SZGR2

Summary ?

GeneID	6885
Symbol	MAP3K7
Synonyms	MEKK7\|TAK1\|TGF1a
Description	mitogen-activated protein kinase kinase kinase 7
Reference	MIM:602614\|HGNC:HGNC:6859\|Ensembl:ENSG00000135341\|HPRD:04011\|Vega:OTTHUMG00000015217
Gene type	protein-coding
Map location	6q15
Pascal p-value	0.066
Sherlock p-value	0.221
Fetal beta	-0.352
DMG	1 (# studies)

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0024

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg01087382	6	91297190	MAP3K7	9E-8	-0.019	2.06E-5	DMG:Jaffe_2016

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ZBTB10	0.89	0.93
SPIRE1	0.89	0.94
IL17RD	0.89	0.88
MED13	0.88	0.93
RCOR1	0.88	0.91
ZNF192	0.87	0.88
CCNG2	0.87	0.90
BMPR1A	0.87	0.90
RBM12	0.87	0.92
RBM15	0.87	0.91

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AIFM3	-0.65	-0.74
FXYD1	-0.63	-0.84
S100B	-0.63	-0.80
AF347015.31	-0.63	-0.82
HLA-F	-0.63	-0.70
C5orf53	-0.63	-0.69
MT-CO2	-0.62	-0.83
TSC22D4	-0.62	-0.74
AF347015.27	-0.62	-0.79
AF347015.33	-0.62	-0.79

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0000287	magnesium ion binding	IEA		-
GO:0004708	MAP kinase kinase activity	IEA		-
GO:0005515	protein binding	IEA		-
GO:0005515	protein binding	IPI		15075345
GO:0005524	ATP binding	IEA		-
GO:0004674	protein serine/threonine kinase activity	IEA		-
GO:0004713	protein tyrosine kinase activity	IEA		-
GO:0004709	MAP kinase kinase kinase activity	TAS		9466656
GO:0016740	transferase activity	IEA		-
GO:0016301	kinase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000165	MAPKKK cascade	IEA		-
GO:0001525	angiogenesis	IEA		-
GO:0002726	positive regulation of T cell cytokine production	IMP		15125833
GO:0001841	neural tube formation	IEA		-
GO:0006468	protein amino acid phosphorylation	IEA		-
GO:0007252	I-kappaB phosphorylation	IEA		-
GO:0007250	activation of NF-kappaB-inducing kinase activity	IMP		15125833
GO:0007179	transforming growth factor beta receptor signaling pathway	IEA		-
GO:0007179	transforming growth factor beta receptor signaling pathway	TAS		9466656
GO:0043066	negative regulation of apoptosis	IEA		-
GO:0050852	T cell receptor signaling pathway	NAS		15125833
GO:0050870	positive regulation of T cell activation	IC		15125833
GO:0032743	positive regulation of interleukin-2 production	IMP		15125833
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	IEA		-
GO:0046330	positive regulation of JNK cascade	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		9162092 \|9744859 \|10066798 \|12609980

