Summary ?
Descriptionunc-119 lipid binding chaperone
Gene typeprotein-coding
Map location17q11.2
Pascal p-value0.631
Sherlock p-value0.521
Fetal beta0.164
DMG2 (# studies)
eGeneFrontal Cortex BA9
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 2
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation

Section III. Gene Ontology annotation

Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)9538874 
GO:0007601visual perceptionTAS10329014 
GO:0050896response to stimulusIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005625soluble fractionTAS9538874 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ALDH2ALDH-E2 | ALDHI | ALDM | MGC1806aldehyde dehydrogenase 2 family (mitochondrial)Two-hybridBioGRID16169070 
ANKRD24KIAA1981ankyrin repeat domain 24Two-hybridBioGRID16169070 
ANXA3ANX3annexin A3Two-hybridBioGRID16169070 
AOF2BHC110 | KDM1 | KIAA0601 | LSD1amine oxidase (flavin containing) domain 2Two-hybridBioGRID16169070 
ARL15ARFRP2 | FLJ20051ADP-ribosylation factor-like 15Two-hybridBioGRID16169070 
ARL2ARFL2ADP-ribosylation factor-like 2HRG4 interacts with ARL2.BIND12527357 
ARL2ARFL2ADP-ribosylation factor-like 2Affinity Capture-Western
Reconstituted Complex
ARL3ARFL3ADP-ribosylation factor-like 3-HPRD,BioGRID11303027 
ARL4DARF4L | ARL6ADP-ribosylation factor-like 4DTwo-hybridBioGRID16169070 
ASH2LASH2 | ASH2L1 | ASH2L2 | Bre2ash2 (absent, small, or homeotic)-like (Drosophila)Two-hybridBioGRID16169070 
BCRALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHLbreakpoint cluster regionTwo-hybridBioGRID16169070 
BTBD2-BTB (POZ) domain containing 2Two-hybridBioGRID16169070 
BXDC2BRIX | FLJ11100brix domain containing 2Two-hybridBioGRID16169070 
C16orf74MGC17624chromosome 16 open reading frame 74Two-hybridBioGRID16189514 
CBX8HPC3 | PC3 | RC1chromobox homolog 8 (Pc class homolog, Drosophila)Two-hybridBioGRID16169070 
CCL18AMAC-1 | AMAC1 | CKb7 | DC-CK1 | DCCK1 | MIP-4 | PARC | SCYA18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)Two-hybridBioGRID16169070 
CD247CD3-ZETA | CD3H | CD3Q | CD3Z | T3Z | TCRZCD247 molecule-HPRD,BioGRID14757743 
CD4CD4mutCD4 molecule-HPRD,BioGRID14757743 
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)Two-hybridBioGRID16169070 
CDKN2CINK4C | p18 | p18-INK4Ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)Two-hybridBioGRID16169070 
CETN3CEN3 | MGC12502 | MGC138245centrin, EF-hand protein, 3 (CDC31 homolog, yeast)Two-hybridBioGRID16169070 
CKMT2SMTCKcreatine kinase, mitochondrial 2 (sarcomeric)Two-hybridBioGRID16169070 
CKS2CKSHS2CDC28 protein kinase regulatory subunit 2Two-hybridBioGRID16169070 
COX17MGC104397 | MGC117386COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)Two-hybridBioGRID16169070 
CYB561D2101F6 | TSP10cytochrome b-561 domain containing 2Two-hybridBioGRID16169070 
EIF2S2DKFZp686L18198 | EIF2 | EIF2B | EIF2beta | MGC8508eukaryotic translation initiation factor 2, subunit 2 beta, 38kDaTwo-hybridBioGRID16169070 
ERHDROER | FLJ27340enhancer of rudimentary homolog (Drosophila)Two-hybridBioGRID16169070 
FKBPLDIR1 | NG7 | WISP39FK506 binding protein likeTwo-hybridBioGRID16169070 
