Gene Page: SPG7

Summary
GeneID  6687
Symbol  SPG7
Synonyms  CAR|CMAR|FLJ37308|MGC126331|MGC126332|PGN|SPG5C
Description  spastic paraplegia 7 (pure and complicated autosomal recessive)
See related  HGNC:11237|MIM:602783|Ensembl:ENSG00000197912|HPRD:04149|
Locus tag  -
Gene type  protein-coding
Map location  16q24.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MRPL90.880.85
RPL26L10.880.87
PSMA70.880.90
ARL30.870.86
DIABLO0.860.86
PSMB70.860.87
SARNP0.860.85
EIF3G0.860.85
ERH0.850.84
PFDN20.850.80
Top 10 negatively co-expressed genes
AF347015.33-0.63-0.66
MT-CO2-0.63-0.61
MT-CYB-0.62-0.65
AF347015.8-0.62-0.63
AF347015.2-0.62-0.65
AF347015.27-0.61-0.64
AF347015.15-0.61-0.65
AF347015.26-0.61-0.66
AF347015.31-0.60-0.61
AF347015.9-0.58-0.65
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003674molecular_functionND-
GO:0005524ATP bindingIEA-
GO:0004222metalloendopeptidase activityIDA11549317 
GO:0004222metalloendopeptidase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0017111nucleoside-triphosphatase activityIEA-
GO:0008233peptidase activityTAS9635427 
GO:0051082unfolded protein bindingTAS9635427 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008089anterograde axon cargo transportIEAaxon (GO term level: 9)-
GO:0007399nervous system developmentTASneurite (GO term level: 5)9635427 
GO:0006508proteolysisTAS9635427 
GO:0007165signal transductionNAS9405655 
GO:0007005mitochondrion organizationIEA-
GO:0030155regulation of cell adhesionNAS9405655 
GO:0030163protein catabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005575cellular_componentND-
GO:0005739mitochondrionTAS9635427 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0031966mitochondrial membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
C1orf103FLJ11269 | RIF1 | RP11-96K19.1chromosome 1 open reading frame 103Two-hybridBioGRID16169070 
KRTAP4-12KAP4.12 | KRTAP4.12keratin associated protein 4-12Two-hybridBioGRID16189514 
MDFII-MF | I-mfaMyoD family inhibitorTwo-hybridBioGRID16189514 
PLSCR1MMTRA1Bphospholipid scramblase 1Two-hybridBioGRID16189514 
RALYHNRPCL2 | MGC117312 | P542RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))Two-hybridBioGRID16169070 
TRIM28FLJ29029 | KAP1 | RNF96 | TF1B | TIF1Btripartite motif-containing 28Two-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
LIU_CMYB_TARGETS_UP 165106All SZGR genes in this pathway
RODRIGUES_NTN1_TARGETS_DN 158102All SZGR genes in this pathway
WANG_CLIM2_TARGETS_UP 269146All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP 276165All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_UP 13983All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP 341197All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP 293179All SZGR genes in this pathway
BARRIER_CANCER_RELAPSE_NORMAL_SAMPLE_DN 3119All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_16Q24_AMPLICON 5338All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_UP 8648All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
GRATIAS_RETINOBLASTOMA_16Q24 1715All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
MOOTHA_MITOCHONDRIA 447277All SZGR genes in this pathway
SENGUPTA_EBNA1_ANTICORRELATED 17385All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway


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