Summary ?
GeneID7082
SymbolTJP1
SynonymsZO-1
Descriptiontight junction protein 1
ReferenceMIM:601009|HGNC:HGNC:11827|Ensembl:ENSG00000104067|HPRD:03002|Vega:OTTHUMG00000137397
Gene typeprotein-coding
Map location15q13
Pascal p-value0.27
Sherlock p-value0.002
Fetal beta-0.826
DMG1 (# studies)
eGeneCerebellum
SupportG2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.humanNRC
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWAScatGenome-wide Association StudiesThis data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg124003361530114871TJP18.97E-50.4860.027DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MYLPF0.510.19
MXRA70.510.55
TESC0.500.68
SPOCK30.470.61
ACYP20.470.62
C9orf1030.470.53
CPLX10.460.60
FAM102A0.460.60
PNLDC10.450.57
HABP40.450.60
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
KIAA1211-0.41-0.45
AL033532.1-0.39-0.45
ST8SIA2-0.39-0.45
KIAA1949-0.38-0.50
SEMA4G-0.38-0.40
PNPLA3-0.38-0.44
GMIP-0.38-0.41
TTC28-0.38-0.38
GJC1-0.38-0.46
JUP-0.38-0.42

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI11042084 |12154091 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007043cell-cell junction assemblyTAS8486731 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005923tight junctionIEABrain (GO term level: 10)-
GO:0005923tight junctionTASBrain (GO term level: 10)8486731 
GO:0005737cytoplasmIDA18029348 
GO:0005913cell-cell adherens junctionTAS8486731 
GO:0005886plasma membraneIDA18029348 
GO:0005886plasma membraneIEA-
GO:0016323basolateral plasma membraneIDA16427635 
GO:0030054cell junctionIDA18029348 
GO:0030054cell junctionIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CGNDKFZp779N1112 | FLJ39281 | KIAA1319cingulin-HPRD,BioGRID10613913 |12023291|11042084 
CGNDKFZp779N1112 | FLJ39281 | KIAA1319cingulin-HPRD11042084 
CGNDKFZp779N1112 | FLJ39281 | KIAA1319cingulinCingulin interacts with ZO-1.BIND10613913 
CLDN1CLD1 | ILVASC | SEMP1claudin 1-HPRD,BioGRID10601346 
CLDN2-claudin 2-HPRD,BioGRID10601346 
CLDN3C7orf1 | CPE-R2 | CPETR2 | HRVP1 | RVP1claudin 3-HPRD,BioGRID10601346 
CLDN4CPE-R | CPER | CPETR | CPETR1 | WBSCR8 | hCPE-Rclaudin 4-HPRD,BioGRID10601346 
CLDN5AWAL | BEC1 | CPETRL1 | TMVCFclaudin 5-HPRD,BioGRID10601346 
CLDN6-claudin 6Reconstituted ComplexBioGRID10601346 
CLDN7CEPTRL2 | CPETRL2 | Hs.84359 | claudin-1claudin 7-HPRD,BioGRID10601346 
CLDN8-claudin 8-HPRD,BioGRID10601346 
CTTNEMS1 | FLJ34459cortactin-HPRD9792678|11018051 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID12708492 
F11RCD321 | JAM | JAM-1 | JAM-A | JAM1 | JAMA | JCAM | KAT | PAM-1F11 receptorAffinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID10856295 |12953056 
GJA1CX43 | DFNB38 | GJAL | ODDDgap junction protein, alpha 1, 43kDa-HPRD,BioGRID9707407 
GJA3CX46 | CZP3gap junction protein, alpha 3, 46kDa-HPRD,BioGRID12808044 
GJA8CAE | CAE1 | CX50 | CZP1 | MP70gap junction protein, alpha 8, 50kDa-HPRD,BioGRID12808044 
GJB3CX31 | DFNA2 | EKV | FLJ22486 | MGC102938gap junction protein, beta 3, 31kDa-HPRD12154091 
GJC1CX45 | DKFZp686P0738 | GJA7gap junction protein, gamma 1, 45kDa-HPRD11557048 |12064590|12064590 
GJC1CX45 | DKFZp686P0738 | GJA7gap junction protein, gamma 1, 45kDa-HPRD,BioGRID12064590 
GJD3CX31.9 | Cx30.2 | GJA11 | GJC1gap junction protein, delta 3, 31.9kDaAffinity Capture-Western
Reconstituted Complex
BioGRID12154091 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1-HPRD10862698 
GRIN2DEB11 | NMDAR2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2D-HPRD10862698 
JAM2C21orf43 | CD322 | JAM-B | JAMB | PRO245 | VE-JAM | VEJAMjunctional adhesion molecule 2-HPRD,BioGRID12953056 
JAM3FLJ14529 | JAM-C | JAMCjunctional adhesion molecule 3-HPRD,BioGRID12953056 
KIRRELFLJ10845 | MGC129542 | MGC129543 | NEPH1kin of IRRE like (Drosophila)-HPRD,BioGRID12578837 |12865409 
MLLT4AF-6 | AF6 | AFADIN | FLJ34371 | RP3-431P23.3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4-HPRD,BioGRID10334923 
NPHS1CNF | NPHNnephrosis 1, congenital, Finnish type (nephrin)Reconstituted ComplexBioGRID15331416 
OCLN-occludinAffinity Capture-Western
Reconstituted Complex
BioGRID9792688 |12169098 
OCLN-occludin-HPRD7798316 |9792688 
|10575001 |10601346 
|11700038 |12169098 
