey and unspecified species.	BIND	15664191
PKM2	CTHBP \| MGC3932 \| OIP3 \| PK3 \| PKM \| TCB \| THBP1	pyruvate kinase, muscle	-	HPRD	12620389
			C-RAF interacts with PyK.	BIND	12620389
			RAF1 (C-Raf) interacts with PKM2 (PyK).	BIND	12620389
PPP2R2A	B55-ALPHA \| B55A \| FLJ26613 \| MGC52248 \| PR52A \| PR55A	protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform	RAF1 (c-Raf) interact with an unspecified isoform of PPP2R2A (PP2A-A).	BIND	16041367
PPP2R2B	B55-BETA \| FLJ95686 \| MGC24888 \| PP2A-B55BETA \| PP2A-PR55B \| PP2AB-BETA \| PP2APR55-BETA \| PR2AB-BETA \| PR2AB55-BETA \| PR2APR55-BETA \| PR52B \| PR55-BETA \| SCA12	protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform	RAF1 (c-Raf) interacts with an unspecified isoform of PPP2R2B (PP2A-B).	BIND	16041367
PPP2R2C	B55-GAMMA \| IMYPNO \| IMYPNO1 \| MGC33570 \| PR52 \| PR55G	protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform	RAF1 (c-Raf) interacts with an unspecified isoform of PPP2R2C (PP2A-C).	BIND	16041367
PRKCE	MGC125656 \| MGC125657 \| PKCE \| nPKC-epsilon	protein kinase C, epsilon	-	HPRD,BioGRID	11350735
PRKCZ	PKC-ZETA \| PKC2	protein kinase C, zeta	-	HPRD,BioGRID	10620507
PRKG1	CGKI \| DKFZp686K042 \| FLJ36117 \| MGC71944 \| PGK \| PKG \| PRKG1B \| PRKGR1B \| cGKI-BETA \| cGKI-alpha	protein kinase, cGMP-dependent, type I	Affinity Capture-Western	BioGRID	12237340
PRPF6	ANT-1 \| C20orf14 \| TOM \| U5-102K \| hPrp6	PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)	Two-hybrid	BioGRID	10848612
RAP1A	KREV-1 \| KREV1 \| RAP1 \| SMGP21	RAP1A, member of RAS oncogene family	Co-crystal Structure Reconstituted Complex Two-hybrid	BioGRID	7791872 \|7862125 \|9867809 \|10454553
RAP1A	KREV-1 \| KREV1 \| RAP1 \| SMGP21	RAP1A, member of RAS oncogene family	-	HPRD	7791872\|9867809\|10454553
RAP2A	K-REV \| KREV \| RAP2 \| RbBP-30	RAP2A, member of RAS oncogene family	Raf-1 interacts with Rap2. This interaction was modeled on a demonstrated interaction between Raf-1 from unspecified species and human Rap2.	BIND	15752761
RASD2	MGC:4834 \| Rhes \| TEM2	RASD family, member 2	Reconstituted Complex	BioGRID	14724584
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	-	HPRD,BioGRID	9819434
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	Raf-1 interacts with Rb.	BIND	9819434
RBL2	FLJ26459 \| P130 \| Rb2	retinoblastoma-like 2 (p130)	Raf-1 interacts with p130.	BIND	9819434
RBL2	FLJ26459 \| P130 \| Rb2	retinoblastoma-like 2 (p130)	-	HPRD,BioGRID	9819434
RHEB	MGC111559 \| RHEB2	Ras homolog enriched in brain	-	HPRD,BioGRID	9001246
RHEB	MGC111559 \| RHEB2	Ras homolog enriched in brain	RAF interacts with Rheb.	BIND	15854902
RP6-213H19.1	MASK \| MST4	serine/threonine protein kinase MST4	-	HPRD,BioGRID	11306563
RRAS	-	related RAS viral (r-ras) oncogene homolog	Two-hybrid	BioGRID	10848612
RRAS2	TC21	related RAS viral (r-ras) oncogene homolog 2	RAF1 (C-Raf) interacts with RRAS2 (R-Ras).	BIND	12620389
			Reconstituted Complex Two-hybrid	BioGRID	10557073 \|10783161
			-	HPRD	10064593
SFN	YWHAS	stratifin	Affinity Capture-MS	BioGRID	15778465
SHOC2	FLJ60412 \| KIAA0862 \| SIAA0862 \| SOC-2 \| SOC2 \| SUR-8 \| SUR8	soc-2 suppressor of clear homolog (C. elegans)	-	HPRD,BioGRID	10783161
SPRY2	MGC23039 \| hSPRY2	sprouty homolog 2 (Drosophila)	Affinity Capture-Western	BioGRID	12717443
SPRY4	-	sprouty homolog 4 (Drosophila)	-	HPRD,BioGRID	12717443
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD,BioGRID	7517401
STK3	FLJ90748 \| KRS1 \| MST2	serine/threonine kinase 3 (STE20 homolog, yeast)	Raf-1 interacts with MST2. This interaction was modeled on a demonstrated interaction between human Raf-1 and monkey MST2.	BIND	15618521
