SZGR2

Summary ?

GeneID	7082
Symbol	TJP1
Synonyms	ZO-1
Description	tight junction protein 1
Reference	MIM:601009\|HGNC:HGNC:11827\|Ensembl:ENSG00000104067\|HPRD:03002\|Vega:OTTHUMG00000137397
Gene type	protein-coding
Map location	15q13
Pascal p-value	0.27
Sherlock p-value	0.002
Fetal beta	-0.826
DMG	1 (# studies)
eGene	Cerebellum
Support	G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.humanNRC G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWAScat	Genome-wide Association Studies	This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 2

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg12400336	15	30114871	TJP1	8.97E-5	0.486	0.027	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MYLPF	0.51	0.19
MXRA7	0.51	0.55
TESC	0.50	0.68
SPOCK3	0.47	0.61
ACYP2	0.47	0.62
C9orf103	0.47	0.53
CPLX1	0.46	0.60
FAM102A	0.46	0.60
PNLDC1	0.45	0.57
HABP4	0.45	0.60

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
KIAA1211	-0.41	-0.45
AL033532.1	-0.39	-0.45
ST8SIA2	-0.39	-0.45
KIAA1949	-0.38	-0.50
SEMA4G	-0.38	-0.40
PNPLA3	-0.38	-0.44
GMIP	-0.38	-0.41
TTC28	-0.38	-0.38
GJC1	-0.38	-0.46
JUP	-0.38	-0.42

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IEA		-
GO:0005515	protein binding	IPI		11042084 \|12154091
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007043	cell-cell junction assembly	TAS		8486731
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005923	tight junction	IEA	Brain (GO term level: 10)	-
GO:0005923	tight junction	TAS	Brain (GO term level: 10)	8486731
GO:0005737	cytoplasm	IDA		18029348
GO:0005913	cell-cell adherens junction	TAS		8486731
GO:0005886	plasma membrane	IDA		18029348
GO:0005886	plasma membrane	IEA		-
GO:0016323	basolateral plasma membrane	IDA		16427635
GO:0030054	cell junction	IDA		18029348
GO:0030054	cell junction	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CGN	DKFZp779N1112 \| FLJ39281 \| KIAA1319	cingulin	-	HPRD,BioGRID	10613913 \|12023291\|11042084
CGN	DKFZp779N1112 \| FLJ39281 \| KIAA1319	cingulin	-	HPRD	11042084
CGN	DKFZp779N1112 \| FLJ39281 \| KIAA1319	cingulin	Cingulin interacts with ZO-1.	BIND	10613913
CLDN1	CLD1 \| ILVASC \| SEMP1	claudin 1	-	HPRD,BioGRID	10601346
CLDN2	-	claudin 2	-	HPRD,BioGRID	10601346
CLDN3	C7orf1 \| CPE-R2 \| CPETR2 \| HRVP1 \| RVP1	claudin 3	-	HPRD,BioGRID	10601346
CLDN4	CPE-R \| CPER \| CPETR \| CPETR1 \| WBSCR8 \| hCPE-R	claudin 4	-	HPRD,BioGRID	10601346
CLDN5	AWAL \| BEC1 \| CPETRL1 \| TMVCF	claudin 5	-	HPRD,BioGRID	10601346
CLDN6	-	claudin 6	Reconstituted Complex	BioGRID	10601346
CLDN7	CEPTRL2 \| CPETRL2 \| Hs.84359 \| claudin-1	claudin 7	-	HPRD,BioGRID	10601346
CLDN8	-	claudin 8	-	HPRD,BioGRID	10601346
CTTN	EMS1 \| FLJ34459	cortactin	-	HPRD	9792678\|11018051
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	-	HPRD,BioGRID	12708492
F11R	CD321 \| JAM \| JAM-1 \| JAM-A \| JAM1 \| JAMA \| JCAM \| KAT \| PAM-1	F11 receptor	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10856295 \|12953056
GJA1	CX43 \| DFNB38 \| GJAL \| ODDD	gap junction protein, alpha 1, 43kDa	-	HPRD,BioGRID	9707407
GJA3	CX46 \| CZP3	gap junction protein, alpha 3, 46kDa	-	HPRD,BioGRID	12808044
GJA8	CAE \| CAE1 \| CX50 \| CZP1 \| MP70	gap junction protein, alpha 8, 50kDa	-	HPRD,BioGRID	12808044
GJB3	CX31 \| DFNA2 \| EKV \| FLJ22486 \| MGC102938	gap junction protein, beta 3, 31kDa	-	HPRD	12154091
GJC1	CX45 \| DKFZp686P0738 \| GJA7	gap junction protein, gamma 1, 45kDa	-	HPRD	11557048 \|12064590\|12064590
GJC1	CX45 \| DKFZp686P0738 \| GJA7	gap junction protein, gamma 1, 45kDa	-	HPRD,BioGRID	12064590
GJD3	CX31.9 \| Cx30.2 \| GJA11 \| GJC1	gap junction protein, delta 3, 31.9kDa	Affinity Capture-Western Reconstituted Complex	BioGRID	12154091
GRIN1	NMDA1 \| NMDAR1 \| NR1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	-	HPRD	10862698
GRIN2D	EB11 \| NMDAR2D	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	-	HPRD	10862698
JAM2	C21orf43 \| CD322 \| JAM-B \| JAMB \| PRO245 \| VE-JAM \| VEJAM	junctional adhesion molecule 2	-	HPRD,BioGRID	12953056
JAM3	FLJ14529 \| JAM-C \| JAMC	junctional adhesion molecule 3	-	HPRD,BioGRID	12953056
KIRREL	FLJ10845 \| MGC129542 \| MGC129543 \| NEPH1	kin of IRRE like (Drosophila)	-	HPRD,BioGRID	12578837 \|12865409
MLLT4	AF-6 \| AF6 \| AFADIN \| FLJ34371 \| RP3-431P23.3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	-	HPRD,BioGRID	10334923
NPHS1	CNF \| NPHN	nephrosis 1, congenital, Finnish type (nephrin)	Reconstituted Complex	BioGRID	15331416
OCLN	-	occludin	Affinity Capture-Western Reconstituted Complex	BioGRID	9792688 \|12169098
OCLN	-	occludin	-	HPRD	7798316 \|9792688 \|10575001 \|10601346 \|11700038 \|12169098
PTPN14	MGC126803 \| PEZ \| PTP36	protein tyrosine phosphatase, non-receptor type 14	-	HPRD,BioGRID	12808048
RAB8B	FLJ38125	RAB8B, member RAS oncogene family	Affinity Capture-Western	BioGRID	12639940
TJP2	MGC26306 \| X104 \| ZO-2 \| ZO2	tight junction protein 2 (zona occludens 2)	Affinity Capture-Western Reconstituted Complex	BioGRID	9792688 \|10026224 \|10575001
TJP2	MGC26306 \| X104 \| ZO-2 \| ZO2	tight junction protein 2 (zona occludens 2)	-	HPRD	7542259
TJP3	MGC119546 \| ZO-3	tight junction protein 3 (zona occludens 3)	Affinity Capture-Western	BioGRID	10575001
TJP3	MGC119546 \| ZO-3	tight junction protein 3 (zona occludens 3)	-	HPRD	9531559

