SZGR2

Summary ?

GeneID	6004
Symbol	RGS16
Synonyms	A28-RGS14\|A28-RGS14P\|RGS-R
Description	regulator of G-protein signaling 16
Reference	MIM:602514\|HGNC:HGNC:9997\|Ensembl:ENSG00000143333\|HPRD:03945\|Vega:OTTHUMG00000035212
Gene type	protein-coding
Map location	1q25-q31
Sherlock p-value	0.564
Fetal beta	0.218
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0073

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs2820477	chr1	68708633	RGS16	6004	0.2	trans
rs277655	chr3	100044586	RGS16	6004	0.1	trans
rs6551878	chr4	65690588	RGS16	6004	0.12	trans
rs7448921	chr5	3329277	RGS16	6004	0.05	trans
rs6893753	chr5	35451871	RGS16	6004	0.15	trans
rs1565895	chr5	116574878	RGS16	6004	0.03	trans
rs9384190	chr6	154524473	RGS16	6004	0.09	trans
rs4242415	chr8	24597175	RGS16	6004	0.11	trans
rs17109578	chr10	90351347	RGS16	6004	0.18	trans
rs12312877	chr12	79751818	RGS16	6004	0.13	trans
rs17128893	chr14	93615606	RGS16	6004	0.1	trans
rs7888404	chrX	20508308	RGS16	6004	1.696E-4	trans
rs17342483	chrX	102250155	RGS16	6004	0.05	trans
rs5957194	chrX	118769609	RGS16	6004	0.03	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
S100A9	0.71	0.43
C1QB	0.70	0.51
BCL2A1	0.66	0.35
S100A8	0.65	0.39
SERPINA1	0.61	0.48
FTL	0.61	0.38
RGS1	0.61	0.30
IFIT3	0.60	0.33
GPR183	0.60	0.34
MT1M	0.59	0.30

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ZC3H13	-0.29	-0.30
ANKRD11	-0.28	-0.19
UPF2	-0.28	-0.26
SFRS12	-0.27	-0.30
MYO18A	-0.27	-0.22
BOD1L	-0.27	-0.23
RTF1	-0.27	-0.28
PPIG	-0.27	-0.30
RBM25	-0.27	-0.34
HNRNPUL2	-0.27	-0.25

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004871	signal transducer activity	IEA		-
GO:0005096	GTPase activator activity	TAS		10747990
GO:0005516	calmodulin binding	TAS		10747990
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0009968	negative regulation of signal transduction	IEA		-
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	TAS		10747990
GO:0007601	visual perception	TAS		9469939

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CSK	MGC117393	c-src tyrosine kinase	CSK phosphorylates RGS16. This interaction was modeled on a demonstrated interaction between CSK from an unspecified species and human RSG16.	BIND	12588871
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	-	HPRD,BioGRID	11602604
GDE1	363E6.2 \| MIR16	glycerophosphodiester phosphodiesterase 1	-	HPRD,BioGRID	10760272
GNA13	G13 \| MGC46138	guanine nucleotide binding protein (G protein), alpha 13	-	HPRD,BioGRID	14634662
GNAI1	Gi	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	Biochemical Activity	BioGRID	10878019
GNAI2	GIP \| GNAI2B \| H_LUCA15.1 \| H_LUCA16.1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	Reconstituted Complex	BioGRID	9079700
GNAI3	87U6 \| FLJ26559	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	-	HPRD,BioGRID	10072511
GNAO1	DKFZp686O0962 \| G-ALPHA-o \| GNAO	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	Reconstituted Complex	BioGRID	9079700
GNAQ	G-ALPHA-q \| GAQ	guanine nucleotide binding protein (G protein), q polypeptide	Affinity Capture-Western Reconstituted Complex	BioGRID	14634662
LYN	FLJ26625 \| JTK8	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	LYN phosphorylates RGS16. This interaction was modeled on a demonstrated interaction between LYN from an unspecified species and human RSG16.	BIND	12588871
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	SRC phosphorylates RGS16. This interaction was modeled on a demonstrated interaction between SRC from an unspecified species and human RSG16.	BIND	12588871

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PARENT MTOR SIGNALING DN	46	29	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP	473	314	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP	485	293	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA DN	104	59	All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS UP	269	146	All SZGR 2.0 genes in this pathway
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP	158	103	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP	544	308	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP	530	342	All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN	232	154	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS CDC25 UP	58	39	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS UP	126	72	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN	378	231	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP	329	196	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP	1142	669	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
TAKADA GASTRIC CANCER COPY NUMBER DN	29	15	All SZGR 2.0 genes in this pathway
LA MEN1 TARGETS	24	15	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP	358	245	All SZGR 2.0 genes in this pathway
YANG BREAST CANCER ESR1 BULK DN	23	15	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A UP	142	104	All SZGR 2.0 genes in this pathway
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE UP	167	92	All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS	775	494	All SZGR 2.0 genes in this pathway
UEDA CENTRAL CLOCK	88	62	All SZGR 2.0 genes in this pathway
CHESLER BRAIN QTL CIS	75	51	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA DN	65	44	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 DN	64	38	All SZGR 2.0 genes in this pathway
BROCKE APOPTOSIS REVERSED BY IL6	144	98	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC DN	63	40	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
NEMETH INFLAMMATORY RESPONSE LPS UP	88	64	All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS	126	90	All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD UP	131	87	All SZGR 2.0 genes in this pathway
ZHAN V2 LATE DIFFERENTIATION GENES	45	34	All SZGR 2.0 genes in this pathway
RADMACHER AML PROGNOSIS	78	52	All SZGR 2.0 genes in this pathway
JAZAERI BREAST CANCER BRCA1 VS BRCA2 DN	43	31	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR UP	180	125	All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP	77	57	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN	287	208	All SZGR 2.0 genes in this pathway
VARELA ZMPSTE24 TARGETS UP	40	30	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP	953	554	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP	783	442	All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN	409	268	All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN	105	67	All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP	299	167	All SZGR 2.0 genes in this pathway
OSADA ASCL1 TARGETS UP	46	30	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP	425	298	All SZGR 2.0 genes in this pathway
LIN TUMOR ESCAPE FROM IMMUNE ATTACK	18	12	All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP	259	185	All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP	288	168	All SZGR 2.0 genes in this pathway
MARSON FOXP3 TARGETS UP	66	43	All SZGR 2.0 genes in this pathway
TIAN TNF SIGNALING NOT VIA NFKB	22	16	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
HOELZEL NF1 TARGETS UP	139	93	All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS UP	84	51	All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP	281	183	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B	549	316	All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS UP	135	96	All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7	403	240	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR UP	199	143	All SZGR 2.0 genes in this pathway
WANG MLL TARGETS	289	188	All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 2HR UP	53	33	All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR UP	166	97	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	1493	1499	m8	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
				hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-144	180	186	m8	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-410	1631	1637	m8	hsa-miR-410	AAUAUAACACAGAUGGCCUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: RGS16