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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: SNAP23

Summary

GeneID

8773

Symbol

SNAP23

Synonyms

HsT17016|SNAP23A|SNAP23B

Description

synaptosomal-associated protein, 23kDa

Locus tag

Gene type

protein-coding

Map location

15q15.1

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0308

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

ADD3

0.92

0.91

PMP2

0.90

CYBRD1

0.89

0.87

GRAMD3

0.88

0.83

ALDH6A1

0.88

SLC9A9

0.87

0.86

AHCYL1

0.87

SSFA2

0.87

0.89

SLC4A4

0.86

0.91

SSPN

0.86

0.88

Top 10 negatively co-expressed genes

NR2C2AP

-0.52

-0.55

AC011491.1

-0.51

-0.57

MED19

-0.49

-0.53

ZNF821

-0.49

-0.44

MPP3

-0.49

-0.41

TUBB

-0.49

-0.41

BZW2

-0.49

-0.46

GMIP

-0.49

-0.39

IGFBP2

-0.49

-0.52

MYCN

-0.48

-0.37

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005515

protein binding

IPI

16189514

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006944

membrane fusion

TAS

10839363

GO:0006903

vesicle targeting

TAS

8663154

GO:0006892

post-Golgi vesicle-mediated transport

TAS

9727496

GO:0015031

protein transport

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0019717

synaptosome

IEA

Synap, Brain (GO term level: 7)

GO:0045202

synapse

IEA

neuron, Synap, Neurotransmitter, Glial (GO term level: 2)

GO:0005792

microsome

IEA

GO:0005634

nucleus

IDA

18029348

GO:0005737

cytoplasm

IDA

18029348

GO:0005886

plasma membrane

TAS

9727496

GO:0030054

cell junction

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABI2	ABI-2 \| ABI2B \| AIP-1 \| AblBP3 \| SSH3BP2 \| argBPIA \| argBPIB	abl interactor 2	Two-hybrid	BioGRID	16189514
ABI3	NESH \| SSH3BP3	ABI family, member 3	Two-hybrid	BioGRID	16189514
CFTR	ABC35 \| ABCC7 \| CF \| CFTR/MRP \| MRP7 \| TNR-CFTR \| dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	-	HPRD,BioGRID	12209004
FXR2	FMR1L2	fragile X mental retardation, autosomal homolog 2	Two-hybrid	BioGRID	16189514
ITSN1	ITSN \| MGC134948 \| MGC134949 \| SH3D1A \| SH3P17	intersectin 1 (SH3 domain protein)	-	HPRD,BioGRID	10373452
KIF5B	KINH \| KNS \| KNS1 \| UKHC	kinesin family member 5B	Reconstituted Complex Two-hybrid	BioGRID	12475239
NAPA	SNAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha	Affinity Capture-Western Two-hybrid	BioGRID	16189514
SCAMP1	SCAMP \| SCAMP37	secretory carrier membrane protein 1	-	HPRD,BioGRID	12124380
SCAMP2	-	secretory carrier membrane protein 2	-	HPRD,BioGRID	12124380
SCGN	CALBL \| DJ501N12.8 \| SECRET \| SEGN \| setagin	secretagogin, EF-hand calcium binding protein	Two-hybrid	BioGRID	16189514
SNAPIN	SNAPAP	SNAP-associated protein	SNAP23 interacts with Snapin.	BIND	15635093
SNAPIN	SNAPAP	SNAP-associated protein	-	HPRD,BioGRID	12877659
SNTG1	G1SYN \| SYN4	syntrophin, gamma 1	Reconstituted Complex	BioGRID	12877659
STX11	FHL4 \| HLH4 \| HPLH4	syntaxin 11	-	HPRD,BioGRID	10036234
STX12	MGC51957 \| STX13 \| STX14	syntaxin 12	-	HPRD,BioGRID	9507000
STX18	DKFZp686O15149 \| Ufe1	syntaxin 18	Affinity Capture-MS	BioGRID	15029241
STX1A	HPC-1 \| STX1 \| p35-1	syntaxin 1A (brain)	-	HPRD	12209004\|12651853
STX1A	HPC-1 \| STX1 \| p35-1	syntaxin 1A (brain)	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	8663154 \|9168999 \|9852078 \|12651853 \|12828989
STX1B	STX1B1 \| STX1B2	syntaxin 1B	Reconstituted Complex	BioGRID	12651853
STX2	EPIM \| EPM \| MGC51014 \| STX2A \| STX2B \| STX2C	syntaxin 2	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	8663154 \|9168999 \|12651853 \|12828989
STX3	STX3A	syntaxin 3	-	HPRD	9701566
STX3	STX3A	syntaxin 3	-	HPRD,BioGRID	12828989
STX4	STX4A \| p35-2	syntaxin 4	-	HPRD,BioGRID	9168999
STX5	SED5 \| STX5A	syntaxin 5	Reconstituted Complex	BioGRID	12651853
STX6	-	syntaxin 6	-	HPRD,BioGRID	11001914
STXBP2	Hunc18b \| MUNC18-2 \| UNC18-2 \| UNC18B \| pp10122	syntaxin binding protein 2	-	HPRD	12773094
STXBP3	MUNC18-3 \| MUNC18C \| PSP \| UNC-18C	syntaxin binding protein 3	Affinity Capture-Western	BioGRID	12773094
STXBP5	FLJ30922 \| LGL3 \| LLGL3 \| MGC141942 \| MGC141968 \| Nbla04300	syntaxin binding protein 5 (tomosyn)	-	HPRD,BioGRID	12832401
SYN2	SYNII \| SYNIIa \| SYNIIb	synapsin II	Affinity Capture-Western	BioGRID	10820264
TLK1	KIAA0137 \| PKU-beta	tousled-like kinase 1	-	HPRD	10588641
VAMP1	DKFZp686H12131 \| SYB1 \| VAMP-1	vesicle-associated membrane protein 1 (synaptobrevin 1)	-	HPRD	8663154
VAMP2	FLJ11460 \| SYB2 \| VAMP-2	vesicle-associated membrane protein 2 (synaptobrevin 2)	SNAP23 interacts with VAMP2.	BIND	15610015
VAMP2	FLJ11460 \| SYB2 \| VAMP-2	vesicle-associated membrane protein 2 (synaptobrevin 2)	-	HPRD,BioGRID	10713150
VAMP3	CEB	vesicle-associated membrane protein 3 (cellubrevin)	Affinity Capture-Western	BioGRID	10820264 \|12828989
			-	HPRD	12130530
			SNAP23 interacts with VAMP3.	BIND	15610015
VAMP7	SYBL1 \| TI-VAMP \| VAMP-7	vesicle-associated membrane protein 7	SNAP23 interacts with VAMP7.	BIND	15610015
VAMP7	SYBL1 \| TI-VAMP \| VAMP-7	vesicle-associated membrane protein 7	-	HPRD,BioGRID	9614185
VAMP8	EDB	vesicle-associated membrane protein 8 (endobrevin)	Affinity Capture-Western	BioGRID	10820264 \|12828989
VAMP8	EDB	vesicle-associated membrane protein 8 (endobrevin)	-	HPRD	10820264 \|12130530 \|12828989