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTG1	ACT \| ACTG \| DFNA20 \| DFNA26	actin, gamma 1	-	HPRD	14743216
CAD	-	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	-	HPRD	14743216
CALM3	PHKD \| PHKD3	calmodulin 3 (phosphorylase kinase, delta)	-	HPRD	14743216
CDC37	P50CDC37	cell division cycle 37 homolog (S. cerevisiae)	-	HPRD	14743216
CHUK	IKBKA \| IKK-alpha \| IKK1 \| IKKA \| NFKBIKA \| TCF16	conserved helix-loop-helix ubiquitous kinase	-	HPRD,BioGRID	10187861
CLTC	CHC \| CHC17 \| CLH-17 \| CLTCL2 \| Hc \| KIAA0034	clathrin, heavy chain (Hc)	-	HPRD	14743216
DARS	DKFZp781B11202 \| MGC111579	aspartyl-tRNA synthetase	-	HPRD	14743216
DDX5	DKFZp686J01190 \| G17P1 \| HLR1 \| HUMP68 \| p68	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	-	HPRD	14743216
DNAJA1	DJ-2 \| DjA1 \| HDJ2 \| HSDJ \| HSJ2 \| HSPF4 \| hDJ-2	DnaJ (Hsp40) homolog, subfamily A, member 1	-	HPRD	14743216
E2F4	E2F-4	E2F transcription factor 4, p107/p130-binding	E2F4 interacts with MAP3K7 promoter.	BIND	15782160
EEF1A1	CCS-3 \| CCS3 \| EEF-1 \| EEF1A \| EF-Tu \| EF1A \| FLJ25721 \| GRAF-1EF \| HNGC:16303 \| LENG7 \| MGC102687 \| MGC131894 \| MGC16224 \| PTI1 \| eEF1A-1	eukaryotic translation elongation factor 1 alpha 1	-	HPRD	14743216
ENO1	ENO1L1 \| MBP-1 \| MPB1 \| NNE \| PPH	enolase 1, (alpha)	-	HPRD	14743216
EPRS	DKFZp313B047 \| EARS \| GLUPRORS \| PARS \| PIG32 \| QARS \| QPRS	glutamyl-prolyl-tRNA synthetase	-	HPRD	14743216
FKBP5	FKBP51 \| FKBP54 \| MGC111006 \| P54 \| PPIase \| Ptg-10	FK506 binding protein 5	-	HPRD	14743216
FLNA	ABP-280 \| ABPX \| DKFZp434P031 \| FLN \| FLN1 \| FMD \| MNS \| NHBP \| OPD \| OPD1 \| OPD2	filamin A, alpha (actin binding protein 280)	-	HPRD	14743216
FOS	AP-1 \| C-FOS	v-fos FBJ murine osteosarcoma viral oncogene homolog	-	HPRD	11397816
HGS	HRS \| ZFYVE8	hepatocyte growth factor-regulated tyrosine kinase substrate	-	HPRD,BioGRID	11397816
HIST1H4I	H4/m \| H4FM \| H4M	histone cluster 1, H4i	-	HPRD	14743216
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	-	HPRD	14743216
HSP90AB1	D6S182 \| FLJ26984 \| HSP90-BETA \| HSP90B \| HSPC2 \| HSPCB	heat shock protein 90kDa alpha (cytosolic), class B member 1	-	HPRD	14743216
HSPA1B	FLJ54328 \| HSP70-1B \| HSP70-2 \| HSPA1A	heat shock 70kDa protein 1B	-	HPRD	14743216
HSPA1L	HSP70-1L \| HSP70-HOM \| HSP70T \| hum70t	heat shock 70kDa protein 1-like	-	HPRD	14743216
HSPA5	BIP \| FLJ26106 \| GRP78 \| MIF2	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	-	HPRD	14743216
HSPA8	HSC54 \| HSC70 \| HSC71 \| HSP71 \| HSP73 \| HSPA10 \| LAP1 \| MGC131511 \| MGC29929 \| NIP71	heat shock 70kDa protein 8	-	HPRD	14743216
HSPA9	CSA \| GRP75 \| HSPA9B \| MGC4500 \| MOT \| MOT2 \| MTHSP75 \| PBP74 \| mot-2	heat shock 70kDa protein 9 (mortalin)	-	HPRD	14743216
IARS	FLJ20736 \| IARS1 \| ILRS \| PRO0785	isoleucyl-tRNA synthetase	-	HPRD	14743216
MAP2K4	JNKK \| JNKK1 \| MAPKK4 \| MEK4 \| MKK4 \| PRKMK4 \| SEK1 \| SERK1	mitogen-activated protein kinase kinase 4	-	HPRD	12556533
MAP2K6	MAPKK6 \| MEK6 \| MKK6 \| PRKMK6 \| SAPKK3	mitogen-activated protein kinase kinase 6	-	HPRD,BioGRID	11460167
MAP3K14	FTDCR1B \| HS \| HSNIK \| NIK	mitogen-activated protein kinase kinase kinase 14	-	HPRD,BioGRID	10094049
MAP3K5	ASK1 \| MAPKKK5 \| MEKK5	mitogen-activated protein kinase kinase kinase 5	-	HPRD,BioGRID	10921914
MAP3K7	TAK1 \| TGF1a	mitogen-activated protein kinase kinase kinase 7	Reconstituted Complex	BioGRID	9556573
MAP3K7IP1	3'-Tab1 \| MGC57664 \| TAB1	mitogen-activated protein kinase kinase kinase 7 interacting protein 1	-	HPRD,BioGRID	10838074