TIMM50	MGC102733 \| TIM50 \| TIM50L	translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)	C-RAF interacts with TIMM50.	BIND	12620389
TIMM50	MGC102733 \| TIM50 \| TIM50L		RAF1 (C-Raf) interacts with TIMM50 (hC22).	BIND	12620389
TSC22D3	DIP \| DKFZp313A1123 \| DSIPI \| GILZ \| TSC-22R \| hDIP	TSC22 domain family, member 3	-	HPRD,BioGRID	12391160
UBE2D2	E2(17)KB2 \| PUBC1 \| UBC4 \| UBC4/5 \| UBCH5B	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	Biochemical Activity	BioGRID	11676916
VAV1	VAV	vav 1 guanine nucleotide exchange factor	-	HPRD,BioGRID	8900182
VDAC1	MGC111064 \| PORIN \| PORIN-31-HL	voltage-dependent anion channel 1	Affinity Capture-Western	BioGRID	12079506
YWHAB	GW128 \| HS1 \| KCIP-1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	C-RAF interacts with 14-3-3-beta.	BIND	12620389
			-	HPRD	8702721 \|12360521
			RAF1 (C-Raf) interacts with YWHAB (14-3-3-beta).	BIND	12620389
			Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	8702721 \|10620507 \|10848612 \|12360521 \|12620389
YWHAE	14-3-3E \| FLJ45465 \| KCIP-1 \| MDCR \| MDS	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	-	HPRD,BioGRID	7644510
YWHAE	14-3-3E \| FLJ45465 \| KCIP-1 \| MDCR \| MDS		14-3-3-epsilon interacts with Raf-1.	BIND	7644510
YWHAG	14-3-3GAMMA	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	-	HPRD	8702721 \|10433554
YWHAG	14-3-3GAMMA		Affinity Capture-MS Affinity Capture-Western	BioGRID	10433554 \|10620507 \|17353931
YWHAH	YWHA1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	-	HPRD,BioGRID	8702721
YWHAQ	14-3-3 \| 1C5 \| HS1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	Affinity Capture-MS Affinity Capture-Western Far Western Reconstituted Complex	BioGRID	8663231 \|10620507 \|10757792 \|17353931
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	Raf-1 interacts with 14-3-3 zeta. This interaction was modelled on a demonstrated interaction between human Raf-1 and murine 14-3-3-zeta.	BIND	7559537
			Affinity Capture-Western Reconstituted Complex	BioGRID	7628630 \|9261098 \|10620507 \|10887173
			-	HPRD	7628630 \|7939632

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_MAPK_SIGNALING_PATHWAY	267	205	All SZGR genes in this pathway
KEGG_ERBB_SIGNALING_PATHWAY	87	71	All SZGR genes in this pathway
KEGG_CHEMOKINE_SIGNALING_PATHWAY	190	128	All SZGR genes in this pathway
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION	115	81	All SZGR genes in this pathway
KEGG_VEGF_SIGNALING_PATHWAY	76	53	All SZGR genes in this pathway
KEGG_FOCAL_ADHESION	201	138	All SZGR genes in this pathway
KEGG_GAP_JUNCTION	90	68	All SZGR genes in this pathway
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	137	92	All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY	108	89	All SZGR genes in this pathway
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY	75	56	All SZGR genes in this pathway
KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY	79	58	All SZGR genes in this pathway
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS	97	71	All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION	70	57	All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY	126	103	All SZGR genes in this pathway
KEGG_LONG_TERM_DEPRESSION	70	53	All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	216	144	All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY	137	103	All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY	101	77	All SZGR genes in this pathway
KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION	86	59	All SZGR genes in this pathway
KEGG_MELANOGENESIS	102	80	All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER	328	259	All SZGR genes in this pathway
