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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: NCK2

Summary

GeneID

8440

Symbol

NCK2

Synonyms

GRB4|NCKbeta

Description

NCK adaptor protein 2

Locus tag

Gene type

protein-coding

Map location

2q12

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.0004

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.00755

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0995

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

SLC12A5

0.97

0.90

EHD3

0.96

0.90

MAP1A

0.96

0.93

SCN2B

0.95

0.92

RAB11FIP5

0.95

0.82

IQSEC3

0.94

0.90

ZFYVE28

0.94

0.91

PTPRN

0.93

0.90

LYNX1

0.93

0.91

RPH3A

0.93

0.94

Top 10 negatively co-expressed genes

BCL7C

-0.58

-0.69

C9orf46

-0.55

-0.64

GTF3C6

-0.54

-0.57

TRAF4

-0.54

-0.63

RPL23A

-0.53

-0.66

TUBB2B

-0.52

-0.60

EXOSC8

-0.52

-0.56

FADS2

-0.52

-0.47

DYNLT1

-0.52

-0.69

KIAA1949

-0.52

-0.47

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005515

protein binding

IPI

12110186

GO:0008093

cytoskeletal adaptor activity

NAS

12110186

GO:0030159

receptor signaling complex scaffold activity

NAS

12110186

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006417

regulation of translation

IEA

GO:0007176

regulation of epidermal growth factor receptor activity

TAS

9737977

GO:0007173

epidermal growth factor receptor signaling pathway

TAS

9737977

GO:0007172

signal complex assembly

NAS

12110186

GO:0007165

signal transduction

TAS

9737977

GO:0008285

negative regulation of cell proliferation

TAS

9737977

GO:0007015

actin filament organization

IEA

GO:0016477

cell migration

IEA

GO:0042110

T cell activation

NAS

12110186

GO:0042102

positive regulation of T cell proliferation

IMP

12110186

GO:0030838

positive regulation of actin filament polymerization

IMP

12110186

GO:0030032

lamellipodium biogenesis

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0012506

vesicle membrane

IEA

GO:0005737

cytoplasm

NAS

12110186

GO:0005783

endoplasmic reticulum

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABI1	ABI-1 \| E3B1 \| NAP1BP \| SSH3BP \| SSH3BP1	abl-interactor 1	-	HPRD	11557983
ABI2	ABI-2 \| ABI2B \| AIP-1 \| AblBP3 \| SSH3BP2 \| argBPIA \| argBPIB	abl interactor 2	Two-hybrid	BioGRID	16189514
AXIN1	AXIN \| MGC52315	axin 1	-	HPRD	11557983
AXL	JTK11 \| UFO	AXL receptor tyrosine kinase	Axl interacts with an unspecified isoform of Nck2.	BIND	12470648
BCR	ALL \| BCR-ABL1 \| BCR1 \| CML \| D22S11 \| D22S662 \| FLJ16453 \| PHL	breakpoint cluster region	-	HPRD	10887126
CBLB	DKFZp686J10223 \| DKFZp779A0729 \| DKFZp779F1443 \| FLJ36865 \| FLJ41152 \| Nbla00127 \| RNF56	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	Two-hybrid	BioGRID	16189514
CD3E	FLJ18683 \| T3E \| TCRE	CD3e molecule, epsilon (CD3-TCR complex)	-	HPRD,BioGRID	12110186
CPSF6	CFIM \| CFIM68 \| HPBRII-4 \| HPBRII-7	cleavage and polyadenylation specific factor 6, 68kDa	Two-hybrid	BioGRID	16189514
DNM1	DNM	dynamin 1	-	HPRD	11557983
DOCK1	DOCK180 \| ced5	dedicator of cytokinesis 1	-	HPRD,BioGRID	11240126
DOK1	MGC117395 \| MGC138860 \| P62DOK	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	-	HPRD,BioGRID	9737977
EEF1G	EF1G \| GIG35	eukaryotic translation elongation factor 1 gamma	Two-hybrid	BioGRID	16169070
EFNB1	CFND \| CFNS \| EFL3 \| EPLG2 \| Elk-L \| LERK2 \| MGC8782	ephrin-B1	-	HPRD	11557983
EFNB2	EPLG5 \| HTKL \| Htk-L \| LERK5 \| MGC126226 \| MGC126227 \| MGC126228	ephrin-B2	-	HPRD	12206665
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	Affinity Capture-Western Reconstituted Complex	BioGRID	9737977 \|10026169
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA		-	HPRD	1333047 \|9737977
FGFR1	BFGFR \| CD331 \| CEK \| FGFBR \| FLG \| FLJ99988 \| FLT2 \| HBGFR \| KAL2 \| N-SAM	fibroblast growth factor receptor 1	An unspecified isoform of FGFR1 interacts with NCK2. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human NCK2.	BIND	15117958
FLJ12529	FLJ39024 \| MGC9315	pre-mRNA cleavage factor I, 59 kDa subunit	Two-hybrid	BioGRID	16189514
FXR2	FMR1L2	fragile X mental retardation, autosomal homolog 2	Two-hybrid	BioGRID	16189514
HNRNPK	CSBP \| FLJ41122 \| HNRPK \| TUNP	heterogeneous nuclear ribonucleoprotein K	-	HPRD	11557983
HNRNPK	CSBP \| FLJ41122 \| HNRPK \| TUNP	heterogeneous nuclear ribonucleoprotein K	Two-hybrid	BioGRID	16189514
ILK	DKFZp686F1765 \| P59	integrin-linked kinase	-	HPRD,BioGRID	10022929
KIAA1217	DKFZp761L0424 \| MGC31990 \| SKT	KIAA1217	Two-hybrid	BioGRID	16189514
LIMS1	PINCH \| PINCH1	LIM and senescent cell antigen-like domains 1	Nck-2 interacts with PINCH	BIND	9843575
LIMS1	PINCH \| PINCH1	LIM and senescent cell antigen-like domains 1	-	HPRD,BioGRID	9843575
NCKIPSD	AF3P21 \| DIP \| DIP1 \| MGC23891 \| ORF1 \| SPIN90 \| WASLBP \| WISH	NCK interacting protein with SH3 domain	Two-hybrid	BioGRID	16189514
NTRK2	GP145-TrkB \| TRKB	neurotrophic tyrosine kinase, receptor, type 2	-	HPRD,BioGRID	12074588
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	-	HPRD,BioGRID	10026169 \|11557983
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	-	HPRD,BioGRID	11027258
PKN2	MGC150606 \| MGC71074 \| PAK2 \| PRK2 \| PRKCL2 \| PRO2042 \| Pak-2	protein kinase N2	-	HPRD,BioGRID	10026169
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	-	HPRD,BioGRID	11950595
SF3B4	MGC10828 \| SAP49 \| SF3b49	splicing factor 3b, subunit 4, 49kDa	Two-hybrid	BioGRID	16189514
SOS1	GF1 \| GGF1 \| GINGF \| HGF \| NS4	son of sevenless homolog 1 (Drosophila)	-	HPRD,BioGRID	10026169
TRIP6	MGC10556 \| MGC10558 \| MGC29959 \| MGC3837 \| MGC4423 \| OIP1 \| ZRP-1	thyroid hormone receptor interactor 6	Two-hybrid	BioGRID	16189514
WBP11	DKFZp779M1063 \| NPWBP \| SIPP1	WW domain binding protein 11	Two-hybrid	BioGRID	16189514
WIPF2	WICH \| WIRE	WAS/WASL interacting protein family, member 2	-	HPRD,BioGRID	12213210