MAP3K7IP1	3'-Tab1 \| MGC57664 \| TAB1	mitogen-activated protein kinase kinase kinase 7 interacting protein 1	An unspecified isoform of TAK1 interacts with TAB1. This interaction was modeled on a demonstrated interaction between TAK1 from an unspecified species and human TAB1.	BIND	9878061
MAP3K7IP1	3'-Tab1 \| MGC57664 \| TAB1	mitogen-activated protein kinase kinase kinase 7 interacting protein 1	-	HPRD	10838074\|14743216
MAP3K7IP2	FLJ21885 \| KIAA0733 \| TAB2	mitogen-activated protein kinase kinase kinase 7 interacting protein 2	-	HPRD,BioGRID	11259596
MAP3K7IP2	FLJ21885 \| KIAA0733 \| TAB2	mitogen-activated protein kinase kinase kinase 7 interacting protein 2	-	HPRD	11259596 \|14743216
MAP3K7IP3	MGC45404 \| NAP1 \| TAB3	mitogen-activated protein kinase kinase kinase 7 interacting protein 3	Affinity Capture-Western	BioGRID	14633987 \|14670075
MAP4K1	HPK1	mitogen-activated protein kinase kinase kinase kinase 1	-	HPRD,BioGRID	10224067
MAP4K4	FLH21957 \| FLJ10410 \| FLJ20373 \| FLJ90111 \| HGK \| KIAA0687 \| NIK	mitogen-activated protein kinase kinase kinase kinase 4	-	HPRD,BioGRID	10807933
MAPK8	JNK \| JNK1 \| JNK1A2 \| JNK21B1/2 \| PRKM8 \| SAPK1	mitogen-activated protein kinase 8	-	HPRD	11865055
NAIP	BIRC1 \| FLJ18088 \| FLJ42520 \| FLJ58811 \| NLRB1 \| psiNAIP	NLR family, apoptosis inhibitory protein	-	HPRD	11865055
NRIP1	FLJ77253 \| RIP140	nuclear receptor interacting protein 1	-	HPRD	9556573
NUDT21	CFIM25 \| CPSF5 \| DKFZp686H1588	nudix (nucleoside diphosphate linked moiety X)-type motif 21	-	HPRD	14743216
PEBP1	HCNP \| PBP \| PEBP \| RKIP	phosphatidylethanolamine binding protein 1	-	HPRD,BioGRID	11585904
PELI3	MGC35521	pellino homolog 3 (Drosophila)	-	HPRD	12874243
PPM1B	MGC21657 \| PP2C-beta-X \| PP2CB \| PP2CBETA \| PPC2BETAX	protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform	-	HPRD,BioGRID	11104763
PPM1L	MGC132545 \| MGC132547 \| PP2C-epsilon \| PP2CE \| PPM1-LIKE	protein phosphatase 1 (formerly 2C)-like	-	HPRD	12556533
RPLP0	L10E \| MGC111226 \| MGC88175 \| P0 \| PRLP0 \| RPP0	ribosomal protein, large, P0	-	HPRD	14743216
RPS3	FLJ26283 \| FLJ27450 \| MGC87870	ribosomal protein S3	-	HPRD	14743216
RUVBL1	ECP54 \| INO80H \| NMP238 \| PONTIN \| Pontin52 \| RVB1 \| TIH1 \| TIP49 \| TIP49A	RuvB-like 1 (E. coli)	-	HPRD	14743216
RUVBL2	CGI-46 \| ECP51 \| INO80J \| REPTIN \| RVB2 \| TIH2 \| TIP48 \| TIP49B	RuvB-like 2 (E. coli)	-	HPRD	14743216
SMAD6	HsT17432 \| MADH6 \| MADH7	SMAD family member 6	-	HPRD,BioGRID	10748100
SMAD7	CRCS3 \| FLJ16482 \| MADH7 \| MADH8	SMAD family member 7	-	HPRD,BioGRID	12589052
STRADB	ALS2CR2 \| CALS-21 \| ILPIP \| ILPIPA \| MGC102916 \| PAPK \| PRO1038	STE20-related kinase adaptor beta	-	HPRD,BioGRID	12048196
TNFRSF11A	CD265 \| FEO \| LOH18CR1 \| ODFR \| OFE \| OPTB7 \| OSTS \| PDB2 \| RANK \| TRANCER	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	-	HPRD,BioGRID	11809792
TRAF2	MGC:45012 \| TRAP \| TRAP3	TNF receptor-associated factor 2	Affinity Capture-Western	BioGRID	14633987
TRAF2	MGC:45012 \| TRAP \| TRAP3	TNF receptor-associated factor 2	-	HPRD	14743216
TRAF3IP2	ACT1 \| C6orf2 \| C6orf4 \| C6orf5 \| C6orf6 \| CIKS \| DKFZp586G0522 \| MGC3581	TRAF3 interacting protein 2	-	HPRD	12089335
TRAF6	MGC:3310 \| RNF85	TNF receptor-associated factor 6	-	HPRD,BioGRID	10094049
TUBA3C	TUBA2 \| bA408E5.3	tubulin, alpha 3c	-	HPRD	14743216
TUBB2A	TUBB \| TUBB2 \| dJ40E16.7	tubulin, beta 2A	-	HPRD	14743216
TUBB2B	DKFZp566F223 \| FLJ98847 \| MGC8685 \| TUBB-PARALOG \| bA506K6.1	tubulin, beta 2B	-	HPRD	14743216
TUBB4	TUBB5 \| beta-5	tubulin, beta 4	-	HPRD	14743216
XIAP	API3 \| BIRC4 \| ILP1 \| MIHA \| XLP2	X-linked inhibitor of apoptosis	-	HPRD,BioGRID	12048196