FXYD6-FXYD domain containing ion transport regulator 6Two-hybridBioGRID16169070 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID14757743 
GIPC2FLJ20075 | SEMCAP-2 | SEMCAP2GIPC PDZ domain containing family, member 2Two-hybridBioGRID16169070 
GSTM4GSTM4-4 | GTM4 | MGC131945 | MGC9247glutathione S-transferase mu 4Two-hybridBioGRID16169070 
HCKJTK9hemopoietic cell kinase-HPRD,BioGRID12496276 
HLA-DQA1CD | CELIAC1 | DQ-A1 | FLJ27088 | FLJ27328 | GSE | HLA-DQA | MGC149527major histocompatibility complex, class II, DQ alpha 1Two-hybridBioGRID16169070 
HMGB1DKFZp686A04236 | HMG1 | HMG3 | SBP-1high-mobility group box 1Two-hybridBioGRID16169070 
HSPB3HSPL27heat shock 27kDa protein 3Two-hybridBioGRID16169070 
HSPE1CPN10 | GROES | HSP10heat shock 10kDa protein 1 (chaperonin 10)Two-hybridBioGRID16169070 
ID2GIG8 | ID2A | ID2H | MGC26389 | bHLHb26inhibitor of DNA binding 2, dominant negative helix-loop-helix proteinTwo-hybridBioGRID16169070 
IL5RACD125 | CDw125 | HSIL5R3 | IL5R | MGC26560interleukin 5 receptor, alpha-HPRD,BioGRID12496276 
ITSN1ITSN | MGC134948 | MGC134949 | SH3D1A | SH3P17intersectin 1 (SH3 domain protein)Two-hybridBioGRID16169070 
LAMA4DKFZp686D23145 | LAMA3 | LAMA4*-1laminin, alpha 4Two-hybridBioGRID16169070 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD,BioGRID14757743 
LUC7L2CGI-59 | CGI-74 | FLJ10657 | LUC7B2LUC7-like 2 (S. cerevisiae)Two-hybridBioGRID16169070 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homolog-HPRD,BioGRID12496276 
MAPK10FLJ12099 | FLJ33785 | JNK3 | JNK3A | MGC50974 | PRKM10 | p493F12 | p54bSAPKmitogen-activated protein kinase 10Two-hybridBioGRID16169070 
MPHOSPH6MPP | MPP-6 | MPP6M-phase phosphoprotein 6Two-hybridBioGRID16169070 
MRPS12MPR-S12 | MT-RPS12 | RPMS12 | RPS12 | RPSM12mitochondrial ribosomal protein S12Two-hybridBioGRID16169070 
ORAI2C7orf19 | CBCIP2 | FLJ12474 | FLJ14733 | FLJ44818 | TMEM142BORAI calcium release-activated calcium modulator 2Two-hybridBioGRID16169070 
PAFAH1B3-platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDaTwo-hybridBioGRID16169070 
PAPSS1ATPSK1 | PAPSS | SK13'-phosphoadenosine 5'-phosphosulfate synthase 1Two-hybridBioGRID16169070 
PCDHA4CNR1 | CNRN1 | CRNR1 | MGC138307 | MGC142169 | PCDH-ALPHA4protocadherin alpha 4Two-hybridBioGRID16169070 
PFN1-profilin 1Two-hybridBioGRID16169070 
PHF10FLJ10975 | MGC111009 | XAP135PHD finger protein 10Two-hybridBioGRID16169070 
PPA1IOPPP | MGC111556 | PP | PP1 | SID6-8061pyrophosphatase (inorganic) 1Two-hybridBioGRID16169070 
PPAP2CLPP2 | PAP-2c | PAP2-gphosphatidic acid phosphatase type 2CTwo-hybridBioGRID16169070 
PSMD11MGC3844 | Rpn6 | S9 | p44.5proteasome (prosome, macropain) 26S subunit, non-ATPase, 11Two-hybridBioGRID16169070 
PSMD2MGC14274 | P97 | Rpn1 | S2 | TRAP2proteasome (prosome, macropain) 26S subunit, non-ATPase, 2Two-hybridBioGRID16169070 
PTPRSPTPSIGMAprotein tyrosine phosphatase, receptor type, STwo-hybridBioGRID16169070 
QTRT1FP3235 | TGTqueuine tRNA-ribosyltransferase 1Two-hybridBioGRID16169070 
RFC5MGC1155 | RFC36replication factor C (activator 1) 5, 36.5kDaTwo-hybridBioGRID16169070 
RGL2HKE1.5 | KE1.5 | RAB2Lral guanine nucleotide dissociation stimulator-like 2Two-hybridBioGRID16169070 
RPA2REPA2 | RPA32replication protein A2, 32kDaTwo-hybridBioGRID16169070 
