Gene Page: IKBKAP

Summary
GeneID  8518
Symbol  IKBKAP
Synonyms  DKFZp781H1425|DYS|ELP1|FD|FLJ12497|IKAP|IKI3|TOT1
Description  inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
See related  HGNC:5959|MIM:603722|Ensembl:ENSG00000070061|HPRD:04763|
Locus tag  RP11-3J11.4
Gene type  protein-coding
Map location  9q31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1609 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityTAS9751059 
GO:0003677DNA bindingIDA11714725 
GO:0005515protein bindingIPI10094049 |14667819 |15383276 
GO:0008607phosphorylase kinase regulator activityIDA11818576 
GO:0016944RNA polymerase II transcription elongation factor activityIDA11714725 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006357regulation of transcription from RNA polymerase II promoterIDA11818576 
GO:0006350transcriptionIEA-
GO:0006461protein complex assemblyTAS9751059 
GO:0006468protein amino acid phosphorylationTAS9751059 
GO:0006955immune responseTAS9751059 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005730nucleolusIDA11714725 
GO:0005737cytoplasmIDA11714725 
GO:0008023transcription elongation factor complexIDA11714725 
GO:0016591DNA-directed RNA polymerase II, holoenzymeIDA11714725 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BAT3BAG-6 | BAG6 | D6S52E | G3HLA-B associated transcript 3Two-hybridBioGRID16169070 
C11orf79FLJ20487chromosome 11 open reading frame 79Two-hybridBioGRID16169070 
CCT5CCT-epsilon | CCTE | KIAA0098 | TCP-1-epsilonchaperonin containing TCP1, subunit 5 (epsilon)Two-hybridBioGRID16169070 
CDKN2BCDK4I | INK4B | MTS2 | P15 | TP15 | p15INK4bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)Two-hybridBioGRID16169070 
CHUKIKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16conserved helix-loop-helix ubiquitous kinaseIKAP interacts with IKK-alpha. This interaction was modeled on a demonstrated interaction between human IKAP and IKK-alpha from an unspecified species.BIND9751059 
-HPRD,BioGRID9751059 
CSTF2CstF-64cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDaTwo-hybridBioGRID16169070 
ELP2FLJ10879 | SHINC-2 | STATIP1 | StIPelongation protein 2 homolog (S. cerevisiae)Co-purificationBioGRID11714725 
ELP3FLJ10422 | KAT9elongation protein 3 homolog (S. cerevisiae)-HPRD10936 
Affinity Capture-Western
Co-purification
BioGRID11714725 
ELP4C11orf19 | FLJ20498 | PAX6NEB | PAXNEB | dJ68P15A.1elongation protein 4 homolog (S. cerevisiae)Co-purificationBioGRID11714725 
IKBKBFLJ40509 | IKK-beta | IKK2 | IKKB | MGC131801 | NFKBIKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betaIKAP interacts with IKK-beta.BIND9751059 
-HPRD,BioGRID9751059 
MAN2A2MANA2Xmannosidase, alpha, class 2A, member 2Two-hybridBioGRID16169070 
MAP3K14FTDCR1B | HS | HSNIK | NIKmitogen-activated protein kinase kinase kinase 14-HPRD,BioGRID9751059 
IKAP interacts with NIK.BIND9751059 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8-HPRD,BioGRID12058026 
MRPL42HSPC204 | MRP-L31 | MRPL31 | MRPS32 | PTD007 | RPML31mitochondrial ribosomal protein L42Two-hybridBioGRID16169070 
NDUFB9B22 | DKFZp566O173 | FLJ22885 | LYRM3 | UQOR22NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDaTwo-hybridBioGRID16169070 
NFKBIAIKBA | MAD-3 | NFKBInuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaReconstituted ComplexBioGRID9751059 
NIPSNAP3ADKFZp564D177 | FLJ13953 | HSPC299 | MGC14553 | NIPSNAP4 | TASSCnipsnap homolog 3A (C. elegans)Two-hybridBioGRID16169070 
PLP2A4 | A4-LSB | MGC126187proteolipid protein 2 (colonic epithelium-enriched)Two-hybridBioGRID16169070 
SNAPINSNAPAPSNAP-associated proteinTwo-hybridBioGRID16169070 
TAC3NKB | NKNB | PRO1155 | ZNEUROK1tachykinin 3Two-hybridBioGRID16169070 
TTRHsT2651 | PALB | TBPAtransthyretinTwo-hybridBioGRID16169070 
TXNDC9APACDthioredoxin domain containing 9Two-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_CD40_PATHWAY 1513All SZGR genes in this pathway
BIOCARTA_TNFR2_PATHWAY 1815All SZGR genes in this pathway
GARY_CD5_TARGETS_DN 431263All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
SANSOM_APC_TARGETS 212121All SZGR genes in this pathway
WORSCHECH_TUMOR_REJECTION_DN 106All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G1_UP 11370All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_UP 207143All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/98313319m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-4942993061A,m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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