Gene Page: DHX16

Summary ?
GeneID8449
SymbolDHX16
SynonymsDBP2|DDX16|PRO2014|PRP8|PRPF2|Prp2
DescriptionDEAH-box helicase 16
ReferenceMIM:603405|HGNC:HGNC:2739|Ensembl:ENSG00000204560|HPRD:04555|Vega:OTTHUMG00000031060
Gene typeprotein-coding
Map location6p21.3
Pascal p-value4.552E-15
Sherlock p-value0.619
Fetal beta0.134
eGeneCerebellum
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
GSMA_IGenome scan meta-analysisPsr: 0.033 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17072268chr1349383760DHX1684490.05trans
rs16955618chr1529937543DHX1684490.05trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ATHL10.570.62
PEAR10.570.62
SNED10.570.64
ADAM330.560.64
TENC10.560.58
ITIH40.560.58
ABCA90.560.64
AC055839.10.560.61
WIPI10.550.55
COL16A10.540.58
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PFDN2-0.40-0.43
TMSB10-0.38-0.44
MED19-0.38-0.42
C19orf43-0.37-0.40
ALKBH2-0.37-0.43
LSM7-0.37-0.43
C12orf45-0.37-0.45
FAM128B-0.36-0.47
RPL31-0.36-0.49
STRA13-0.36-0.47

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003676nucleic acid bindingIEA-
GO:0003724RNA helicase activityTAS9547260 
GO:0005524ATP bindingIEA-
GO:0016787hydrolase activityIEA-
GO:0008026ATP-dependent helicase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006397mRNA processingIEA-
GO:0008380RNA splicingTAS9547260 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusTAS9547260 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG SPLICEOSOME 12872All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN 180101All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
LIU BREAST CANCER 3019All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 24HR DN 3321All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN 161105All SZGR 2.0 genes in this pathway
LEE METASTASIS AND RNA PROCESSING UP 179All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863514All SZGR 2.0 genes in this pathway
MOOTHA PGC 420269All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351238All SZGR 2.0 genes in this pathway