PTPN14MGC126803 | PEZ | PTP36protein tyrosine phosphatase, non-receptor type 14-HPRD,BioGRID12808048 
RAB8BFLJ38125RAB8B, member RAS oncogene familyAffinity Capture-WesternBioGRID12639940 
TJP2MGC26306 | X104 | ZO-2 | ZO2tight junction protein 2 (zona occludens 2)Affinity Capture-Western
Reconstituted Complex
BioGRID9792688 |10026224 
|10575001 
TJP2MGC26306 | X104 | ZO-2 | ZO2tight junction protein 2 (zona occludens 2)-HPRD7542259 
TJP3MGC119546 | ZO-3tight junction protein 3 (zona occludens 3)Affinity Capture-WesternBioGRID10575001 
TJP3MGC119546 | ZO-3tight junction protein 3 (zona occludens 3)-HPRD9531559 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ADHERENS JUNCTION 7553All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION 13486All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION 9068All SZGR 2.0 genes in this pathway
KEGG VIBRIO CHOLERAE INFECTION 5632All SZGR 2.0 genes in this pathway
KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION 6844All SZGR 2.0 genes in this pathway
PID ECADHERIN NASCENT AJ PATHWAY 3933All SZGR 2.0 genes in this pathway
PID NEPHRIN NEPH1 PATHWAY 3124All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 4026All SZGR 2.0 genes in this pathway
REACTOME MEMBRANE TRAFFICKING 12974All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY HIPPO 2215All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS 126All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS 14894All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC EXECUTION PHASE 5437All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP 205140All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526357All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 6HR DN 167100All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE UP 283177All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 240 MCF10A 5736All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
BRUNO HEMATOPOIESIS 6648All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND H2O2 3929All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP 206118All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C2 5439All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298200All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504323All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION DN 9867All SZGR 2.0 genes in this pathway
KANG DOXORUBICIN RESISTANCE DN 198All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS DN 14294All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373196All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 2G 17196All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
NADELLA PRKAR1A TARGETS UP 95All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435289All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES DN 210141All SZGR 2.0 genes in this pathway
BAE BRCA1 TARGETS DN 3227All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN DN 15099All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB 14583All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP 271165All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824528All SZGR 2.0 genes in this pathway
VANOEVELEN MYOGENESIS SIN3A TARGETS 220133All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF 222159All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1017417471Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-103/107117811841Ahsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-137109611021Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-142-3p134513511Ahsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-1447407471A,m8hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-18510561062m8hsa-miR-185brainUGGAGAGAAAGGCAGUUC
miR-1912973041A,m8hsa-miR-191brainCAACGGAAUCCCAAAAGCAGCU
miR-1933133191Ahsa-miR-193aAACUGGCCUACAAAGUCCCAG
hsa-miR-193bAACUGGCCCUCAAAGUCCCGCUUU
miR-194116311691Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-330242248m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-335106810741Ahsa-miR-335brainUCAAGAGCAAUAACGAAAAAUGU
miR-45513101316m8hsa-miR-455UAUGUGCCUUUGGACUACAUCG
miR-493-5p488494m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU