SZGR2

Summary ?

GeneID	70
Symbol	ACTC1
Synonyms	ACTC\|ASD5\|CMD1R\|CMH11\|LVNC4
Description	actin, alpha, cardiac muscle 1
Reference	MIM:102540\|HGNC:HGNC:143\|Ensembl:ENSG00000159251\|HPRD:00015\|Vega:OTTHUMG00000129675
Gene type	protein-coding
Map location	15q14
Pascal p-value	0.006
eGene	Meta

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0172

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0005515	protein binding	IEA		-
GO:0005524	ATP binding	IDA		16611632
GO:0005198	structural molecule activity	IEA		-
GO:0017022	myosin binding	IPI		16611632
GO:0016887	ATPase activity	IDA		16611632 \|17765196
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0055008	cardiac muscle morphogenesis	ISS		-
GO:0055003	cardiac myofibril assembly	ISS		-
GO:0030240	muscle thin filament assembly	ISS		-
GO:0030048	actin filament-based movement	IDA		16611632
GO:0006915	apoptosis	ISS		-
GO:0031032	actomyosin structure organization	ISS		-
GO:0060047	heart contraction	IMP		9563954 \|17611253 \|17947298
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005856	cytoskeleton	IEA		-
GO:0005737	cytoplasm	IEA		-
GO:0031674	I band	ISS		-
GO:0042643	actomyosin, actin part	IDA		16611632

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABLIM3	HMFN1661	actin binding LIM protein family, member 3	-	HPRD,BioGRID	15337165
ABRA	STARS	actin-binding Rho activating protein	-	HPRD	11983702
ACTB	PS1TP5BP1	actin, beta	-	HPRD	8913639
ACTN4	ACTININ-4 \| DKFZp686K23158 \| FSGS \| FSGS1	actinin, alpha 4	-	HPRD	12042308
ACTR2	ARP2	ARP2 actin-related protein 2 homolog (yeast)	-	HPRD,BioGRID	12019562
AFAP1	AFAP \| AFAP-110 \| FLJ56849	actin filament associated protein 1	Reconstituted Complex	BioGRID	12134071
ANG	ALS9 \| HEL168 \| MGC22466 \| MGC71966 \| RNASE4 \| RNASE5	angiogenin, ribonuclease, RNase A family, 5	-	HPRD	8127865
CAPN1	CANP \| CANP1 \| CANPL1 \| muCANP \| muCL	calpain 1, (mu/I) large subunit	CAPN1 interacts with ACTC.	BIND	12358155
CFL1	CFL	cofilin 1 (non-muscle)	-	HPRD	12207032
DMD	BMD \| CMD3B \| DXS142 \| DXS164 \| DXS206 \| DXS230 \| DXS239 \| DXS268 \| DXS269 \| DXS270 \| DXS272	dystrophin	-	HPRD	11997265
DYNLL1	DLC1 \| DLC8 \| DNCL1 \| DNCLC1 \| LC8 \| LC8a \| MGC126137 \| MGC126138 \| PIN \| hdlc1	dynein, light chain, LC8-type 1	-	HPRD	14760703
EPB49	DMT \| FLJ78462 \| FLJ98848	erythrocyte membrane protein band 4.9 (dematin)	-	HPRD	12011427
EZR	CVIL \| CVL \| DKFZp762H157 \| FLJ26216 \| MGC1584 \| VIL2	ezrin	-	HPRD	12271120
FSCN1	FLJ38511 \| SNL \| p55	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	-	HPRD	12139639
GC	DBP \| DBP/GC \| VDBG \| VDBP	group-specific component (vitamin D binding protein)	-	HPRD,BioGRID	12452439 \|12554937
KLHL17	RP11-54O7.6	kelch-like 17 (Drosophila)	-	HPRD	12063253
KPTN	2E4	kaptin (actin binding protein)	-	HPRD	12019562
LASP1	Lasp-1 \| MLN50	LIM and SH3 protein 1	-	HPRD	9848085
MIB2	FLJ20648 \| FLJ39787 \| ZZANK1 \| ZZZ5	mindbomb homolog 2 (Drosophila)	-	HPRD	14507647
MYLK	DKFZp686I10125 \| FLJ12216 \| KRP \| MLCK \| MLCK1 \| MLCK108 \| MLCK210 \| MSTP083 \| MYLK1 \| smMLCK	myosin light chain kinase	-	HPRD	12110694
PLEC1	EBS1 \| EBSO \| HD1 \| PCN \| PLEC1b \| PLTN	plectin 1, intermediate filament binding protein 500kDa	-	HPRD	12136158
PPP1R9B	FLJ30345 \| PPP1R6 \| PPP1R9 \| SPINO \| Spn	protein phosphatase 1, regulatory (inhibitor) subunit 9B	-	HPRD	12270929\|12417592
PRKCE	MGC125656 \| MGC125657 \| PKCE \| nPKC-epsilon	protein kinase C, epsilon	-	HPRD	11968018
SCIN	KIAA1905	scinderin	-	HPRD	12438125
SYNE1	8B \| CPG2 \| DKFZp781J13156 \| FLJ30878 \| FLJ41140 \| KIAA0796 \| KIAA1262 \| KIAA1756 \| MYNE1 \| SCAR8	spectrin repeat containing, nuclear envelope 1	-	HPRD	12408964
SYNE2	DKFZp434H2235 \| DKFZp686E01115 \| DKFZp686H1931 \| FLJ11014 \| FLJ43727 \| FLJ45710 \| FLJ46790 \| KIAA1011 \| NUA \| NUANCE \| Nesprin-2 \| SYNE-2	spectrin repeat containing, nuclear envelope 2	-	HPRD,BioGRID	12118075 \|12408964
TNNI3K	CARK \| MGC142099 \| MGC33828	TNNI3 interacting kinase	-	HPRD,BioGRID	12721663
TWF1	A6 \| MGC23788 \| MGC41876 \| PTK9	twinfilin, actin-binding protein, homolog 1 (Drosophila)	-	HPRD	12207032
WAS	IMD2 \| THC \| WASP	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	-	HPRD	12029088
WIPF1	MGC111041 \| PRPL-2 \| WASPIP \| WIP	WAS/WASL interacting protein family, member 1	-	HPRD	12029088