KEGG_COLORECTAL_CANCER	62	47	All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA	70	60	All SZGR genes in this pathway
KEGG_PANCREATIC_CANCER	70	56	All SZGR genes in this pathway
KEGG_ENDOMETRIAL_CANCER	52	45	All SZGR genes in this pathway
KEGG_GLIOMA	65	56	All SZGR genes in this pathway
KEGG_PROSTATE_CANCER	89	75	All SZGR genes in this pathway
KEGG_MELANOMA	71	57	All SZGR genes in this pathway
KEGG_BLADDER_CANCER	42	33	All SZGR genes in this pathway
KEGG_CHRONIC_MYELOID_LEUKEMIA	73	59	All SZGR genes in this pathway
KEGG_ACUTE_MYELOID_LEUKEMIA	60	47	All SZGR genes in this pathway
KEGG_NON_SMALL_CELL_LUNG_CANCER	54	47	All SZGR genes in this pathway
BIOCARTA_AT1R_PATHWAY	36	28	All SZGR genes in this pathway
BIOCARTA_SPPA_PATHWAY	22	18	All SZGR genes in this pathway
BIOCARTA_BCR_PATHWAY	37	28	All SZGR genes in this pathway
BIOCARTA_BIOPEPTIDES_PATHWAY	45	35	All SZGR genes in this pathway
BIOCARTA_CDMAC_PATHWAY	16	15	All SZGR genes in this pathway
BIOCARTA_CCR3_PATHWAY	23	21	All SZGR genes in this pathway
BIOCARTA_CERAMIDE_PATHWAY	22	16	All SZGR genes in this pathway
BIOCARTA_CXCR4_PATHWAY	24	22	All SZGR genes in this pathway
BIOCARTA_EGF_PATHWAY	31	25	All SZGR genes in this pathway
BIOCARTA_EPO_PATHWAY	19	13	All SZGR genes in this pathway
BIOCARTA_ECM_PATHWAY	24	17	All SZGR genes in this pathway
BIOCARTA_ERK_PATHWAY	28	22	All SZGR genes in this pathway
BIOCARTA_FCER1_PATHWAY	41	30	All SZGR genes in this pathway
BIOCARTA_FMLP_PATHWAY	39	29	All SZGR genes in this pathway
BIOCARTA_GH_PATHWAY	28	22	All SZGR genes in this pathway
BIOCARTA_IGF1_PATHWAY	21	16	All SZGR genes in this pathway
BIOCARTA_IL2_PATHWAY	22	16	All SZGR genes in this pathway
BIOCARTA_IL3_PATHWAY	15	11	All SZGR genes in this pathway
BIOCARTA_IL6_PATHWAY	22	16	All SZGR genes in this pathway
BIOCARTA_IL2RB_PATHWAY	38	26	All SZGR genes in this pathway
BIOCARTA_RACCYCD_PATHWAY	26	23	All SZGR genes in this pathway
BIOCARTA_GLEEVEC_PATHWAY	23	17	All SZGR genes in this pathway
BIOCARTA_INSULIN_PATHWAY	22	16	All SZGR genes in this pathway
BIOCARTA_INTEGRIN_PATHWAY	38	29	All SZGR genes in this pathway
BIOCARTA_KERATINOCYTE_PATHWAY	46	38	All SZGR genes in this pathway
BIOCARTA_PYK2_PATHWAY	31	24	All SZGR genes in this pathway
BIOCARTA_MAPK_PATHWAY	87	68	All SZGR genes in this pathway
BIOCARTA_IGF1R_PATHWAY	23	20	All SZGR genes in this pathway
BIOCARTA_NGF_PATHWAY	18	13	All SZGR genes in this pathway
BIOCARTA_NFAT_PATHWAY	56	45	All SZGR genes in this pathway
BIOCARTA_PDGF_PATHWAY	32	25	All SZGR genes in this pathway
BIOCARTA_CDK5_PATHWAY	11	11	All SZGR genes in this pathway
BIOCARTA_RAS_PATHWAY	23	20	All SZGR genes in this pathway
BIOCARTA_HER2_PATHWAY	22	17	All SZGR genes in this pathway
BIOCARTA_MAL_PATHWAY	19	17	All SZGR genes in this pathway
BIOCARTA_BARR_MAPK_PATHWAY	12	11	All SZGR genes in this pathway
BIOCARTA_BARRESTIN_SRC_PATHWAY	15	14	All SZGR genes in this pathway
BIOCARTA_MET_PATHWAY	37	30	All SZGR genes in this pathway
BIOCARTA_GPCR_PATHWAY	37	31	All SZGR genes in this pathway
BIOCARTA_SPRY_PATHWAY	18	15	All SZGR genes in this pathway
BIOCARTA_TCR_PATHWAY	49	37	All SZGR genes in this pathway
BIOCARTA_TPO_PATHWAY	24	17	All SZGR genes in this pathway
ST_GA12_PATHWAY	23	16	All SZGR genes in this pathway
ST_G_ALPHA_S_PATHWAY	16	11	All SZGR genes in this pathway
ST_G_ALPHA_I_PATHWAY	35	29	All SZGR genes in this pathway
SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	27	23	All SZGR genes in this pathway
ST_ADRENERGIC	36	29	All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY	82	62	All SZGR genes in this pathway
SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	51	41	All SZGR genes in this pathway
ST_T_CELL_SIGNAL_TRANSDUCTION	45	33	All SZGR genes in this pathway
SIG_BCR_SIGNALING_PATHWAY	46	38	All SZGR genes in this pathway
ST_B_CELL_ANTIGEN_RECEPTOR	40	32	All SZGR genes in this pathway
PID_FCER1_PATHWAY	62	43	All SZGR genes in this pathway
PID_ENDOTHELIN_PATHWAY	63	52	All SZGR genes in this pathway
PID_BCR_5PATHWAY	65	50	All SZGR genes in this pathway
PID_GMCSF_PATHWAY	37	31	All SZGR genes in this pathway
PID_MET_PATHWAY	80	60	All SZGR genes in this pathway
PID_CDC42_PATHWAY	70	51	All SZGR genes in this pathway
PID_SHP2_PATHWAY	58	46	All SZGR genes in this pathway
PID_MTOR_4PATHWAY	69	55	All SZGR genes in this pathway
PID_IL2_1PATHWAY	55	43	All SZGR genes in this pathway
PID_IGF1_PATHWAY	30	23	All SZGR genes in this pathway
PID_TCR_RAS_PATHWAY	14	14	All SZGR genes in this pathway
PID_CERAMIDE_PATHWAY	48	37	All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY	105	78	All SZGR genes in this pathway
PID_ERBB2_ERBB3_PATHWAY	44	35	All SZGR genes in this pathway
PID_PDGFRB_PATHWAY	129	103	All SZGR genes in this pathway
PID_P38_MK2_PATHWAY	21	19	All SZGR genes in this pathway
PID_AR_NONGENOMIC_PATHWAY	31	27	All SZGR genes in this pathway
PID_ERBB1_INTERNALIZATION_PATHWAY	41	35	All SZGR genes in this pathway
PID_CXCR3_PATHWAY	43	34	All SZGR genes in this pathway
PID_KIT_PATHWAY	52	40	All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY	69	57	All SZGR genes in this pathway
PID_PI3KCI_AKT_PATHWAY	35	30	All SZGR genes in this pathway
PID_MAPK_TRK_PATHWAY	34	31	All SZGR genes in this pathway
PID_CD8_TCR_DOWNSTREAM_PATHWAY	65	56	All SZGR genes in this pathway
PID_RB_1PATHWAY	65	46	All SZGR genes in this pathway
PID_FAK_PATHWAY	59	45	All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF	217	167	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_SCF_KIT	78	59	All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY	396	292	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB4	90	67	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2	101	78	All SZGR genes in this pathway
REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING	22	20	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_EGFR_IN_CANCER	109	80	All SZGR genes in this pathway
REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING	20	17	All SZGR genes in this pathway
REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE	87	64	All SZGR genes in this pathway
REACTOME_ARMS_MEDIATED_ACTIVATION	17	17	All SZGR genes in this pathway
REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS	19	18	All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_RAS	27	23	All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE	137	105	All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_ERKS	36	30	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE	127	88	All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN	15	14	All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK	205	136	All SZGR genes in this pathway
REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING	15	13	All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	186	155	All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM	279	221	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR	920	449	All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL	137	110	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF	122	93	All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION	95	76	All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE	251	188	All SZGR genes in this pathway
REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH	64	49	All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NMDA_RECEPTOR_UPON_GLUTAMATE_BINDING_AND_POSTSYNAPTIC_EVENTS	37	32	All SZGR genes in this pathway
REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS	27	23	All SZGR genes in this pathway
REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS	33	28	All SZGR genes in this pathway
REACTOME_FRS2_MEDIATED_CASCADE	36	27	All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR	100	74	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS	107	86	All SZGR genes in this pathway
REACTOME_RAP1_SIGNALLING	17	12	All SZGR genes in this pathway
REACTOME_IL_2_SIGNALING	41	34	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_INSULIN_RECEPTOR	108	72	All SZGR genes in this pathway
REACTOME_SOS_MEDIATED_SIGNALLING	14	13	All SZGR genes in this pathway
REACTOME_HEMOSTASIS	466	331	All SZGR genes in this pathway
REACTOME_RAF_MAP_KINASE_CASCADE	10	10	All SZGR genes in this pathway
REACTOME_SHC_MEDIATED_SIGNALLING	15	12	All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM	933	616	All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM	539	350	All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM	270	204	All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION	208	138	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR	112	80	All SZGR genes in this pathway
REACTOME_SHC_RELATED_EVENTS	17	13	All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN	309	191	All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN	526	357	All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP	305	185	All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_2HR_DN	88	53	All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_UP	329	196	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP	117	85	All SZGR genes in this pathway
BARIS_THYROID_CANCER_DN	59	45	All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN	800	473	All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_DN	203	134	All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK	1442	892	All SZGR genes in this pathway
LOPEZ_MBD_TARGETS	957	597	All SZGR genes in this pathway
TAGHAVI_NEOPLASTIC_TRANSFORMATION	12	10	All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP	424	268	All SZGR genes in this pathway
SUNG_METASTASIS_STROMA_UP	110	70	All SZGR genes in this pathway
BYSTROEM_CORRELATED_WITH_IL5_UP	51	30	All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN	225	163	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_UP	225	139	All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C2	54	39	All SZGR genes in this pathway
JI_RESPONSE_TO_FSH_DN	58	43	All SZGR genes in this pathway
MEDINA_SMARCA4_TARGETS	44	29	All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D5	39	26	All SZGR genes in this pathway
GENTILE_UV_HIGH_DOSE_DN	312	203	All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION	175	125	All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002	429	260	All SZGR genes in this pathway
MOOTHA_MITOCHONDRIA	447	277	All SZGR genes in this pathway
CHAUHAN_RESPONSE_TO_METHOXYESTRADIOL_DN	102	65	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP	1305	895	All SZGR genes in this pathway
BRUNEAU_SEPTATION_VENTRICULAR	10	8	All SZGR genes in this pathway
PHESSE_TARGETS_OF_APC_AND_MBD2_UP	20	14	All SZGR genes in this pathway
TERAO_AOX4_TARGETS_HG_UP	28	20	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	139	145	1A	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-19	461	468	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	461	468	1A,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-331	27	34	1A,m8	hsa-miR-331^brain	GCCCCUGGGCCUAUCCUAGAA
miR-503	108	114	1A	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG
miR-7	674	681	1A,m8	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.