SZGR2

Summary ?

GeneID	9094
Symbol	UNC119
Synonyms	HRG4\|IMD13\|POC7\|POC7A
Description	unc-119 lipid binding chaperone
Reference	MIM:604011\|HGNC:HGNC:12565\|Ensembl:ENSG00000109103\|HPRD:04927\|Vega:OTTHUMG00000132606
Gene type	protein-coding
Map location	17q11.2
Pascal p-value	0.631
Sherlock p-value	0.521
Fetal beta	0.164
DMG	2 (# studies)
eGene	Frontal Cortex BA9 Hypothalamus Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
DMG:vanEijk_2014	Genome-wide DNA methylation analysis	This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250).	2
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	2
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg14315198	17	26879866	UNC119	5.2E-4	0.197	0.048	DMG:Wockner_2014
cg21237418	17	27045043	UNC119	2.111E-4	-2.903		DMG:vanEijk_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs3747659	chr2	111744806	UNC119	9094		4.325E-5		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MORF4L2	0.92	0.90
RAB18	0.91	0.91
RAB2A	0.90	0.88
PPP2CA	0.90	0.87
CMPK1	0.89	0.88
MRPS10	0.89	0.87
ATG5	0.89	0.89
SLC30A9	0.88	0.86
STRAP	0.88	0.85
PPP1CB	0.88	0.88

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MT-CO2	-0.67	-0.55
AF347015.8	-0.67	-0.55
AF347015.21	-0.66	-0.48
AF347015.18	-0.66	-0.58
AF347015.2	-0.65	-0.54
AF347015.26	-0.65	-0.55
AF347015.33	-0.64	-0.53
MT-CYB	-0.63	-0.52
AF347015.15	-0.63	-0.53
FXYD1	-0.61	-0.55

Section III. Gene Ontology annotation

Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007268	synaptic transmission	TAS	neuron, Synap, Neurotransmitter (GO term level: 6)	9538874
GO:0007602	phototransduction	TAS		9538874
GO:0007601	visual perception	TAS		10329014
GO:0050896	response to stimulus	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	TAS		9538874
GO:0005625	soluble fraction	TAS		9538874

