Gene Page: SQSTM1

Summary
GeneID  8878
Symbol  SQSTM1
Synonyms  A170|OSIL|PDB3|ZIP3|p60|p62|p62B
Description  sequestosome 1
See related  HGNC:11280|MIM:601530|Ensembl:ENSG00000161011|HPRD:03319|
Locus tag  -
Gene type  protein-coding
Map location  5q35
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.0276 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0685 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PINK10.890.89
PRRT30.880.90
CEND10.870.90
TOM10.870.87
DLGAP30.870.91
TUBG20.870.91
LENG30.860.86
PPAPDC30.860.86
ZFYVE280.850.89
VGF0.850.91
Top 10 negatively co-expressed genes
TUBB2B-0.57-0.56
RBMX2-0.57-0.64
CARHSP1-0.56-0.60
TIGD1-0.56-0.47
KIAA1949-0.56-0.45
ZNF300-0.56-0.39
C9orf46-0.56-0.62
IGF2BP3-0.56-0.52
TRAF4-0.56-0.60
EXOSC8-0.56-0.57
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI14676191 
GO:0005515protein bindingISS-
GO:0008270zinc ion bindingIEA-
GO:0042169SH2 domain bindingIDA8650207 
GO:0042169SH2 domain bindingISS-
GO:0030971receptor tyrosine kinase bindingTAS8650207 
GO:0019901protein kinase bindingIDA8650207 
GO:0019901protein kinase bindingISS-
GO:0043130ubiquitin bindingIDA12857745 
GO:0043130ubiquitin bindingISS-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006511ubiquitin-dependent protein catabolic processTAS8702753 
GO:0007242intracellular signaling cascadeTAS8650207 
GO:0006950response to stressTAS12857745 
GO:0008104protein localizationTAS8650207 
GO:0006955immune responseIEA-
GO:0006915apoptosisIEA-
GO:0016197endosome transportTAS12857745 
GO:0030154cell differentiationIEA-
GO:0043122regulation of I-kappaB kinase/NF-kappaB cascadeIMP12857745 
GO:0043122regulation of I-kappaB kinase/NF-kappaB cascadeISS-
GO:0045944positive regulation of transcription from RNA polymerase II promoterTAS12857745 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolNAS-
GO:0005829cytosolTAS8650207 
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
GO:0005770late endosomeIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
C14orf139FLJ21276chromosome 14 open reading frame 139Two-hybridBioGRID16169070 
ERCC2COFS2 | EM9 | MGC102762 | MGC126218 | MGC126219 | TTD | XPDexcision repair cross-complementing rodent repair deficiency, complementation group 2-HPRD8652557 
GABARAPL1APG8-LIKE | APG8L | ATG8 | ATG8L | GEC1GABA(A) receptor-associated protein like 1Two-hybridBioGRID16189514 
GABARAPL2ATG8 | GATE-16 | GATE16 | GEF-2 | GEF2GABA(A) receptor-associated protein-like 2Two-hybridBioGRID16189514 
IRAK1IRAK | pelleinterleukin-1 receptor-associated kinase 1-HPRD12034707 
Affinity Capture-WesternBioGRID10747026 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD,BioGRID8650207 
MAP1LC3BLC3B | MAP1A/1BLC3microtubule-associated protein 1 light chain 3 betaTwo-hybridBioGRID16169070 
MAP2K5HsT17454 | MAPKK5 | MEK5 | PRKMK5mitogen-activated protein kinase kinase 5MEK5 interacts with p62. This interaction was modelled on a demonstrated interaction between mouse MEK5 and human p62.BIND12813044 
NR2F2ARP1 | COUP-TFII | COUPTFB | MGC117452 | SVP40 | TFCOUP2nuclear receptor subfamily 2, group F, member 2-HPRD8910285 
NTRK1DKFZp781I14186 | MTC | TRK | TRK1 | TRKA | p140-TrkAneurotrophic tyrosine kinase, receptor, type 1Affinity Capture-WesternBioGRID11244088 |12471037 
NTRK2GP145-TrkB | TRKBneurotrophic tyrosine kinase, receptor, type 2-HPRD,BioGRID12471037 
NTRK3TRKC | gp145(trkC)neurotrophic tyrosine kinase, receptor, type 3-HPRD,BioGRID12471037 
PRKCIDXS1179E | MGC26534 | PKCI | nPKC-iotaprotein kinase C, iota-HPRD,BioGRID9566925 
lamdaPKC interacts with p62. This interaction was modelled on a demonstrated interaction between mouse lamdaPKC and human p62.BIND12813044 
PRKCZPKC-ZETA | PKC2protein kinase C, zetazetaPKC interacts with p62. This interaction was modelled on a demonstrated interaction between rat zetaPKC and human p62.BIND12813044 
-HPRD9566925 |10356400 
Affinity Capture-WesternBioGRID10747026 
PTPRJCD148 | DEP1 | HPTPeta | R-PTP-ETA | SCC1protein tyrosine phosphatase, receptor type, J-HPRD9115287 
RAD23AHHR23A | MGC111083RAD23 homolog A (S. cerevisiae)Affinity Capture-Western
Two-hybrid		BioGRID16189514 
RIPK1FLJ39204 | RIP | RIP1receptor (TNFRSF)-interacting serine-threonine kinase 1-HPRD,BioGRID10356400 