RUFY3KIAA0871 | RIPX | SINGAR1RUN and FYVE domain containing 3Two-hybridBioGRID16169070 
S100A418A2 | 42A | CAPL | FSP1 | MTS1 | P9KA | PEL98S100 calcium binding protein A4Two-hybridBioGRID16169070 
S100A860B8AG | CAGA | CFAG | CGLA | CP-10 | L1Ag | MA387 | MIF | MRP8 | NIF | P8S100 calcium binding protein A8Two-hybridBioGRID16169070 
SAT1DC21 | KFSD | SAT | SSAT | SSAT-1spermidine/spermine N1-acetyltransferase 1Two-hybridBioGRID16169070 
SEPHS1MGC4980 | SELD | SPS | SPS1selenophosphate synthetase 1Two-hybridBioGRID16169070 
SERPINB9CAP-3 | CAP3 | PI9serpin peptidase inhibitor, clade B (ovalbumin), member 9Two-hybridBioGRID16169070 
SMN1BCD541 | SMA | SMA1 | SMA2 | SMA3 | SMA4 | SMA@ | SMN | SMNT | T-BCD541survival of motor neuron 1, telomericTwo-hybridBioGRID16169070 
SULT1E1EST | EST-1 | MGC34459 | STEsulfotransferase family 1E, estrogen-preferring, member 1Two-hybridBioGRID16169070 
TK1TK2thymidine kinase 1, solubleTwo-hybridBioGRID16169070 
TP53BP253BP2 | ASPP2 | BBP | PPP1R13A | p53BP2tumor protein p53 binding protein, 2Two-hybridBioGRID16169070 
TP53I3PIG3tumor protein p53 inducible protein 3Two-hybridBioGRID16169070 
TRDMT1DNMT2 | M.HsaIIP | PuMet | RNMT1tRNA aspartic acid methyltransferase 1Two-hybridBioGRID16169070 
UBE2BE2-17kDa | HHR6B | HR6B | RAD6B | UBC2ubiquitin-conjugating enzyme E2B (RAD6 homolog)Two-hybridBioGRID16169070 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)Two-hybridBioGRID16169070 
UBQLN4A1U | C1orf6 | CIP75 | UBINubiquilin 4Two-hybridBioGRID16169070 
ZFP64MGC940 | ZNF338zinc finger protein 64 homolog (mouse)Two-hybridBioGRID16169070 
ZNF24KOX17 | RSG-A | ZNF191 | ZSCAN3 | Zfp191zinc finger protein 24Two-hybridBioGRID16169070 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
MULLIGHAN MLL SIGNATURE 1 UP 380236All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418263All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 3 4WK UP 214144All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 DN 6638All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM2 153102All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q11 Q21 AMPLICON 13378All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION UP 14293All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION UP 4826All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS DN 8769All SZGR 2.0 genes in this pathway
YAGI AML FAB MARKERS 191131All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING UP 10176All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP 428266All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 6 189112All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P6 9144All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299189All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE 346192All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER BRCA1 DN 4428All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC UP 7253All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP 211131All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP 281183All SZGR 2.0 genes in this pathway
LIU IL13 MEMORY MODEL UP 1712All SZGR 2.0 genes in this pathway