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ALDH2	ALDH-E2 \| ALDHI \| ALDM \| MGC1806	aldehyde dehydrogenase 2 family (mitochondrial)	Two-hybrid	BioGRID	16169070
ANKRD24	KIAA1981	ankyrin repeat domain 24	Two-hybrid	BioGRID	16169070
ANXA3	ANX3	annexin A3	Two-hybrid	BioGRID	16169070
AOF2	BHC110 \| KDM1 \| KIAA0601 \| LSD1	amine oxidase (flavin containing) domain 2	Two-hybrid	BioGRID	16169070
ARL15	ARFRP2 \| FLJ20051	ADP-ribosylation factor-like 15	Two-hybrid	BioGRID	16169070
ARL2	ARFL2	ADP-ribosylation factor-like 2	HRG4 interacts with ARL2.	BIND	12527357
ARL2	ARFL2	ADP-ribosylation factor-like 2	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	12527357
ARL3	ARFL3	ADP-ribosylation factor-like 3	-	HPRD,BioGRID	11303027
ARL4D	ARF4L \| ARL6	ADP-ribosylation factor-like 4D	Two-hybrid	BioGRID	16169070
ASH2L	ASH2 \| ASH2L1 \| ASH2L2 \| Bre2	ash2 (absent, small, or homeotic)-like (Drosophila)	Two-hybrid	BioGRID	16169070
BCR	ALL \| BCR-ABL1 \| BCR1 \| CML \| D22S11 \| D22S662 \| FLJ16453 \| PHL	breakpoint cluster region	Two-hybrid	BioGRID	16169070
BTBD2	-	BTB (POZ) domain containing 2	Two-hybrid	BioGRID	16169070
BXDC2	BRIX \| FLJ11100	brix domain containing 2	Two-hybrid	BioGRID	16169070
C16orf74	MGC17624	chromosome 16 open reading frame 74	Two-hybrid	BioGRID	16189514
CBX8	HPC3 \| PC3 \| RC1	chromobox homolog 8 (Pc class homolog, Drosophila)	Two-hybrid	BioGRID	16169070
CCL18	AMAC-1 \| AMAC1 \| CKb7 \| DC-CK1 \| DCCK1 \| MIP-4 \| PARC \| SCYA18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	Two-hybrid	BioGRID	16169070
CD247	CD3-ZETA \| CD3H \| CD3Q \| CD3Z \| T3Z \| TCRZ	CD247 molecule	-	HPRD,BioGRID	14757743
CD4	CD4mut	CD4 molecule	-	HPRD,BioGRID	14757743
CDC42	CDC42Hs \| G25K	cell division cycle 42 (GTP binding protein, 25kDa)	Two-hybrid	BioGRID	16169070
CDKN2C	INK4C \| p18 \| p18-INK4C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	Two-hybrid	BioGRID	16169070
CETN3	CEN3 \| MGC12502 \| MGC138245	centrin, EF-hand protein, 3 (CDC31 homolog, yeast)	Two-hybrid	BioGRID	16169070
CKMT2	SMTCK	creatine kinase, mitochondrial 2 (sarcomeric)	Two-hybrid	BioGRID	16169070
CKS2	CKSHS2	CDC28 protein kinase regulatory subunit 2	Two-hybrid	BioGRID	16169070
COX17	MGC104397 \| MGC117386	COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)	Two-hybrid	BioGRID	16169070
CYB561D2	101F6 \| TSP10	cytochrome b-561 domain containing 2	Two-hybrid	BioGRID	16169070
EIF2S2	DKFZp686L18198 \| EIF2 \| EIF2B \| EIF2beta \| MGC8508	eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa	Two-hybrid	BioGRID	16169070
ERH	DROER \| FLJ27340	enhancer of rudimentary homolog (Drosophila)	Two-hybrid	BioGRID	16169070
FKBPL	DIR1 \| NG7 \| WISP39	FK506 binding protein like	Two-hybrid	BioGRID	16169070
FXYD6	-	FXYD domain containing ion transport regulator 6	Two-hybrid	BioGRID	16169070
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	-	HPRD,BioGRID	14757743
GIPC2	FLJ20075 \| SEMCAP-2 \| SEMCAP2	GIPC PDZ domain containing family, member 2	Two-hybrid	BioGRID	16169070
GSTM4	GSTM4-4 \| GTM4 \| MGC131945 \| MGC9247	glutathione S-transferase mu 4	Two-hybrid	BioGRID	16169070
HCK	JTK9	hemopoietic cell kinase	-	HPRD,BioGRID	12496276
HLA-DQA1	CD \| CELIAC1 \| DQ-A1 \| FLJ27088 \| FLJ27328 \| GSE \| HLA-DQA \| MGC149527	major histocompatibility complex, class II, DQ alpha 1	Two-hybrid	BioGRID	16169070
HMGB1	DKFZp686A04236 \| HMG1 \| HMG3 \| SBP-1	high-mobility group box 1	Two-hybrid	BioGRID	16169070
HSPB3	HSPL27	heat shock 27kDa protein 3	Two-hybrid	BioGRID	16169070
HSPE1	CPN10 \| GROES \| HSP10	heat shock 10kDa protein 1 (chaperonin 10)	Two-hybrid	BioGRID	16169070
ID2	GIG8 \| ID2A \| ID2H \| MGC26389 \| bHLHb26	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	Two-hybrid	BioGRID	16169070
IL5RA	CD125 \| CDw125 \| HSIL5R3 \| IL5R \| MGC26560	interleukin 5 receptor, alpha	-	HPRD,BioGRID	12496276
ITSN1	ITSN \| MGC134948 \| MGC134949 \| SH3D1A \| SH3P17	intersectin 1 (SH3 domain protein)	Two-hybrid	BioGRID	16169070
LAMA4	DKFZp686D23145 \| LAMA3 \| LAMA4*-1	laminin, alpha 4	Two-hybrid	BioGRID	16169070
LCK	YT16 \| p56lck \| pp58lck	lymphocyte-specific protein tyrosine kinase	-	HPRD,BioGRID	14757743
LUC7L2	CGI-59 \| CGI-74 \| FLJ10657 \| LUC7B2	LUC7-like 2 (S. cerevisiae)	Two-hybrid	BioGRID	16169070
LYN	FLJ26625 \| JTK8	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	-	HPRD,BioGRID	12496276
MAPK10	FLJ12099 \| FLJ33785 \| JNK3 \| JNK3A \| MGC50974 \| PRKM10 \| p493F12 \| p54bSAPK	mitogen-activated protein kinase 10	Two-hybrid	BioGRID	16169070
MPHOSPH6	MPP \| MPP-6 \| MPP6	M-phase phosphoprotein 6	Two-hybrid	BioGRID	16169070
MRPS12	MPR-S12 \| MT-RPS12 \| RPMS12 \| RPS12 \| RPSM12	mitochondrial ribosomal protein S12	Two-hybrid	BioGRID	16169070
ORAI2	C7orf19 \| CBCIP2 \| FLJ12474 \| FLJ14733 \| FLJ44818 \| TMEM142B	ORAI calcium release-activated calcium modulator 2	Two-hybrid	BioGRID	16169070
PAFAH1B3	-	platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa	Two-hybrid	BioGRID	16169070
