SZGR2

Summary ?

GeneID	8773
Symbol	SNAP23
Synonyms	HsT17016\|SNAP-23\|SNAP23A\|SNAP23B
Description	synaptosome associated protein 23kDa
Reference	MIM:602534\|HGNC:HGNC:11131\|Ensembl:ENSG00000092531\|HPRD:03962\|Vega:OTTHUMG00000130625
Gene type	protein-coding
Map location	15q14
Pascal p-value	0.001
Sherlock p-value	0.345
eGene	Myers' cis & trans
Support	EXOCYTOSIS

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:PGCnp	Genome-wide Association Study	GWAS
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0308

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs16894557	chr6	28999825	SNAP23	8773		0.19		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ADD3	0.92	0.91
PMP2	0.90	0.90
CYBRD1	0.89	0.87
GRAMD3	0.88	0.83
ALDH6A1	0.88	0.88
SLC9A9	0.87	0.86
AHCYL1	0.87	0.87
SSFA2	0.87	0.89
SLC4A4	0.86	0.91
SSPN	0.86	0.88

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
NR2C2AP	-0.52	-0.55
AC011491.1	-0.51	-0.57
MED19	-0.49	-0.53
ZNF821	-0.49	-0.44
MPP3	-0.49	-0.41
TUBB	-0.49	-0.41
BZW2	-0.49	-0.46
GMIP	-0.49	-0.39
IGFBP2	-0.49	-0.52
MYCN	-0.48	-0.37