SNCAMGC110988 | NACP | PARK1 | PARK4 | PD1synuclein, alpha (non A4 component of amyloid precursor)-HPRD11447312 
SQSTM1A170 | OSIL | PDB3 | ZIP3 | p60 | p62 | p62Bsequestosome 1p62 forms a dimer.BIND12813044 
Two-hybridBioGRID16169070 
TRAF6MGC:3310 | RNF85TNF receptor-associated factor 6-HPRD,BioGRID10747026 |11244088 
TTNCMD1G | CMH9 | CMPD4 | CONNECTIN | DKFZp451N061 | EOMFC | FLJ26020 | FLJ26409 | FLJ32040 | FLJ34413 | FLJ39564 | FLJ43066 | HMERF | LGMD2J | TMDtitinTitin interacts with p62. This interaction was modelled on a demonstrated interaction between human Titin and rat p62.BIND15802564 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_IL1_PATHWAY 3428All SZGR genes in this pathway
PID_TNF_PATHWAY 4633All SZGR genes in this pathway
PID_P75_NTR_PATHWAY 6951All SZGR genes in this pathway
PID_TRKR_PATHWAY 6248All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_P75NTR_RECRUITS_SIGNALLING_COMPLEXES 128All SZGR genes in this pathway
REACTOME_P75NTR_SIGNALS_VIA_NFKB 1410All SZGR genes in this pathway
REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS 1510All SZGR genes in this pathway
REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL 118All SZGR genes in this pathway
REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 6043All SZGR genes in this pathway
REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 8161All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_IL1_SIGNALING 3930All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_DN 244147All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_UP 7950All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_UP 456228All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
HUMMEL_BURKITTS_LYMPHOMA_DN 1510All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_DN 214133All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_REVERSIBLY_UP 86All SZGR genes in this pathway
MARKEY_RB1_CHRONIC_LOF_DN 11878All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP 239157All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
MISSIAGLIA_REGULATED_BY_METHYLATION_UP 12678All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_2 12792All SZGR genes in this pathway
HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_2_UP 6445All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
DIRMEIER_LMP1_RESPONSE_LATE_UP 5741All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_DN 9859All SZGR genes in this pathway
NAKAYAMA_FRA2_TARGETS 4327All SZGR genes in this pathway
SUH_COEXPRESSED_WITH_ID1_AND_ID2_UP 1914All SZGR genes in this pathway
COLIN_PILOCYTIC_ASTROCYTOMA_VS_GLIOBLASTOMA_DN 2821All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP 223140All SZGR genes in this pathway
UEDA_PERIFERAL_CLOCK 169111All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_UP 205126All SZGR genes in this pathway
GOLUB_ALL_VS_AML_DN 2414All SZGR genes in this pathway
GALINDO_IMMUNE_RESPONSE_TO_ENTEROTOXIN 8567All SZGR genes in this pathway
ASTIER_INTEGRIN_SIGNALING 5944All SZGR genes in this pathway
NEMETH_INFLAMMATORY_RESPONSE_LPS_UP 8864All SZGR genes in this pathway
BRUNO_HEMATOPOIESIS 6648All SZGR genes in this pathway
CHIBA_RESPONSE_TO_TSA 5031All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C0 10772All SZGR genes in this pathway
GERHOLD_ADIPOGENESIS_UP 4940All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_DN 314188All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
WONG_PROTEASOME_GENE_MODULE 4935All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K9ME3_DN 12071All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP 439257All SZGR genes in this pathway
SMID_BREAST_CANCER_ERBB2_UP 14783All SZGR genes in this pathway
PODAR_RESPONSE_TO_ADAPHOSTIN_UP 14798All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP 338225All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_UP 217131All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_GROUP2 6038All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
KOHOUTEK_CCNT1_TARGETS 5026All SZGR genes in this pathway
HUANG_GATA2_TARGETS_UP 14996All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_PARTIAL 160106All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-17-5p/20/93.mr/106/519.d6496561A,m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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