Gene Page: CALCA

Summary ?
GeneID796
SymbolCALCA
SynonymsCALC1|CGRP|CGRP-I|CGRP1|CT|KC|PCT
Descriptioncalcitonin related polypeptide alpha
ReferenceMIM:114130|HGNC:HGNC:1437|Ensembl:ENSG00000110680|HPRD:00238|Vega:OTTHUMG00000159731
Gene typeprotein-coding
Map location11p15.2
Pascal p-value0.706
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 4
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg268331691114994045CALCA4.48E-5-0.3810.021DMG:Wockner_2014
cg091889801114993378CALCA1E-4-0.530.028DMG:Wockner_2014
cg257833521114993509CALCA1.029E-4-0.4490.028DMG:Wockner_2014
cg228635231114995201CALCA3.306E-40.9390.041DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GOLIM40.810.83
COBLL10.780.79
TLN10.750.81
PTRF0.730.76
CGNL10.720.78
FYCO10.720.82
COL14A10.710.73
GIMAP80.710.74
MYH110.710.71
FAM129A0.700.73
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ZNF32-0.49-0.59
COMMD3-0.47-0.56
NDUFAF2-0.47-0.55
PFDN5-0.47-0.59
PHPT1-0.46-0.57
OXSM-0.46-0.54
C11orf73-0.46-0.54
MRPS24-0.46-0.50
AC034193.4-0.46-0.50
DCTN3-0.46-0.49

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005179hormone activityIEA-
GO:0031716calcitonin receptor bindingIEA-
GO:0031716calcitonin receptor bindingIPI8078488 |8940110 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007218neuropeptide signaling pathwayIEANeurotransmitter (GO term level: 8)-
GO:0001984vasodilation of artery during baroreceptor response to increased systemic arterial blood pressureIEA-
GO:0002027regulation of heart rateIEA-
GO:0001944vasculature developmentIDA17267696 
GO:0001935endothelial cell proliferationIDA17267696 
GO:0001976regulation of systemic arterial blood pressure by neurological processIDA10642343 
GO:0007190activation of adenylate cyclase activityIDA10822112 |16014619 
GO:0007267cell-cell signalingTAS2408883 
GO:0009408response to heatIEA-
GO:0007631feeding behaviorIEA-
GO:0007566embryo implantationIDA17983652 
GO:0006954inflammatory responseIEA-
GO:0007159leukocyte adhesionIDA1326102 
GO:0016481negative regulation of transcriptionIDA11014233 
GO:0050965detection of temperature stimulus involved in sensory perception of painIEA-
GO:0032757positive regulation of interleukin-8 productionIDA16904178 
GO:0032730positive regulation of interleukin-1 alpha productionIDA16904178 
GO:0048265response to painIEA-
GO:0030279negative regulation of ossificationIEA-
GO:0031645negative regulation of neurological system processIEA-
GO:0032147activation of protein kinase activityIDA17983652 
GO:0045779negative regulation of bone resorptionIDA10822112 |17241109 
GO:0045778positive regulation of ossificationIEA-
GO:0045651positive regulation of macrophage differentiationIDA10822112 
GO:0045762positive regulation of adenylate cyclase activityIDA8078488 |11014233 
GO:0045909positive regulation of vasodilationIDA3266556 
GO:0045671negative regulation of osteoclast differentiationIDA10822112 
GO:0043542endothelial cell migrationIDA17267696 
GO:0045986negative regulation of smooth muscle contractionIEA-
GO:0045776negative regulation of blood pressureIDA10642343 
GO:0051480cytosolic calcium ion homeostasisIDA9685362 
GO:0051482elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)IDA8078488 |9685362 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043025cell somaIEAaxon, dendrite (GO term level: 4)-
GO:0043195terminal buttonIEAaxon, Synap, Neurotransmitter (GO term level: 8)-
GO:0030424axonIEAneuron, axon, Neurotransmitter (GO term level: 6)-
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIDA2408883 |18057382 
GO:0005622intracellularIEA-
GO:0005737cytoplasmIDA17267696 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS 8858All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA S SIGNALLING EVENTS 12182All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
REACTOME AMYLOIDS 8363All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239157All SZGR 2.0 genes in this pathway
TANAKA METHYLATED IN ESOPHAGEAL CARCINOMA 10358All SZGR 2.0 genes in this pathway
SCHLESINGER METHYLATED DE NOVO IN CANCER 8864All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP 176115All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR DN 5745All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487286All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT DN 10267All SZGR 2.0 genes in this pathway
BRUNO HEMATOPOIESIS 6648All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430288All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS MODEL DN 4328All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293203All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14 14386All SZGR 2.0 genes in this pathway
KOHOUTEK CCNT2 TARGETS 5835All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-488247253m8hsa-miR-488CCCAGAUAAUGGCACUCUCAA