Summary ?
GeneID8440
SymbolNCK2
SynonymsGRB4|NCKbeta
DescriptionNCK adaptor protein 2
ReferenceMIM:604930|HGNC:HGNC:7665|Ensembl:ENSG00000071051|HPRD:05378|Vega:OTTHUMG00000153116
Gene typeprotein-coding
Map location2q12
Pascal p-value0.032
Fetal beta0.824
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GSMA_IGenome scan meta-analysisPsr: 0.0004 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00755 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0995 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg202688932106362547NCK26.85E-50.7640.024DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs12447283chr1665595638NCK284400.19trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SLC12A50.970.90
EHD30.960.90
MAP1A0.960.93
SCN2B0.950.92
RAB11FIP50.950.82
IQSEC30.940.90
ZFYVE280.940.91
PTPRN0.930.90
LYNX10.930.91
RPH3A0.930.94
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
BCL7C-0.58-0.69
C9orf46-0.55-0.64
GTF3C6-0.54-0.57
TRAF4-0.54-0.63
RPL23A-0.53-0.66
TUBB2B-0.52-0.60
EXOSC8-0.52-0.56
FADS2-0.52-0.47
DYNLT1-0.52-0.69
KIAA1949-0.52-0.47

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12110186 
GO:0008093cytoskeletal adaptor activityNAS12110186 
GO:0030159receptor signaling complex scaffold activityNAS12110186 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006417regulation of translationIEA-
GO:0007176regulation of epidermal growth factor receptor activityTAS9737977 
GO:0007173epidermal growth factor receptor signaling pathwayTAS9737977 
GO:0007172signal complex assemblyNAS12110186 
GO:0007165signal transductionTAS9737977 
GO:0008285negative regulation of cell proliferationTAS9737977 
GO:0007015actin filament organizationIEA-
GO:0016477cell migrationIEA-
GO:0042110T cell activationNAS12110186 
GO:0042102positive regulation of T cell proliferationIMP12110186 
GO:0030838positive regulation of actin filament polymerizationIMP12110186 
GO:0030032lamellipodium biogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0012506vesicle membraneIEA-
GO:0005737cytoplasmNAS12110186 
GO:0005783endoplasmic reticulumIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABI1ABI-1 | E3B1 | NAP1BP | SSH3BP | SSH3BP1abl-interactor 1-HPRD11557983 
ABI2ABI-2 | ABI2B | AIP-1 | AblBP3 | SSH3BP2 | argBPIA | argBPIBabl interactor 2Two-hybridBioGRID16189514 
AXIN1AXIN | MGC52315axin 1-HPRD11557983 
AXLJTK11 | UFOAXL receptor tyrosine kinaseAxl interacts with an unspecified isoform of Nck2.BIND12470648 
BCRALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHLbreakpoint cluster region-HPRD10887126 
CBLBDKFZp686J10223 | DKFZp779A0729 | DKFZp779F1443 | FLJ36865 | FLJ41152 | Nbla00127 | RNF56Cas-Br-M (murine) ecotropic retroviral transforming sequence bTwo-hybridBioGRID16189514 
CD3EFLJ18683 | T3E | TCRECD3e molecule, epsilon (CD3-TCR complex)-HPRD,BioGRID12110186 
CPSF6CFIM | CFIM68 | HPBRII-4 | HPBRII-7cleavage and polyadenylation specific factor 6, 68kDaTwo-hybridBioGRID16189514 
DNM1DNMdynamin 1-HPRD11557983 
DOCK1DOCK180 | ced5dedicator of cytokinesis 1-HPRD,BioGRID11240126 
DOK1MGC117395 | MGC138860 | P62DOKdocking protein 1, 62kDa (downstream of tyrosine kinase 1)-HPRD,BioGRID9737977 
EEF1GEF1G | GIG35eukaryotic translation elongation factor 1 gammaTwo-hybridBioGRID16169070 
EFNB1CFND | CFNS | EFL3 | EPLG2 | Elk-L | LERK2 | MGC8782ephrin-B1-HPRD11557983 
EFNB2EPLG5 | HTKL | Htk-L | LERK5 | MGC126226 | MGC126227 | MGC126228ephrin-B2-HPRD12206665 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)Affinity Capture-Western
Reconstituted Complex
BioGRID9737977 |10026169 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD1333047 |9737977 
FGFR1BFGFR | CD331 | CEK | FGFBR | FLG | FLJ99988 | FLT2 | HBGFR | KAL2 | N-SAMfibroblast growth factor receptor 1An unspecified isoform of FGFR1 interacts with NCK2. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human NCK2.BIND15117958 
FLJ12529FLJ39024 | MGC9315pre-mRNA cleavage factor I, 59 kDa subunitTwo-hybridBioGRID16189514 
FXR2FMR1L2fragile X mental retardation, autosomal homolog 2Two-hybridBioGRID16189514 
HNRNPKCSBP | FLJ41122 | HNRPK | TUNPheterogeneous nuclear ribonucleoprotein K-HPRD11557983 
HNRNPKCSBP | FLJ41122 | HNRPK | TUNPheterogeneous nuclear ribonucleoprotein KTwo-hybridBioGRID16189514 
ILKDKFZp686F1765 | P59integrin-linked kinase-HPRD,BioGRID10022929 
KIAA1217DKFZp761L0424 | MGC31990 | SKTKIAA1217Two-hybridBioGRID16189514 
LIMS1PINCH | PINCH1LIM and senescent cell antigen-like domains 1Nck-2 interacts with PINCHBIND9843575 
LIMS1PINCH | PINCH1LIM and senescent cell antigen-like domains 1-HPRD,BioGRID9843575 