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	38	25	All SZGR genes in this pathway
REACTOME_MEMBRANE_TRAFFICKING	129	74	All SZGR genes in this pathway
REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING	60	31	All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN	526	357	All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP	423	283	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP	1382	904	All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP	457	269	All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_UP	238	144	All SZGR genes in this pathway
SENESE_HDAC2_TARGETS_UP	114	66	All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP	501	327	All SZGR genes in this pathway
KIM_WT1_TARGETS_8HR_UP	164	122	All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN	805	505	All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK	1442	892	All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN	1024	594	All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP	811	508	All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN	206	136	All SZGR genes in this pathway
PETRETTO_CARDIAC_HYPERTROPHY	34	26	All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS	882	572	All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN	225	163	All SZGR genes in this pathway
BRUNO_HEMATOPOIESIS	66	48	All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN	408	274	All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN	830	547	All SZGR genes in this pathway
JI_RESPONSE_TO_FSH_DN	58	43	All SZGR genes in this pathway
MARIADASON_REGULATED_BY_HISTONE_ACETYLATION_UP	83	49	All SZGR genes in this pathway
LU_AGING_BRAIN_UP	262	186	All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP	461	298	All SZGR genes in this pathway
CHUNG_BLISTER_CYTOTOXICITY_DN	44	29	All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP	518	299	All SZGR genes in this pathway
CROONQUIST_NRAS_VS_STROMAL_STIMULATION_UP	41	26	All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_UP	242	159	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE	317	190	All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3	824	528	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	1205	1211	1A	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-141/200a	1447	1453	1A	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	1447	1453	1A	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-182	309	316	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-186	15	21	1A	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-330	1277	1284	1A,m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-9	312	318	1A	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-96	310	316	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.