Gene Page: SLC15A1

Summary ?
GeneID6564
SymbolSLC15A1
SynonymsHPECT1|HPEPT1|PEPT1
Descriptionsolute carrier family 15 member 1
ReferenceMIM:600544|HGNC:HGNC:10920|Ensembl:ENSG00000088386|HPRD:02768|Vega:OTTHUMG00000017255
Gene typeprotein-coding
Map location13q32.3
Pascal p-value0.98
Fetal beta-0.331

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RP11-544M22.10.810.85
NME20.810.83
PHPT10.800.84
NME1-NME20.790.79
NT5C3L0.790.77
C12orf730.770.79
HTRA20.770.79
ARD1A0.770.78
C14orf1790.770.85
CUTA0.770.77
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MYH14-0.58-0.65
PTRF-0.54-0.60
FOXO4-0.53-0.62
ZBTB7B-0.53-0.59
KIF1C-0.53-0.61
MUC5B-0.53-0.60
DAAM2-0.52-0.57
SYNM-0.52-0.51
AF347015.26-0.52-0.58
EPAS1-0.52-0.58

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005427proton-dependent oligopeptide secondary active transmembrane transporter activityIEA-
GO:0005215transporter activityIEA-
GO:0015333peptide:hydrogen symporter activityTAS7896779 
GO:0015293symporter activityIEA-
GO:0015198oligopeptide transporter activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007586digestionTAS7896779 
GO:0006857oligopeptide transportIEA-
GO:0015031protein transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005575cellular_componentND-
GO:0005624membrane fractionTAS7896779 
GO:0016020membraneIEA-
GO:0005887integral to plasma membraneTAS7896779 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413270All SZGR 2.0 genes in this pathway
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 241157All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 9465All SZGR 2.0 genes in this pathway
REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 4936All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367220All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN 291176All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR UP 17496All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN 274165All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648398All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING 246152All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 DN 170105All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462273All SZGR 2.0 genes in this pathway