NCKIPSDAF3P21 | DIP | DIP1 | MGC23891 | ORF1 | SPIN90 | WASLBP | WISHNCK interacting protein with SH3 domainTwo-hybridBioGRID16189514 
NTRK2GP145-TrkB | TRKBneurotrophic tyrosine kinase, receptor, type 2-HPRD,BioGRID12074588 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1-HPRD,BioGRID10026169 |11557983 
PDGFRBCD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1platelet-derived growth factor receptor, beta polypeptide-HPRD,BioGRID11027258 
PKN2MGC150606 | MGC71074 | PAK2 | PRK2 | PRKCL2 | PRO2042 | Pak-2protein kinase N2-HPRD,BioGRID10026169 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD,BioGRID11950595 
SF3B4MGC10828 | SAP49 | SF3b49splicing factor 3b, subunit 4, 49kDaTwo-hybridBioGRID16189514 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)-HPRD,BioGRID10026169 
TRIP6MGC10556 | MGC10558 | MGC29959 | MGC3837 | MGC4423 | OIP1 | ZRP-1thyroid hormone receptor interactor 6Two-hybridBioGRID16189514 
WBP11DKFZp779M1063 | NPWBP | SIPP1WW domain binding protein 11Two-hybridBioGRID16189514 
WIPF2WICH | WIREWAS/WASL interacting protein family, member 2-HPRD,BioGRID12213210 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ERBB SIGNALING PATHWAY 8771All SZGR 2.0 genes in this pathway
KEGG AXON GUIDANCE 129103All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 10889All SZGR 2.0 genes in this pathway
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION 5936All SZGR 2.0 genes in this pathway
PID INSULIN PATHWAY 4532All SZGR 2.0 genes in this pathway
PID MET PATHWAY 8060All SZGR 2.0 genes in this pathway
PID REELIN PATHWAY 2929All SZGR 2.0 genes in this pathway
PID ILK PATHWAY 4532All SZGR 2.0 genes in this pathway
PID IGF1 PATHWAY 3023All SZGR 2.0 genes in this pathway
PID ERBB1 RECEPTOR PROXIMAL PATHWAY 3529All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129103All SZGR 2.0 genes in this pathway
PID NEPHRIN NEPH1 PATHWAY 3124All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY 6957All SZGR 2.0 genes in this pathway
PID EPHRINB REV PATHWAY 3025All SZGR 2.0 genes in this pathway
PID FAK PATHWAY 5945All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION 12077All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF 12293All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 9576All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251188All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF RAC 1411All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ROBO RECEPTOR 3026All SZGR 2.0 genes in this pathway
REACTOME NEPHRIN INTERACTIONS 2015All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP 485293All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA DN 10459All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544308All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 DN 11671All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770415All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514319All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487286All SZGR 2.0 genes in this pathway
SWEET KRAS TARGETS UP 8451All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
SU THYMUS 2012All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373196All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491310All SZGR 2.0 genes in this pathway
ZHENG FOXP3 TARGETS IN THYMUS UP 196137All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN 220147All SZGR 2.0 genes in this pathway
HANN RESISTANCE TO BCL2 INHIBITOR DN 4831All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G12 UP 3917All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP 178108All SZGR 2.0 genes in this pathway
KAPOSI LIVER CANCER MET UP 1811All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221135All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER DN 11683All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN 321200All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367231All SZGR 2.0 genes in this pathway
DURAND STROMA S UP 297194All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/20610061012m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-124/506536542m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-183643649m8hsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-1869719771Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-200bc/429108510911Ahsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-25/32/92/363/3675555611Ahsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-30-5p8848901Ahsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-3398668721Ahsa-miR-339UCCCUGUCCUCCAGGAGCUCA
miR-369-3p10861092m8hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-45510031009m8hsa-miR-455UAUGUGCCUUUGGACUACAUCG