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG ADHERENS JUNCTION	75	53	All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION	134	86	All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION	90	68	All SZGR 2.0 genes in this pathway
KEGG VIBRIO CHOLERAE INFECTION	56	32	All SZGR 2.0 genes in this pathway
KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION	68	44	All SZGR 2.0 genes in this pathway
PID ECADHERIN NASCENT AJ PATHWAY	39	33	All SZGR 2.0 genes in this pathway
PID NEPHRIN NEPH1 PATHWAY	31	24	All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	40	26	All SZGR 2.0 genes in this pathway
REACTOME MEMBRANE TRAFFICKING	129	74	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY HIPPO	22	15	All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	12	6	All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS	148	94	All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC EXECUTION PHASE	54	37	All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP	205	140	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN	526	357	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 6HR DN	167	100	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP	769	437	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE UP	283	177	All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 240 MCF10A	57	36	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP	398	262	All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION	475	313	All SZGR 2.0 genes in this pathway
BRUNO HEMATOPOIESIS	66	48	All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND H2O2	39	29	All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP	206	118	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C2	54	39	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN	298	200	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN	504	323	All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION DN	98	67	All SZGR 2.0 genes in this pathway
KANG DOXORUBICIN RESISTANCE DN	19	8	All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS DN	142	94	All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN	373	196	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 2G	171	96	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
NADELLA PRKAR1A TARGETS UP	9	5	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN	435	289	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES DN	210	141	All SZGR 2.0 genes in this pathway
BAE BRCA1 TARGETS DN	32	27	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN DN	150	99	All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB	145	83	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP	271	165	All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3	824	528	All SZGR 2.0 genes in this pathway
VANOEVELEN MYOGENESIS SIN3A TARGETS	220	133	All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF	222	159	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	741	747	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-103/107	1178	1184	1A	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	1178	1184	1A	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-137	1096	1102	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-142-3p	1345	1351	1A	hsa-miR-142-3p	UGUAGUGUUUCCUACUUUAUGGA
miR-144	740	747	1A,m8	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-185	1056	1062	m8	hsa-miR-185^brain	UGGAGAGAAAGGCAGUUC
miR-191	297	304	1A,m8	hsa-miR-191^brain	CAACGGAAUCCCAAAAGCAGCU
miR-193	313	319	1A	hsa-miR-193a	AACUGGCCUACAAAGUCCCAG
miR-193	313	319	1A	hsa-miR-193b	AACUGGCCCUCAAAGUCCCGCUUU
miR-194	1163	1169	1A	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-330	242	248	m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-335	1068	1074	1A	hsa-miR-335^brain	UCAAGAGCAAUAACGAAAAAUGU
miR-455	1310	1316	m8	hsa-miR-455	UAUGUGCCUUUGGACUACAUCG
miR-493-5p	488	494	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: TJP1