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IPI		16189514
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006944	membrane fusion	TAS		10839363
GO:0006903	vesicle targeting	TAS		8663154
GO:0006892	post-Golgi vesicle-mediated transport	TAS		9727496
GO:0015031	protein transport	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0019717	synaptosome	IEA	Synap, Brain (GO term level: 7)	-
GO:0045202	synapse	IEA	neuron, Synap, Neurotransmitter, Glial (GO term level: 2)	-
GO:0005792	microsome	IEA		-
GO:0005634	nucleus	IDA		18029348
GO:0005737	cytoplasm	IDA		18029348
GO:0005886	plasma membrane	TAS		9727496
GO:0030054	cell junction	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABI2	ABI-2 \| ABI2B \| AIP-1 \| AblBP3 \| SSH3BP2 \| argBPIA \| argBPIB	abl interactor 2	Two-hybrid	BioGRID	16189514
ABI3	NESH \| SSH3BP3	ABI family, member 3	Two-hybrid	BioGRID	16189514
CFTR	ABC35 \| ABCC7 \| CF \| CFTR/MRP \| MRP7 \| TNR-CFTR \| dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	-	HPRD,BioGRID	12209004
FXR2	FMR1L2	fragile X mental retardation, autosomal homolog 2	Two-hybrid	BioGRID	16189514
ITSN1	ITSN \| MGC134948 \| MGC134949 \| SH3D1A \| SH3P17	intersectin 1 (SH3 domain protein)	-	HPRD,BioGRID	10373452
KIF5B	KINH \| KNS \| KNS1 \| UKHC	kinesin family member 5B	Reconstituted Complex Two-hybrid	BioGRID	12475239
NAPA	SNAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha	Affinity Capture-Western Two-hybrid	BioGRID	16189514
SCAMP1	SCAMP \| SCAMP37	secretory carrier membrane protein 1	-	HPRD,BioGRID	12124380
SCAMP2	-	secretory carrier membrane protein 2	-	HPRD,BioGRID	12124380
SCGN	CALBL \| DJ501N12.8 \| SECRET \| SEGN \| setagin	secretagogin, EF-hand calcium binding protein	Two-hybrid	BioGRID	16189514
SNAPIN	SNAPAP	SNAP-associated protein	SNAP23 interacts with Snapin.	BIND	15635093
SNAPIN	SNAPAP	SNAP-associated protein	-	HPRD,BioGRID	12877659
SNTG1	G1SYN \| SYN4	syntrophin, gamma 1	Reconstituted Complex	BioGRID	12877659
STX11	FHL4 \| HLH4 \| HPLH4	syntaxin 11	-	HPRD,BioGRID	10036234
STX12	MGC51957 \| STX13 \| STX14	syntaxin 12	-	HPRD,BioGRID	9507000
STX18	DKFZp686O15149 \| Ufe1	syntaxin 18	Affinity Capture-MS	BioGRID	15029241
STX1A	HPC-1 \| STX1 \| p35-1	syntaxin 1A (brain)	-	HPRD	12209004\|12651853
STX1A	HPC-1 \| STX1 \| p35-1	syntaxin 1A (brain)	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	8663154 \|9168999 \|9852078 \|12651853 \|12828989
STX1B	STX1B1 \| STX1B2	syntaxin 1B	Reconstituted Complex	BioGRID	12651853
STX2	EPIM \| EPM \| MGC51014 \| STX2A \| STX2B \| STX2C	syntaxin 2	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	8663154 \|9168999 \|12651853 \|12828989
STX3	STX3A	syntaxin 3	-	HPRD	9701566
STX3	STX3A	syntaxin 3	-	HPRD,BioGRID	12828989
STX4	STX4A \| p35-2	syntaxin 4	-	HPRD,BioGRID	9168999
STX5	SED5 \| STX5A	syntaxin 5	Reconstituted Complex	BioGRID	12651853
STX6	-	syntaxin 6	-	HPRD,BioGRID	11001914
STXBP2	Hunc18b \| MUNC18-2 \| UNC18-2 \| UNC18B \| pp10122	syntaxin binding protein 2	-	HPRD	12773094
STXBP3	MUNC18-3 \| MUNC18C \| PSP \| UNC-18C	syntaxin binding protein 3	Affinity Capture-Western	BioGRID	12773094
STXBP5	FLJ30922 \| LGL3 \| LLGL3 \| MGC141942 \| MGC141968 \| Nbla04300	syntaxin binding protein 5 (tomosyn)	-	HPRD,BioGRID	12832401
SYN2	SYNII \| SYNIIa \| SYNIIb	synapsin II	Affinity Capture-Western	BioGRID	10820264
TLK1	KIAA0137 \| PKU-beta	tousled-like kinase 1	-	HPRD	10588641
VAMP1	DKFZp686H12131 \| SYB1 \| VAMP-1	vesicle-associated membrane protein 1 (synaptobrevin 1)	-	HPRD	8663154
VAMP2	FLJ11460 \| SYB2 \| VAMP-2	vesicle-associated membrane protein 2 (synaptobrevin 2)	SNAP23 interacts with VAMP2.	BIND	15610015
VAMP2	FLJ11460 \| SYB2 \| VAMP-2	vesicle-associated membrane protein 2 (synaptobrevin 2)	-	HPRD,BioGRID	10713150
VAMP3	CEB	vesicle-associated membrane protein 3 (cellubrevin)	Affinity Capture-Western	BioGRID	10820264 \|12828989
VAMP3	CEB	vesicle-associated membrane protein 3 (cellubrevin)	-	HPRD	12130530
VAMP3	CEB	vesicle-associated membrane protein 3 (cellubrevin)	SNAP23 interacts with VAMP3.	BIND	15610015
VAMP7	SYBL1 \| TI-VAMP \| VAMP-7	vesicle-associated membrane protein 7	SNAP23 interacts with VAMP7.	BIND	15610015
VAMP7	SYBL1 \| TI-VAMP \| VAMP-7	vesicle-associated membrane protein 7	-	HPRD,BioGRID	9614185
VAMP8	EDB	vesicle-associated membrane protein 8 (endobrevin)	Affinity Capture-Western	BioGRID	10820264 \|12828989
VAMP8	EDB	vesicle-associated membrane protein 8 (endobrevin)	-	HPRD	10820264 \|12130530 \|12828989

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG SNARE INTERACTIONS IN VESICULAR TRANSPORT	38	25	All SZGR 2.0 genes in this pathway
REACTOME MEMBRANE TRAFFICKING	129	74	All SZGR 2.0 genes in this pathway
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING	60	31	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN	526	357	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP	457	269	All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP	238	144	All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS UP	114	66	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR UP	164	122	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN	805	505	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN	206	136	All SZGR 2.0 genes in this pathway
PETRETTO CARDIAC HYPERTROPHY	34	26	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	All SZGR 2.0 genes in this pathway
BRUNO HEMATOPOIESIS	66	48	All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN	408	274	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH DN	58	43	All SZGR 2.0 genes in this pathway
MARIADASON REGULATED BY HISTONE ACETYLATION UP	83	49	All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP	262	186	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP	461	298	All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY DN	44	29	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
CROONQUIST NRAS VS STROMAL STIMULATION UP	41	26	All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP	242	159	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE	317	190	All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3	824	528	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	1205	1211	1A	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-141/200a	1447	1453	1A	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	1447	1453	1A	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-182	309	316	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-186	15	21	1A	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-330	1277	1284	1A,m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-9	312	318	1A	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-96	310	316	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: SNAP23