Gene Page: NME5
Summary ?
| GeneID | 8382 |
| Symbol | NME5 |
| Synonyms | NM23-H5|NM23H5|RSPH23 |
| Description | NME/NM23 family member 5 |
| Reference | MIM:603575|HGNC:HGNC:7853|Ensembl:ENSG00000112981|HPRD:04655|Vega:OTTHUMG00000129207 |
| Gene type | protein-coding |
| Map location | 5q31 |
| Pascal p-value | 0.037 |
| Sherlock p-value | 0.807 |
| eGene | Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.0032 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CSE1L | 0.94 | 0.94 |
| COPB1 | 0.93 | 0.94 |
| KARS | 0.92 | 0.93 |
| CCT5 | 0.92 | 0.93 |
| CCT8 | 0.92 | 0.94 |
| CCT6A | 0.92 | 0.94 |
| DYM | 0.92 | 0.93 |
| MKI67IP | 0.91 | 0.92 |
| ZNF410 | 0.91 | 0.91 |
| USP39 | 0.91 | 0.93 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.33 | -0.76 | -0.86 |
| AF347015.27 | -0.75 | -0.84 |
| MT-CO2 | -0.75 | -0.84 |
| AF347015.8 | -0.75 | -0.85 |
| MT-CYB | -0.73 | -0.83 |
| AF347015.15 | -0.72 | -0.84 |
| HLA-F | -0.72 | -0.79 |
| AF347015.31 | -0.72 | -0.81 |
| AF347015.2 | -0.71 | -0.84 |
| FXYD1 | -0.71 | -0.81 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005524 | ATP binding | IEA | - | |
| GO:0004550 | nucleoside diphosphate kinase activity | TAS | 9742940 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0009116 | nucleoside metabolic process | TAS | 9742940 | |
| GO:0007286 | spermatid development | ISS | - | |
| GO:0006241 | CTP biosynthetic process | IEA | - | |
| GO:0006228 | UTP biosynthetic process | IEA | - | |
| GO:0006183 | GTP biosynthetic process | IEA | - | |
| GO:0006916 | anti-apoptosis | ISS | - | |
| GO:0007275 | multicellular organismal development | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005575 | cellular_component | ND | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG PURINE METABOLISM | 159 | 96 | All SZGR 2.0 genes in this pathway |
| KEGG PYRIMIDINE METABOLISM | 98 | 53 | All SZGR 2.0 genes in this pathway |
| SOTIRIOU BREAST CANCER GRADE 1 VS 3 DN | 52 | 34 | All SZGR 2.0 genes in this pathway |
| GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN | 493 | 298 | All SZGR 2.0 genes in this pathway |
| VECCHI GASTRIC CANCER EARLY DN | 367 | 220 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| PATIL LIVER CANCER | 747 | 453 | All SZGR 2.0 genes in this pathway |
| LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL DN | 114 | 58 | All SZGR 2.0 genes in this pathway |
| KIM MYCN AMPLIFICATION TARGETS DN | 103 | 59 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 2 | 473 | 224 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL DN | 701 | 446 | All SZGR 2.0 genes in this pathway |
| FIRESTEIN PROLIFERATION | 175 | 125 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 DN | 448 | 282 | All SZGR 2.0 genes in this pathway |