PAPSS1	ATPSK1 \| PAPSS \| SK1	3'-phosphoadenosine 5'-phosphosulfate synthase 1	Two-hybrid	BioGRID	16169070
PCDHA4	CNR1 \| CNRN1 \| CRNR1 \| MGC138307 \| MGC142169 \| PCDH-ALPHA4	protocadherin alpha 4	Two-hybrid	BioGRID	16169070
PFN1	-	profilin 1	Two-hybrid	BioGRID	16169070
PHF10	FLJ10975 \| MGC111009 \| XAP135	PHD finger protein 10	Two-hybrid	BioGRID	16169070
PPA1	IOPPP \| MGC111556 \| PP \| PP1 \| SID6-8061	pyrophosphatase (inorganic) 1	Two-hybrid	BioGRID	16169070
PPAP2C	LPP2 \| PAP-2c \| PAP2-g	phosphatidic acid phosphatase type 2C	Two-hybrid	BioGRID	16169070
PSMD11	MGC3844 \| Rpn6 \| S9 \| p44.5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	Two-hybrid	BioGRID	16169070
PSMD2	MGC14274 \| P97 \| Rpn1 \| S2 \| TRAP2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	Two-hybrid	BioGRID	16169070
PTPRS	PTPSIGMA	protein tyrosine phosphatase, receptor type, S	Two-hybrid	BioGRID	16169070
QTRT1	FP3235 \| TGT	queuine tRNA-ribosyltransferase 1	Two-hybrid	BioGRID	16169070
RFC5	MGC1155 \| RFC36	replication factor C (activator 1) 5, 36.5kDa	Two-hybrid	BioGRID	16169070
RGL2	HKE1.5 \| KE1.5 \| RAB2L	ral guanine nucleotide dissociation stimulator-like 2	Two-hybrid	BioGRID	16169070
RPA2	REPA2 \| RPA32	replication protein A2, 32kDa	Two-hybrid	BioGRID	16169070
RUFY3	KIAA0871 \| RIPX \| SINGAR1	RUN and FYVE domain containing 3	Two-hybrid	BioGRID	16169070
S100A4	18A2 \| 42A \| CAPL \| FSP1 \| MTS1 \| P9KA \| PEL98	S100 calcium binding protein A4	Two-hybrid	BioGRID	16169070
S100A8	60B8AG \| CAGA \| CFAG \| CGLA \| CP-10 \| L1Ag \| MA387 \| MIF \| MRP8 \| NIF \| P8	S100 calcium binding protein A8	Two-hybrid	BioGRID	16169070
SAT1	DC21 \| KFSD \| SAT \| SSAT \| SSAT-1	spermidine/spermine N1-acetyltransferase 1	Two-hybrid	BioGRID	16169070
SEPHS1	MGC4980 \| SELD \| SPS \| SPS1	selenophosphate synthetase 1	Two-hybrid	BioGRID	16169070
SERPINB9	CAP-3 \| CAP3 \| PI9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	Two-hybrid	BioGRID	16169070
SMN1	BCD541 \| SMA \| SMA1 \| SMA2 \| SMA3 \| SMA4 \| SMA@ \| SMN \| SMNT \| T-BCD541	survival of motor neuron 1, telomeric	Two-hybrid	BioGRID	16169070
SULT1E1	EST \| EST-1 \| MGC34459 \| STE	sulfotransferase family 1E, estrogen-preferring, member 1	Two-hybrid	BioGRID	16169070
TK1	TK2	thymidine kinase 1, soluble	Two-hybrid	BioGRID	16169070
TP53BP2	53BP2 \| ASPP2 \| BBP \| PPP1R13A \| p53BP2	tumor protein p53 binding protein, 2	Two-hybrid	BioGRID	16169070
TP53I3	PIG3	tumor protein p53 inducible protein 3	Two-hybrid	BioGRID	16169070
TRDMT1	DNMT2 \| M.HsaIIP \| PuMet \| RNMT1	tRNA aspartic acid methyltransferase 1	Two-hybrid	BioGRID	16169070
UBE2B	E2-17kDa \| HHR6B \| HR6B \| RAD6B \| UBC2	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	Two-hybrid	BioGRID	16169070
UBE2I	C358B7.1 \| P18 \| UBC9	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	Two-hybrid	BioGRID	16169070
UBQLN4	A1U \| C1orf6 \| CIP75 \| UBIN	ubiquilin 4	Two-hybrid	BioGRID	16169070
ZFP64	MGC940 \| ZNF338	zinc finger protein 64 homolog (mouse)	Two-hybrid	BioGRID	16169070
ZNF24	KOX17 \| RSG-A \| ZNF191 \| ZSCAN3 \| Zfp191	zinc finger protein 24	Two-hybrid	BioGRID	16169070

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
MULLIGHAN MLL SIGNATURE 1 UP	380	236	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP	418	263	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN	508	354	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 3 4WK UP	214	144	All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS	1174	695	All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 DN	66	38	All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM2	153	102	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q11 Q21 AMPLICON	133	78	All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION UP	142	93	All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION UP	48	26	All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS DN	87	69	All SZGR 2.0 genes in this pathway
YAGI AML FAB MARKERS	191	131	All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING UP	101	76	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP	428	266	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 6	189	112	All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P6	91	44	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP	461	298	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN	701	446	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE	346	192	All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER BRCA1 DN	44	28	All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2	491	319	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC UP	72	53	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP	857	456	All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP	211	131	All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP	281	183	All SZGR 2.0 genes in this pathway
LIU IL13 MEMORY MODEL UP	17	12	All SZGR 2.0 genes in this pathway

Gene Page: UNC119