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CARDIAC MUSCLE CONTRACTION	80	51	All SZGR 2.0 genes in this pathway
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM	85	65	All SZGR 2.0 genes in this pathway
KEGG DILATED CARDIOMYOPATHY	92	68	All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS DN	68	49	All SZGR 2.0 genes in this pathway
PAPASPYRIDONOS UNSTABLE ATEROSCLEROTIC PLAQUE DN	43	29	All SZGR 2.0 genes in this pathway
BERENJENO ROCK SIGNALING NOT VIA RHOA DN	48	34	All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER F	54	32	All SZGR 2.0 genes in this pathway
BENPORATH ES 1	379	235	All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 HELA	164	118	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP	398	262	All SZGR 2.0 genes in this pathway
BHATTACHARYA EMBRYONIC STEM CELL	89	60	All SZGR 2.0 genes in this pathway
GUO HEX TARGETS DN	65	36	All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS UP	214	133	All SZGR 2.0 genes in this pathway
LEE AGING NEOCORTEX DN	80	49	All SZGR 2.0 genes in this pathway
APRELIKOVA BRCA1 TARGETS	49	33	All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION MUSCLE UP	43	33	All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN	312	203	All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS DN	135	88	All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE UP	25	13	All SZGR 2.0 genes in this pathway
KUNINGER IGF1 VS PDGFB TARGETS UP	82	51	All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL	311	205	All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN WITHOUT MGMT 48HR DN	32	25	All SZGR 2.0 genes in this pathway
GENTILE UV LOW DOSE DN	67	46	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM	66	47	All SZGR 2.0 genes in this pathway
LEIN OLIGODENDROCYTE MARKERS	74	53	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN	543	317	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN	353	226	All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE E2	28	21	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP	425	298	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN	435	289	All SZGR 2.0 genes in this pathway
LIU VAV3 PROSTATE CARCINOGENESIS UP	89	61	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 16	79	47	All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN	315	215	All SZGR 2.0 genes in this pathway
WANG NFKB TARGETS	25	15	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-142-5p	148	154	1A	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-299-5p	157	163	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-30-5p	105	112	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-495	102	108	m8	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: ACTC1