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG WNT SIGNALING PATHWAY	151	112	All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION	75	53	All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY	102	88	All SZGR 2.0 genes in this pathway
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY	62	47	All SZGR 2.0 genes in this pathway
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY	71	51	All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY	108	89	All SZGR 2.0 genes in this pathway
KEGG LEISHMANIA INFECTION	72	56	All SZGR 2.0 genes in this pathway
BIOCARTA ALK PATHWAY	37	29	All SZGR 2.0 genes in this pathway
BIOCARTA FAS PATHWAY	30	22	All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY	87	68	All SZGR 2.0 genes in this pathway
BIOCARTA NTHI PATHWAY	24	20	All SZGR 2.0 genes in this pathway
BIOCARTA NFKB PATHWAY	23	19	All SZGR 2.0 genes in this pathway
BIOCARTA P38MAPK PATHWAY	40	31	All SZGR 2.0 genes in this pathway
BIOCARTA IL1R PATHWAY	33	29	All SZGR 2.0 genes in this pathway
BIOCARTA TGFB PATHWAY	19	14	All SZGR 2.0 genes in this pathway
BIOCARTA PAR1 PATHWAY	37	28	All SZGR 2.0 genes in this pathway
BIOCARTA TNFR1 PATHWAY	29	21	All SZGR 2.0 genes in this pathway
BIOCARTA TOLL PATHWAY	37	31	All SZGR 2.0 genes in this pathway
BIOCARTA WNT PATHWAY	26	24	All SZGR 2.0 genes in this pathway
ST TUMOR NECROSIS FACTOR PATHWAY	29	20	All SZGR 2.0 genes in this pathway
ST P38 MAPK PATHWAY	37	28	All SZGR 2.0 genes in this pathway
ST JNK MAPK PATHWAY	40	30	All SZGR 2.0 genes in this pathway
PID BCR 5PATHWAY	65	50	All SZGR 2.0 genes in this pathway
PID P38 MKK3 6PATHWAY	26	21	All SZGR 2.0 genes in this pathway
PID WNT NONCANONICAL PATHWAY	32	26	All SZGR 2.0 genes in this pathway
PID PS1 PATHWAY	46	39	All SZGR 2.0 genes in this pathway
PID IL1 PATHWAY	34	28	All SZGR 2.0 genes in this pathway
PID TNF PATHWAY	46	33	All SZGR 2.0 genes in this pathway
PID BMP PATHWAY	42	31	All SZGR 2.0 genes in this pathway
PID TCR JNK PATHWAY	14	11	All SZGR 2.0 genes in this pathway
PID CMYB PATHWAY	84	61	All SZGR 2.0 genes in this pathway
PID EPHRINB REV PATHWAY	30	25	All SZGR 2.0 genes in this pathway
PID TGFBR PATHWAY	55	38	All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING	74	54	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	97	66	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	64	43	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	126	90	All SZGR 2.0 genes in this pathway
REACTOME TCR SIGNALING	54	46	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM TCR SIGNALING	37	32	All SZGR 2.0 genes in this pathway
REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	23	17	All SZGR 2.0 genes in this pathway
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE	50	37	All SZGR 2.0 genes in this pathway
REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	16	9	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	18	12	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS	107	86	All SZGR 2.0 genes in this pathway
REACTOME IL1 SIGNALING	39	30	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION	77	57	All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE	72	53	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX	14	7	All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE	83	63	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING	93	69	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES	118	84	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME NOD1 2 SIGNALING PATHWAY	30	22	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	46	33	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN	431	263	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP	276	165	All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 UP	341	197	All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS DN	73	51	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 UP	121	71	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5	147	89	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE UP	134	93	All SZGR 2.0 genes in this pathway
KIM MYCN AMPLIFICATION TARGETS DN	103	59	All SZGR 2.0 genes in this pathway
LIANG HEMATOPOIESIS STEM CELL NUMBER LARGE VS TINY DN	45	24	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
HASLINGER B CLL WITH 6Q21 DELETION	20	15	All SZGR 2.0 genes in this pathway
LEE AGING NEOCORTEX DN	80	49	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN	271	175	All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP	393	244	All SZGR 2.0 genes in this pathway
HOWLIN CITED1 TARGETS 2 UP	17	10	All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED	728	415	All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN	220	147	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17	181	101	All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS UP	91	59	All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN UP	90	58	All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN	157	106	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN	448	282	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-10	455	462	1A,m8	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	455	462	1A,m8	hsa-miR-10b	UACCCUGUAGAACCGAAUUUGU
miR-103/107	128	134	1A	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	128	134	1A	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-141/200a	84	90	1A	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	84	90	1A	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-143	399	406	1A,m8	hsa-miR-143^brain	UGAGAUGAAGCACUGUAGCUCA
miR-339	454	460	m8	hsa-miR-339	UCCCUGUCCUCCAGGAGCUCA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: MAP3K7