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_ERBB_SIGNALING_PATHWAY	87	71	All SZGR genes in this pathway
KEGG_AXON_GUIDANCE	129	103	All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY	108	89	All SZGR genes in this pathway
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION	59	36	All SZGR genes in this pathway
PID_INSULIN_PATHWAY	45	32	All SZGR genes in this pathway
PID_MET_PATHWAY	80	60	All SZGR genes in this pathway
PID_REELIN_PATHWAY	29	29	All SZGR genes in this pathway
PID_ILK_PATHWAY	45	32	All SZGR genes in this pathway
PID_IGF1_PATHWAY	30	23	All SZGR genes in this pathway
PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY	35	29	All SZGR genes in this pathway
PID_PDGFRB_PATHWAY	129	103	All SZGR genes in this pathway
PID_NEPHRIN_NEPH1_PATHWAY	31	24	All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY	69	57	All SZGR genes in this pathway
PID_EPHRINB_REV_PATHWAY	30	25	All SZGR genes in this pathway
PID_FAK_PATHWAY	59	45	All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY	396	292	All SZGR genes in this pathway
REACTOME_CELL_CELL_COMMUNICATION	120	77	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF	122	93	All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION	95	76	All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE	251	188	All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_RAC	14	11	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ROBO_RECEPTOR	30	26	All SZGR genes in this pathway
REACTOME_NEPHRIN_INTERACTIONS	20	15	All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP	485	293	All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_DN	104	59	All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP	544	308	All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_CD4_DN	116	71	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN	770	415	All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN	514	319	All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN	584	395	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP	487	286	All SZGR genes in this pathway
SWEET_KRAS_TARGETS_UP	84	51	All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN	830	547	All SZGR genes in this pathway
SU_THYMUS	20	12	All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_DN	373	196	All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3	491	310	All SZGR genes in this pathway
ZHENG_FOXP3_TARGETS_IN_THYMUS_UP	196	137	All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_DN	220	147	All SZGR genes in this pathway
HANN_RESISTANCE_TO_BCL2_INHIBITOR_DN	48	31	All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN	940	425	All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G12_UP	39	17	All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_UP	178	108	All SZGR genes in this pathway
KAPOSI_LIVER_CANCER_MET_UP	18	11	All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION	422	277	All SZGR genes in this pathway
CHANDRAN_METASTASIS_UP	221	135	All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_DN	116	83	All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN	321	200	All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF	367	231	All SZGR genes in this pathway
DURAND_STROMA_S_UP	297	194	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	1006	1012	m8	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-124/506	536	542	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	536	542	m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-183	643	649	m8	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-186	971	977	1A	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-200bc/429	1085	1091	1A	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-25/32/92/363/367	555	561	1A	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-30-5p	884	890	1A	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-339	866	872	1A	hsa-miR-339	UCCCUGUCCUCCAGGAGCUCA
miR-369-3p	1086	1092	m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-455	1003	1009	m8	hsa-miR-455	UAUGUGCCUUUGGACUACAUCG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.